International Journal of Obesity, Год журнала: 2020, Номер 45(1), С. 1 - 11
Опубликована: Окт. 8, 2020
Язык: Английский
Current Obesity Reports, Год журнала: 2021, Номер 10(4), С. 458 - 466
Опубликована: Окт. 2, 2021
Язык: Английский
Процитировано
325
Diabetes, Год журнала: 2020, Номер 69(9), С. 1857 - 1863
Опубликована: Июль 15, 2020
Coronavirus disease 2019 (COVID-19) is a novel threat that seems to result from the collusion between new pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and an existing metabolic driven by obesity. This Perspective explores evolving epidemiological, clinical, biological, molecular evidence propose unfolding paradigm in which old age, chronic (such as obesity, type diabetes, syndrome), male biological sex produce deadly symbiosis dysregulated immunometabolism systemic inflammation intensifies virally induced hyperinflammation associated with SARS-CoV-2 infection. It intended inspire research directions stimulate funding this field.
Язык: Английский
Процитировано
163
JACC. Cardiovascular imaging, Год журнала: 2022, Номер 15(6), С. 1078 - 1088
Опубликована: Апрель 13, 2022
Язык: Английский
Процитировано
102
Journal of Endocrinological Investigation, Год журнала: 2023, Номер 47(2), С. 299 - 306
Опубликована: Сен. 23, 2023
Abstract Purpose There is a growing awareness of the importance understanding gender differences in obesity. The aim this short review was to revise current evidence on anthropometric characteristics and nutritional pharmacological aspects obesity from perspective. Methods A literature search within PubMed performed. Selected publications related were reviewed. Results prevalence among men higher than women, but women have percentage body fat content compared men, appears be an important factor manifestation central (android) or peripheral (gynoid) In addition, while most clinical trials, are still underrepresented, registration trials anti-obesity drugs, commonly up-represented gender-specific analysis uncommon. Considering that adipose tissue one factors affecting volume distribution many mainly lipophilic might expected pharmacokinetics pharmacodynamics drugs. Indeed, although Liraglutide 3 mg, long-acting glucagon-like peptide-1 receptor agonist, naltrexone/bupropion display properties, currently, gender–dose adjustment for both these drugs administration not recommended. despite predicted responders treatment offer substantial opportunities efficient use, especially expensive new therapies, such as data identify early yet been investigated. Finally, bariatric surgery disparity reflects healthcare practices. Weight loss similar, differing effects: need more correction face psychology challenges; worse physiology fewer comorbidity improvements. Conclusion Gender exist phenotype, distribution, drug efficacy, trial representation, different secondary effects surgery. variable analysis.
Язык: Английский
Процитировано
55
International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(2), С. 1588 - 1588
Опубликована: Янв. 13, 2023
Metabolic syndrome (Mets) is a clinical condition characterized by cluster of major risk factors for cardiovascular disease (CVD) and type 2 diabetes: proatherogenic dyslipidemia, elevated blood pressure, dysglycemia, abdominal obesity. Each factor has an independent effect, but, when aggregated, they become synergistic, doubling the developing diseases causing 1.5-fold increase in all-cause mortality. We will highlight gender differences epidemiology, etiology, pathophysiology, expression aforementioned Mets components. Moreover, we discuss new biochemical markers metabolic risk.
Язык: Английский
Процитировано
48
Scientific Reports, Год журнала: 2019, Номер 9(1)
Опубликована: Фев. 25, 2019
Abstract Studying circadian rhythms in most human tissues is hampered by difficulty collecting serial samples. Here we reveal the transcriptome and metabolic pathways of white adipose tissue. Subcutaneous tissue was taken from seven healthy males under highly controlled ‘constant routine’ conditions. Five biopsies per participant were at six-hourly intervals for microarray analysis silico integrative modelling. We identified 837 transcripts exhibiting expression profiles (2% 41619 transcript targeting probes on array), with clear separation peaking morning (258 probes) evening (579 probes). There only partial overlap our rhythmic published animal blood data. Morning-peaking associated regulation gene expression, nitrogen compound metabolism, nucleic acid biology; evening-peaking organic cofactor metabolism redox activity. In pathway further indicated lipid metabolism; it also predicted variation key such as citric cycle branched chain amino degradation. summary, vivo exist multiple pathways, including those involved core aspects cellular biochemistry.
Язык: Английский
Процитировано
79
Obesity Surgery, Год журнала: 2020, Номер 30(12), С. 5086 - 5100
Опубликована: Окт. 6, 2020
Abstract Emerging evidence highlights that dysfunction of adipose tissue contributes to impaired insulin sensitivity and systemic metabolic deterioration in obese state. Of note, adipocyte hypertrophy serves as a critical event which associates closely with dysfunction. An increase cell size exacerbates hypoxia inflammation well excessive collagen deposition, finally leading dysregulation. Specific mechanisms include dysregulated differentiation maturation preadipocytes, enlargement lipid droplets, abnormal osmolarity sensors. Also, weight loss therapies exert profound influence on size. Here, we summarize the role development disturbances. Future studies are required establish standard criterion measurement better clarify impact changes homeostasis.
Язык: Английский
Процитировано
79
Open Biology, Год журнала: 2020, Номер 10(12)
Опубликована: Дек. 1, 2020
Adipose, or fat, tissue (AT) was once considered an inert that primarily existed to store lipids, and not historically recognized as important organ in the regulation maintenance of health. With rise obesity more rigorous research, AT is now a highly complex metabolic involved host physiological functions, including glucose homeostasis multitude endocrine capabilities. dysfunction has been implicated several disease states, most notably obesity, syndrome type 2 diabetes. The study provided useful insight developing strategies combat these prevalent diseases. This review highlights major functions adipose consequences can occur when disruption leads systemic dysfunction.
Язык: Английский
Процитировано
76
Obesity Reviews, Год журнала: 2021, Номер 23(S1)
Опубликована: Ноя. 12, 2021
We conducted a systematic review and meta-analysis of the associations between prenatal exposure to persistent organic pollutants (POPs) childhood obesity. focused on organochlorines (dichlorodiphenyltrichloroethane [DDT], dichlorodiphenyldichloroethylene [DDE], hexachlorobenzene [HCB], polychlorinated biphenyls [PCBs]), perfluoroalkyl polyfluoroalkyl substances (PFAS), polybrominated diphenyl ethers (PBDEs) that are POPs more widely studied in environmental birth cohorts so far. search two databases (PubMed Embase) through July/09/2021 identified 33 studies reporting with organochlorine exposure, 21 PFAS, five PBDEs. qualitative review. Additionally, we performed random-effects meta-analyses POP exposures, data estimates from at least three prospective studies, BMI-z. Prenatal DDE HCB levels were associated higher BMI z-score (beta: 0.12, 95% CI: 0.03, 0.21; I
Язык: Английский
Процитировано
65
Current Diabetes Reports, Год журнала: 2022, Номер 22(1), С. 27 - 37
Опубликована: Янв. 1, 2022
Язык: Английский
Процитировано
64