Cancers,
Год журнала:
2024,
Номер
16(5), С. 983 - 983
Опубликована: Фев. 28, 2024
This
exploratory
narrative
review
paper
delves
into
the
intricate
interplay
between
per-
and
polyfluoroalkyl
substances
(PFAS)
exposure,
sociodemographic
factors,
influence
of
stressors
in
context
endometrial
cancer.
PFAS,
ubiquitous
environmental
contaminants
notorious
for
their
persistence
ecosystem,
have
garnered
attention
potential
to
disrupt
endocrine
systems
provoke
immune
responses.
We
comprehensively
examine
various
sources
PFAS
encompassing
household
items,
water,
air,
soil,
thus
shedding
light
on
multifaceted
routes
through
which
individuals
encounter
these
compounds.
Furthermore,
we
explore
such
as
income,
education,
occupation,
ethnicity/race,
geographical
location
relationship
cancer
risk.
also
investigated
role
stress
exposure
The
results
revealed
a
significant
impact
factors
both
levels
Stress
emerged
notable
contributing
factor
influencing
development
cancer,
further
emphasizing
importance
management
practices
overall
well-being.
By
synthesizing
evidence
from
diverse
fields,
this
underscores
need
interdisciplinary
research
targeted
interventions
address
complex
stressors,
PLoS ONE,
Год журнала:
2024,
Номер
19(4), С. e0297362 - e0297362
Опубликована: Апрель 3, 2024
Background
Toxoplasma
gondii
(
T
.
)
is
a
worldwide
distributed
protozoan
parasite
which
has
infected
wide
range
of
warm-blooded
animals
and
humans.
The
most
common
form
infection
asymptomatic
(latent);
nevertheless,
latent
toxoplasmosis
can
induce
various
alterations
sex
hormones,
especially
testosterone,
in
humans
animals.
On
the
other
hand,
testosterone
involved
behavioral
traits
reproductive
functions
both
sexes.
Hence,
purpose
this
systematic
review
to
summarize
available
evidence
regarding
association
between
alteration.
Methods
In
setting
review,
an
electronic
search
(any
date
10
January
2023)
without
language
restrictions
was
performed
using
Science
Direct,
Web
Science,
PubMed,
Scopus,
Google
Scholar.
PRISMA
guidelines
were
followed.
Following
initial
search,
total
12,306
titles
abstracts
screened
initially;
12,281
excluded
due
lack
eligibility
criteria
or
duplication.
Finally,
24
articles
met
included
criteria.
A
mean±standard
deviation
(SD)
calculated
assess
difference
positive
negative
possibility
publication
bias
assessed
Egger’s
regression.
P
-value
<
0.05
considered
statistically
significant.
Results
This
identified
(18
studies
six
animals).
Most
human
(13
out
19)
reported
increased
level
following
males,
while
three
decreased
levels
two
insignificant
change.
Eleven
(seven
datasets
males
seven
females)
eligible
be
data
synthesis.
Based
on
random-effects
model,
pooled
mean±
SD
than
by
0.73
0.55
units
females,
respectively.
regression
did
not
detect
significant
females
p
=
value
0.95
0.71),
Three
male
(rats,
mice,
spotted
hyenas)
female
(mice
decline
compared
with
non-infected
While,
one
study
rats
no
changes
Moreover,
Conclusions
provides
new
insights
about
alteration
identifies
relevant
gaps
that
inform
encourage
further
studies.
consequence
could
partly
associated
sexual
behavior
transmission
parasite.
declining
may
impairments,
observed
-infected
Furthermore,
these
findings
suggest
great
need
for
more
epidemiological
experimental
investigations
depth
understand
relationship
alongside
future
consequences
Toxics,
Год журнала:
2023,
Номер
11(12), С. 1000 - 1000
Опубликована: Дек. 7, 2023
Reproductive
disorders
are
considered
a
global
health
problem
influenced
by
physiological,
genetic,
environmental,
and
lifestyle
factors.
The
increased
exposure
to
bisphenols,
chemical
used
in
large
quantities
for
the
production
of
polycarbonate
plastics,
has
raised
concerns
regarding
risks
humans,
particularly
their
endocrine-disrupting
effects
on
female
reproductive
health.
To
provide
basis
future
research
environmental
interference
health,
we
reviewed
relevant
studies
patterns
levels
bisphenols
matrices
humans
(including
susceptible
populations
such
as
pregnant
women
children).
