Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 256, P. 155252 - 155252
Published: March 5, 2024
Language: Английский
Phytomedicine, Journal Year: 2024, Volume and Issue: 135, P. 156094 - 156094
Published: Sept. 24, 2024
Language: Английский
Citations
14
Discover Oncology, Journal Year: 2025, Volume and Issue: 16(1)
Published: Jan. 10, 2025
With the increasing impact of hepatocellular carcinoma (HCC) on society, there is an urgent need to propose new HCC diagnostic biomarkers and identification models. Histone lysine lactylation (Kla) affects prognosis cancer patients emerging target in treatment. However, potential Kla-related genes poorly understood. A variety machine learning methods were used construct validate a model differentially expressed Kla with comprehensive evaluations included ROC, Kaplan‒Meier curve, Cox regression, decision curve. Immune infiltration gathered spatial transcriptome was performed using integrated data from multiple databases. Furthermore, single-cell analysis discover cell–cell communication Mendelian randomization study causal relationships between immune cell HCC. Lastly, qRT-PCR verify expression genes. We established consisting 12 that had well prognostic performance identified as independent factors. Single-cell showed CD8 T+ cells conventional dendritic enriched patients. Spatial transcriptomics indicated influenced characteristics results TBNK monocytes main risk validation Huh7 significantly higher than LO2 cells. Overall, established, which may provide strategies insights for treatment diagnosis
Language: Английский
Citations
1
Cellular Signalling, Journal Year: 2025, Volume and Issue: 131, P. 111742 - 111742
Published: March 11, 2025
Language: Английский
Citations
1
PubMed, Journal Year: 2024, Volume and Issue: 23, P. 570 - 599
Published: Jan. 1, 2024
Cancer poses intricate challenges to treatment due its complexity and diversity. Ferroptosis circular RNAs (circRNAs) are emerging as innovative therapeutic avenues amid the evolving landscape of cancer therapy. Extensive investigations into circRNAs reveal their diverse roles, ranging from molecular regulators pivotal influencers ferroptosis in cell lines. The results underscore significance modulating pathways that impact crucial aspects development, including survival, proliferation, metastasis. A detailed analysis delineates these pathways, shedding light on mechanisms through which influence ferroptosis. Building upon recent experimental findings, study evaluates potential targeting induce By identifying specific associated with etiology cancer, this paves way for development targeted therapeutics exploit vulnerabilities cells. This review consolidates existing understanding circRNAs, emphasizing role therapy providing impetus ongoing research dynamic field. See also graphical abstract(Fig. 1).
Language: Английский
Citations
7
Journal of Cancer, Journal Year: 2024, Volume and Issue: 15(4), P. 1030 - 1040
Published: Jan. 1, 2024
Epidermal growth factor receptor substrate 15 (EPS15) is part of the EGFR pathway and has been implicated in various tumorigenesis.Increasing evidence suggests that long noncoding RNA (lncRNA) plays an essential role liver hepatocellular carcinoma (LIHC) by regulating expression proteins genes.Through analysis cancer genome atlas (TCGA) database, we found EPS15 highly expressed LIHC tissue, lncRNA EPS15-antisense1 (EPS15-AS1) decreased cell lines.However, function EPS15-AS1 still unknown.When was overexpressed HepG2 lines, reduced activity invasiveness were inhibited.In addition, observed increase Fe 2+ ion lipid peroxidation after overexpression EPS15-AS1, further showed susceptibility to ferroptosis increased.Aldo-keto reductase family 1 member B (AKR1B1) belongs aldo/keto superfamily involved maintaining cellular redox balance.Survival revealed patients with a higher level AKR1B1 have lower survival rate TCGA database.We also enhanced LIHC, had ability promote invasiveness.Moreover, alleviated promoting effect on ferroptosis.Therefore, can induce cells inhibiting disrupting balance.EPS15 may serve as biomarkers for diagnosis potential drug LIHC.
