Investigation of potential detrimental effects of nano- and microplastics in human endometrial stromal cells DOI Creative Commons
Nara Kim, Joo Hyun Park,

Gee Soo Jung

и другие.

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Апрель 11, 2024

Abstract Nanoplastics (NPs) and Microplastics (MPs) have become a global concern in recent years. However, the effects of NPs MPs on female reproductive system not been elucidated, yet. In this study, we aimed to establish proper vitro exposure protocol investigate possible cytotoxic human endometrial cells, using different plastic size concentrations. It was noted that smaller plastics, specifically 100 nm 1 µm MPs, exhibited higher propensity for cellular uptake compared larger counterparts such as 5 MPs. These particles demonstrated ability induce notable morphological changes provoke cell death at concentrations exceeding µg/mL over 24-hour period. Furthermore, confirmed accumulations these nucleus cytoplasm cells confocal microscopy real-time imaging device. A significantly rate internalization observed, manifesting discernible correlation between plastics degree penetration into both cytoplasm. conclusion, is first study demonstrate exposures results dynamic within stromal leading specific Our findings imply potential adverse impacts fertility health, underscoring need further research elucidate exact underlying molecular mechanisms.

Язык: Английский

Microplastics and Oxidative Stress—Current Problems and Prospects DOI Creative Commons
Kornelia Kadac-Czapska, Justyna Ośko, Eliza Knez

и другие.

Antioxidants, Год журнала: 2024, Номер 13(5), С. 579 - 579

Опубликована: Май 8, 2024

Microplastics (MPs) are plastic particles between 0.1 and 5000 µm in size that have attracted considerable attention from the scientific community general public, as they threaten environment. contribute to various harmful effects, including lipid peroxidation, DNA damage, activation of mitogen-activated protein kinase pathways, cell membrane breakages, mitochondrial dysfunction, lysosomal defects, inflammation, apoptosis. They affect cells, tissues, organs, overall health, potentially contributing conditions like cancer cardiovascular disease. pose a significant danger due their widespread occurrence food. In recent years, information has emerged indicating MPs can cause oxidative stress (OS), known factor accelerating aging organisms. This comprehensive evaluation exposed notable variability reported connection OS. work aims provide critical review whether harmfulness constitute environmental contaminants may result OS through analysis research existing literature, well an assessment characteristics causing Additionally, article covers analytical methodology used this field. The conclusions point necessity for further into effects on

Язык: Английский

Процитировано

60
The alarming link between environmental microplastics and health hazards with special emphasis on cancer DOI

Sohini Goswami,

Satadal Adhikary, Suchandra Bhattacharya

и другие.

Life Sciences, Год журнала: 2024, Номер 355, С. 122937 - 122937

Опубликована: Авг. 3, 2024

Язык: Английский

Процитировано

27
Comparing the effects and mechanisms of exposure to polystyrene nanoplastics with different functional groups on the male reproductive system DOI
Xiao Gao, Ke Xu, Wanting Du

и другие.

The Science of The Total Environment, Год журнала: 2024, Номер 922, С. 171299 - 171299

Опубликована: Фев. 27, 2024

Язык: Английский

Процитировано

21
The histopathological and functional consequences of microplastic exposure DOI Creative Commons

Yujeong Lee,

Min Kyung Sung, Soo‐Eun Sung

и другие.

Deleted Journal, Год журнала: 2025, Номер 7(1)

Опубликована: Янв. 11, 2025

As the production, usage, and disposal of plastics increase, microplastics generated—plastic particles smaller than 5 mm—increases, exacerbating environmental pollution. In turn, various organisms become increasingly exposed to contaminated environments, potentially affecting humans through food chain. Crucial findings from in vivo experiments indicate histopathological changes caused by impact morphology physiological function organisms. This study describes induced across circulatory, nervous, digestive, respiratory, reproductive systems explains associated functional alterations. Except nervous system, main morphological involve degenerative throughout body, such as apoptosis, inflammation, fibrosis. Most were inflammatory responses microplastics, leading fibrosis subsequent impairments. Various studies confirm that stimulate cells, increased reactive oxygen species cell death. Consequently, these impair related systemic functions. review highlights fundamental organs cells due discusses limitations involving showing no changes.

Язык: Английский

Процитировано

2
Detrimental consequences of micropolymers associated plasticizers on endocrinal disruption DOI Creative Commons

Utsa Saha,

Puja Kumari,

Aishee Ghosh

и другие.

Materials Today Bio, Год журнала: 2024, Номер 27, С. 101139 - 101139

Опубликована: Июнь 24, 2024

The prevalence of polymer usage in everyday activities has emerged as a detriment to both human life and the environment. A large number studies describe severe impacts micropolymers (MP) nanopolymers (NP) on various organ systems, including endocrine system. Additionally, plasticizers utilized additives have been identified endocrine-disrupting chemicals (EDCs). MP/NP, along with associated plasticizers, affect principal signalling pathways glands such pituitary, thyroid, adrenal, gonads, thereby disrupting hormone function metabolic processes crucial for maintaining homeostasis, fertility, neural development, fetal growth. This review delves into sources, distribution, effects micropolymers, nanopolymers, acting EDCs. Furthermore, it provides detailed mechanisms underlying disruption relation different types MP/NP.

