Accelerated Aging in Cancer Survivors: Cellular Senescence, Frailty, and Possible Opportunities for Interventions
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(6), С. 3319 - 3319
Опубликована: Март 14, 2024
The
population
of
cancer
survivors
has
markedly
increased
due
to
the
rapid
improvements
in
treatment.
However,
experience
accelerated
aging,
which
leads
chronic
diseases
and
other
age-related
conditions,
such
as
frailty.
Those
conditions
may
persist
years
after
diagnosis
Cellular
senescence,
a
hallmark
is
one
mechanisms
that
contribute
aging
survivors.
Several
measures,
including
measures
based
on
clinical
markers
biomarkers,
have
been
proposed
estimate
process,
some
them
shown
associations
with
mortality
frailty
anti-aging
interventions,
lifestyle
changes
drugs,
proposed.
Future
research,
particularly
large-scale
studies,
needed
determine
efficiency
these
interventions
before
considering
their
application
clinics.
This
review
focuses
cellular
senescence
survivors,
assessment
process
using
high
prevalence
population,
well
possible
opportunities
for
interventions.
A
deeper
understanding
will
development
effective
strategies
mitigate
improve
quality
life.
Язык: Английский
GDF‐15 is associated with sarcopenia and frailty in acutely admitted older medical patients
Journal of Cachexia Sarcopenia and Muscle,
Год журнала:
2024,
Номер
15(4), С. 1549 - 1557
Опубликована: Июнь 18, 2024
Growth
differentiation
factor-15
(GDF-15)
has
been
associated
with
senescence,
lower
muscle
strength,
and
physical
performance
in
healthy
older
people.
Still,
it
is
not
clear
whether
GDF-15
can
be
utilized
as
a
biomarker
of
sarcopenia
frailty
the
early
stages
hospitalization.
We
investigated
association
plasma
older,
acutely
admitted
medical
patients.
Язык: Английский
Enhancing immunity during ageing by targeting interactions within the tissue environment
Nature Reviews Drug Discovery,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 28, 2025
Язык: Английский
The Role of Trace Elements in COPD: Pathogenetic Mechanisms and Therapeutic Potential of Zinc, Iron, Magnesium, Selenium, Manganese, Copper, and Calcium
Nutrients,
Год журнала:
2024,
Номер
16(23), С. 4118 - 4118
Опубликована: Ноя. 28, 2024
Background:
Chronic
obstructive
pulmonary
disease
(COPD)
is
a
progressive,
inflammatory
airway
disorder
characterized
by
gradual
decline
in
lung
function
and
increased
oxidative
stress.
Both
stress
inflammation
are
central
to
its
pathophysiology,
with
trace
elements
such
as
zinc,
copper,
iron,
manganese,
magnesium,
selenium,
calcium
playing
key
roles
various
cellular
processes.
Objective:
This
article
reviews
the
role
of
COPD,
focusing
on
their
involvement
pathogenesis
therapeutic
potential.
Specifically,
we
examine
effects
COPD.
Methods:
We
performed
comprehensive
narrative
review
literature
across
databases
including
PubMed,
Web
Science,
Cochrane
Library,
Google
Scholar,
identifying
studies
that
explore
The
included
consisted
cohort
analyses,
randomized
controlled
trials,
clinical
investigations.
Results:
Zinc,
critical
both
pathophysiology
management
These
contribute
regulation
inflammation,
modulation
stress,
maintenance
function.
Zinc
for
instance,
reduce
modulate
immune
responses,
while
iron
essential
oxygen
transport.
Magnesium,
vital
muscle
function,
respiratory
performance,
reducing
improving
Conclusions:
minerals
may
beneficial
part
standard
Maintaining
optimal
levels
these
support
processes,
reduction
an
improvement
However,
further
research
necessary
confirm
efficacy
establish
safe
dosage
recommendations
COPD
treatment.
Язык: Английский
Exploring Causal Links Between Gut Microbiota and Geriatric Syndromes: A Two-Sample Mendelian Randomization Analysis
International Journal of Medical Sciences,
Год журнала:
2024,
Номер
21(10), С. 1945 - 1963
Опубликована: Янв. 1, 2024
Both
observational
studies
and
clinical
trials
have
demonstrated
a
link
between
the
gut
microbiota
geriatric
syndrome.
Nevertheless,
exact
nature
of
this
relationship,
particularly
concerning
causality,
remains
elusive.
Mendelian
randomization
(MR)
is
method
inference
based
on
genetic
variation
to
assess
causal
relationship
an
exposure
outcome.
In
study,
we
conducted
two-sample
(TSMR)
study
fully
reveal
potential
effects
syndromes.
Язык: Английский
Association between pre-stroke frailty status and stroke risk and impact on outcomes: a systematic review and meta-analysis of 1,660,328 participants
Shu-Fan Chen,
Hai-Han Li,
Zi-Ning Guo
и другие.
Aging Clinical and Experimental Research,
Год журнала:
2024,
Номер
36(1)
Опубликована: Сен. 11, 2024
Язык: Английский
Deciphering Osteosarcopenia through the hallmarks of aging
Mechanisms of Ageing and Development,
Год журнала:
2024,
Номер
222, С. 111997 - 111997
Опубликована: Окт. 11, 2024
Osteosarcopenia
is
a
major
driver
of
functional
loss
and
risk
factor
for
falls,
fractures,
disability
mortality
in
older
adults,
urgently
requiring
the
development
effective
interventions
to
address
it.
The
hallmarks
aging
provide
theoretical
practical
framework
that
allows
structured
organization
current
knowledge
planning
new
lines.
This
article
comprehensively
reviews
currently
available
literature
on
role
osteosarcopenia,
thereby
offering
panoramic
view
state
art
gaps
this
field.
Язык: Английский