Naunyn-Schmiedeberg s Archives of Pharmacology,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 28, 2024
Abstract
Hypoxia
and
tumor
cell
immunological
escape
greatly
hinder
the
hepatocellular
carcinoma
(HCC)
treatment
efficiency.
This
study
is
designed
to
investigate
capability
of
carvacrol
(CVR)
enhance
sorafenib
(SOR)
anti-cancer
efficacy
modulate
anti-HCC
immunity.
CVR
target
biological
activities
were
predicted
using
Swiss
Target
Prediction
website
PASS
web
server.
UALCAN
LinkedOmics
databases
used
examine
hypoxia-inducible
factor
1-alpha
(HIF-1α)
expression
relationship
between
studied
genes
clinical
features.
Kaplan–Meier
plotter
(KM
plotter)
TISIDB
illustrate
correlation
HIF-1α
with
HCC
prognosis
immune
infiltration.
The
binding
affinities
p300,
KAT2B,
CREBBP,
Hsp90
demonstrated
by
molecular
docking.
In
vivo
analysis
was
performed
in
male
Sprague–Dawley
rats.
STAT3,
JAK2,
fibrinogen-like
protein
1
(FGL1)
expressions
assessed
qRT-PCR.
FGL1
determined
ELISA.
CD8
+
T
number
counted
flow
cytometry.
immunohistochemistry.
showed
an
inhibitory
potential,
which
highly
expressed
tissues.
Also,
elevated
has
been
found
be
correlated
clinicopathological
characteristics,
poor
survival
patients,
CVR/SOR
enhanced
liver
functions
decreased
AFP
level.
hindered
progression
downregulating
FGL1.
induced
immunity
via
increasing
cells.
a
powerful
combination
for
repression
enhancing
SOR
efficiency
modulating
Moreover,
might
exert
aforementioned
effects
through
HIF-1α/STAT3/FGL1
pathway.
Journal of Biochemical and Molecular Toxicology,
Journal Year:
2024,
Volume and Issue:
38(3)
Published: March 1, 2024
Abstract
Cadmium
(Cd)
is
a
multitarget,
carcinogenic,
nonessential
environmental
pollutant.
Due
to
its
toxic
effects
at
very
low
concentrations,
lengthy
biological
half‐life,
and
excretion
rate,
exposure
Cd
carries
concern.
Prolonged
causes
severe
injury
the
nervous
system
of
both
humans
animals.
Nevertheless,
precise
mechanisms
responsible
for
neurotoxic
have
yet
be
fully
elucidated.
The
accurate
chemical
mechanism
potentially
entails
destruction
metal‐ion
homeostasis,
inducing
oxidative
stress,
apoptosis,
autophagy.
Here
we
review
evidence
corresponding
strategies
protect
against
Cd‐induced
central
injury.
Environmental Toxicology,
Journal Year:
2024,
Volume and Issue:
39(12), P. 5227 - 5237
Published: Aug. 6, 2024
ABSTRACT
Mercuric
chloride
(HgCl
2
)
is
extremely
toxic
to
both
humans
and
animals.
It
could
be
absorbed
via
ingestion,
inhalation,
skin
contact.
Exposure
HgCl
can
cause
severe
health
effects,
including
damages
the
gastrointestinal,
respiratory,
central
nervous
systems.
The
purpose
of
this
work
was
explore
if
carvacrol
(CRV)
protect
rats
lungs
from
damage
caused
by
.
Intraperitoneal
injections
at
a
dose
1.23
mg/kg
body
weight
were
given
either
alone
or
in
conjunction
with
oral
CRV
administration
doses
25
50
for
7
days.
study
included
biochemical
histological
techniques
examine
lung
tissue's
oxidative
stress,
apoptosis,
inflammation,
autophagy
processes.
‐induced
reductions
GSH
levels
antioxidant
enzymes
(SOD,
CAT,
GPx)
activity
enhanced
co‐administration.
Furthermore,
MDA
lowered
CRV.
inflammatory
mediators
NF‐κB,
IκB,
NLRP3,
TNF‐α,
IL‐1β,
IL6,
COX‐2,
iNOS
all
reduced
When
exposed
,
apoptotic
Bax,
caspase‐3,
Apaf1,
p53,
caspase‐6,
caspase‐9
increased,
but
antiapoptotic
Bcl‐2
after
treatment.
decreased
Beclin‐1,
LC3A,
LC3B,
which
turn
damage.
After
treatment,
higher
pathological
observed
terms
alveolar
septal
thickening,
congestion,
edema,
cell
infiltration
compared
control
group
while
ameliorated
these
effects.
Consequently,
preventing
increases
stress
corresponding
autophagy,
disturbance
tissue
integrity
tissues,
might
seen
as
useful
therapeutic
alternative.
Toxics,
Journal Year:
2025,
Volume and Issue:
13(2), P. 87 - 87
Published: Jan. 24, 2025
This
study
investigated
the
protective
effect
of
selenium
(Se)
in
a
cadmium
(Cd)-induced
nephrotoxicity
model
rats
and
role
TRPM2
channel
this
mechanism.
For
purpose,
Cd
(25
mg/kg
orally),
Se
(0.5
i.p.),
2-aminoethoxydiphenyl
borate
(2-APB),
antagonist,
(3
i.p.)
were
administered
to
every
day
for
5
days.
At
end
study,
kidney
tissues
analysed
using
histological
biochemical
methods.
A
histopathological
examination
revealed
congestion,
tubular
degeneration,
necrosis,
glomerular
adhesion
group.
However,
these
lesions
significantly
reduced
+
2-APB
groups,
while
group
showed
appearance
similar
control
Immunohistochemical
analysis
that
Caspase-3,
Bax,
expression
was
higher
group,
levels
lower
treatment
groups
(p
<
0.05).
Among
received
Cd,
urea,
creatinine,
TOS,
TNF-α,
IL-1β
at
highest
level
TAS
lowest
The
modulated
parameters;
however,
compared
brought
closer
These
findings
indicated
targeting
inactivation
together
with
could
alleviate
Cd-induced
nephrotoxicity.