Язык: Английский

Процитировано

9
Subchronic co-exposure of polystyrene nanoplastics and 3-BHA significantly aggravated the reproductive toxicity of ovaries and uterus in female mice DOI
Guanghua Xiong, Haiyan Zhang, Yulin Peng

и другие.

Environmental Pollution, Год журнала: 2024, Номер 351, С. 124101 - 124101

Опубликована: Май 4, 2024

Язык: Английский

Процитировано

8
Concerning influences of micro/nano plastics on female reproductive health: focusing on cellular and molecular pathways from animal models to human studies DOI Creative Commons

Hasti Balali,

Ali Morabbi,

Mohammad Karimian

и другие.

Reproductive Biology and Endocrinology, Год журнала: 2024, Номер 22(1)

Опубликована: Ноя. 11, 2024

The female reproductive system can face serious disorders and show abnormalities under the influence of environmental pollutants. Microplastics (MPs) nanoplastics (NPs) as emerging pollutants, by affecting different components this system, may make fertility a challenge. Animal studies have demonstrated that exposure to these substances weakens function ovaries causes decrease in ovarian reserve capacity. Also, continuous micro/nano plastics (MNPs) leads increased levels reactive oxygen species, induction oxidative stress, inflammatory responses, apoptosis granulosa cells, reduction number follicles. Furthermore, interfering with hypothalamic-pituitary-ovarian axis, particles disturb normal androgens endocrine balance delay growth gonads. Exposure MNPs accelerate carcinogenesis humans animal models. determined accumulate placenta, causing metabolic changes, disrupting development fetus, endangering health future generations. In humans, presence micro/nanoplastics placenta tissue, infant feces, breast milk has been reported. These directly affect mother increasing risk premature birth other pregnancy complications. This review aims outline hazardous effects on fetal discuss results experiments human research focusing cellular molecular pathways.

Язык: Английский

Процитировано

8
Impact of microplastics on female reproductive health: insights from animal and human experimental studies: a systematic review DOI Creative Commons
Özen İnam

Archives of Gynecology and Obstetrics, Год журнала: 2025, Номер unknown

Опубликована: Янв. 16, 2025

This systematic review aims to evaluate the impact of microplastics on female reproductive health by analyzing experimental studies. A comprehensive search was conducted in PubMed, Web Science, and Scopus databases identify studies published between 2021 2023. Studies investigating effects organs, hormone levels, fertility rates, offspring development subjects were included. The quality assessed using Cochrane risk bias tool. total 15 met inclusion criteria. results indicate that exposure significantly affects ovarian function, decreases disrupts levels subjects. Several also reported negative embryo offsprings health. varied, with some showing a high bias. evidence from suggests have detrimental effect However, variation study highlights need for more rigorous research confirm these better understand underlying mechanisms.

Язык: Английский

Процитировано

1
Exposure to polyethylene and polyvinylchloride microplastics caused advanced puberty onset in females through promoting hypothalamic GnRH expression DOI Creative Commons

Shaolian Zang,

Fei Wang, Yang Ouyang

и другие.

Ecotoxicology and Environmental Safety, Год журнала: 2025, Номер 291, С. 117906 - 117906

Опубликована: Фев. 1, 2025

Precocious puberty (PP) is a common pediatric endocrine disorder that affects children's growth and sexual development. Environmental pollutants, especially microplastics (MPs), may be an important triggering factors in PP. MPs were widely found living environment, while the impact of on pubertal development remains unknown. In this study, 14 serum samples collected from central precocious (CPP) girls healthy controls. The concentration total CPP (68.19 ± 26.49 mg/kg) showed significant increase than controls (36.94 13.22 mg/kg). 5 11 types detected, among which PE (CPP, 28.22 %; Control, 31.62 %) PVC 62.67 58.14 being dominant ones. Correlation analysis between sex hormone revealed negatively correlated with progesterone positively dehydroepiandrosterone (DHEAS). order to investigate toxic effects onset, young female mice at 21 days orally administered various concentrations for two weeks. Female exposed (PE, 3 mg/day; PVC, 6 mg/day) had advanced vaginal opening, none changes body weight. Immunohistochemical staining demonstrated exposure during could activate microglia, astrocytes promote GnRH expression hypothalamus, leading earlier onset. These data suggested can absorbed accumulated brain gonad after gavage, accelerate initiation. This study provided valuable evidence threatened normal progression

Язык: Английский

Процитировано

1
Micro(nano)plastics: an Emerging Burden for Human Health DOI Creative Commons

Isabella Donisi,

Antonino Colloca,

Camilla Anastasio

и другие.

International Journal of Biological Sciences, Год журнала: 2024, Номер 20(14), С. 5779 - 5792

Опубликована: Окт. 21, 2024

The escalation of plastic pollution represents a global environmental and health problem. Important toxic effects have been attributed to the increasing diffusion microplastics (MPs) nanoplastics (NPs) derived from degradation plastics. These particles ubiquitously observed in environment, with humans being continuously exposed via ingestion, inhalation skin contact. Nonetheless, cellular homeostasis imbalance induced by micro- nano- plastics (MNPs) human has only recently shown, while most evidence molecular mechanisms studies

Язык: Английский

Процитировано

6