Language: Английский
Citations
6
Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)
Published: Feb. 15, 2025
Language: Английский
Citations
0
World Journal of Gastrointestinal Oncology, Journal Year: 2025, Volume and Issue: 17(4)
Published: March 24, 2025
Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality worldwide. Transarterial chemoembolization (TACE) combined with percutaneous radiofrequency ablation (RFA) has emerged as promising treatment strategy for patients unresectable HCC. To evaluate the effectiveness and safety TACE RFA compared to alone in management primary A comprehensive retrospective analysis was conducted at our institution from January 2020 2024, involving 106 diagnosed intermediate advanced-stage Patients were divided into two groups: Those receiving (n = 56) those undergoing therapy 50). Treatment efficacy assessed based on tumor response rates, serum alpha-fetoprotein (AFP) levels, survival outcomes. Statistical analyses, including χ 2 tests Kaplan-Meier analysis, performed compare outcomes between groups. The + group demonstrated significantly higher rates complete (15 vs 4, P < 0.01) partial (23 15, 0.046) group. Conversely, exhibited stable disease (25 7, progressive (12 5, 0.01). Serum AFP levels decreased over time group, while they increased Survival revealed superior prolonged median combination could offer enhanced HCC alone. These findings might support adoption multimodal therapeutic approaches, emphasizing importance personalized strategies
Language: Английский
Citations
0
Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16
Published: March 28, 2025
In recent years, natural compounds have attracted wide attention for the treatment of liver cancer due to their therapeutic potential and reduced toxicity. Among these, Schisandrin B (Sch B), a primary bioactive component derived from Schisandra chinensis, has shown notable antitumor activity; however, its specific mechanism remains unclear. The effect Sch on growth hepatocellular carcinoma(HCC) cells were assessed using CCK-8 assay, colony formation assay EdU apoptosis was detected by flow cytometry. co-culture system macrophages HCC established detect cell viability cycle changes in system. Then, migration studied subtoxic concentration B. Exosomes with or without collected identification protein spectrum analysis. differential analyzed KEGG enrichment analysis interaction network, which verified western blotting. Meanwhile, expression macrophage polarization markers detected. Finally, inhibitory FN1 vivo experiments. inhibited growth; moreover, it significantly suppressed proliferation induced S-phase arrest downregulating CDK4, CDK2, cyclin A2 while upregulating p27 Kip1. Additionally, system.The differentially expressed fibronectin 1(FN1) patients higher than that healthy people. Moreover, after SchB treatment, exosomes decreased exhibited M1 polarization. experiments also downregulated tumor tissues. may inhibit development inhibiting exosomal FN1during interactions between cells.
Language: Английский
Citations
0
Hepatología, Journal Year: 2025, Volume and Issue: 6(1), P. 34 - 46
Published: Jan. 2, 2025
Introducción. El carcinoma hepatocelular (CHC) es actualmente uno de los cánceres más prevalentes a nivel mundial, ocupando el sexto lugar, y una las principales causas mortalidad por cáncer, ubicándose en tercer lugar. La cirrosis hepática factor riesgo predominante, con etiologías comunes que incluyen la esteatohepatitis asociada disfunción metabólica (MASH), hepatitis virales consumo alcohol. Hasta fecha, no disponemos estudios epidemiológicos locales caractericen forma detallada esta población. objetivo este estudio describir características demográficas, clínicas desenlaces interés pacientes adultos diagnóstico CHC hígado cirrótico. Metodología. Estudio observacional, descriptivo longitudinal, basado historias clínicas. Se incluyeron mayores 18 años atendidos Fundación Valle del Lili entre enero 2014 diciembre 2019 CHC. realizaron descripciones detalladas variables sociodemográficas, clínicas, paraclínicas tumorales. Los muerte, progresión enfermedad supervivencia tanto pre como postrasplante. Resultados. 212 pacientes, mayoría hombres (62 %) mediana edad 70 (RIC= 63-76). principal etiología fue MASH (35 %), seguida alcohol (17,5 C (17 %). tenían clasificación ChildPugh A (57,5 un puntaje MELD (Model for End-stage Liver Disease) 10 puntos. 45,3 % tuvo Barcelona Clinic Cancer (BCLC) al momento diagnóstico, terapia primera línea utilizada quimioembolización transarterial (TACE). Durante seguimiento, se observó global 26 meses y, durante periodo postrasplante, tasas fueron 88 %, 85 79 12, 24 60 meses, respectivamente. Conclusión. datos encontrados son similares pocos han sido descritos población colombiana, aunque algunas discrepancias. personas continúa siendo muy alta, lo subraya necesidad creciente concientización sobre tamizaje enfermedad. Esto crucial para lograr detección estadios tempranos poder ofrecer opciones tratamiento curativas.
Citations
0
Journal of Hepatocellular Carcinoma, Journal Year: 2025, Volume and Issue: Volume 12, P. 149 - 167
Published: Jan. 1, 2025
Artesunate can inhibit the proliferation of various tumor cells and has practical value in developing anti-tumor drugs. However, its biological activity against hepatocellular carcinoma is weak. The efficacy effect needs to be improved. 11 compounds three types were designed synthesized. Their antitumor was detected by MTT assay vitro subcutaneous xenograft model vivo. Then, DCFH-DA probe detection NAC intervention experiments used detect ROS levels. ferroptosis inhibitor (Liproxstatin-1) study compound 6c inducing ferroptosis. Western blot observe expression apoptosis-related proteins. ability induce apoptosis Annexin V-FITC/PI double staining Hoechst 33342 experiment. on cycle arrest flow cytometry. Molecular simulations several hybrids with vascular endothelial growth factor receptor 2 (VEGFR-2) Transferrin protein 1 (TFR1) performed using MOE molecular docking software. A series new artemisinin-4-(4-substituted phenoxy) pyridine derivatives synthesized their anticancer activities tested lines (HCC) cells. Among hybrid hits activity, a representative increased reactive oxygen species (ROS) level activated mitochondrial ferroptosis, leading cell at G2/M phase. shows binding oncogenic that are overexpressed malignant epithelial tumors. Taken together, our identification promising may hold developmental potential for therapy carcinoma.
Language: Английский
Citations
0