Efficacy and safety of neoadjuvant systemic therapy in resectable hepatocellular carcinoma: a Systematic Review and meta-analysis DOI Creative Commons
Dongdong Wu, Ning Liu, Hao Dong

и другие.

Frontiers in Oncology, Год журнала: 2025, Номер 15

Опубликована: Май 9, 2025

Background Neoadjuvant systemic therapy has been shown to benefit patients with solid tumors such as breast cancer and colorectal cancer, but its application in hepatocellular carcinoma (HCC) is still the exploratory stage, no established effective regimen. This systematic review meta-analysis aims investigate efficacy safety of neoadjuvant resectable HCC. Methods The clinical trials HCC PubMed, Embase Cochrane Library were systematically searched. A was performed using STATA/MP18.0 software, effect size calculated either a fixed effects model or random model, 95% confidence intervals (CIs) calculated. Subgroup analysis according Results included 328 from 15 studies. In HCC, pooled pathologic complete response (pCR) rate 15% (95%CI: 10%–21%), major (MPR) 28% 21%–35%), incidence grade 3–4 treatment-related adverse events (TRAEs) 11% (95% CI: 4%–20%), objective (ORR) 27% 20%–35%), surgical resection 84% 75%–92%), delay 0.00% 0%–4%). results subgroup showed that targeted combined immunotherapy superior dual ICI (immune checkpoint inhibitor) combination monotherapy, while monotherapy highest, ICIs immunotherapy. Conclusion shows preliminarily beneficial outcomes treatment. However, future large-scale multicenter randomized controlled are needed confirm this conclusion. Systematic registration https://www.crd.york.ac.uk/prospero/ , identifier CRD42024562257

Язык: Английский

A multi-omic analysis reveals that gamabufotalin exerts anti-hepatocellular carcinoma effects by regulating amino acid metabolism through targeting STAMBPL1 DOI
Piao Zheng,

Die Xu,

Yisi Cai

и другие.

Phytomedicine, Год журнала: 2024, Номер 135, С. 156094 - 156094

Опубликована: Сен. 24, 2024

Язык: Английский

Процитировано

18
Ferroptosis and circular RNAs: new horizons in cancer therapy. DOI
Asif Ahmad Bhat,

Neelima Kukreti,

Muhammad Afzal

и другие.

PubMed, Год журнала: 2024, Номер 23, С. 570 - 599

Опубликована: Янв. 1, 2024

Cancer poses intricate challenges to treatment due its complexity and diversity. Ferroptosis circular RNAs (circRNAs) are emerging as innovative therapeutic avenues amid the evolving landscape of cancer therapy. Extensive investigations into circRNAs reveal their diverse roles, ranging from molecular regulators pivotal influencers ferroptosis in cell lines. The results underscore significance modulating pathways that impact crucial aspects development, including survival, proliferation, metastasis. A detailed analysis delineates these pathways, shedding light on mechanisms through which influence ferroptosis. Building upon recent experimental findings, study evaluates potential targeting induce By identifying specific associated with etiology cancer, this paves way for development targeted therapeutics exploit vulnerabilities cells. This review consolidates existing understanding circRNAs, emphasizing role therapy providing impetus ongoing research dynamic field. See also graphical abstract(Fig. 1).

Язык: Английский

Процитировано

7
The role of histone lactylation genes in hepatocellular carcinoma prognostic models and their immune cell infiltration features: a comprehensive analysis of single-cell, spatial transcriptome, Mendelian randomization and experiment DOI Creative Commons
Shanjie Luan

Discover Oncology, Год журнала: 2025, Номер 16(1)

