Analytica Chimica Acta, Год журнала: 2025, Номер 1350, С. 343794 - 343794
Опубликована: Фев. 13, 2025
Язык: Английский
Angewandte Chemie International Edition, Год журнала: 2023, Номер 63(11)
Опубликована: Дек. 12, 2023
Abstract Organic fluorophores are indispensable tools in cells, tissue and vivo imaging, have enabled much progress the wide range of biological biomedical fields. However, many available dyes suffer from insufficient performances, such as short absorption emission wavelength, low brightness, poor stability, small Stokes shift, unsuitable permeability, restricting their application advanced imaging technology complex imaging. Over past two decades, efforts been made to improve these performances fluorophores. Starting with luminescence principle fluorophores, this review clarifies mechanisms performance for traditional a certain extent, systematically summarizes modified approaches optimizing properties, highlights typical applications improved sensing, indicates existing problems challenges area. This not only proves significance improving but also provide theoretical guidance development high‐performance
Язык: Английский
Процитировано
51
Journal of Analysis and Testing, Год журнала: 2023, Номер 7(3), С. 260 - 271
Опубликована: Авг. 14, 2023
Язык: Английский
Процитировано
23
Science China Chemistry, Год журнала: 2024, Номер unknown
Опубликована: Дек. 5, 2024
Язык: Английский
Процитировано
10
ACS Nano, Год журнала: 2024, Номер 18(36), С. 25144 - 25154
Опубликована: Авг. 27, 2024
Near-infrared II (NIR-II) imaging and photothermal therapy hold tremendous potential in precision diagnosis treatment within biological organisms. However, a significant challenge is the shortage of NIR-II fluorescent probes with both high conversion coefficient (PCE) fluorescence quantum yield (Φ
Язык: Английский
Процитировано
9
Analytical Chemistry, Год журнала: 2024, Номер 96(26), С. 10724 - 10731
Опубликована: Июнь 19, 2024
Carboxylesterase (CE), an enzyme widely present in organisms, is involved various physiological and pathological processes. Changes the levels of CEs liver may predict presence type 2 diabetes mellitus (T2DM). Here, a novel dicyanoisophorone (DCI)-based proximity-labeled far-red fluorescent probe DCI2F-Ac with endoplasmic reticulum targeting was proposed for real-time monitoring imaging activity. featured very low cytotoxicity biotoxicity highly selective sensitive CEs. Compared traditional probes, covalently anchored directly to CEs, thus effectively reducing loss situ signals due diffusion. Through "on–off" fluorescence signal readout, able distinguish cell lines screen inhibitors. In terms (ER) stress, it found that thapsigargin (Tg) induced upregulation but not tunicamycin (Tm), which related calcium homeostasis ER. could efficiently detect downregulated livers T2DM, therapeutic efficacy metformin, acarbose, combination these two drugs assessed by tracking fluctuation levels. The results showed combining metformin acarbose restore near-normal best antidiabetic effect. Thus, provides great opportunity explore untapped potential metabolic disorders drug assessment.
Язык: Английский
Процитировано
8
Analytical Chemistry, Год журнала: 2025, Номер 97(1), С. 382 - 391
Опубликована: Янв. 2, 2025
Evaluating tumor radiosensitivity is beneficial for the prediction of treatment efficacy, customization plans, and minimization side effects. Tracking mitochondrial DNA (mtDNA) repair process helps to assess as mtDNA determines fate cell under radiation-induced damage. However, current probes developed monitor levels enzymes suffered from complex synthesis, uncontrollable preparation, limited selectivity, poor organelle-targeting ability. Especially, correlation between activity inherent tumors has not yet been explored. Here, we present a mitochondria-targeted DNA-based nanoprobe (TPP-Apt-tFNA) in situ monitoring enzyme evaluating radiosensitivity. TPP-Apt-tFNA consists tetrahedral framework precisely modified with three functional modules on each vertexes, that is, cell-targeting aptamer, mitochondrion-targeting moiety, apurinic/apyrimidinic endonuclease 1 (APE1)-responsive molecule beacon. Once selectively internalized by cells, targeted mitochondrion specifically recognized APE1 activate fluorescence, allowing observation activity. The showed elevated mitochondria cells oxidative stress. Moreover, enabled illumination different APE1-mediated cycle phases. Furthermore, using vitro vivo, found high repair, which allowed them recover lesions, had low sensitivity radiation an unsatisfactory radiotherapy outcome. Our work provides new imaging tool exploring roles diverse biological processes guiding treatment.
Язык: Английский
Процитировано
1
Science China Chemistry, Год журнала: 2025, Номер unknown
Опубликована: Янв. 2, 2025
Язык: Английский
Процитировано
1
Angewandte Chemie, Год журнала: 2023, Номер 136(11)
Опубликована: Дек. 12, 2023
Abstract Organic fluorophores are indispensable tools in cells, tissue and vivo imaging, have enabled much progress the wide range of biological biomedical fields. However, many available dyes suffer from insufficient performances, such as short absorption emission wavelength, low brightness, poor stability, small Stokes shift, unsuitable permeability, restricting their application advanced imaging technology complex imaging. Over past two decades, efforts been made to improve these performances fluorophores. Starting with luminescence principle fluorophores, this review clarifies mechanisms performance for traditional a certain extent, systematically summarizes modified approaches optimizing properties, highlights typical applications improved sensing, indicates existing problems challenges area. This not only proves significance improving but also provide theoretical guidance development high‐performance
Язык: Английский
Процитировано
21
Chinese Chemical Letters, Год журнала: 2023, Номер 35(5), С. 109156 - 109156
Опубликована: Сен. 27, 2023
Язык: Английский
Процитировано
17
Talanta, Год журнала: 2024, Номер 279, С. 126515 - 126515
Опубликована: Июль 9, 2024
Язык: Английский
Процитировано
8