Accelerated Aging in Cancer Survivors: Cellular Senescence, Frailty, and Possible Opportunities for Interventions

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(6), P. 3319 - 3319

Published: March 14, 2024

The population of cancer survivors has markedly increased due to the rapid improvements in treatment. However, experience accelerated aging, which leads chronic diseases and other age-related conditions, such as frailty. Those conditions may persist years after diagnosis Cellular senescence, a hallmark is one mechanisms that contribute aging survivors. Several measures, including measures based on clinical markers biomarkers, have been proposed estimate process, some them shown associations with mortality frailty anti-aging interventions, lifestyle changes drugs, proposed. Future research, particularly large-scale studies, needed determine efficiency these interventions before considering their application clinics. This review focuses cellular senescence survivors, assessment process using high prevalence population, well possible opportunities for interventions. A deeper understanding will development effective strategies mitigate improve quality life.

Language: Английский

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GDF‐15 is associated with sarcopenia and frailty in acutely admitted older medical patients

Journal of Cachexia Sarcopenia and Muscle, Journal Year: 2024, Volume and Issue: 15(4), P. 1549 - 1557

Published: June 18, 2024

Growth differentiation factor-15 (GDF-15) has been associated with senescence, lower muscle strength, and physical performance in healthy older people. Still, it is not clear whether GDF-15 can be utilized as a biomarker of sarcopenia frailty the early stages hospitalization. We investigated association plasma older, acutely admitted medical patients.

Language: Английский

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Enhancing immunity during ageing by targeting interactions within the tissue environment

Nature Reviews Drug Discovery, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 28, 2025

Language: Английский

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The Role of Trace Elements in COPD: Pathogenetic Mechanisms and Therapeutic Potential of Zinc, Iron, Magnesium, Selenium, Manganese, Copper, and Calcium

Nutrients, Journal Year: 2024, Volume and Issue: 16(23), P. 4118 - 4118

Published: Nov. 28, 2024

Background: Chronic obstructive pulmonary disease (COPD) is a progressive, inflammatory airway disorder characterized by gradual decline in lung function and increased oxidative stress. Both stress inflammation are central to its pathophysiology, with trace elements such as zinc, copper, iron, manganese, magnesium, selenium, calcium playing key roles various cellular processes. Objective: This article reviews the role of COPD, focusing on their involvement pathogenesis therapeutic potential. Specifically, we examine effects COPD. Methods: We performed comprehensive narrative review literature across databases including PubMed, Web Science, Cochrane Library, Google Scholar, identifying studies that explore The included consisted cohort analyses, randomized controlled trials, clinical investigations. Results: Zinc, critical both pathophysiology management These contribute regulation inflammation, modulation stress, maintenance function. Zinc for instance, reduce modulate immune responses, while iron essential oxygen transport. Magnesium, vital muscle function, respiratory performance, reducing improving Conclusions: minerals may beneficial part standard Maintaining optimal levels these support processes, reduction an improvement However, further research necessary confirm efficacy establish safe dosage recommendations COPD treatment.

Language: Английский

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Exploring Causal Links Between Gut Microbiota and Geriatric Syndromes: A Two-Sample Mendelian Randomization Analysis

International Journal of Medical Sciences, Journal Year: 2024, Volume and Issue: 21(10), P. 1945 - 1963

Published: Jan. 1, 2024

Both observational studies and clinical trials have demonstrated a link between the gut microbiota geriatric syndrome. Nevertheless, exact nature of this relationship, particularly concerning causality, remains elusive. Mendelian randomization (MR) is method inference based on genetic variation to assess causal relationship an exposure outcome. In study, we conducted two-sample (TSMR) study fully reveal potential effects syndromes.

Language: Английский

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Association between pre-stroke frailty status and stroke risk and impact on outcomes: a systematic review and meta-analysis of 1,660,328 participants

Aging Clinical and Experimental Research, Journal Year: 2024, Volume and Issue: 36(1)

Published: Sept. 11, 2024

Language: Английский

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Deciphering Osteosarcopenia through the hallmarks of aging

Mechanisms of Ageing and Development, Journal Year: 2024, Volume and Issue: 222, P. 111997 - 111997

Published: Oct. 11, 2024

Osteosarcopenia is a major driver of functional loss and risk factor for falls, fractures, disability mortality in older adults, urgently requiring the development effective interventions to address it. The hallmarks aging provide theoretical practical framework that allows structured organization current knowledge planning new lines. This article comprehensively reviews currently available literature on role osteosarcopenia, thereby offering panoramic view state art gaps this field.

Language: Английский

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