Advances in Polysaccharide-Based Microneedle Systems for the Treatment of Ocular Diseases
Qingdong Bao,
Xiaoting Zhang,
Zhankun Hao
и другие.
Nano-Micro Letters,
Год журнала:
2024,
Номер
16(1)
Опубликована: Авг. 13, 2024
Abstract
The
eye,
a
complex
organ
isolated
from
the
systemic
circulation,
presents
significant
drug
delivery
challenges
owing
to
its
protective
mechanisms,
such
as
blood-retinal
barrier
and
corneal
impermeability.
Conventional
administration
methods
often
fail
sustain
therapeutic
levels
may
compromise
patient
safety
compliance.
Polysaccharide-based
microneedles
(PSMNs)
have
emerged
transformative
solution
for
ophthalmic
delivery.
However,
comprehensive
review
of
PSMNs
in
ophthalmology
has
not
been
published
date.
In
this
review,
we
critically
examine
synergy
between
polysaccharide
chemistry
microneedle
technology
enhancing
ocular
We
provide
thorough
analysis
PSMNs,
summarizing
design
principles,
fabrication
processes,
addressed
during
fabrication,
including
improving
comfort
also
describe
recent
advances
performance
various
both
research
clinical
scenarios.
Finally,
current
regulatory
frameworks
market
barriers
that
are
relevant
commercial
advancement
final
perspective
on
area.
Язык: Английский
Recent advances in stimuli-responsive tailored nanogels for cancer therapy; from bench to personalized treatment
Journal of Materials Chemistry B,
Год журнала:
2023,
Номер
12(2), С. 382 - 412
Опубликована: Дек. 14, 2023
To
improve
the
quality
of
health
in
a
personalized
manner,
better
control
over
pharmacologically
relevant
cargo
formulation,
organ-specific
targeted
delivery,
and
on-demand
release
therapeutic
agents
is
crucial.
Significant
work
has
been
put
into
designing
developing
revolutionary
nanotherapeutics
approaches
for
effective
monitoring
treatment
disease.
Nanogel
(NG)
attracted
significant
interest
because
its
tremendous
potential
cancer
therapy
environmental
stimuli
responsiveness.
NG
considered
next-generation
delivery
technology
due
to
benefits
like
as
size
tunability,
high
loading,
responsiveness,
prolonged
drug
Язык: Английский