Communications in computer and information science, Год журнала: 2023, Номер unknown, С. 213 - 227
Опубликована: Янв. 1, 2023
Язык: Английский
Journal of Medicinal Chemistry, Год журнала: 2024, Номер 67(8), С. 6537 - 6548
Опубликована: Апрель 11, 2024
Herein, we have compared the effectivity of light-based photoactivated cancer therapy and ultrasound-based sonodynamic with Re(I)-tricarbonyl complexes (Re1–Re3) against cells. The observed photophysical TD-DFT calculations indicated potential Re1–Re3 to act as good anticancer agents under visible light/ultrasound exposure. Re1 did not display any dark- or light- ultrasound-triggered activity. However, Re2 Re3 displayed concentration-dependent activity upon light ultrasound Interestingly, produced 1O2 OH• on Moreover, induced NADH photo-oxidation in PBS H2O2. To best our knowledge, has been achieved here Re(I) complex for first time PBS. Additionally, released CO cell death mechanism revealed that an apoptotic response HeLa cells via ROS generation. showed slightly better exposure
Язык: Английский
Процитировано
14
ACS Applied Materials & Interfaces, Год журнала: 2024, Номер 16(22), С. 28118 - 28133
Опубликована: Май 24, 2024
Growing challenges with antibiotic resistance pose immense in combating microbial infections and biofilm prevention on medical devices. Lately, antibacterial photodynamic therapy (aPDT) is now emerging as an alternative to overcome this problem. Herein, we synthesized characterized four Ru(II)-complexes, viz., [Ru(ph-tpy)(bpy)Cl]PF6 (Ru1), [Ru(ph-tpy)(dpq)Cl]PF6 (Ru2), [Ru(ph-tpy)(dppz)Cl]PF6 (Ru3), [Ru(ph-tpy)(dppn)Cl]PF6 (Ru4) (where 4′-phenyl-2,2′:6′,2″-terpyridine = ph-tpy; 2,2′-bipyridine bpy; dipyrido[3,2-f:2′,3′-h]quinoxaline dpq; dipyrido[3,2-a:2′,3′-c]phenazine dppz; Benzo[I]dipyrido[3,2-a:2′,3′-c]phenazine dppn), among which Ru2–Ru4 are novel. Octahedral geometry of the complexes a RuN5Cl core was evident from crystal structure Ru2. Ru1–Ru4 showed MLCT absorption band 450–600 nm region, useful for aPDT performances. Further, optimum triplet excited state energy excellent photostability made them good photosensitizers aPDT. demonstrated enhanced antimicrobial activity visible-light exposure (400–700 nm, 10 J cm–2), confirmed using different assays. Mechanistic studies revealed that inhibition bacterial growth due generation oxidative stress (via NADH oxidation ROS generation) upon treatment Ru2–Ru4, resulting destruction wall. Ru2 performed best killing performance against both Gram-negative (Escherichia coli) Gram-positive (Bacillus subtilis) bacteria when exposed light. coated polydimethylsiloxane (PDMS) disk, long-term reusability durable antibiofilm properties. Molecular docking efficient interaction FabH (regulates fatty acid biosynthesis E. PgaB (gives structural stability helps formation coli), probable downregulation. In vivo healthy Wistar rats biocompatibility This study shows these lead (Ru2–Ru4) can be used potent agents low concentrations toward eradication (PDT).
Язык: Английский
Процитировано
13
Inorganic Chemistry Frontiers, Год журнала: 2024, Номер 11(17), С. 5435 - 5448
Опубликована: Янв. 1, 2024
Coumarin 6 appended Ir( iii ) photocatalysts exhibited light activated anticancer effects against cancer cells via mitochondrial depolarization driven apoptosis by inducing type-I (NADH oxidation) and type-II (ROS generation) mechanisms.
