Drug and Chemical Toxicology,
Год журнала:
2024,
Номер
unknown, С. 1 - 10
Опубликована: Ноя. 13, 2024
Maternal
exposure
to
zearalenone
(ZEA),
a
mycotoxin,
can
impact
fetal
liver
development.
This
study
investigated
the
protective
effects
of
carvacrol
(CRV)
against
ZEA-induced
damage.
Thirty-two
pregnant
rats
were
allocated
four
groups
(eight
rats/group);
control,
CRV
(75
mg/kg),
ZEA
(5
and
co-treated
group
(ZEA
+
CRV).
The
animals
given
their
doses
during
gestation
period.
revealed
significant
increase
in
malondialdehyde
(MDA)
level
liver.
In
contrast,
glutathione
S-transferase
(GST),
superoxide
dismutase
(SOD),
catalase
(CAT)
activities,
besides
(GSH)
levels,
decreased
ZEA-intoxicated
rats.
Additionally,
increased
expression
pro-apoptotic
genes
(P53,
Bax,
caspase-9),
elevated
immunoreactivity
caspase-3,
anti-apoptotic
Bcl-2,
induced
severe
fatty
degeneration,
congestion,
necrosis
comet
assays
DNA
damage,
as
evidenced
by
reduced
head
content
tail
moment
ZEA-exposed
Surprisingly,
co-treatment
with
significantly
mitigated
hepatic
lipid
peroxidation,
antioxidant
disturbance,
apoptosis,
damage
after
maternal
ZEA.
These
findings
highlight
potential
promising
approach
mitigate
ZEA-associated
developmental
hepatotoxicity.
Journal of Biochemical and Molecular Toxicology,
Год журнала:
2024,
Номер
38(3)
Опубликована: Март 1, 2024
Abstract
Cadmium
(Cd)
is
a
multitarget,
carcinogenic,
nonessential
environmental
pollutant.
Due
to
its
toxic
effects
at
very
low
concentrations,
lengthy
biological
half‐life,
and
excretion
rate,
exposure
Cd
carries
concern.
Prolonged
causes
severe
injury
the
nervous
system
of
both
humans
animals.
Nevertheless,
precise
mechanisms
responsible
for
neurotoxic
have
yet
be
fully
elucidated.
The
accurate
chemical
mechanism
potentially
entails
destruction
metal‐ion
homeostasis,
inducing
oxidative
stress,
apoptosis,
autophagy.
Here
we
review
evidence
corresponding
strategies
protect
against
Cd‐induced
central
injury.
Biomedicines,
Год журнала:
2024,
Номер
12(2), С. 365 - 365
Опубликована: Фев. 4, 2024
Ageing
is
a
natural
process
characterized
by
time-dependent
decline
of
physiological
integrity
that
compromises
functionality
and
inevitably
leads
to
death.
This
also
quite
relevant
in
major
human
pathologies,
being
primary
risk
factor
neurodegenerative
diseases,
metabolic
disorders,
cardiovascular
diseases
musculoskeletal
disorders.
Bearing
this
mind,
it
not
surprising
research
aiming
at
improving
health
during
has
burst
the
last
decades.
Importantly,
hallmarks
ageing
phenotype
have
been
identified,
knowledge
for
future
studies
towards
identification
putative
pharmaceutical
targets,
enabling
development
preventive/therapeutic
strategies
improve
longevity.
In
context,
aromatic
plants
emerged
as
source
potential
bioactive
volatile
molecules,
mainly
monoterpenes,
with
many
referring
their
anti-ageing
potential.
Nevertheless,
an
integrated
review
on
current
lacking,
several
approaches
studying
isolated
or
overall
effect,
without
depicting
possible
mechanisms
action.
Herein,
we
aim
provide
updated
systematization
monoterpenes
recently
proposed
hallmarks,
highlight
main
action
already
well
chemical
entity–activity
relations.
By
gathering
categorizing
available
scattered
information,
identify
important
gaps
could
help
pave
way
field.
Environmental Toxicology,
Год журнала:
2024,
Номер
39(12), С. 5227 - 5237
Опубликована: Авг. 6, 2024
ABSTRACT
Mercuric
chloride
(HgCl
2
)
is
extremely
toxic
to
both
humans
and
animals.
It
could
be
absorbed
via
ingestion,
inhalation,
skin
contact.
Exposure
HgCl
can
cause
severe
health
effects,
including
damages
the
gastrointestinal,
respiratory,
central
nervous
systems.
