Heliyon,
Год журнала:
2024,
Номер
10(22), С. e40233 - e40233
Опубликована: Ноя. 1, 2024
Premenstrual
syndrome
(PMS)
encompasses
a
range
of
emotional,
physiological,
and
behavioral
symptoms
that
occur
during
the
luteal
phase
menstrual
cycle
(MC)
resolve
with
onset
menstruation.
These
symptoms,
which
can
include
fatigue,
physical
pain,
anxiety,
irritability,
depression,
significantly
affect
women's
daily
lives
overall
well-being.
In
severe
cases,
PMS
progress
to
premenstrual
dysphoric
disorder
(PMDD),
profoundly
impairing
quality
life.
Despite
its
prevalence,
neural
mechanisms
underlying
PMS-particularly
those
related
stress-are
not
fully
understood.This
review
aims
explore
complex
interactions
between
stress,
focus
on
hormonal
pathways
involved.
We
propose
abnormal
stress
coping
styles
reactivity
patterns,
collectively
referred
as
dysfunction,
are
crucial
factors
influencing
vulnerability
PMS.
examine
relationship
from
four
perspectives:
(1)
shares
neuroendocrine
metabolic
circuits
based
fluctuations
systems;
(2)
there
is
comorbidity
stress-related
disorders;
(3)
itself
may
act
stressor,
potentially
creating
negative
feedback
loop
exacerbates
symptoms;
(4)
biofeedback
training
used
for
disorders
be
effective
in
treating
By
providing
detailed
analysis
changes
their
effects
PMS,
this
offers
new
insights
into
physiological
processes
Understanding
these
inform
development
targeted
interventions
improve
life
women
affected
by
Although
childhood
maltreatment
(CM)
is
widely
recognized
as
a
transdiagnostic
risk
factor
for
various
internalizing
and
externalizing
psychological
disorders,
the
neural
basis
underlying
this
association
remain
unclear.
The
potential
reasons
inconsistent
findings
may
be
attributed
to
involvement
of
both
common
specific
pathways
that
mediate
influence
on
emergence
psychopathological
conditions.
This
study
aimed
delineate
distinct
linking
depression
aggression.
First,
we
employed
Network-Based
Statistics
(NBS)
resting-state
functional
magnetic
resonance
imaging
(fMRI)
data
identify
connectivity
(FC)
patterns
associated
with
Mediation
analyses
were
then
conducted
assess
role
these
FC
in
relationship
between
each
outcome.
results
demonstrated
within
default
mode
network
(DMN)
cingulo-opercular
(CON)
dorsal
attention
(DAN)
mediated
aggression,
whereas
reward
system
CON
link
depression.
We
speculate
control
serve
accounting
sequela
maltreatment,
act
respectively.
Cells,
Год журнала:
2025,
Номер
14(6), С. 397 - 397
Опубликована: Март 8, 2025
Advanced
glycation
end
products
(AGEs)
are
a
series
of
structurally
complex
and
harmful
compounds
formed
through
the
reaction
between
carbonyl
group
reducing
sugars
(such
as
glucose
fructose)
free
amino
groups
proteins,
lipids,
or
nucleic
acids.
Excessive
accumulation
AGEs
in
body
can
trigger
oxidative
stress,
induce
inflammatory
responses,
contribute
to
development
diabetes,
atherosclerosis,
neurological
disorders.
Within
category
dicarbonyl
compounds,
methylglyoxal
(MGO)—a
byproduct
resulting
from
degradation—serves
pivotal
precursor
formation
induction
neurotoxicity.
Specifically,
generated
MGO
display
significant
cytotoxicity
toward
cells
central
nervous
system.
Therefore,
we
aimed
investigate
role
MGO-AGEs
neuroinflammation
mediated
by
CUMS.
Interestingly,
found
that
overexpression
glyoxalase
1
(GLO1)
reduced
levels
corticosterone-treated
microglia,
thereby
alleviating
response.
Furthermore,
GLO1
hippocampus
chronically
stressed
mice
levels,
mitigating
CUMS-induced
cognitive
impairment.
Additionally,
when
using
receptor
for
advanced
(RAGE)
inhibitor
FPS-ZM1
primary
microglia
cells,
observed
despite
corticosterone-induced
elevation
MGO,
no
response
occurred.
This
suggests
RAGE
clearance
reduce
MGO-AGE-mediated
Subsequently,
used
treat
it
significantly
ameliorated
dysfunction.
