Background
and
objective:
Obesity
is
a
growing
global
epidemic.
The
composition
of
the
intestinal
microbiota
can
be
influenced
by
several
factors.
Studies
highlight
role
bacteria
in
pathophysiology
obesity.
So,
objective
this
study
was
to
investigate
whether
use
probiotics,
together
with
healthy
lifestyle
habits,
contributes
weight
reduction
obese
indi-viduals
analyzing
profile.
Methods:
A
prospective
carried
out
45
adults
Participants
underwent
guidance
on
re-ceived
probiotic
component
containing
different
microbiological
strains
were
followed
for
60
days.
Clinical
parameters,
body
composition,
biochemical
analysis
assessment
performed
before
after
treatment.
After
days,
it
observed
that
bacterial
present
patients'
microbiota.
Par-ticipants
also
showed
improvements
physical
activity,
sleep
quality,
anxiety
management,
as
well
changes
some
eating
such
consumption
processed
foods
significant
increase
water
intake.
Results:
BMI,
fasting
glucose,
insulin,
HOMA-IR,
LDL
cholesterol
triglycerides
observed,
addition
an
HDL
cholesterol,
improvement
bowel
movement
frequency
stool
consistency.
Analysis
revealed
microbial
diversity
better
balance
between
phyla
Firmicutes
Bacteroidetes.
Conclusions:
related
improving
microbiota,
dietary
increased
reduced
anxiety,
quality
have
significantly
contributed
loss
physiological
parameters
individuals.
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(13), С. 10672 - 10672
Опубликована: Июнь 26, 2023
Endocrine
homeostasis
and
metabolic
diseases
have
been
the
subject
of
extensive
research
in
recent
years.
The
development
new
techniques
insights
has
led
to
a
deeper
understanding
mechanisms
underlying
these
conditions
opened
up
avenues
for
diagnosis
treatment.
In
this
review,
we
discussed
rise
diseases,
especially
Western
countries,
genetical,
psychological,
behavioral
basis
role
nutrition
physical
activity
single-cell
transcriptomics,
gut
microbiota,
epigenetics,
advanced
imaging
techniques,
cell-based
therapies
diseases.
Finally,
practical
applications
derived
from
information
are
made.
Journal of Clinical Medicine,
Год журнала:
2024,
Номер
13(5), С. 1436 - 1436
Опубликована: Март 1, 2024
A
growing
number
of
probiotic-containing
products
are
on
the
market,
and
their
use
is
increasing.
Probiotics
thought
to
support
health
gut
microbiota,
which
in
turn
might
prevent
or
delay
onset
gastrointestinal
tract
disorders.
Obesity,
type
2
diabetes,
autism,
osteoporosis,
some
immunological
illnesses
among
conditions
that
have
been
shown
possibly
benefit
from
probiotics.
In
addition
ability
favorably
affect
diseases,
probiotics
represent
a
defense
system
enhancing
intestinal,
nutritional,
oral
health.
Depending
microbial
strain
utilized,
can
variable
beneficial
properties.
Although
many
species
available,
most
widely
employed
ones
lactic
acid
bacteria
bifidobacteria.
The
usefulness
these
dependent
both
origin
capacity
promote
valuable
clinical
tool
supporting
health,
immune
function,
metabolic
balance.
When
used
appropriately,
may
provide
benefits
such
as
reduced
risk
disorders,
enhanced
immunity,
improved
Most
popular
probiotics,
advantages,
mode
action
topic
this
narrative
review
article,
aimed
reader
with
comprehensive
reappraisal
matter.
Journal of Agricultural and Food Chemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Апрель 12, 2024
Nonalcoholic
fatty
liver
disease
(NAFLD)
is
characterized
by
fat
accumulation
and
inflammation.
Epigallocatechin
gallate
(EGCG)
has
been
proven
to
be
effective
against
NAFLD,
but
its
hepatoprotective
mechanisms
based
on
the
"gut
microbiota-barrier-liver
axis"
are
still
not
fully
understood.
