
Research Square (Research Square), Год журнала: 2024, Номер unknown
Опубликована: Дек. 13, 2024
Язык: Английский
Research Square (Research Square), Год журнала: 2024, Номер unknown
Опубликована: Дек. 13, 2024
Язык: Английский
Ageing Research Reviews, Год журнала: 2024, Номер 95, С. 102233 - 102233
Опубликована: Фев. 14, 2024
Язык: Английский
Процитировано
20Molecular Biology Reports, Год журнала: 2025, Номер 52(1)
Опубликована: Янв. 20, 2025
Язык: Английский
Процитировано
5Diabetes Obesity and Metabolism, Год журнала: 2024, Номер 26(8), С. 3031 - 3044
Опубликована: Май 27, 2024
Abstract Depression is a mood disorder that may increase risk for the development of insulin resistance (IR) and type 2 diabetes (T2D), vice versa. However, mechanistic pathway linking depression T2D not fully elucidated. The aim this narrative review, therefore, was to discuss possible link between T2D. coexistence twice as great compared occurrence either condition independently. Hyperglycaemia dyslipidaemia promote incidence by enhancing inflammation reducing brain serotonin (5‐hydroxytryptamine [5HT]). Dysregulation signalling in impairs 5HT signalling, leading depression. Furthermore, associated with hyperglycaemia poor glycaemic control. Psychological stress In conclusion, could be potential factor through induction inflammatory reactions oxidative affect neurotransmission. addition, chronic induce dysregulation hypothalamic–pituitary–adrenal axis circulating cortisol levels, which triggers IR
Язык: Английский
Процитировано
17Brain Research Bulletin, Год журнала: 2025, Номер 221, С. 111189 - 111189
Опубликована: Янв. 5, 2025
Epilepsy is a neurological disease characterized by unprovoked recurrent epileptic seizures. Temporal lobe epilepsy (TLE) the commonest type of focal in adults that resist to conventional anti-seizure medications (ASMs). Interestingly, ASMs do not affect epileptogenesis and progression disease. Therefore, repurposing natural products with anti-inflammatory, anti-oxidant effects such as berberine (BRB) may be logical treating refractory TLE. However, molecular mechanism BRB against development seizure mainly TLE was fully elucidated. we attempt this review discuss potential underlying
Язык: Английский
Процитировано
1Journal of Central Nervous System Disease, Год журнала: 2024, Номер 16
Опубликована: Апрель 22, 2024
Epilepsy is a chronic neurological disorder manifested by recurring unprovoked seizures resulting from an imbalance in the inhibitory and excitatory neurotransmitters brain. The process of epileptogenesis involves complex interplay between reduction gamma-aminobutyric acid (GABA) enhancement glutamate. Pro-BDNF/p75 NTR expression augmented both glial cells neurons following epileptic status epileptics (SE). Over-expression p75 linked with pathogenesis epilepsy, augmentation pro-BDNF/p75 implicated epilepsy. However, precise mechanistic function epilepsy has not been completely elucidated. Therefore, this review aimed to revise pathway
Язык: Английский
Процитировано
6ACS Chemical Neuroscience, Год журнала: 2024, Номер 15(16), С. 2966 - 2981
Опубликована: Июль 31, 2024
Sinapic acid (SA) is a phenylpropanoid derivative found in various natural sources that exhibits remarkable versatile properties, including antioxidant, anti-inflammatory, and metal-chelating capabilities, establishing itself as promising candidate for the prevention treatment of conditions affecting central nervous system, such Alzheimer's disease (AD), Parkinson's (PD), ischemic stroke, other neurological disorders. These effects also include neuroprotection epilepsy models, evidenced by reduction seizure-like behavior, cell death specific hippocampal regions, lowered neuroinflammatory markers. In AD, SA enhances memory, reverses cognitive deficits, attenuates astrocyte activation. has positive on cognition improving memory lowering oxidative stress. This shown lower levels stress markers, higher antioxidant enzyme activity, better retention. Additionally, stroke PD provides microglial protection exerts anti-inflammatory effects. review emphasizes SA's multifaceted neuroprotective properties its potential role brain Despite need further research to fully understand mechanisms action clinical applicability, stands out valuable bioactive compound ongoing quest combat neurodegenerative diseases enhance quality life affected individuals.
Язык: Английский
Процитировано
5CNS Neuroscience & Therapeutics, Год журнала: 2024, Номер 30(12)
Опубликована: Дек. 1, 2024
Brain-derived neurotrophic factor (BDNF) is a neurotrophin, acting as signal and neuromodulator in the central nervous system (CNS). BDNF synthesized from its precursor proBDNF within CNS peripheral tissues. Through activation of NTRK2/TRKB (neurotrophic receptor tyrosine kinase 2), promotes neuronal survival, synaptic plasticity, growth, whereas it inhibits microglial release pro-inflammatory cytokines. dysregulated different neurodegenerative diseases depressions. However, there major controversy concerning levels stages multiple sclerosis (MS). Therefore, this review discusses potential role signaling MS, how modulators affect pathogenesis outcomes disease.
Язык: Английский
Процитировано
5Pathology - Research and Practice, Год журнала: 2024, Номер 254, С. 155146 - 155146
Опубликована: Янв. 19, 2024
Язык: Английский
Процитировано
3Epilepsy & Behavior Reports, Год журнала: 2025, Номер unknown, С. 100756 - 100756
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
0Brain Research Bulletin, Год журнала: 2025, Номер unknown, С. 111338 - 111338
Опубликована: Апрель 1, 2025
Acute ischemic stroke (AIS) is a focal neurological deficit due to sudden occlusion of cerebral vessels in the brain. AIS-induced neuronal injury and associated excite-toxicity neurodegeneration affect synthesis release different neurotrophic factors such as brain-derived neurotropic factor (BDNF) its precursor proBDNF. Both BDNF proBDNF act on specific receptors with effects. activates tropomyosin receptor kinase B (TrkB) results promoting survival, synaptic plasticity, growth. However, p75 neurotrophin (p75NTR) sortilin which attenuates plasticity promotes apoptosis. Dysregulation central peripheral expression proBDNF/BDNF linked severity clinical outcomes AIS. Therefore, this review aims discuss alterations signaling Findings from present illustrated that proBDNF/p75NTR/sortilin pathway exaggerated whereas; BDNF-TrkB reduced AIS leading activation signaling, inhibition could be promising therapeutic strategy management
Язык: Английский
Процитировано
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