Metabolically‐Driven Active Targeting of Magnetic Nanoparticles Functionalized with Glucuronic Acid to Glioblastoma: Application to MRI‐Tracked Magnetic Hyperthermia Therapy DOI
Carlos Caro, Jose María Páez-Muñoz, Manuel Pernía Leal

и другие.

Advanced Healthcare Materials, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 22, 2024

Abstract Glioblastoma continues to pose a major global health challenge due its incurable nature. The need for new strategies combat this devastating tumor is therefore paramount. Nanotechnology offers unique opportunities develop innovative and more effective therapeutic approaches. However, most nanosystems developed treat glioblastomas, especially those based on metallic nanoparticles (NPs), have proven unsuccessful their inability efficiently target these tumors, which are particularly inaccessible the restrictions imposed by blood‐brain barrier (BBTB). Here, an strategy presented NPs glioblastomas through glucose transporters (GLUT) overexpressed endothelial cells of glioblastoma microvasculature, GLUT1. Specifically, Iron Oxide Nanoparticles (IONPs) functionalized with glucuronic acid promote GLUT‐mediated transcytosis drastically boosted inducing mild hypoglycemia. This metabolically‐driven active targeting has yielded unprecedented efficacy in glioblastomas. Moreover, IONPs, designed act as magnetic hyperthermia (MH) mediators, used conduct proof‐of‐concept preclinical study MRI‐tracked MH therapy following intravenous administration, resulting significant growth delay. These findings demonstrate unparalleled efficiency lay ground developing alternative glioblastoma.

Язык: Английский

Magnetic nanoparticles and clusters for magnetic hyperthermia: optimizing their heat performance and developing combinatorial therapies to tackle cancer DOI
Helena Gavilán, Sahitya Kumar Avugadda, Tamara Fernández

и другие.

Chemical Society Reviews, Год журнала: 2021, Номер 50(20), С. 11614 - 11667

Опубликована: Янв. 1, 2021

Magnetic hyperthermia (MHT) is a therapeutic modality for the treatment of solid tumors that has now accumulated more than 30 years experience. In ongoing MHT clinical trials brain and prostate tumors, iron oxide nanoparticles are employed as intra-tumoral agents under patient-safe 100 kHz alternating magnetic field (AMF) applicator. Although currently approved by FDA imaging purposes anemia, (MNPs) designed efficient must respond to specific physical-chemical properties in terms magneto-energy conversion, heat dose production, surface chemistry aggregation state. Accordingly, past few decades, these requirements have boosted development new generation MNPs specifically aimed MHT. this review, we present an overview on their assemblies produced via different synthetic routes, focusing which MNP features allowed unprecedented heating efficiency levels be achieved highlighting nanoplatforms prevent loss intracellular environment. Moreover, review advances MNP-based embrace concept multimodal therapy, aims combine with chemotherapy, radiotherapy, immunotherapy, photodynamic or phototherapy. Next, better control temperature at tumor, focus studies optimized maintain gold-standard performance also tackling aim quantitatively assess amount tumor site regulate conditions. To conclude, future perspectives guidance how advance therapy will provided.

Язык: Английский

Процитировано

339
Antiviral properties of copper and its alloys to inactivate covid-19 virus: a review DOI Creative Commons

V. Govind,

Shiv Bharadwaj,

M. Ganesh

и другие.

BioMetals, Год журнала: 2021, Номер 34(6), С. 1217 - 1235

Опубликована: Авг. 16, 2021

Язык: Английский

Процитировано

127
Superparamagnetic Ag-Fe3O4 composites nanoparticles for magnetic fluid hyperthermia DOI
Abdollah Hajalilou, Liliana P. Ferreira, M. E. Melo Jorge

и другие.

Journal of Magnetism and Magnetic Materials, Год журнала: 2021, Номер 537, С. 168242 - 168242

Опубликована: Июнь 26, 2021

Язык: Английский

Процитировано

74
Magnetite Nanoparticles: Synthesis and Applications in Optics and Nanophotonics DOI Open Access
N.O. Dudchenko, Shweta Pawar, Ilana Perelshtein

и другие.

Materials, Год журнала: 2022, Номер 15(7), С. 2601 - 2601

Опубликована: Апрель 1, 2022

Magnetite nanoparticles with different surface coverages are of great interest for many applications due to their intrinsic magnetic properties, nanometer size, and definite morphology. widely used medical-biological while usage in optics is not as widespread. In recent years, nanomagnetite suspensions, so-called ferrofluids, applied magneto-optical properties. This review gives an overview synthesis its addition, the preparation application nanofluids optics, nanophotonics, imaging described.

Язык: Английский

Процитировано

65
Magnetic Nanoparticles: Current Advances in Nanomedicine, Drug Delivery and MRI DOI Creative Commons
Cezar C. Comanescu

Chemistry, Год журнала: 2022, Номер 4(3), С. 872 - 930

Опубликована: Авг. 27, 2022

Magnetic nanoparticles (MNPs) have evolved tremendously during recent years, in part due to the rapid expansion of nanotechnology and their active magnetic core with a high surface-to-volume ratio, while surface functionalization opened door plethora drug, gene bioactive molecule immobilization. Taming reactivity was achieved by various techniques, producing MNPs tailored for diagnosis treatment cardiovascular or neurological disease, tumors cancer. Superparamagnetic iron oxide (SPIONs) are established at drug-delivery systems could act as efficient agents MFH (magnetic fluid hyperthermia). Depending on intrinsic morphological features, now cover broad scope which current review aims overview. Considering exponential field, will be limited roughly past three years.