Herein,
results
demonstrated
that
EGCG
effectively
ameliorated
NAFLD
phenotypes
metabolic
disorders
in
rats
fed
a
high-fat
diet
(HFD),
inhibited
intestinal
barrier
dysfunction
inflammation,
which
also
supported
experiment
of
Caco-2
cells.
Moreover,
could
restore
gut
microbiota
diversity
composition,
particularly
promoting
beneficial
microbes,
including
short-chain
acids
(SCFAs)
producers,
such
as
Lactobacillus,
suppressing
Gram-negative
bacteria,
Desulfovibrio.
The
microbial
modulation
raised
SCFA
levels,
decreased
lipopolysaccharide
TLR4/NF-κB
pathway,
strengthened
function
via
Nrf2
pathway
activation,
thereby
alleviating
steatosis
Spearman's
correlation
analysis
showed
24
key
OTUs,
negatively
or
positively
associated
with
disorders,
were
reshaped
EGCG.
Our
suggested
combinative
improvement
dysbiosis,
dysfunction,
inflammation
might
potential
therapeutic
target
for
NAFLD.
The Journal of Clinical Endocrinology & Metabolism,
Год журнала:
2024,
Номер
109(11), С. 2709 - 2719
Опубликована: Июль 23, 2024
Abstract
The
gut
microbiota
(GM),
comprising
trillions
of
microorganisms
in
the
gastrointestinal
tract,
is
a
key
player
development
obesity
and
related
metabolic
disorders,
such
as
type
2
diabetes
(T2D),
syndrome
(MS),
cardiovascular
diseases.
This
mini-review
delves
into
intricate
roles
mechanisms
GM
these
conditions,
offering
insights
potential
therapeutic
strategies
targeting
microbiota.
review
elucidates
diversity
human
GM,
highlighting
its
pivotal
functions
host
physiology,
including
nutrient
absorption,
immune
regulation,
energy
metabolism.
Studies
show
that
dysbiosis
linked
to
increased
extraction,
altered
pathways,
inflammation,
contributing
obesity,
MS,
T2D.
interplay
between
dietary
habits
composition
explored,
underscoring
influence
diet
on
microbial
functions.
Additionally,
addresses
impact
common
medications
interventions
like
fecal
transplantation
composition.
evidence
so
far
advocates
for
further
research
delineate
modulation
mitigating
diseases,
emphasizing
necessity
clinical
trials
establish
effective
sustainable
treatment
protocols.
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(5), С. 4294 - 4294
Опубликована: Фев. 21, 2023
Metabolic
syndrome
is
manifested
by
visceral
obesity,
hypertension,
glucose
intolerance,
hyperinsulinism,
and
dyslipidemia.
According
to
the
CDC,
metabolic
in
US
has
increased
drastically
since
1960s
leading
chronic
diseases
rising
healthcare
costs.
Hypertension
a
key
component
of
associated
with
an
increase
morbidity
mortality
due
stroke,
cardiovascular
ailments,
kidney
disease.
The
pathogenesis
hypertension
syndrome,
however,
remains
poorly
understood.
results
primarily
from
caloric
intake
decreased
physical
activity.
Epidemiologic
studies
show
that
enhanced
consumption
sugars,
form
fructose
sucrose,
correlates
amplified
prevalence
syndrome.
Diets
high
fat
content,
conjunction
elevated
salt
intake,
accelerate
development
This
review
article
discusses
latest
literature
specific
emphasis
on
role
its
stimulatory
effect
absorption
small
intestine
tubules.
Biomedicines,
Год журнала:
2024,
Номер
12(1), С. 221 - 221
Опубликована: Янв. 18, 2024
This
comprehensive
review
article
delves
into
the
critical
role
of
human
microbiota
in
development
and
management
endocrine-related
diseases.
We
explore
complex
interactions
between
endocrine
system,
emphasizing
implications
dysbiosis
for
onset
progression
various
disorders.
The
aims
to
synthesize
current
knowledge,
highlighting
recent
advancements
potential
novel
therapeutic
approaches
targeting
microbiota-endocrine
interactions.
