Sex‐ and age‐specific associations between cardiometabolic risk and white matter brain age in the UK Biobank cohort DOI Creative Commons
Sivaniya Subramaniapillai, Sana Suri, Cláudia Barth

et al.

Human Brain Mapping, Journal Year: 2022, Volume and Issue: 43(12), P. 3759 - 3774

Published: April 23, 2022

Abstract Cardiometabolic risk (CMR) factors are associated with accelerated brain aging and increased for sex‐dimorphic illnesses such as Alzheimer's disease (AD). Yet, it is unknown how CMRs interact sex apolipoprotein E‐ ϵ 4 ( APOE4 ), a known genetic factor AD, to influence age across different life stages. Using prediction based on multi‐shell diffusion‐weighted imaging data in 21,308 UK Biobank participants, we investigated whether associations between white matter Brain Age Gap (BAG) body mass index (BMI), waist‐to‐hip ratio (WHR), fat percentage (BF%), status varied (i) males females, (ii) according at menopause (iii) groups females. We report differences BAG all three CMRs, stronger positive among compared Independent of status, higher (older relative chronological age) was greater BMI, WHR, BF% males, whereas but not BMI BF%. These divergent were most prominent within the oldest group females (66–81 years), where linked lower BAG. Earlier transition BAG, no interactions found CMRs. In conclusion, findings point sex‐ age‐specific age. Incorporating interest studies addressing CMR may promote sex‐specific precision medicine, consequently improving health care both

Language: Английский

Sex/Gender Differences in Obesity Prevalence, Comorbidities, and Treatment DOI

Ashley J. Cooper,

Sapana R. Gupta,

Afaf F. Moustafa

et al.

Current Obesity Reports, Journal Year: 2021, Volume and Issue: 10(4), P. 458 - 466

Published: Oct. 2, 2021

Language: Английский

Citations

320
Aging, Male Sex, Obesity, and Metabolic Inflammation Create the Perfect Storm for COVID-19 DOI Open Access
Franck Mauvais‐Jarvis

Diabetes, Journal Year: 2020, Volume and Issue: 69(9), P. 1857 - 1863

Published: July 15, 2020

Coronavirus disease 2019 (COVID-19) is a novel threat that seems to result from the collusion between new pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and an existing metabolic driven by obesity. This Perspective explores evolving epidemiological, clinical, biological, molecular evidence propose unfolding paradigm in which old age, chronic (such as obesity, type diabetes, syndrome), male biological sex produce deadly symbiosis dysregulated immunometabolism systemic inflammation intensifies virally induced hyperinflammation associated with SARS-CoV-2 infection. It intended inspire research directions stimulate funding this field.

Language: Английский

Citations

162
Pericoronary Adipose Tissue Attenuation, Low-Attenuation Plaque Burden, and 5-Year Risk of Myocardial Infarction DOI Creative Commons
Evangelos Tzolos, Michelle C. Williams, Priscilla McElhinney

et al.

JACC. Cardiovascular imaging, Journal Year: 2022, Volume and Issue: 15(6), P. 1078 - 1088

Published: April 13, 2022

Language: Английский

Citations

100
Obesity: a gender-view DOI Creative Commons
Giovanna Muscogiuri, Ludovica Verde, Claudia Vetrani

et al.

Journal of Endocrinological Investigation, Journal Year: 2023, Volume and Issue: 47(2), P. 299 - 306

Published: Sept. 23, 2023

Abstract Purpose There is a growing awareness of the importance understanding gender differences in obesity. The aim this short review was to revise current evidence on anthropometric characteristics and nutritional pharmacological aspects obesity from perspective. Methods A literature search within PubMed performed. Selected publications related were reviewed. Results prevalence among men higher than women, but women have percentage body fat content compared men, appears be an important factor manifestation central (android) or peripheral (gynoid) In addition, while most clinical trials, are still underrepresented, registration trials anti-obesity drugs, commonly up-represented gender-specific analysis uncommon. Considering that adipose tissue one factors affecting volume distribution many mainly lipophilic might expected pharmacokinetics pharmacodynamics drugs. Indeed, although Liraglutide 3 mg, long-acting glucagon-like peptide-1 receptor agonist, naltrexone/bupropion display properties, currently, gender–dose adjustment for both these drugs administration not recommended. despite predicted responders treatment offer substantial opportunities efficient use, especially expensive new therapies, such as data identify early yet been investigated. Finally, bariatric surgery disparity reflects healthcare practices. Weight loss similar, differing effects: need more correction face psychology challenges; worse physiology fewer comorbidity improvements. Conclusion Gender exist phenotype, distribution, drug efficacy, trial representation, different secondary effects surgery. variable analysis.

