Molecular Biology Reports, Год журнала: 2024, Номер 52(1)
Опубликована: Дек. 9, 2024
Язык: Английский
Frontiers in Pharmacology, Год журнала: 2025, Номер 16
Опубликована: Янв. 24, 2025
Polyphenols, naturally occurring phytonutrients found in plant-based foods, have attracted significant attention for their potential therapeutic effects neurological diseases and neuroinflammation. These compounds possess diverse neuroprotective capabilities, including antioxidant, anti-inflammatory, anti-amyloid properties, which contribute to mitigating the progression of neurodegenerative conditions such as Alzheimer's Disease (AD), Parkinson's (PD), Dementia, Multiple Sclerosis (MS), Stroke, Huntington's (HD). Polyphenols been extensively studied ability regulate inflammatory responses by modulating activity pro-inflammatory genes influencing signal transduction pathways, thereby reducing neuroinflammation neuronal death. Additionally, polyphenols shown promise various cellular signaling pathways associated with viability, synaptic plasticity, cognitive function. Epidemiological clinical studies highlight polyphenol-rich diets decrease risk alleviate symptoms disorders Furthermore, demonstrated through regulation key Akt, Nrf2, STAT, MAPK, play critical roles neuroprotection body's immune response. This review emphasizes growing body evidence supporting combating neurodegeneration neuroinflammation, well enhancing brain health. Despite substantial promising hypotheses, further research investigations are necessary fully understand role establish them advanced targets age-related neuroinflammatory conditions.
Язык: Английский
Процитировано
3
ACS Chemical Neuroscience, Год журнала: 2024, Номер 15(16), С. 2966 - 2981
Опубликована: Июль 31, 2024
Sinapic acid (SA) is a phenylpropanoid derivative found in various natural sources that exhibits remarkable versatile properties, including antioxidant, anti-inflammatory, and metal-chelating capabilities, establishing itself as promising candidate for the prevention treatment of conditions affecting central nervous system, such Alzheimer's disease (AD), Parkinson's (PD), ischemic stroke, other neurological disorders. These effects also include neuroprotection epilepsy models, evidenced by reduction seizure-like behavior, cell death specific hippocampal regions, lowered neuroinflammatory markers. In AD, SA enhances memory, reverses cognitive deficits, attenuates astrocyte activation. has positive on cognition improving memory lowering oxidative stress. This shown lower levels stress markers, higher antioxidant enzyme activity, better retention. Additionally, stroke PD provides microglial protection exerts anti-inflammatory effects. review emphasizes SA's multifaceted neuroprotective properties its potential role brain Despite need further research to fully understand mechanisms action clinical applicability, stands out valuable bioactive compound ongoing quest combat neurodegenerative diseases enhance quality life affected individuals.
Язык: Английский
Процитировано
4
Molecular Pharmaceutics, Год журнала: 2024, Номер 21(10), С. 4786 - 4803
Опубликована: Сен. 4, 2024
Recently, the incidence of brain diseases, such as central nervous system degenerative tumors, and cerebrovascular has increased. However, blood-brain barrier (BBB) limits effective delivery drugs to disease areas. Therefore, mainstream direction new drug development for these diseases is engineer that can better cross BBB exert their effects in brain. This paper reviews research progress application main trans-BBB strategies (receptor/transporter-mediated crossing, focused ultrasound open BBB, adenosine agonist reversible opening aromatic resuscitation, transnasal administration, cell-mediated viral vector system-mediated delivery). Meanwhile, potential applications, advantages, disadvantages crossing are analyzed. Finally, future prospects also discussed. These have value treating diseases.
Язык: Английский
Процитировано
3
Phytotherapy Research, Год журнала: 2024, Номер unknown
Опубликована: Дек. 11, 2024
With the passage of time, people step toward old age and become more prone to several diseases associated with age. One such is Alzheimer's disease (AD) which results into neuronal damage dementia progression The existing therapeutics has been hindered by various enkindles like less eminent between remote populations, affordability issues toxicity profiles. Moreover, lack suitable therapeutic option further worsens quality life in older population. Developing an efficient intervention cure AD still a challenge for medical fraternity. Recently, alternative approaches attain attention researchers focus on plant-based therapy mitigating AD. In this context, flavonoids gained centrality as feasible treatment modifying neurological deficits. This review mainly focuses pathological facets economic burden Furthermore, we have explored possible mechanism preclinical clinical aspects curing Flavonoids being potential therapeutic, target pathogenic factors oxidative stress, inflammation, metal toxicity, Aβ accumulation, modulate neurotransmission insulin signaling. review, emphasized neuroprotective effects pathology, both experimental findings. While studies suggest promising benefits, data remains limited inconclusive. Thus, high-quality trials are necessary validate efficacy study aim promote therapies encourage add regular diet avail beneficial preventive
Язык: Английский
Процитировано
2
Neurochemistry International, Год журнала: 2024, Номер 180, С. 105859 - 105859
Опубликована: Сен. 10, 2024
Язык: Английский
Процитировано
1
Molecular Biology Reports, Год журнала: 2024, Номер 52(1)
Опубликована: Дек. 9, 2024
Язык: Английский
Процитировано
1