Relationship Between Serum Brain-Derived Neurotrophic Factor Levels and Neurological Complications in Patients with Intracranial Tumor DOI Creative Commons
Fasihah Irfani Fitri,

Khansa Salsabila,

Irina Kemala Nasution

и другие.

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Дек. 13, 2024

Abstract Background and Aim: Brain-Derived Neurotrophic Factor (BDNF) plays a vital role in neuronal survival plasticity. Deficits BDNF are associated with neurological disorders, including complications such as delirium seizures patients intracranial tumors. This study aimed to explore the relationship between serum levels tumor patients. Methods: A cross-sectional was conducted at Adam Malik Hospital, Medan, from August October 2024, involving diagnosed Serum were measured, assessed using Confusion Assessment Method (CAM), observed clinically. Results: Among 50 (58% female, mean age 50.56 years), most common complication (32%). One-Way ANOVA revealed significant association (p < 0.001). Post-hoc analysis showed differences groups 0.001), but no difference found seizure non-complication > 0.05). Conclusion: Lower significantly patients, suggesting that may serve potential biomarker for this population.

Язык: Английский

Role of ketogenic diet in neurodegenerative diseases focusing on Alzheimer diseases: The guardian angle DOI
Hayder M. Al‐kuraishy, Majid S. Jabir,

Ali K. Albuhadily

и другие.

Ageing Research Reviews, Год журнала: 2024, Номер 95, С. 102233 - 102233

Опубликована: Фев. 14, 2024

Язык: Английский

Процитировано

21
Exploring the impact of exercise-induced BDNF on neuroplasticity in neurodegenerative and neuropsychiatric conditions DOI
Mega Obukohwo Oyovwi,

Ugushida Thankgod Ogenma,

Anthonia Onyenweny

и другие.

Molecular Biology Reports, Год журнала: 2025, Номер 52(1)

Опубликована: Янв. 20, 2025

Язык: Английский

Процитировано

5
Depression and type 2 diabetes: A causal relationship and mechanistic pathway DOI Creative Commons
Wael Y. Khawagi, Hayder M. Al‐kuraishy,

Nawar R. Hussein

и другие.

Diabetes Obesity and Metabolism, Год журнала: 2024, Номер 26(8), С. 3031 - 3044

Опубликована: Май 27, 2024

Abstract Depression is a mood disorder that may increase risk for the development of insulin resistance (IR) and type 2 diabetes (T2D), vice versa. However, mechanistic pathway linking depression T2D not fully elucidated. The aim this narrative review, therefore, was to discuss possible link between T2D. coexistence twice as great compared occurrence either condition independently. Hyperglycaemia dyslipidaemia promote incidence by enhancing inflammation reducing brain serotonin (5‐hydroxytryptamine [5HT]). Dysregulation signalling in impairs 5HT signalling, leading depression. Furthermore, associated with hyperglycaemia poor glycaemic control. Psychological stress In conclusion, could be potential factor through induction inflammatory reactions oxidative affect neurotransmission. addition, chronic induce dysregulation hypothalamic–pituitary–adrenal axis circulating cortisol levels, which triggers IR

Язык: Английский

Процитировано

17
The potential therapeutic role of berberine in treating epilepsy focusing on temporal lobe epilepsy: State of art and ongoing perspective DOI Creative Commons
Bshra A. Alsfouk, Hayder M. Al‐kuraishy,

Ali K. Albuhadily

и другие.

Brain Research Bulletin, Год журнала: 2025, Номер 221, С. 111189 - 111189

Опубликована: Янв. 5, 2025

Epilepsy is a neurological disease characterized by unprovoked recurrent epileptic seizures. Temporal lobe epilepsy (TLE) the commonest type of focal in adults that resist to conventional anti-seizure medications (ASMs). Interestingly, ASMs do not affect epileptogenesis and progression disease. Therefore, repurposing natural products with anti-inflammatory, anti-oxidant effects such as berberine (BRB) may be logical treating refractory TLE. However, molecular mechanism BRB against development seizure mainly TLE was fully elucidated. we attempt this review discuss potential underlying

Язык: Английский

Процитировано

1
The functional and molecular roles of p75 neurotrophin receptor (p75NTR) in epilepsy DOI Creative Commons
Areej Turkistani, Hayder M. Al‐kuraishy, Ali I. Al‐Gareeb

и другие.