Язык: Английский

Процитировано

57
Magnetic Fields and Cancer: Epidemiology, Cellular Biology, and Theranostics DOI Open Access
Massimo E. Maffei

International Journal of Molecular Sciences, Год журнала: 2022, Номер 23(3), С. 1339 - 1339

Опубликована: Янв. 25, 2022

Humans are exposed to a complex mix of man-made electric and magnetic fields (MFs) at many different frequencies, home work. Epidemiological studies indicate that there is positive relationship between residential/domestic occupational exposure extremely low frequency electromagnetic some types cancer, although other no relationship. In this review, after an introduction on the MF definition description natural/anthropogenic sources, epidemiology MFs cancer reviewed, with reference leukemia, brain, breast cancer. The in vivo vitro effects reviewed considering both human animal cells, particular involvement reactive oxygen species (ROS). application diagnostic therapy (theranostic) also by describing use resonance imaging (MRI) applications for detection several cancers. Finally, nanoparticles described terms treatment nanomedical precise delivery anticancer drugs, nanosurgery magnetomechanic methods, selective killing cells hyperthermia. supplementary tables provide quantitative data methodologies epidemiological cell biology studies. Although scientists do not generally agree cause-effect might be direct cause but may contribute produce ROS generate oxidative stress, which could trigger or enhance expression oncogenes.

Язык: Английский

Процитировано

43
Magnetic-silica nanocomposites and the functionalized forms for environment and medical applications: A review DOI
Is Fatimah, Ganjar Fadillah, Gani Purwiandono

и другие.

Inorganic Chemistry Communications, Год журнала: 2022, Номер 137, С. 109213 - 109213

Опубликована: Янв. 10, 2022

Язык: Английский

Процитировано

40
Modulation of calcium signaling and metabolic pathways in endothelial cells with magnetic fields DOI Creative Commons
Oksana Gorobets, Svitlana Gorobets, Tatyana Polyakova

и другие.

Nanoscale Advances, Год журнала: 2024, Номер 6(4), С. 1163 - 1182

Опубликована: Янв. 1, 2024

Magnetic field switches the frequency bands of calcium waves, thereby changing/closing enzyme activity and metabolic pathways.

Язык: Английский

Процитировано

14
Catalytic Nanoparticles in Biomedical Applications: Exploiting Advanced Nanozymes for Therapeutics and Diagnostics DOI
Divinah Manoharan,

Liu‐Chun Wang,

Ying‐Chi Chen

и другие.

Advanced Healthcare Materials, Год журнала: 2024, Номер 13(22)

Опубликована: Апрель 29, 2024

Catalytic nanoparticles (CNPs) as heterogeneous catalyst reveals superior activity due to their physio-chemical features, such high surface-to-volume ratio and unique optical, electric, magnetic properties. The CNPs, based on nature, can either increase the reactive oxygen species (ROS) level for tumor antibacterial therapy or eliminate ROS cytoprotection, anti-inflammation, anti-aging. In addition, catalytic of nanozymes specifically trigger a specific reaction accompanied by optical feature change, presenting feasibility biosensor bioimaging applications. Undoubtedly, CNPs play pivotal role in pushing evolution technologies medical clinical fields, advanced strategies nanomaterials rely input chemical experts develop. Herein, systematic comprehensive review challenges recent development biomedical applications is presented from viewpoint nanomaterial with additional functions. Furthermore, biosafety issue applying biodegradable non-biodegradable future perspectives are critically discussed guide promising direction developing span-new more intelligent overcoming current limitations.

Язык: Английский

Процитировано

14
Nanoparticle-mediated thermal Cancer therapies: Strategies to improve clinical translatability DOI Creative Commons
Martin Bravo, Beatrice Fortuni, Paul Mulvaney

и другие.

Journal of Controlled Release, Год журнала: 2024, Номер 372, С. 751 - 777

Опубликована: Июль 4, 2024

Despite significant advances, cancer remains a leading global cause of death. Current therapies often fail due to incomplete tumor removal and nonspecific targeting, spurring interest in alternative treatments. Hyperthermia, which uses elevated temperatures kill cells or boost their sensitivity radio/chemotherapy, has emerged as promising alternative. Recent advancements employ nanoparticles (NPs) heat mediators for selective cell destruction, minimizing damage healthy tissues. This approach, known NP hyperthermia, falls into two categories: photothermal (PTT) magnetothermal (MTT). PTT utilizes NPs that convert light heat, while MTT magnetic activated by alternating fields (AMF), both achieving localized damage. These methods offer advantages like precise minimal invasiveness, reduced systemic toxicity. However, the efficacy hyperthermia depends on many factors, particular, properties, microenvironment (TME), TME-NP interactions. Optimizing this treatment requires accurate monitoring strategies, such nanothermometry biologically relevant screening models can better mimic physiological features human body. review explores state-of-the-art NP-mediated discussing available nanomaterials, strengths weaknesses, characterization methods, future directions. Our particular focus lies preclinical techniques, providing an updated perspective relevance journey towards clinical trials.

Язык: Английский

Процитировано

11