Polymeric Nanoparticles for Drug Delivery

Chemical Reviews, Год журнала: 2024, Номер 124(9), С. 5505 - 5616

Опубликована: Апрель 16, 2024

The recent emergence of nanomedicine has revolutionized the therapeutic landscape and necessitated creation more sophisticated drug delivery systems. Polymeric nanoparticles sit at forefront numerous promising designs, due to their unmatched control over physiochemical properties such as size, shape, architecture, charge, surface functionality. Furthermore, polymeric have ability navigate various biological barriers precisely target specific sites within body, encapsulate a diverse range cargo efficiently release this in response internal external stimuli. However, despite these remarkable advantages, presence wider clinical application is minimal. This review will provide comprehensive understanding vehicles. affecting be outlined first, followed by description nanoparticle designs preparation methods, beginning with polymers on which they are based. meticulously explore current performance against myriad diseases including cancer, viral bacterial infections, before finally evaluating advantages crucial challenges that determine potential decades come.

Язык: Английский

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Energy Transfer Influence on Superfast Calcium Carbonate Synthesis: using Microwave Heating, Ultrasound Cavitation and Mechanical Stirring

Journal of Materials Research and Technology, Год журнала: 2025, Номер unknown

Опубликована: Фев. 1, 2025

Язык: Английский

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Advanced Nanomaterials for Cancer Therapy: Gold, Silver, and Iron Oxide Nanoparticles in Oncological Applications

Advanced Healthcare Materials, Год журнала: 2024, Номер 14(4)

Опубликована: Ноя. 6, 2024

Cancer remains one of the most challenging health issues globally, demanding innovative therapeutic approaches for effective treatment. Nanoparticles, particularly those composed gold, silver, and iron oxide, have emerged as promising candidates changing cancer therapy. This comprehensive review demonstrates landscape nanoparticle-based oncological interventions, focusing on remarkable advancements potentials oxide nanoparticles. Gold nanoparticles garnered significant attention their exceptional biocompatibility, tunable surface chemistry, distinctive optical properties, rendering them ideal various diagnostic strategies. Silver nanoparticles, renowned antimicrobial exhibit potential in therapy through multiple mechanisms, including apoptosis induction, angiogenesis inhibition, drug delivery enhancement. With magnetic properties offer unique diagnosis targeted opportunities. critically examines recent synthesis, functionalization, biomedical applications these Moreover, challenges are discussed, toxicity concerns, immunogenicity, translational barriers, ongoing efforts to overcome hurdles highlighted. Finally, insights into future directions regulatory considerations, provided aiming accelerate translation technologies from bench bedside.

Язык: Английский

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Detection and photothermal inactivation of Gram-positive and Gram-negative bloodstream bacteria using photonic crystal biosensor and plasmonic core–shell

RSC Advances, Год журнала: 2024, Номер 14(16), С. 11594 - 11603

Опубликована: Янв. 1, 2024

Plasmonics and core-shell nanomaterials hold great potential to develop pharmaceuticals medical equipment due their eco-friendly cost effective fabrication procedures. Despite these advancements, combating drug-resistant bacterial infections remains a global challenge. Therefore, this study aims introduce tailored theoretical framework for one-dimensional (1D) photonic crystal biosensor (PCB) composed of (ZrO

Язык: Английский

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Engineering colloidal systems for cell manipulation, delivery, and tracking

Advances in Colloid and Interface Science, Год журнала: 2025, Номер 340, С. 103462 - 103462

Опубликована: Фев. 27, 2025

Язык: Английский

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A novel dilution strategy for tuning Janus particle morphology

Journal of Colloid and Interface Science, Год журнала: 2025, Номер 693, С. 137613 - 137613

Опубликована: Апрель 16, 2025

Язык: Английский

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Neurological insights into brain-targeted cancer therapy and bioinspired microrobots

Drug Discovery Today, Год журнала: 2024, Номер 29(9), С. 104105 - 104105

Опубликована: Сен. 1, 2024

Язык: Английский

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Cutting-edge advances in nano/biomedicine: A review on transforming thrombolytic therapy

Biochemical Pharmacology, Год журнала: 2024, Номер 229, С. 116523 - 116523

Опубликована: Сен. 7, 2024

Язык: Английский

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Nonspherical Particle Stabilized Emulsions Formed through Destabilization and Arrested Coalescence

Langmuir, Год журнала: 2024, Номер unknown

Опубликована: Дек. 26, 2024

To form nonspherical emulsion droplets, the interfacial tension driving droplet sphericity must be overcome. This can achieved through particle jamming; however, careful control of coverage is required. In this work, we present a scalable novel batch process to particle-stabilized emulsions. by concurrently forming interfacially active particles and drastically accelerating destabilization addition electrolyte. achieve this, surfactant-stabilized oil-in-water emulsions in presence dopamine were first produced. These then treated with tris(hydroxymethyl)aminomethane hydrochloride buffer both simultaneously initiate polymerization continuous phase reduce Debye length system, thus coalescence while surface-active particles. The concentration imposed shear was systematically varied, behavior at interface studied using pendent drop tensiometry rheology. It found that polydopamine nanoparticles formed adsorbed reducing during coalescence, resulting anisotropic droplets via arrested coalescence. Greater rates resulted accelerated formation secondary whereas lower thicker films. efficacy method further demonstrated second system consisting sodium dodecyl sulfate as surfactant polypyrrole particles, which also for optimized conditions.

Язык: Английский

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Synthesis and pH-responsive properties of bacteria mimicking hydrogel capsules

RSC Applied Polymers, Год журнала: 2024, Номер unknown

Опубликована: Янв. 1, 2024

Synthetic imitation of nonspherical microorganisms can enhance therapeutic delivery in the body. Hydrogel microcapsules with bacteria-mimicking shapes were synthesized through a multilayer assembly polymers on sacrificial microparticle surfaces.

Язык: Английский

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