Язык: Английский
Процитировано
10
Inorganic Chemistry, Год журнала: 2024, Номер 63(16), С. 7493 - 7503
Опубликована: Апрель 5, 2024
The relentless increase in drug resistance of platinum-based chemotherapeutics has opened the scope for other new cancer therapies with novel mechanisms action (MoA). Recently, photocatalytic therapy, an intrusive catalytic treatment, is receiving significant interest due to its multitargeting cell death mechanism high selectivity. Here, we report synthesis and characterization three photoresponsive Ru(II) complexes, viz., [Ru(ph-tpy)(bpy)Cl]PF6 (Ru1), [Ru(ph-tpy)(phen)Cl]PF6 (Ru2), [Ru(ph-tpy)(aip)Cl]PF6 (Ru3), where, ph-tpy = 4′-phenyl-2,2′:6′,2″-terpyridine, bpy 2,2′-bipyridine, phen 1,10-phenanthroline, aip 2-(anthracen-9-yl)-1H-imidazo[4,5-f][1,10] phenanthroline, showing anticancer activity. X-ray crystal structures Ru1 Ru2 revealed a distorted octahedral geometry RuN5Cl core. complexes showed intense absorption band 440–600 nm range corresponding metal-to-ligand charge transfer (MLCT) that was further used achieve green light-induced effect. mitochondria-targeting photostable complex Ru3 induced phototoxicity IC50 PI values ca. 0.7 μM 88, respectively, under white light irradiation 1.9 35 against HeLa cells. (Ru1–Ru3) negligible dark cytotoxicity toward normal splenocytes (IC50s > 50 μM). mechanistic study ROS-mediated apoptosis cells via mitochondrial depolarization or exposure. Interestingly, also acted as highly potent catalyst NADH photo-oxidation light. This process contributed photocytotoxicity complexes. Overall, presented synergistic type I II photochemotherapeutic effects.
Язык: Английский
Процитировано
9
Chemical Engineering Journal, Год журнала: 2024, Номер 490, С. 151599 - 151599
Опубликована: Апрель 23, 2024
Язык: Английский
Процитировано
8
Journal of Medicinal Chemistry, Год журнала: 2024, Номер 67(13), С. 11125 - 11137
Опубликована: Июнь 21, 2024
The design of the dinuclear Ru(II) complex (Ru2) with strong near-infrared (NIR) absorption properties has been reported for efficient anticancer phototherapy. Under 700 nm LED light excitation, Ru2 exhibited remarkable synergistic type I/II photosensitization ability and photocatalytic activity toward intracellular biomolecules. showed impressive light-triggered under normoxia hypoxia compared clinically used photosensitizer Chlorin e6. mechanistic studies that induced redox imbalance perturbed energy metabolism biosynthesis in A549 cancer cells. Overall, this work provides a new strategy developing metal-based complexes phototherapy NIR light.
Язык: Английский
Процитировано
8
Advanced Healthcare Materials, Год журнала: 2024, Номер unknown
Опубликована: Апрель 18, 2024
Abstract Photoactivable chemotherapy (PACT) using metallic complexes provides spatiotemporal selectivity over drug activation for targeted anticancer therapy. However, the poor absorption in near‐infrared (NIR) light region of most renders tissue penetration challenging. Herein, an NIR triggered dinuclear photoactivable Ru(II) complex ( Ru2 ) is presented and antitumor mechanism comprehensively investigated. The introduction a donor–acceptor–donor (D–A–D) linker greatly enhances intramolecular charge transition, resulting high molar extinction coefficient with extended triplet excited state lifetime. Most importantly, when activated by 700 nm light, exhibits unique slow photodissociation kinetics that facilitates synergistic photosensitization photocatalytic activity to destroy diverse intracellular biomolecules. In vitro vivo experiments show nanomolar photocytotoxicity toward 4T1 cancer cells via induction calcium overload endoplasmic reticulum (ER) stress. These findings provide robust foundation development NIR‐activated PACT phototherapeutic application.
Язык: Английский
Процитировано
5
Science China Chemistry, Год журнала: 2025, Номер unknown
Опубликована: Фев. 25, 2025
Язык: Английский
Процитировано
0
Science China Chemistry, Год журнала: 2023, Номер 66(12), С. 3525 - 3531
Опубликована: Ноя. 22, 2023
Язык: Английский
Процитировано
11
Journal of Medicinal Chemistry, Год журнала: 2025, Номер unknown
Опубликована: Янв. 24, 2025
The hypoxic environment of solid tumors significantly diminishes the therapeutic efficacy oxygen-dependent photodynamic therapy. Developing efficient photosensitizers that operate via photoredox catalysis presents a promising strategy to overcome this challenge. Herein, we report rational design two rhenium(I) tricarbonyl complexes (Re-TPO and Re-TP) with electron donor–acceptor–donor configuration. Notably, Re-TP exhibits aggregation-induced emission properties enhanced spin–orbit coupling compared Re-TPO, thus exhibiting promoted photosensitizing capability. In addition generating type I II reactive oxygen species, excited facilitates photocatalytic oxidation NADH NAD+ photoreduction pyruvic acid lactic acid. This metabolic intervention triggers PD-L1-linked immune responses disrupts tumor redox balance, leading ferroptosis immunogenic cell death. combined immunotherapy effects suppress both primary distant B16 tumors. investigation provides compelling model for designing metal-based PSs photoredox-mediated photoimmunotherapy against
Язык: Английский
Процитировано
0