The
purpose
of
this
work
was
explore
if
carvacrol
(CRV)
protect
rats
lungs
from
damage
caused
by
.
Intraperitoneal
injections
at
a
dose
1.23
mg/kg
body
weight
were
given
either
alone
or
in
conjunction
with
oral
CRV
administration
doses
25
50
for
7
days.
study
included
biochemical
histological
techniques
examine
lung
tissue's
oxidative
stress,
apoptosis,
inflammation,
autophagy
processes.
‐induced
reductions
GSH
levels
antioxidant
enzymes
(SOD,
CAT,
GPx)
activity
enhanced
co‐administration.
Furthermore,
MDA
lowered
CRV.
inflammatory
mediators
NF‐κB,
IκB,
NLRP3,
TNF‐α,
IL‐1β,
IL6,
COX‐2,
iNOS
all
reduced
When
exposed
,
apoptotic
Bax,
caspase‐3,
Apaf1,
p53,
caspase‐6,
caspase‐9
increased,
but
antiapoptotic
Bcl‐2
after
treatment.
decreased
Beclin‐1,
LC3A,
LC3B,
which
turn
damage.
After
treatment,
higher
pathological
observed
terms
alveolar
septal
thickening,
congestion,
edema,
cell
infiltration
compared
control
group
while
ameliorated
these
effects.
Consequently,
preventing
increases
stress
corresponding
autophagy,
disturbance
tissue
integrity
tissues,
might
seen
as
useful
therapeutic
alternative.
Clinical and Experimental Pharmacology and Physiology,
Год журнала:
2024,
Номер
51(3)
Опубликована: Янв. 20, 2024
Abstract
The
study
aimed
to
investigate
the
harmful
effects
of
acrylamide
(AA),
which
forms
in
carbohydrate‐rich
foods
at
temperatures
above
120°C,
on
central
and
peripheral
nervous
systems
evaluate
potential
neuroprotective
carvacrol
(CRV).
Male
Wistar
Albino
rats
were
subjected
AA
(40
mg/kg/bw/day)
CRV
(50
for
15
days.
Following
last
administration,
evaluations
revealed
disrupted
gait,
heightened
thermal
sensitivity
altered
paw
withdrawal
thresholds
AA‐exposed
rats.
Notably,
reduced
glutathione
(GSH)
raised
malondialdehyde
(MDA)
levels
both
brain
sciatic
nerve
tissues.
nuclear
factor
erythroid
2‐related
2
(Nrf2),
caspase
3
κB
(NF‐κB)
gene
expressions
while
decreasing
NR4A2.
co‐administration
mitigated
gait
abnormalities,
elevated
GSH
lowered
MDA
also
modulated
expression,
reducing
Nrf2
NF‐κB
increasing
Histopathological
signs
AA‐induced
neurodegeneration
glial
fibrillary
acidic
protein
observed
tissues
rectified
with
simultaneous
administration
CRV,
thereby
demonstrating
efficacy
regions.
This
is
pioneering
CRV's
against
neurotoxicity
systems,
effectively
addressing
limitations
literature.
In
conclusion,
nerve,
significantly
mitigating
this
neurotoxicity.
novel
research
underscores
promise
as
a
agent
adverse
systems.
Toxics,
Год журнала:
2025,
Номер
13(2), С. 87 - 87
Опубликована: Янв. 24, 2025
This
study
investigated
the
protective
effect
of
selenium
(Se)
in
a
cadmium
(Cd)-induced
nephrotoxicity
model
rats
and
role
TRPM2
channel
this
mechanism.
For
purpose,
Cd
(25
mg/kg
orally),
Se
(0.5
i.p.),
2-aminoethoxydiphenyl
borate
(2-APB),
antagonist,
(3
i.p.)
were
administered
to
every
day
for
5
days.
At
end
study,
kidney
tissues
analysed
using
histological
biochemical
methods.
A
histopathological
examination
revealed
congestion,
tubular
degeneration,
necrosis,
glomerular
adhesion
group.
However,
these
lesions
significantly
reduced
+
2-APB
groups,
while
group
showed
appearance
similar
control
Immunohistochemical
analysis
that
Caspase-3,
Bax,
expression
was
higher
group,
levels
lower
treatment
groups
(p
<
0.05).
Among
received
Cd,
urea,
creatinine,
TOS,
TNF-α,
IL-1β
at
highest
level
TAS
lowest
The
modulated
parameters;
however,
compared
brought
closer
These
findings
indicated
targeting
inactivation
together
with
could
alleviate
Cd-induced
nephrotoxicity.
