Prophylactic and therapeutic vaccine development: advancements and challenges

Molecular Biomedicine, Journal Year: 2024, Volume and Issue: 5(1)

Published: Nov. 11, 2024

Biomedical research is fundamental in developing preventive and therapeutic vaccines, serving as a cornerstone of global public health. This review explores the key concepts, methodologies, tools, challenges vaccine development landscape, focusing on transitioning from basic biomedical sciences to clinical applications. Foundational disciplines such virology, immunology, molecular biology lay groundwork for creation, while recent innovations like messenger RNA (mRNA) technology reverse vaccinology have transformed field. Additionally, it highlights role pharmaceutical advancements translating lab discoveries into solutions. Techniques CRISPR-Cas9, genome sequencing, monoclonal antibodies, computational modeling significantly enhanced precision efficacy, expediting vaccines against infectious diseases. The also discusses that continue hinder progress, including stringent regulatory pathways, hesitancy, rapid emergence new pathogens. These obstacles underscore need interdisciplinary collaboration adoption innovative strategies. Integrating personalized medicine, nanotechnology, artificial intelligence expected revolutionize science further. By embracing these advancements, has potential overcome existing usher era prophylactic ultimately improving health outcomes. emphasizes critical combating current future threats, advocating continued investment technology.

Language: Английский

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Mapping knowledge landscapes and emerging trends of the biomarkers in melanoma: a bibliometric analysis from 2004 to 2022

Frontiers in Oncology, Journal Year: 2023, Volume and Issue: 13

Published: June 23, 2023

Melanoma is a skin tumor with high mortality rate, and early diagnosis effective treatment are the key to reduce its rate. Therefore, more attention has been paid for biomarker identification diagnosis, prognosis prediction evaluation of melanoma. However, there still lack report that comprehensively objectively evaluates research status melanoma biomarkers. this study aims intuitively analyze trend biomarkers through methods bibliometrics knowledge graph.This uses in melanoma, summarize field's history current research, predict future directions.Articles Reviews related were retrieved by using Web Science core collection subject search. Bibliometric analysis was performed Excel 365, CiteSpace, VOSviewer Bibliometrix (R-Tool R-Studio).A total 5584 documents from 2004 2022 included bibliometric analysis. The results show number publications frequency citations field increasing year year, increased rapidly after 2018. United States most productive influential country field, largest institutions citation frequency. Caroline Robert, F. Stephen Hodi, Suzanne L. Topalian others authoritative authors New England Journal Medicine, Clinical Oncology Cancer Research journals field. Biomarkers hot topics cutting-edge hotspots field.For first time, used method visualize biomarkers, revealing trends frontiers which provides useful reference scholars find issues partners.

Language: Английский

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Interdisciplinary symposium on challenges and opportunities for vaccines: A comprehensive approach of current and future vaccine strategies to improve vaccine effectiveness in complex chronic infectious contexts

Vaccine X, Journal Year: 2025, Volume and Issue: unknown, P. 100615 - 100615

Published: Feb. 1, 2025

Language: Английский

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Antifungal immunity: advances in PRR recognition, adaptive responses, and immune-based therapies

Science China Life Sciences, Journal Year: 2025, Volume and Issue: unknown

Published: March 5, 2025

Language: Английский

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Advances in Immunotherapy and Targeted Therapy for Gastric Cancer: A Comprehensive Review

British Journal of Hospital Medicine, Journal Year: 2025, Volume and Issue: 86(3), P. 1 - 24

Published: March 26, 2025

Gastric cancer remains one of the most prevalent and lethal malignancies worldwide, characterized by poor survival rates, particularly in advanced stages. In recent years, a paradigm shift gastric treatment has been witnessed with introduction immunotherapy targeted therapies. This review provides detailed examination current immunotherapeutic strategies, including adoptive cell therapy (ACT), immune checkpoint inhibitors (ICIs), vaccines. Additionally, it explores advancements therapies, focusing on human epidermal growth factor receptor 2 (HER2) vascular endothelial (VEGFR) signaling pathways, as well emerging targets such claudin 18.2. Clinical trials investigating chimeric antigen T-cell (CAR-T) therapy, receptor-engineered (TCR-T) natural killer (NK) cell-based treatments have shown promise, when combined conventional chemotherapeutic regimens. However, challenges cytokine release syndrome, immune-related toxicities, scalability issues remain significant. The combination therapies represents promising approach to enhance outcomes. Future directions emphasize need overcome resistance mechanisms refine strategies improve efficacy while reducing adverse effects. aims elucidate landscape explore their potential shaping future clinical management for this devastating disease.

