Mapping knowledge landscapes and emerging trends of the biomarkers in melanoma: a bibliometric analysis from 2004 to 2022

Frontiers in Oncology, Год журнала: 2023, Номер 13

Опубликована: Июнь 23, 2023

Melanoma is a skin tumor with high mortality rate, and early diagnosis effective treatment are the key to reduce its rate. Therefore, more attention has been paid for biomarker identification diagnosis, prognosis prediction evaluation of melanoma. However, there still lack report that comprehensively objectively evaluates research status melanoma biomarkers. this study aims intuitively analyze trend biomarkers through methods bibliometrics knowledge graph.This uses in melanoma, summarize field's history current research, predict future directions.Articles Reviews related were retrieved by using Web Science core collection subject search. Bibliometric analysis was performed Excel 365, CiteSpace, VOSviewer Bibliometrix (R-Tool R-Studio).A total 5584 documents from 2004 2022 included bibliometric analysis. The results show number publications frequency citations field increasing year year, increased rapidly after 2018. United States most productive influential country field, largest institutions citation frequency. Caroline Robert, F. Stephen Hodi, Suzanne L. Topalian others authoritative authors New England Journal Medicine, Clinical Oncology Cancer Research journals field. Biomarkers hot topics cutting-edge hotspots field.For first time, used method visualize biomarkers, revealing trends frontiers which provides useful reference scholars find issues partners.

Язык: Английский

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Deficiency of betaine-homocysteine methyltransferase activates glucose-6-phosphate dehydrogenase (G6PD) by decreasing arginine methylation of G6PD in hepatocellular carcinogenesis

Science China Life Sciences, Год журнала: 2024, Номер 67(8), С. 1648 - 1665

Опубликована: Апрель 25, 2024

Язык: Английский

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Prophylactic and therapeutic vaccine development: advancements and challenges

Molecular Biomedicine, Год журнала: 2024, Номер 5(1)

Опубликована: Ноя. 11, 2024

Biomedical research is fundamental in developing preventive and therapeutic vaccines, serving as a cornerstone of global public health. This review explores the key concepts, methodologies, tools, challenges vaccine development landscape, focusing on transitioning from basic biomedical sciences to clinical applications. Foundational disciplines such virology, immunology, molecular biology lay groundwork for creation, while recent innovations like messenger RNA (mRNA) technology reverse vaccinology have transformed field. Additionally, it highlights role pharmaceutical advancements translating lab discoveries into solutions. Techniques CRISPR-Cas9, genome sequencing, monoclonal antibodies, computational modeling significantly enhanced precision efficacy, expediting vaccines against infectious diseases. The also discusses that continue hinder progress, including stringent regulatory pathways, hesitancy, rapid emergence new pathogens. These obstacles underscore need interdisciplinary collaboration adoption innovative strategies. Integrating personalized medicine, nanotechnology, artificial intelligence expected revolutionize science further. By embracing these advancements, has potential overcome existing usher era prophylactic ultimately improving health outcomes. emphasizes critical combating current future threats, advocating continued investment technology.

Язык: Английский

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Empowering standardization of cancer vaccines through ontology: enhanced modeling and data analysis

Journal of Biomedical Semantics, Год журнала: 2024, Номер 15(1)

Опубликована: Июнь 18, 2024

The exploration of cancer vaccines has yielded a multitude studies, resulting in diverse collection information. heterogeneity vaccine data significantly impedes effective integration and analysis. While CanVaxKB serves as pioneering database for over 670 manually annotated vaccines, it is important to distinguish that database, on its own, does not offer the structured relationships standardized definitions found an ontology. Recognizing this, we expanded Vaccine Ontology (VO) include those present were initially covered, enhancing VO's capacity systematically define interrelate vaccines. An ontology design pattern (ODP) was first developed applied semantically represent various capturing their associated entities relations. By applying ODP, generated template tabular format converted into RDF/OWL generation terms VO. '12MP vaccine' used example demonstrate application ODP. VO also reuses reference such diseases hosts. Description Logic (DL) SPARQL query scripts based different vaccine's features versatility representation. Additionally, ontological modeling illustrate related concepts studies in-depth A vaccine-specific view, referred "CVO," generated, contains 928 classes including 704 CVO OWL file publicly available on: http://purl.obolibrary.org/obo/vo/cvo.owl , sharing applications. To facilitate standardization, integration, analysis data, model We pipeline automate inclusion This only enriches data's standardization but leverages deepen information, maximizing benefits researchers clinicians. VO-cancer GitHub website is: https://github.com/vaccineontology/VO/tree/master/CVO .

Язык: Английский

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Interdisciplinary symposium on challenges and opportunities for vaccines: A comprehensive approach of current and future vaccine strategies to improve vaccine effectiveness in complex chronic infectious contexts

Vaccine X, Год журнала: 2025, Номер unknown, С. 100615 - 100615

Опубликована: Фев. 1, 2025

Язык: Английский

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Antifungal immunity: advances in PRR recognition, adaptive responses, and immune-based therapies

Science China Life Sciences, Год журнала: 2025, Номер unknown

Опубликована: Март 5, 2025

Язык: Английский

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Adenovirus-based strategies for cancer vaccines

Elsevier eBooks, Год журнала: 2025, Номер unknown, С. 545 - 572

Опубликована: Янв. 1, 2025

Язык: Английский

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Value of Vaccinations: A Fundamental Public Health Priority to Be Fully Evaluated

Vaccines, Год журнала: 2025, Номер 13(5), С. 479 - 479

Опубликована: Апрель 29, 2025

Vaccinations are one of the most impactful public health interventions, saving millions lives annually and reducing spread infectious diseases. Numerous vaccines expected to become available in future. Decision-makers will have thoroughly evaluate them. It is essential fully comprehend value vaccinations effectively efficiently guide decisions. This work aims highlight multifaceted benefits vaccination, extending beyond clinical outcomes encompass profound economic societal advantages. should be considered an investment, not a cost. In comparison other expenditures, vaccine costs can moderate. also reduce fiscal burden by avoiding diseases, minimizing lost workdays absenteeism, lowering disability claims, increasing workforce productivity. The non-vaccination represent relevant issue. Vaccination plays key role addressing global challenge antimicrobial resistance. Apart from quantifiable parameters, intangible pain quality life deaths. Comprehensive Health Technology Assessments required understand overall vaccinations.

Язык: Английский

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Nanostrategies synergize with locoregional interventional therapies for boosting antitumor immunity

Bioactive Materials, Год журнала: 2025, Номер 51, С. 634 - 649

Опубликована: Май 31, 2025

Язык: Английский

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Progress in immunotherapy

Science China Life Sciences, Год журнала: 2023, Номер 66(4), С. 653 - 657

Опубликована: Март 14, 2023

Язык: Английский

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