Toxicology and Applied Pharmacology, Год журнала: 2024, Номер 493, С. 117140 - 117140
Опубликована: Ноя. 3, 2024
Язык: Английский
Frontiers in Nutrition, Год журнала: 2024, Номер 11
Опубликована: Авг. 1, 2024
Catechins, a class of phytochemicals found in various fruits and tea leaves, have garnered attention for their diverse health-promoting properties, including potential combating neurodegenerative diseases. Among these catechins, (-)-epigallocatechin-3-gallate (EGCG), the most abundant polyphenol green tea, has emerged as promising therapeutic agent due to its potent antioxidant anti-inflammatory effects. Chronic neuroinflammation oxidative stress are key pathological mechanisms diseases such Alzheimer's disease (AD) Parkinson's (PD). EGCG neuroprotective efficacy scavenging free radicals, reducing attenuating neuroinflammatory processes. This review discusses molecular EGCG's anti-oxidative chronic neuroinflammation, emphasizing effects on autoimmune responses, neuroimmune system interactions, focusing related AD PD. By elucidating action impact processes, this underscores intervention AD, PD, possibly other Overall, emerges natural compound stress, offering novel avenues strategies treatment disorders.
Язык: Английский
Процитировано
16
Pharmaceuticals, Год журнала: 2024, Номер 17(10), С. 1354 - 1354
Опубликована: Окт. 10, 2024
Metabolic-Associated Fatty Liver Disease (MAFLD) is a clinical-pathological scenario that occurs due to the accumulation of triglycerides in hepatocytes which considered significant cause liver conditions and contributes an increased risk death worldwide. Even though possible causes MAFLD can involve interaction genetics, hormones, nutrition, lifestyle (diet sedentary lifestyle) most influential factor developing this condition. Polyphenols comprise many natural chemical compounds be helpful managing metabolic diseases. Therefore, aim review was investigate impact oxidative stress, inflammation, mitochondrial dysfunction, role polyphenols MAFLD. Some reverse part damage related or among them are anthocyanin, baicalin, catechin, curcumin, chlorogenic acid, didymin, epigallocatechin-3-gallate, luteolin, mangiferin, puerarin, punicalagin, resveratrol, silymarin. These have actions reducing plasma enzymes, body mass index, waist circumference, adipose visceral indices, lipids, glycated hemoglobin, insulin resistance, HOMA index. They also reduce nuclear factor-KB (NF-KB), interleukin (IL)-1β, IL-6, tumor necrosis factor-α (TNF-α), blood pressure, fat content, steatosis fibrosis. On other hand, they improve HDL-c, adiponectin levels, fibrogenesis markers. results show promising prevention treatment
Язык: Английский
Процитировано
14
Biomolecules, Год журнала: 2025, Номер 15(1), С. 140 - 140
Опубликована: Янв. 17, 2025
Non-alcoholic fatty liver disease (NAFLD) has become the most common chronic and is closely associated with metabolic diseases such as obesity, type 2 diabetes mellitus (T2DM), syndrome. However, effective treatment strategies for NAFLD are still lacking. In recent years, progress been made in understanding pathogenesis of NAFLD, identifying multiple therapeutic targets providing new directions drug development. This review summarizes advances focusing on mechanisms action natural products, small-synthetic-molecule drugs, combination therapy strategies. aims to provide insights treating NAFLD.
Язык: Английский
Процитировано
2
Food Research International, Год журнала: 2025, Номер 208, С. 116111 - 116111
Опубликована: Март 4, 2025
Язык: Английский
Процитировано
2
Phytotherapy Research, Год журнала: 2024, Номер 38(8), С. 4202 - 4229
Опубликована: Июнь 26, 2024
Abstract Glucolipid metabolism disorder (GLMD) is a complex chronic disease characterized by glucose and lipid disorders with diverse etiology rapidly increasing incidence. Many studies have identified the role of flavonoids in ameliorating GLMD, mechanisms related to peroxisome proliferator‐activated receptors, nuclear factor kappa‐B, AMP‐activated protein kinase, (erythroid‐derived 2)‐like 2, transporter type 4, phosphatidylinositol‐3‐kinase/protein kinase B pathway. However, comprehensive summary flavonoid effects on GLMD lacking. This study reviewed roles natural different structures treatment reported globally past 5 years provides reference for developing as drugs treating GLMD.
Язык: Английский
Процитировано
6
Food Research International, Год журнала: 2024, Номер 197, С. 115192 - 115192
Опубликована: Окт. 25, 2024
Язык: Английский
Процитировано
6
Food Chemistry, Год журнала: 2024, Номер unknown, С. 141785 - 141785
Опубликована: Окт. 1, 2024
Язык: Английский
Процитировано
5
Food Research International, Год журнала: 2024, Номер 199, С. 115383 - 115383
Опубликована: Ноя. 20, 2024
Язык: Английский
Процитировано
3
Biomedicines, Год журнала: 2025, Номер 13(1), С. 206 - 206
Опубликована: Янв. 15, 2025
Epigallocatechin gallate (EGCG) is the predominant bioactive catechin in green tea, and it has been ascribed a range of beneficial health effects. Current increases obesity non-alcoholic fatty liver disease (NAFLD) rates represent persistent burdensome threat to global public health. While many clinical studies have demonstrated that EGCG associated with positive effects on various parameters, including metabolic biomarkers, waist circumference, body weight when consumed by individuals affected NAFLD, there are also some reports suggesting may entail degree hepatotoxicity. The present review provides comprehensive summary extant findings pertaining safety effectiveness managing particular focus how treatment duration dose level affect bioactivity this compound.
Язык: Английский
Процитировано
0
Trends in Food Science & Technology, Год журнала: 2025, Номер unknown, С. 104893 - 104893
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0