Language: Английский

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Adenovirus-based strategies for cancer vaccines

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 545 - 572

Published: Jan. 1, 2025

Language: Английский

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Value of Vaccinations: A Fundamental Public Health Priority to Be Fully Evaluated

Vaccines, Journal Year: 2025, Volume and Issue: 13(5), P. 479 - 479

Published: April 29, 2025

Introduction: Vaccinations are one of the most impactful public health interventions, saving millions lives annually and reducing spread infectious diseases. Numerous vaccines expected to become available in future. Decision-makers will have thoroughly evaluate them. It is essential fully comprehend value vaccinations effectively efficiently guide decisions. Methods: This work aims highlight multifaceted benefits vaccination, extending beyond clinical outcomes encompass profound economic societal advantages. Results: should be considered an investment, not a cost. In comparison other expenditures, vaccine costs can moderate. also reduce fiscal burden by avoiding diseases, minimizing lost workdays absenteeism, lowering disability claims, increasing workforce productivity. The non-vaccination represent relevant issue. Vaccination plays key role addressing global challenge antimicrobial resistance. Apart from quantifiable parameters, intangible pain quality life deaths. Conclusions: Comprehensive Health Technology Assessments required understand overall vaccinations.

Language: Английский

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Progress in immunotherapy

Science China Life Sciences, Journal Year: 2023, Volume and Issue: 66(4), P. 653 - 657

Published: March 14, 2023

Language: Английский

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Empowering standardization of cancer vaccines through ontology: enhanced modeling and data analysis

Journal of Biomedical Semantics, Journal Year: 2024, Volume and Issue: 15(1)

Published: June 18, 2024

The exploration of cancer vaccines has yielded a multitude studies, resulting in diverse collection information. heterogeneity vaccine data significantly impedes effective integration and analysis. While CanVaxKB serves as pioneering database for over 670 manually annotated vaccines, it is important to distinguish that database, on its own, does not offer the structured relationships standardized definitions found an ontology. Recognizing this, we expanded Vaccine Ontology (VO) include those present were initially covered, enhancing VO's capacity systematically define interrelate vaccines. An ontology design pattern (ODP) was first developed applied semantically represent various capturing their associated entities relations. By applying ODP, generated template tabular format converted into RDF/OWL generation terms VO. '12MP vaccine' used example demonstrate application ODP. VO also reuses reference such diseases hosts. Description Logic (DL) SPARQL query scripts based different vaccine's features versatility representation. Additionally, ontological modeling illustrate related concepts studies in-depth A vaccine-specific view, referred "CVO," generated, contains 928 classes including 704 CVO OWL file publicly available on: http://purl.obolibrary.org/obo/vo/cvo.owl , sharing applications. To facilitate standardization, integration, analysis data, model We pipeline automate inclusion This only enriches data's standardization but leverages deepen information, maximizing benefits researchers clinicians. VO-cancer GitHub website is: https://github.com/vaccineontology/VO/tree/master/CVO .

Language: Английский

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Neurotoxicity profiling of aluminum salt-based nanoparticles as adjuvants for therapeutic cancer vaccine

Journal of Pharmacology and Experimental Therapeutics, Journal Year: 2024, Volume and Issue: 390(1), P. 45 - 52

Published: Jan. 25, 2024

Therapeutic vaccines containing aluminum adjuvants have been widely used in the treatment of tumors due to their powerful immune-enhancing effects. However, neurotoxicity with different physicochemical properties has not completely elucidated. In this study, a library engineered oxyhydroxide (EAO) and hydroxyphosphate (EAHP) nanoparticles was synthesized determine vitro. It demonstrated that surface charge EAHPs size EAOs did affect cytotoxicity N9, bEnd.3, HT22 cells; however, soluble ions trigger three cell lines. Moreover, induce apoptosis N9 cells, further mechanistic studies mediated by mitochondrial reactive oxygen species generation membrane potential loss. This study identifies safety profile aluminum-containing salts nervous system during therapeutic vaccine use, provides novel design strategies for safer applications. SIGNIFICANCE STATEMENT: it cells. comparation, triggered significant lines, indicating form which is presenting may play crucial role its safety. induced dependent on damage. confirms formulations.

Language: Английский

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