Melatonin alleviates 3,3′,4,4′,5‐pentachlorobenzene induced colon injury by relieving oxidative stress DOI
Jintao Zhang, Shanshan Li, Yu Xia

и другие.

Environmental Toxicology, Год журнала: 2023, Номер 38(12), С. 2993 - 3005

Опубликована: Авг. 20, 2023

3,3',4,4',5-pentachlorobiphenyl (PCB126) is widely distributed, non-degradable and bioaccumulative, which can affect the function of tissues organs living organisms. Melatonin (MT) a sort indole neurohormone that mainly secreted by pineal gland. Numerous studies have shown MT alleviate intestinal injury through various mechanisms such as antioxidant, anti-inflammatory, anti-apoptosis. For above reasons, aim this study to explore mechanism in mice after exposure PCB126 well antagonistic effect MT. Mice were respectively fed (0.326 mg/kg) and/or (10 vivo. In vitro, colonic epithelial cells (MCEC) treated with (150 μM) (2 mM). We found microscopic structure colon tissue was impaired PCB126. The levels oxidative stress, protein mRNA expression inflammatory related factors significantly increased tight junction decreased. Notably, promote Nrf2/HO-1 level reduce caused Further vitro treatment reactive oxygen species inhibitors (NAC) showed it alleviated PCB126-induced MCEC cell damage. summary, results suggested alleviates inflammation inhibiting overproduction (ROS) up-regulating protein. Our contribute further comprehension toxicity effects significant role preserving injury.

Язык: Английский

Baicalin suppressed necroptosis and inflammation against chlorpyrifos toxicity; involving in ER stress and oxidative stress in carp gills DOI
Xiaojing Li,

Yichen Bai,

Yanju Bi

и другие.

Fish & Shellfish Immunology, Год журнала: 2023, Номер 139, С. 108883 - 108883

Опубликована: Июнь 5, 2023

Язык: Английский

Процитировано

49
Di (2-ethylhexyl) phthalate and polystyrene microplastics co-exposure caused oxidative stress to activate NF-κB/NLRP3 pathway aggravated pyroptosis and inflammation in mouse kidney DOI
Shanshan Li,

Xuedie Gu,

Muyue Zhang

и другие.

The Science of The Total Environment, Год журнала: 2024, Номер 926, С. 171817 - 171817

Опубликована: Март 19, 2024

Язык: Английский

Процитировано

14
Selenium alleviates endoplasmic reticulum calcium depletion-induced endoplasmic reticulum stress and apoptosis in chicken myocardium after mercuric chloride exposure DOI

Pei‐Chao Gao,

Anqi Wang, Xuewei Chen

и другие.

Environmental Science and Pollution Research, Год журнала: 2023, Номер 30(18), С. 51531 - 51541

Опубликована: Фев. 22, 2023

Язык: Английский

Процитировано

21
Resveratrol alleviates imidacloprid‐induced mitochondrial apoptosis, necroptosis, and immune dysfunction in chicken lymphocyte lines by inhibiting the ROS/MAPK signaling pathway DOI
Xiaodan Wang,

Jiatong Sun,

Tong Xu

и другие.

Environmental Toxicology, Год журнала: 2023, Номер 39(4), С. 2052 - 2063

Опубликована: Дек. 14, 2023

Abstract Imidacloprid (IMI) is a neonicotinoid insecticide with the highest global market share, and IMI exposure in environment can negatively affect many nontarget organisms (a general term for affected by drugs other than target organisms). Resveratrol (RSV), non‐flavonoid polyphenolic organic compound derived from peanuts, grapes, plants, has anti‐inflammatory antioxidant effects. It currently unclear how RSV protects against cell damage caused IMI. Therefore, we established an experimental model of chicken lymphocyte lines exposed to 110 μg/mL and/or 0.5 μM 24 h. According results, markedly raised intracellular reactive oxygen species levels diminished activity cellular enzymes (CAT, SOD, GPx), leading MDA accumulation decreased T‐AOC. JNK , ERK P38 essential components mitogen‐activated protein kinase (MAPK) signaling pathway, were also expressed more when was present. Additionally, resulted upregulation mitochondrial apoptosis ( Caspase 3 9 Bax Cyt‐c ) necroptosis 8 RIPK1 RIPK3 MLKL related factors expression, downregulation Bcl‐2 induction cytokine IL‐6 TNF‐α IFN‐γ expression. The combined treatment significantly reduced oxidative stress levels, inhibited MAPK alleviated IMI‐induced apoptosis, necroptosis, immune dysfunction. To summarize, antagonized dysfunction inhibiting ROS/MAPK pathway.

Язык: Английский

Процитировано

16
Mitigation of Imidacloprid Toxicity in Poultry Chicken by Selenium Nanoparticles: Growth Performance, Lipid Peroxidation, and Blood Traits DOI Creative Commons
Yahya Eid,

Yassin Omara,

Asmaa Ragab

и другие.

