Inorganica Chimica Acta, Год журнала: 2024, Номер unknown, С. 122457 - 122457
Опубликована: Ноя. 1, 2024
Язык: Английский
Langmuir, Год журнала: 2024, Номер 40(23), С. 12226 - 12238
Опубликована: Май 30, 2024
We have red-shifted the light absorbance property of a Re(I)-tricarbonyl complex via distant conjugation ferrocene moiety and developed novel ReFctp, [Re(Fctp)(CO)3Cl], where Fctp = 4′-ferrocenyl-2,2′:6′,2″-terpyridine. ReFctp showed green to red absorption ability blue emission, indicating its potential for photodynamic therapy (PDT) application. The introduced ferrocene-based transitions, which lie at higher wavelength within PDT therapeutic window. time-dependent density functional theory excited state calculations revealed an efficient intersystem crossing is helpful PDT. elicited both type I II pathways reactive oxygen species (ROS) generation facilitated NADH (1,4-dihydro-nicotinamide adenine dinucleotide) oxidation upon exposure visible light. Importantly, effective penetration through layers clinically relevant 3D multicellular tumor spheroids localized primarily in mitochondria (Pearson's correlation coefficient, PCC 0.65) A549 cancer cells. produced more than 20 times phototoxicity (IC50 ∼1.5 μM) by inducing ROS altering mitochondrial membrane cells nonferrocene analogue Retp, [Re(CO)3(tp)Cl], tp 2,2′:6′,2″-terpyridine. induced apoptotic mode cell death with notable photocytotoxicity index (PI, PI IC50dark/IC50light) selectivity (SI, SI normal cell's IC50dark/cancer IC50light) range 25–33.
Язык: Английский
Процитировано
9
Dalton Transactions, Год журнала: 2024, Номер 53(32), С. 13591 - 13601
Опубликована: Янв. 1, 2024
Here, we have synthesized and characterized three visible light responsive terpyridine based-Re(I)-tricarbonyl complexes; [Re(CO)
Язык: Английский
Процитировано
5
Dalton Transactions, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
The latest developments in controlling the photoinduced processes of Re( i ) tricarbonyl complexes bearing D–A and D–π–A ligands with six different diimine cores decorated by various electron-rich amine, sulphur-based π-conjugated aryl groups.
Язык: Английский
Процитировано
0
Angewandte Chemie International Edition, Год журнала: 2025, Номер unknown
Опубликована: Янв. 13, 2025
Abstract Photoactivatable metal complexes offer the prospect of novel drugs with low side effects and new mechanisms action to combat resistance current therapy. We highlight recent progress in design platinum, ruthenium, iridium, gold other transition complexes, especially for applications as anticancer anti‐infective agents. In particular, understanding excited state chemistry related identification bioactive species (excited metallomics/pharmacophores) is important. metallodrugs are classified here photocatalysts, photorelease agents ligand‐activated Their activation wavelengths, cellular action, experimental theoretical metallomics states photoproducts discussed explore strategies investigation photoactivatable metallodrugs. These have potential clinical Photodynamic Therapy (PDT), Photoactivated Chemotherapy (PACT) Photothermal (PTT).
Язык: Английский
Процитировано
0
Angewandte Chemie, Год журнала: 2025, Номер unknown
Опубликована: Янв. 13, 2025
Abstract Photoactivatable metal complexes offer the prospect of novel drugs with low side effects and new mechanisms action to combat resistance current therapy. We highlight recent progress in design platinum, ruthenium, iridium, gold other transition complexes, especially for applications as anticancer anti‐infective agents. In particular, understanding excited state chemistry related identification bioactive species (excited metallomics/pharmacophores) is important. metallodrugs are classified here photocatalysts, photorelease agents ligand‐activated Their activation wavelengths, cellular action, experimental theoretical metallomics states photoproducts discussed explore strategies investigation photoactivatable metallodrugs. These have potential clinical Photodynamic Therapy (PDT), Photoactivated Chemotherapy (PACT) Photothermal (PTT).
Язык: Английский
Процитировано
0
Journal of the American Chemical Society, Год журнала: 2025, Номер 147(9), С. 7161 - 7181
Опубликована: Фев. 20, 2025
Photocatalytic cancer therapy (PCT) has emerged as a cutting-edge anticancer mechanism of action, harnessing light energy to mediate the catalytic oxidation intracellular substrates. PCT is significant current importance due its potential address limitations conventional chemotherapy, particularly drug resistance and side effects. This approach offers noninvasive, targeted treatment option by utilizing metal-based photocatalysts induce redox metabolic disorders within cells. The disrupt cell metabolism converting NADH/NAD(P)H NAD+/NAD(P)+ via photoredox processes, altering NAD+/NADH or NAD(P)+/NAD(P)H ratios, which are crucial for cellular metabolism. Ir(III), Ru(II), Re(I), Os(II) demonstrated promising efficacy. Despite these developments, gaps remain in literature translating this new into clinical trials. Perspective critically examines developments research area provides future directions designing efficient PCT.
Язык: Английский
Процитировано
0
New Journal of Chemistry, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
Cyclam-based Mo(0) carbonyl complexes revealed important anticancer activity against human breast cancer cell lines.
Язык: Английский
Процитировано
0
Resonance, Год журнала: 2025, Номер 30(3), С. 341 - 353
Опубликована: Апрель 3, 2025
Язык: Английский
Процитировано
0
Journal of Medicinal Chemistry, Год журнала: 2024, Номер 67(15), С. 13435 - 13445
Опубликована: Июль 30, 2024
Photodynamic therapy has been regarded as a noninvasive treatment for cancer with spatiotemporal control over drug activation. Bis-terpyridyl Ru(II) complexes exhibit promising achiral structure but suffer from low photoreactivity due to deviation the ideal octahedral geometry. Herein, we introduce donor–acceptor–donor motif construct dinuclear bis-terpyridyl complex (Ru2). Ru2 exhibits superior light absorption properties compared mononuclear Ru1. Importantly, upon 595 nm excitation, shows synergetic type I/II photosensitization and photocatalytic activity, while Ru1 is inactive. Anticancer mechanistic studies reflect that induces intracellular redox imbalance affects biosynthetic metabolic processes, leading cell apoptosis. Overall, this work provides simple strategy rouse PDT efficiency of complexes.
Язык: Английский
Процитировано
2
Coordination Chemistry Reviews, Год журнала: 2024, Номер 525, С. 216306 - 216306
Опубликована: Ноя. 22, 2024
Язык: Английский
Процитировано
2