These
results
suggest
targeting
metabolism
could
serve
therapeutic
approach
manage
stress-related
mental
Biomedical Reports,
Год журнала:
2025,
Номер
22(3)
Опубликована: Янв. 14, 2025
Depression
and
coronary
heart
disease
(CHD)
are
two
interconnected
diseases
that
profoundly
impact
global
health.
is
both
a
complex
psychiatric
disorder
an
established
risk
factor
for
CHD.
Sirtuin
1
(SIRT1)
enzyme
requires
the
cofactor
nicotinamide
adenine
dinucleotide
(NAD+)
to
perform
its
deacetylation
function,
involvement
crucial
in
reducing
cardiovascular
risks
associated
with
depression.
SIRT1
exerts
cardioprotective
effects
via
modulating
oxidative
stress,
inflammation
metabolic
processes,
all
of
which
central
pathogenesis
CHD
individuals
Through
influencing
these
pathways,
helps
reduce
endothelial
dysfunction,
prevent
formation
atherosclerotic
plaques
stabilize
existing
plaques,
thereby
decreasing
overall
The
present
review
underscores
important
role
serving
as
therapeutic
intervention
molecule
tackling
complications
stemming
from
Furthermore,
it
highlights
need
further
studies
clarify
how
influences
depression
at
molecular
level.
ultimate
goal
this
research
will
be
translate
findings
into
practical
clinical
strategies.
Nutrients,
Год журнала:
2025,
Номер
17(3), С. 462 - 462
Опубликована: Янв. 27, 2025
Objectives:
Chronic
diseases
are
a
significant
public
health
issue,
especially
for
socioeconomically
vulnerable
population
groups.
The
purpose
of
this
study
is
to
compare
the
prevalence
chronic
in
people
receiving
and
not
BLS
determine
according
physical
activity
dietary
habits
BLS.
Methods:
Data
were
derived
from
sixth
ninth
waves
(2014–2022)
Korea
National
Health
Nutrition
Examination
Survey
(KNHANES),
focusing
on
15,041
participants
aged
65
older.
Demographic
characteristics,
intake,
activity,
disease
status
assessed.
Multivariate
logistic
regression
analysis
was
used
calculate
odds
ratios
habits.
Results:
group
exhibited
higher
rates
hypertension
diabetes,
along
with
lower
intake
energy,
protein,
fat,
carbohydrates,
fiber,
vitamin
C,
compared
non-BLS
group.
A
below-average
energy
carbohydrates
associated
increased
particularly
For
association
diabetes
found
only
Sedentary
behavior
exceeding
9
h
per
day
linked
both
groups,
stronger
associations
Limited
walking
frequency
(less
than
1
week)
further
exacerbated
risks.
Conclusions:
recipients
demonstrated
prevalence,
poorer
habits,
more
sedentary
non-recipients.
between
lifestyle
factors
generally
substantial
group,
suggesting
need
targeted
interventions
improve
quality
patterns
population.
Testosterone
is
a
key
hormone
with
complex
and
essential
role
in
the
physiology
of
healthy
individuals;
it
crucial
for
developing
maintaining
muscle
mass
improved
bone
density.
In
addition
to
these
physical
features,
testosterone
vital
reproductive
health
as
libido,
erectile
function,
spermatogenesis,
process
sperm
production;
its
impact
extends
across
multiple
bodily
systems,
highlighting
importance
traits
overall
fertility.
This
study
aims
explore
critical
multifaceted
individuals.
The
method
was
search
PubMed
from
year
1993
until
current
data
using
MESH
terms:
((((testosterone)
OR
(androgens))
(testosterone
insufficiency))
AND
(healthy
patients))
replacement))).
inclusion
criteria
are
studies
descriptive,
observational,
experimental
approaches
on
patients
that
evaluated
action
testosterone.
updated
review
indicates
supplementation
positively
influences
several
aspects,
including
sexual
health,
strength,
mood
(particularly
reducing
depression),
vascular
endothelial
function.
However,
findings
limited
by
small
sample
sizes
relatively
few
available
this
topic,
warranting
further
research
better
understand
full
scope
testosterone's
effects.
Recent
landmark
trials
have
demonstrated
therapy
offers
modest
benefits,
particularly
older
men
low
levels
symptoms
hypogonadism.
These
benefits
include
improvements
mood,
function
Given
potential
therapy,
ongoing
clinical
exploration
highly
recommended
deepen
our
understanding
range
effects
refine
therapeutic
strategies.
Doing
more
will
help
clarify
both
individuals
those
deficiency,
leading
better-informed
treatment
future.