Опубликована: Янв. 10, 2025

With the increasing impact of hepatocellular carcinoma (HCC) on society, there is an urgent need to propose new HCC diagnostic biomarkers and identification models. Histone lysine lactylation (Kla) affects prognosis cancer patients emerging target in treatment. However, potential Kla-related genes poorly understood. A variety machine learning methods were used construct validate a model differentially expressed Kla with comprehensive evaluations included ROC, Kaplan‒Meier curve, Cox regression, decision curve. Immune infiltration gathered spatial transcriptome was performed using integrated data from multiple databases. Furthermore, single-cell analysis discover cell–cell communication Mendelian randomization study causal relationships between immune cell HCC. Lastly, qRT-PCR verify expression genes. We established consisting 12 that had well prognostic performance identified as independent factors. Single-cell showed CD8 T+ cells conventional dendritic enriched patients. Spatial transcriptomics indicated influenced characteristics results TBNK monocytes main risk validation Huh7 significantly higher than LO2 cells. Overall, established, which may provide strategies insights for treatment diagnosis

Язык: Английский

Процитировано

1
METTL14 suppresses the migration and invasion of hepatocellular carcinoma cells by m6A methylation of RPLP2 DOI Creative Commons

Hong-Mei Rong,

Yan Jiang

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Фев. 15, 2025

Язык: Английский

Процитировано

1
GINS4 silencing mediates hepatocellular cancer cell proliferation, cycle and ferroptosis through POLE2 DOI
Jiarui Yao,

Huaicheng Yang,

Meng Yuan

и другие.

Cellular Signalling, Год журнала: 2025, Номер 131, С. 111742 - 111742

Опубликована: Март 11, 2025

Язык: Английский

Процитировано

1
EPS15-AS1 Inhibits AKR1B1 Expression to Enhance Ferroptosis in Hepatocellular Carcinoma Cells DOI Creative Commons
Quan Man, Guoyou Zhang, Xiaojun Chen

и другие.

Journal of Cancer, Год журнала: 2024, Номер 15(4), С. 1030 - 1040

Опубликована: Янв. 1, 2024

Epidermal growth factor receptor substrate 15 (EPS15) is part of the EGFR pathway and has been implicated in various tumorigenesis.Increasing evidence suggests that long noncoding RNA (lncRNA) plays an essential role liver hepatocellular carcinoma (LIHC) by regulating expression proteins genes.Through analysis cancer genome atlas (TCGA) database, we found EPS15 highly expressed LIHC tissue, lncRNA EPS15-antisense1 (EPS15-AS1) decreased cell lines.However, function EPS15-AS1 still unknown.When was overexpressed HepG2 lines, reduced activity invasiveness were inhibited.In addition, observed increase Fe 2+ ion lipid peroxidation after overexpression EPS15-AS1, further showed susceptibility to ferroptosis increased.Aldo-keto reductase family 1 member B (AKR1B1) belongs aldo/keto superfamily involved maintaining cellular redox balance.Survival revealed patients with a higher level AKR1B1 have lower survival rate TCGA database.We also enhanced LIHC, had ability promote invasiveness.Moreover, alleviated promoting effect on ferroptosis.Therefore, can induce cells inhibiting disrupting balance.EPS15 may serve as biomarkers for diagnosis potential drug LIHC.

Язык: Английский

Процитировано

6
Role of TIM-1 in the development and treatment of tumours DOI Creative Commons

Jinmeng Cao,

Jilin Qing,

Liya Zhu

и другие.

Frontiers in Cell and Developmental Biology, Год журнала: 2024, Номер 12

Опубликована: Май 20, 2024

T-cell immunoglobulin and mucin structural domain 1 (TIM-1, also known as hepatitis A virus cell receptor 1) is a co-stimulatory molecule that expressed predominantly on the surface of T cells. TIM-1 promotes activation proliferation cells, cytokine secretion, can be overexpressed in various types cancer. Upregulation expression may associated with development progression After reviewing literature, we propose affects tumour mainly through two pathways. In Direct pathway: overexpression tumours activates tumour-related signaling pathways, mediates proliferation, apoptosis, invasion metastasis, directly directly. indirect addition to changing microenvironment influencing growth tumours, binds ligands encourage activation, generation cytokines by immune This review examines how stimulates direct ways, exploited target for cancer therapy.

Язык: Английский

Процитировано

3
β,β-Dimethylacrylalkannin, a Natural Naphthoquinone, Inhibits the Growth of Hepatocellular Carcinoma Cells by Modulating Tumor-Associated Macrophages DOI Creative Commons
Lisha Shen,

Zesi Lin,

Rui‐Hong Gong

и другие.