Language: Английский

Citations

53
Gender Differences and Cardiometabolic Risk: The Importance of the Risk Factors DOI Open Access
Antonella Meloni, Christian Cadeddu Dessalvi, Lucia Cugusi

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(2), P. 1588 - 1588

Published: Jan. 13, 2023

Metabolic syndrome (Mets) is a clinical condition characterized by cluster of major risk factors for cardiovascular disease (CVD) and type 2 diabetes: proatherogenic dyslipidemia, elevated blood pressure, dysglycemia, abdominal obesity. Each factor has an independent effect, but, when aggregated, they become synergistic, doubling the developing diseases causing 1.5-fold increase in all-cause mortality. We will highlight gender differences epidemiology, etiology, pathophysiology, expression aforementioned Mets components. Moreover, we discuss new biochemical markers metabolic risk.

Language: Английский

Citations

47
Circadian regulation in human white adipose tissue revealed by transcriptome and metabolic network analysis DOI Creative Commons
Skevoulla Christou, Sophie M. T. Wehrens, C Isherwood

et al.

Scientific Reports, Journal Year: 2019, Volume and Issue: 9(1)

Published: Feb. 25, 2019

Abstract Studying circadian rhythms in most human tissues is hampered by difficulty collecting serial samples. Here we reveal the transcriptome and metabolic pathways of white adipose tissue. Subcutaneous tissue was taken from seven healthy males under highly controlled ‘constant routine’ conditions. Five biopsies per participant were at six-hourly intervals for microarray analysis silico integrative modelling. We identified 837 transcripts exhibiting expression profiles (2% 41619 transcript targeting probes on array), with clear separation peaking morning (258 probes) evening (579 probes). There only partial overlap our rhythmic published animal blood data. Morning-peaking associated regulation gene expression, nitrogen compound metabolism, nucleic acid biology; evening-peaking organic cofactor metabolism redox activity. In pathway further indicated lipid metabolism; it also predicted variation key such as citric cycle branched chain amino degradation. summary, vivo exist multiple pathways, including those involved core aspects cellular biochemistry.

Language: Английский

Citations

79
Adipose Morphology: a Critical Factor in Regulation of Human Metabolic Diseases and Adipose Tissue Dysfunction DOI Creative Commons
Fangcen Liu, Jielei He, Hongdong Wang

et al.

Obesity Surgery, Journal Year: 2020, Volume and Issue: 30(12), P. 5086 - 5100

Published: Oct. 6, 2020

Abstract Emerging evidence highlights that dysfunction of adipose tissue contributes to impaired insulin sensitivity and systemic metabolic deterioration in obese state. Of note, adipocyte hypertrophy serves as a critical event which associates closely with dysfunction. An increase cell size exacerbates hypoxia inflammation well excessive collagen deposition, finally leading dysregulation. Specific mechanisms include dysregulated differentiation maturation preadipocytes, enlargement lipid droplets, abnormal osmolarity sensors. Also, weight loss therapies exert profound influence on size. Here, we summarize the role development disturbances. Future studies are required establish standard criterion measurement better clarify impact changes homeostasis.

Language: Английский

Citations

79
Adipose tissue in health and disease DOI Creative Commons
Innocence Harvey, Anik Boudreau, Jacqueline M. Stephens

et al.

Open Biology, Journal Year: 2020, Volume and Issue: 10(12)

Published: Dec. 1, 2020

Adipose, or fat, tissue (AT) was once considered an inert that primarily existed to store lipids, and not historically recognized as important organ in the regulation maintenance of health. With rise obesity more rigorous research, AT is now a highly complex metabolic involved host physiological functions, including glucose homeostasis multitude endocrine capabilities. dysfunction has been implicated several disease states, most notably obesity, syndrome type 2 diabetes. The study provided useful insight developing strategies combat these prevalent diseases. This review highlights major functions adipose consequences can occur when disruption leads systemic dysfunction.

Language: Английский

Citations

76
Prenatal exposure to persistent organic pollutants and childhood obesity: A systematic review and meta‐analysis of human studies DOI
Nikos Stratakis, Sarah Rock, Michele A. La Merrill

et al.

Obesity Reviews, Journal Year: 2021, Volume and Issue: 23(S1)

Published: Nov. 12, 2021

We conducted a systematic review and meta-analysis of the associations between prenatal exposure to persistent organic pollutants (POPs) childhood obesity. focused on organochlorines (dichlorodiphenyltrichloroethane [DDT], dichlorodiphenyldichloroethylene [DDE], hexachlorobenzene [HCB], polychlorinated biphenyls [PCBs]), perfluoroalkyl polyfluoroalkyl substances (PFAS), polybrominated diphenyl ethers (PBDEs) that are POPs more widely studied in environmental birth cohorts so far. search two databases (PubMed Embase) through July/09/2021 identified 33 studies reporting with organochlorine exposure, 21 PFAS, five PBDEs. qualitative review. Additionally, we performed random-effects meta-analyses POP exposures, data estimates from at least three prospective studies, BMI-z. Prenatal DDE HCB levels were associated higher BMI z-score (beta: 0.12, 95% CI: 0.03, 0.21; I

Language: Английский

Citations

65
Adipose Tissue Inflammation and Cardiovascular Disease: An Update DOI
Mariam Rana, Ian J. Neeland

Current Diabetes Reports, Journal Year: 2022, Volume and Issue: 22(1), P. 27 - 37

Published: Jan. 1, 2022

Language: Английский

Citations

61