
Research Square (Research Square), Год журнала: 2024, Номер unknown
Опубликована: Апрель 11, 2024
Язык: Английский
Research Square (Research Square), Год журнала: 2024, Номер unknown
Опубликована: Апрель 11, 2024
Язык: Английский
Antioxidants, Год журнала: 2024, Номер 13(5), С. 579 - 579
Опубликована: Май 8, 2024
Microplastics (MPs) are plastic particles between 0.1 and 5000 µm in size that have attracted considerable attention from the scientific community general public, as they threaten environment. contribute to various harmful effects, including lipid peroxidation, DNA damage, activation of mitogen-activated protein kinase pathways, cell membrane breakages, mitochondrial dysfunction, lysosomal defects, inflammation, apoptosis. They affect cells, tissues, organs, overall health, potentially contributing conditions like cancer cardiovascular disease. pose a significant danger due their widespread occurrence food. In recent years, information has emerged indicating MPs can cause oxidative stress (OS), known factor accelerating aging organisms. This comprehensive evaluation exposed notable variability reported connection OS. work aims provide critical review whether harmfulness constitute environmental contaminants may result OS through analysis research existing literature, well an assessment characteristics causing Additionally, article covers analytical methodology used this field. The conclusions point necessity for further into effects on
Язык: Английский
Процитировано
60Life Sciences, Год журнала: 2024, Номер 355, С. 122937 - 122937
Опубликована: Авг. 3, 2024
Язык: Английский
Процитировано
27The Science of The Total Environment, Год журнала: 2024, Номер 922, С. 171299 - 171299
Опубликована: Фев. 27, 2024
Язык: Английский
Процитировано
21Deleted Journal, Год журнала: 2025, Номер 7(1)
Опубликована: Янв. 11, 2025
As the production, usage, and disposal of plastics increase, microplastics generated—plastic particles smaller than 5 mm—increases, exacerbating environmental pollution. In turn, various organisms become increasingly exposed to contaminated environments, potentially affecting humans through food chain. Crucial findings from in vivo experiments indicate histopathological changes caused by impact morphology physiological function organisms. This study describes induced across circulatory, nervous, digestive, respiratory, reproductive systems explains associated functional alterations. Except nervous system, main morphological involve degenerative throughout body, such as apoptosis, inflammation, fibrosis. Most were inflammatory responses microplastics, leading fibrosis subsequent impairments. Various studies confirm that stimulate cells, increased reactive oxygen species cell death. Consequently, these impair related systemic functions. review highlights fundamental organs cells due discusses limitations involving showing no changes.
Язык: Английский
Процитировано
2Materials Today Bio, Год журнала: 2024, Номер 27, С. 101139 - 101139
Опубликована: Июнь 24, 2024
The prevalence of polymer usage in everyday activities has emerged as a detriment to both human life and the environment. A large number studies describe severe impacts micropolymers (MP) nanopolymers (NP) on various organ systems, including endocrine system. Additionally, plasticizers utilized additives have been identified endocrine-disrupting chemicals (EDCs). MP/NP, along with associated plasticizers, affect principal signalling pathways glands such pituitary, thyroid, adrenal, gonads, thereby disrupting hormone function metabolic processes crucial for maintaining homeostasis, fertility, neural development, fetal growth. This review delves into sources, distribution, effects micropolymers, nanopolymers, acting EDCs. Furthermore, it provides detailed mechanisms underlying disruption relation different types MP/NP.
Язык: Английский
Процитировано
9Environmental Pollution, Год журнала: 2024, Номер 351, С. 124101 - 124101
Опубликована: Май 4, 2024
Язык: Английский
Процитировано
8Reproductive Biology and Endocrinology, Год журнала: 2024, Номер 22(1)
Опубликована: Ноя. 11, 2024
The female reproductive system can face serious disorders and show abnormalities under the influence of environmental pollutants. Microplastics (MPs) nanoplastics (NPs) as emerging pollutants, by affecting different components this system, may make fertility a challenge. Animal studies have demonstrated that exposure to these substances weakens function ovaries causes decrease in ovarian reserve capacity. Also, continuous micro/nano plastics (MNPs) leads increased levels reactive oxygen species, induction oxidative stress, inflammatory responses, apoptosis granulosa cells, reduction number follicles. Furthermore, interfering with hypothalamic-pituitary-ovarian axis, particles disturb normal androgens endocrine balance delay growth gonads. Exposure MNPs accelerate carcinogenesis humans animal models. determined accumulate placenta, causing metabolic changes, disrupting development fetus, endangering health future generations. In humans, presence micro/nanoplastics placenta tissue, infant feces, breast milk has been reported. These directly affect mother increasing risk premature birth other pregnancy complications. This review aims outline hazardous effects on fetal discuss results experiments human research focusing cellular molecular pathways.
Язык: Английский
Процитировано
8Archives of Gynecology and Obstetrics, Год журнала: 2025, Номер unknown
Опубликована: Янв. 16, 2025
This systematic review aims to evaluate the impact of microplastics on female reproductive health by analyzing experimental studies. A comprehensive search was conducted in PubMed, Web Science, and Scopus databases identify studies published between 2021 2023. Studies investigating effects organs, hormone levels, fertility rates, offspring development subjects were included. The quality assessed using Cochrane risk bias tool. total 15 met inclusion criteria. results indicate that exposure significantly affects ovarian function, decreases disrupts levels subjects. Several also reported negative embryo offsprings health. varied, with some showing a high bias. evidence from suggests have detrimental effect However, variation study highlights need for more rigorous research confirm these better understand underlying mechanisms.
Язык: Английский
Процитировано
1Ecotoxicology and Environmental Safety, Год журнала: 2025, Номер 291, С. 117906 - 117906
Опубликована: Фев. 1, 2025
Precocious puberty (PP) is a common pediatric endocrine disorder that affects children's growth and sexual development. Environmental pollutants, especially microplastics (MPs), may be an important triggering factors in PP. MPs were widely found living environment, while the impact of on pubertal development remains unknown. In this study, 14 serum samples collected from central precocious (CPP) girls healthy controls. The concentration total CPP (68.19 ± 26.49 mg/kg) showed significant increase than controls (36.94 13.22 mg/kg). 5 11 types detected, among which PE (CPP, 28.22 %; Control, 31.62 %) PVC 62.67 58.14 being dominant ones. Correlation analysis between sex hormone revealed negatively correlated with progesterone positively dehydroepiandrosterone (DHEAS). order to investigate toxic effects onset, young female mice at 21 days orally administered various concentrations for two weeks. Female exposed (PE, 3 mg/day; PVC, 6 mg/day) had advanced vaginal opening, none changes body weight. Immunohistochemical staining demonstrated exposure during could activate microglia, astrocytes promote GnRH expression hypothalamus, leading earlier onset. These data suggested can absorbed accumulated brain gonad after gavage, accelerate initiation. This study provided valuable evidence threatened normal progression
Язык: Английский
Процитировано
1International Journal of Biological Sciences, Год журнала: 2024, Номер 20(14), С. 5779 - 5792
Опубликована: Окт. 21, 2024
The escalation of plastic pollution represents a global environmental and health problem. Important toxic effects have been attributed to the increasing diffusion microplastics (MPs) nanoplastics (NPs) derived from degradation plastics. These particles ubiquitously observed in environment, with humans being continuously exposed via ingestion, inhalation skin contact. Nonetheless, cellular homeostasis imbalance induced by micro- nano- plastics (MNPs) human has only recently shown, while most evidence molecular mechanisms studies
Язык: Английский
Процитировано
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