Molecules, Год журнала: 2024, Номер 29(16), С. 3919 - 3919

Опубликована: Авг. 20, 2024

Tumor-associated macrophages (TAMs) are pivotal in the tumor microenvironment (TME) of hepatocellular carcinoma (HCC), influencing various stages from initiation to metastasis. Understanding role TAMs HCC is crucial for developing novel therapeutic strategies. Macrophages exhibit plasticity, resulting M1 and M2 phenotypes, with displaying antitumor properties promoting progression. Targeting alter their polarization could offer new avenues treatment. β,β-dimethylacrylalkannin (DMAKN), a natural naphthoquinone, has gained attention its properties. However, impact on modulation remains unclear. This study investigates DMAKN's anti-HCC activity. Using an vitro model THP-1 cells, we induced LPS/IFN-γ IL-4/IL-13, confirming specific markers. Co-culturing these cells showed that inhibited growth, while promoted it. Screening non-toxic DMAKN concentrations revealed ability induce enhance LPS/IFN-γ-induced macrophages, both showing effects. Conversely, suppressed IL-4/IL-13-induced polarization, inhibiting macrophages' promotion cell viability. In summary, induces enhances thereby growth. These findings suggest potential regulate HCC, offering promise future development.

Язык: Английский

Процитировано

3
KIF18B: an important role in signaling pathways and a potential resistant target in tumor development DOI Creative Commons
Shicheng Chen,

Bo Yu,

Guo Tu DU

и другие.

Discover Oncology, Год журнала: 2024, Номер 15(1)

Опубликована: Сен. 11, 2024

Язык: Английский

Процитировано

3
Caracterización, manejo y desenlaces de pacientes con carcinoma hepatocelular en hígado cirrótico tratados en un centro de referencia en Cali, Colombia DOI Creative Commons
Gabriel Sebastián Díaz-Ramírez, Diana Marcela Escobar-Cárdenas, Christian Camilo Cano-Granda

и другие.

Hepatología, Год журнала: 2025, Номер 6(1), С. 34 - 46

Опубликована: Янв. 2, 2025

Introducción. El carcinoma hepatocelular (CHC) es actualmente uno de los cánceres más prevalentes a nivel mundial, ocupando el sexto lugar, y una las principales causas mortalidad por cáncer, ubicándose en tercer lugar. La cirrosis hepática factor riesgo predominante, con etiologías comunes que incluyen la esteatohepatitis asociada disfunción metabólica (MASH), hepatitis virales consumo alcohol. Hasta fecha, no disponemos estudios epidemiológicos locales caractericen forma detallada esta población. objetivo este estudio describir características demográficas, clínicas desenlaces interés pacientes adultos diagnóstico CHC hígado cirrótico. Metodología. Estudio observacional, descriptivo longitudinal, basado historias clínicas. Se incluyeron mayores 18 años atendidos Fundación Valle del Lili entre enero 2014 diciembre 2019 CHC. realizaron descripciones detalladas variables sociodemográficas, clínicas, paraclínicas tumorales. Los muerte, progresión enfermedad supervivencia tanto pre como postrasplante. Resultados. 212 pacientes, mayoría hombres (62 %) mediana edad 70 (RIC= 63-76). principal etiología fue MASH (35 %), seguida alcohol (17,5 C (17 %). tenían clasificación ChildPugh A (57,5 un puntaje MELD (Model for End-stage Liver Disease) 10 puntos. 45,3 % tuvo Barcelona Clinic Cancer (BCLC) al momento diagnóstico, terapia primera línea utilizada quimioembolización transarterial (TACE). Durante seguimiento, se observó global 26 meses y, durante periodo postrasplante, tasas fueron 88 %, 85 79 12, 24 60 meses, respectivamente. Conclusión. datos encontrados son similares pocos han sido descritos población colombiana, aunque algunas discrepancias. personas continúa siendo muy alta, lo subraya necesidad creciente concientización sobre tamizaje enfermedad. Esto crucial para lograr detección estadios tempranos poder ofrecer opciones tratamiento curativas.

Процитировано

0