In
addition,
focused
Human & Experimental Toxicology,
Год журнала:
2024,
Номер
43
Опубликована: Янв. 1, 2024
An
increasing
number
of
studies
have
investigated
the
effects
Cd
on
human
health.
Cd-induced
dermatotoxicity
is
an
important
field
research,
but
numerous
focused
skin.
Moreover,
most
been
performed
using
HaCaT
cells
not
primary
keratinocytes.
In
this
study,
we
provide
results
describing
cytotoxic
exposure
epidermal
keratinocytes
obtained
from
different
donors.
The
subtoxic
concentration
cadmium
chloride
was
determined
via
MTT
assay,
and
transcriptomic
analysis
exposed
to
(25
µM)
performed.
As
in
cells,
resulted
increased
ROS
levels,
cell
cycle
arrest,
induction
apoptosis.
addition,
report
that
affects
zinc
copper
homeostasis,
induces
metallothionein
expression,
activates
various
signaling
pathways,
including
Nrf2,
NF-kB,
TRAIL,
PI3K.
secretion
cytokines
(IL-1,
IL-6,
IL-10,
PGE2)
upregulates
expression
several
cytokeratins,
such
as
KRT6B,
KRT6C,
KRT16,
KRT17.
a
better
understanding
mechanisms
cadmium-induced
cytotoxicity
its
effect
skin
cells.
Ecotoxicology and Environmental Safety,
Год журнала:
2024,
Номер
272, С. 116030 - 116030
Опубликована: Фев. 3, 2024
Metal
pollution
can
cause
a
decline
in
female
fertility,
however,
previous
studies
have
focused
more
on
the
effect
of
single
metal
fertility.
In
this
study,
we
evaluated
mixtures
fertility
based
nested
case-control
samples.
The
plasma
levels
22
elements
from
180
women
were
determined
by
an
inductively
coupled
mass
spectrometer
(ICP-MS).
Minimum
absolute
contraction
and
selection
operator
(LASSO)
penalty
regression
selected
metals
with
greatest
influence
clinical
outcome.
Logistic
was
used
to
analyze
correlation
between
while
Bayesian
kernel
function
(BKMR)
model
mixed
metals.
Eight
(Calcium
(Ca),
Chromium
(Cr),
Cobalt
(Co),
Copper
(Cu),
Zinc
(Zn),
Rubidium
(Rb),
Strontium
(Sr)
Zirconium
(Zr))
LASSO
for
subsequent
analysis.
After
adjusting
covariates,
logistic
showed
that
Cu
(Odds
Ratio(OR):0.33,
95%
CI:
0.13
−
0.84)
Co
(OR:0.38,
0.15
−0.94)
caused
significant
reduction
identified
protective
Zn
(OR:
2.96,
CI:1.21
−7.50)
Trend
tests
increased
Cr,
Cu,
Rb
associated
reduced
BKMR
Co,
had
nonlinear
relationship
when
controlling
concentrations
other
suggested
Cr
might
exert
Analysis
negative
Rb,
positive
Furthermore,
found
evidence
interaction
Cr.
Our
findings
require
further
validation
may
identify
new
mechanisms
future.
Cancers,
Год журнала:
2024,
Номер
16(5), С. 983 - 983
Опубликована: Фев. 28, 2024
This
exploratory
narrative
review
paper
delves
into
the
intricate
interplay
between
per-
and
polyfluoroalkyl
substances
(PFAS)
exposure,
sociodemographic
factors,
influence
of
stressors
in
context
endometrial
cancer.
PFAS,
ubiquitous
environmental
contaminants
notorious
for
their
persistence
ecosystem,
have
garnered
attention
potential
to
disrupt
endocrine
systems
provoke
immune
responses.
We
comprehensively
examine
various
sources
PFAS
encompassing
household
items,
water,
air,
soil,
thus
shedding
light
on
multifaceted
routes
through
which
individuals
encounter
these
compounds.
Furthermore,
we
explore
such
as
income,
education,
occupation,
ethnicity/race,
geographical
location
relationship
cancer
risk.
also
investigated
role
stress
exposure
The
results
revealed
a
significant
impact
factors
both
levels
Stress
emerged
notable
contributing
factor
influencing
development
cancer,
further
emphasizing
importance
management
practices
overall
well-being.
By
synthesizing
evidence
from
diverse
fields,
this
underscores
need
interdisciplinary
research
targeted
interventions
address
complex
stressors,