Biological Trace Element Research, Год журнала: 2023, Номер 201(11), С. 5379 - 5388

Опубликована: Фев. 15, 2023

Abstract Imidacloprid is an insecticide that protects against insects in the agriculture, animal, and poultry production sectors. Since accumulation of imidacloprid induces adverse impacts on general health status quality food chain, this study tested broilers. Besides, selenium nanoparticles were fed to birds relieve negative growth performance status. Birds (1-day age, initial weight 46.05 ± 1.0 g) divided into four groups (triplicates) where 15 chicks each replicate (45 for group). The first group (control) was basal diet without either or toxicity. second nano form at 3 mg/kg. third exposed 1/10 LT 50 (3 mg/kg body weight). fourth mg/kg) All kept under same conditions 35 days. final gain showed marked improvement compared imidacloprid-exposed group, while feed intake conversion ratio markedly reduced. red blood cells higher values than control those imidacloprid. Interestingly, hemoglobulin hematocrit increased with exposure. Furthermore, white total protein, albumin, globulin feeding. had aspartate aminotransferase (AST), alanine (ALT), malondialdehyde levels remaining groups. Accordingly, dietary are suggested broiler cope effects

Язык: Английский

Процитировано

15
Astilbin targeted Sirt1 to inhibit acetylation of Nrf2 to alleviate grass carp hepatocyte apoptosis caused by PCB126-induced mitochondrial kinetic and metabolism dysfunctions DOI
Xia Yu, Shanshan Li, Xixi Wang

и другие.

Fish & Shellfish Immunology, Год журнала: 2023, Номер 141, С. 109000 - 109000

Опубликована: Авг. 18, 2023

Язык: Английский

Процитировано

15
Signalling regulation of reactive oxygen species in fish inflammation DOI
Feng Gao, Yanjing Zhao, Xiaowei Shi

и другие.

Reviews in Aquaculture, Год журнала: 2024, Номер 16(3), С. 1266 - 1285

Опубликована: Янв. 29, 2024

Abstract Reactive oxygen species (ROS), which are key cellular signalling molecules, reactive chemicals containing oxygen. Cell survival or death is a critical issue in the inflammatory response. Accumulation of ROS involves generation and scavenging, determine homeostasis. Understanding roles modulating response fish vital for helping protect from damage water pollutants harsh environmental conditions. ROS‐related genes pathways relatively conserved but vary among different species. Recent frequent incidences diseases have posed considerable challenge to large‐scale aquaculture. important stress perception, integration diverse stress‐responsive networks, activation animal defence mechanisms, frequently occur during inflammation fish. This review summarises recent studies on Furthermore, it examines relationship between may contribute understanding underlying mechanisms by regulate provide suggestions sustainable development

Язык: Английский

Процитировано

5
Disruption of the intestinal barrier by avermectin in carp involves oxidative stress and apoptosis and leads to intestinal inflammation DOI

Hairui Han,

Nana He,

Enzhuang Pan

и другие.

Pesticide Biochemistry and Physiology, Год журнала: 2023, Номер 195, С. 105531 - 105531

Опубликована: Июль 13, 2023

Язык: Английский

Процитировано

11
Euodiae Fructus: a review of botany, application, processing, phytochemistry, quality control, pharmacology, and toxicology DOI Creative Commons

Yule Hao,

Jiawen Qi,

Xinggui Huang

и другие.

Frontiers in Pharmacology, Год журнала: 2025, Номер 16

Опубликована: Янв. 29, 2025

Euodiae Fructus (EF) is the dried and nearly ripe fruit of Euodia rutaecarpa , first recorded in Shen Nong’s Herbal Classic . EF a versatile Traditional Chinese Medicine (TCM) known for effects dispelling colds alleviating pain, suppressing adverse qi to relieve vomiting, boosting yang mitigate diarrhea. However, it should be noted that possesses mild toxicity. In TCM prescriptions, employed treat various ailments, including abdominal diarrhea, chronic non-atrophic gastritis, irritable bowel syndrome, primary dysmenorrhea. This review collected literature published before September 2024 on EF. An exhaustive analysis was conducted utilizing multiple sources, namely classic books scientific databases like Web Science, PubMed, Elsevier, ACS, ResearchGate, Google Scholar, National Knowledge Infrastructure. So far, more than 300 metabolites have been extracted identified from EF, exhibiting pharmacological effects, such as cardiovascular protection, gastrointestinal neuroprotection, anti-inflammation, analgesia, anti-tumor, glucose lipid metabolism regulation, etc. It also exhibits diverse toxicological properties poses specific toxic risks liver, heart, kidney. Nonetheless, research scarce regarding toxicology especially its cardiotoxicity nephrotoxicity. Further in-depth necessary explore mechanisms underlying EF’s develop strategies quality control toxicity mitigation. The can reduced by processing, but this aspect rarely discussed, needs further standardized. Evodiamine, rutaecarpine, limonin are effective one causes evodiamine rutaecarpine intensely studied, there few studies other Therefore, paper focuses botanical characteristics, traditional applications, processing methods, phytochemistry, control, pharmacology, We hope provides theoretical basis future high-value high-connotation development

Язык: Английский

Процитировано

0
Magnolin ameliorates acetaminophen-induced liver injury in mice via modulating the MAPK pathway and lipid metabolism DOI
Ting Yao, Youhe Wu,

Liyun Fu

и другие.

Toxicology and Applied Pharmacology, Год журнала: 2025, Номер unknown, С. 117264 - 117264

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

0