Key
topics
include
impact
on
hormone
regulation,
its
pathologies,
promising
avenues
modulation
through
diet,
probiotics,
prebiotics,
fecal
transplantation.
underscore
importance
this
research
advancing
personalized
medicine,
offering
insights
more
tailored
effective
treatments
Annals of Nutrition and Metabolism,
Год журнала:
2025,
Номер
unknown, С. 1 - 13
Опубликована: Фев. 6, 2025
Background::
Current
scientific
research
on
breastfeeding
provides
substantial
evidence
of
its
numerous
positive
impacts,
not
only
for
children
in
both
the
short
and
long
term
but
also
mothers
who
engage
breastfeeding.
Summary::
In
addition
to
gold
standard
effect
human
milk
infant
nutrition,
is
associated
with
a
lower
incidence
infections,
reduced
infant/childhood
mortality,
necrotizing
enterocolitis,
obesity
during
childhood
later
life,
better
cognitive
performance,
higher
IQ
score.
For
mothers,
prolongs
lactational
amenorrhea,
may
facilitate
postpartum
weight
loss,
reduce
breast
ovarian
cancers
cardiovascular
diseases.
Breastfeeding
can
play
beneficial
role
preventing
antibiotic
resistance,
which
global
concern
across
all
age
groups.
Implementing
exclusive
infants
has
potential
enhance
child
development
decrease
healthcare
expenses,
leading
economic
savings
individual
families
society.
Human
biologically
active
food
that
functions
as
prebiotic
probiotic
because
oligosaccharides
composition
microbiota,
act
synergistic
synbiotics.
AJP Endocrinology and Metabolism,
Год журнала:
2024,
Номер
327(1), С. E89 - E102
Опубликована: Май 29, 2024
The
gut
microbiome,
a
complex
assembly
of
microorganisms,
significantly
impacts
human
health
by
influencing
nutrient
absorption,
the
immune
system,
and
disease
response.
These
microorganisms
form
dynamic
ecosystem
that
is
critical
to
maintaining
overall
well-being.
Prebiotics
probiotics
are
pivotal
in
regulating
microbiota
composition.
nourish
beneficial
bacteria
promote
their
growth,
whereas
help
maintain
balance
within
microbiome.
This
intricate
extends
several
aspects
health,
including
integrity
barrier,
responses,
producing
metabolites
crucial
for
metabolic
health.
Dysbiosis,
or
an
imbalance
microbiota,
has
been
linked
disorders
such
as
type
2
diabetes,
obesity,
cardiovascular
disease.
Impaired
barrier
function,
endotoxemia,
low-grade
inflammation
associated
with
toll-like
receptors
proinflammatory
pathways.
Short-chain
fatty
acids
derived
from
microbial
fermentation
modulate
anti-inflammatory
system
positively
influence
probiotics,
especially
Lactobacillus
Bifidobacterium
strains,
may
improve
outcomes,
glycemic
control
diabetes.
It
important
consider
strain-specific
effects
study
variability
when
interpreting
these
findings,
highlighting
need
further
research
optimize
therapeutic
potential.
aim
this
report
therefore
review
role
prebiotics
on
microbiome
role,
integrating
broad
understanding
physiological
mechanisms
clinical
perspective.
Nutrients,
Год журнала:
2023,
Номер
15(10), С. 2352 - 2352
Опубликована: Май 17, 2023
Background:
Soy
isoflavones
belong
to
the
group
of
phytoestrogens
and
are
associated
with
beneficial
health
effects
but
also
discussed
have
adverse
effects.
Isoflavones
intensively
metabolized
by
gut
microbiota
leading
metabolites
altered
estrogenic
potency.
The
population
is
classified
into
different
isoflavone
metabotypes
based
on
individual
metabolite
profiles.
So
far,
this
classification
was
capacity
metabolize
daidzein
did
not
reflect
genistein
metabolism.
We
investigated
microbial
profile
considering
genistein.
Methods:
were
quantified
in
urine
postmenopausal
women
receiving
a
soy
extract
for
12
weeks.
Based
these
data,
clustered
metabotypes.
Further,
potency
estimated.
Results:
excreted
urinary
amounts
metabolites,
profiles
could
be
calculated,
resulting
5
applying
hierarchical
cluster
analysis.
differed
part
strongly
regarding
their
estimated