Journal of Central Nervous System Disease, Год журнала: 2024, Номер 16

Опубликована: Апрель 22, 2024

Epilepsy is a chronic neurological disorder manifested by recurring unprovoked seizures resulting from an imbalance in the inhibitory and excitatory neurotransmitters brain. The process of epileptogenesis involves complex interplay between reduction gamma-aminobutyric acid (GABA) enhancement glutamate. Pro-BDNF/p75 NTR expression augmented both glial cells neurons following epileptic status epileptics (SE). Over-expression p75 linked with pathogenesis epilepsy, augmentation pro-BDNF/p75 implicated epilepsy. However, precise mechanistic function epilepsy has not been completely elucidated. Therefore, this review aimed to revise pathway

Язык: Английский

Процитировано

6
The Compelling Role of Brain‐Derived Neurotrophic Factor Signaling in Multiple Sclerosis: Role of BDNF Activators DOI Creative Commons
Hayder M. Al‐kuraishy, Ghassan M. Sulaiman, Hamdoon A. Mohammed

и другие.

CNS Neuroscience & Therapeutics, Год журнала: 2024, Номер 30(12)

Опубликована: Дек. 1, 2024

Brain-derived neurotrophic factor (BDNF) is a neurotrophin, acting as signal and neuromodulator in the central nervous system (CNS). BDNF synthesized from its precursor proBDNF within CNS peripheral tissues. Through activation of NTRK2/TRKB (neurotrophic receptor tyrosine kinase 2), promotes neuronal survival, synaptic plasticity, growth, whereas it inhibits microglial release pro-inflammatory cytokines. dysregulated different neurodegenerative diseases depressions. However, there major controversy concerning levels stages multiple sclerosis (MS). Therefore, this review discusses potential role signaling MS, how modulators affect pathogenesis outcomes disease.

Язык: Английский

Процитировано

6
Pharmacological Activities and Molecular Mechanisms of Sinapic Acid in Neurological Disorders DOI
Mahan Farzan,

Behnaz Abedi,

Iman Bhia

и другие.

ACS Chemical Neuroscience, Год журнала: 2024, Номер 15(16), С. 2966 - 2981

Опубликована: Июль 31, 2024

Sinapic acid (SA) is a phenylpropanoid derivative found in various natural sources that exhibits remarkable versatile properties, including antioxidant, anti-inflammatory, and metal-chelating capabilities, establishing itself as promising candidate for the prevention treatment of conditions affecting central nervous system, such Alzheimer's disease (AD), Parkinson's (PD), ischemic stroke, other neurological disorders. These effects also include neuroprotection epilepsy models, evidenced by reduction seizure-like behavior, cell death specific hippocampal regions, lowered neuroinflammatory markers. In AD, SA enhances memory, reverses cognitive deficits, attenuates astrocyte activation. has positive on cognition improving memory lowering oxidative stress. This shown lower levels stress markers, higher antioxidant enzyme activity, better retention. Additionally, stroke PD provides microglial protection exerts anti-inflammatory effects. review emphasizes SA's multifaceted neuroprotective properties its potential role brain Despite need further research to fully understand mechanisms action clinical applicability, stands out valuable bioactive compound ongoing quest combat neurodegenerative diseases enhance quality life affected individuals.

Язык: Английский

Процитировано

5
The emerging role of miRNAs in epilepsy: From molecular signatures to diagnostic potential DOI
Sherif S. Abdel Mageed, Ahmed A. Rashad, Shereen Saeid Elshaer

и другие.

Pathology - Research and Practice, Год журнала: 2024, Номер 254, С. 155146 - 155146

Опубликована: Янв. 19, 2024

Язык: Английский

Процитировано

4
Examining the role of physical activity in older adults with epilepsy DOI Creative Commons

Stephen P. Klaus,

Serdar Akkol,

Smitha Karavallil Achuthan

и другие.

Epilepsy & Behavior Reports, Год журнала: 2025, Номер unknown, С. 100756 - 100756

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

0
Dysregulation of proBDNF/p75NTR and BDNF/TrkB Signaling in Acute Ischemic Stroke: Different Sides of the Same Coins DOI Creative Commons

Hala Alnoaman,

Hayder M. Al‐kuraishy, Ali I. Al‐Gareeb

и другие.

Brain Research Bulletin, Год журнала: 2025, Номер unknown, С. 111338 - 111338

Опубликована: Апрель 1, 2025

Acute ischemic stroke (AIS) is a focal neurological deficit due to sudden occlusion of cerebral vessels in the brain. AIS-induced neuronal injury and associated excite-toxicity neurodegeneration affect synthesis release different neurotrophic factors such as brain-derived neurotropic factor (BDNF) its precursor proBDNF. Both BDNF proBDNF act on specific receptors with effects. activates tropomyosin receptor kinase B (TrkB) results promoting survival, synaptic plasticity, growth. However, p75 neurotrophin (p75NTR) sortilin which attenuates plasticity promotes apoptosis. Dysregulation central peripheral expression proBDNF/BDNF linked severity clinical outcomes AIS. Therefore, this review aims discuss alterations signaling Findings from present illustrated that proBDNF/p75NTR/sortilin pathway exaggerated whereas; BDNF-TrkB reduced AIS leading activation signaling, inhibition could be promising therapeutic strategy management

Язык: Английский

Процитировано

0