Neurobiology of Disease, Год журнала: 2025, Номер unknown, С. 106885 - 106885
Опубликована: Март 1, 2025
Язык: Английский
Frontiers in Cellular and Infection Microbiology, Год журнала: 2025, Номер 14
Опубликована: Март 4, 2025
Background Recent research has made significant progress in elucidating gastrointestinal complications following acute cerebral infarction (ACI), which includes disorders intestinal motility and dysbiosis of the gut microbiota. Nevertheless, role (which is acknowledged as being largest immune organ) immunoreactive effects polydopamine nanoparticles (PDA) on ischemic stroke remains inadequately understood. In addition to its function nutrient absorption, acts a protective barrier against microbes. Systemic responses, are triggered by disruption integrity, considered one mechanisms underlying stroke, with gut-brain axis (GBA) playing pivotal this process. Methods study, we used PDA intervention an ACI model investigate ACI-like behavior, function, central peripheral inflammation, hippocampal neuron excitability, thus aiming elucidate through improves via GBA. Results Our findings indicated that mice experienced microbiota damage, levels proinflammatory factors serum brain significantly increased. Additionally, activation astrocytes region neuronal apoptosis were observed mice. Importantly, our study first provide evidence demonstrating effectively suppresses neuroimmune interactions epithelial integrity. Conclusion We hope discoveries will serve foundation for further explorations therapeutic ACI, particularly roles well development more targeted clinical interventions ACI.
Язык: Английский
Процитировано
2
Neuroscience Bulletin, Год журнала: 2025, Номер unknown
Опубликована: Фев. 24, 2025
Epilepsy affects over 50 million people worldwide. Drug-resistant epilepsy (DRE) accounts for up to a third of these cases, and neuro-inflammation is thought play role in such cases. Despite being long-debated issue the field DRE, mechanisms underlying neuroinflammation have yet be fully elucidated. The pro-inflammatory microenvironment within brain tissue with DRE has been probed using single-cell multimodal transcriptomics. Evidence suggests that inflammatory cells cytokines nervous system can lead extensive biochemical changes, as connexin hemichannel excitability disruption neurotransmitter homeostasis. presence inflammation may give rise neuronal network abnormalities suppress endogenous antiepileptic systems. We focus on anomalies from multiple perspectives identify critical points clinical application. hope provide an insightful overview advance quest better treatments.
Язык: Английский
Процитировано
1
CNS Neuroscience & Therapeutics, Год журнала: 2024, Номер 30(5)
Опубликована: Май 1, 2024
Stroke is an acute cerebrovascular disease in which brain tissue damaged due to sudden obstruction of blood flow the or rupture vessels brain, can prompt ischemic hemorrhagic stroke. After stroke onset, ischemia, hypoxia, infiltration components into parenchyma, and lysed cell fragments, among other factors, invariably increase blood-brain barrier (BBB) permeability, inflammatory response, edema. These changes lead neuronal death synaptic dysfunction, latter poses a significant challenge treatment.
Язык: Английский
Процитировано
9
Cell Death and Disease, Год журнала: 2024, Номер 15(11)
Опубликована: Ноя. 20, 2024
Abstract Copper (Cu), an indispensable micronutrient for the sustenance of living organisms, contributes significantly to a vast array fundamental metabolic processes. The human body maintains relatively low concentration copper, which is mostly found in bones, liver, and brain. Despite its concentration, Cu plays crucial role as element progression pathogenesis central nervous system (CNS) diseases. Extensive studies have been conducted recent years on copper homeostasis copper-induced cell death CNS disorders, including glioma, Alzheimer’s disease, Amyotrophic lateral sclerosis, Huntington’s stroke. Cuproptosis, novel pathway distinct from apoptosis, necrosis, pyroptosis, ferroptosis, has identified potentially intricately linked pathogenic mechanisms underlying various Therefore, systematic review cuproptosis their relationship with disorders could deepen our understanding these In addition, it may provide new insights strategies treatment disorders.
Язык: Английский
Процитировано
9
Brain Hemorrhages, Год журнала: 2024, Номер 5(3), С. 107 - 116
Опубликована: Янв. 20, 2024
Intracerebral hemorrhage (ICH) is a severe stroke that can adversely affect patient outcomes due to the accompanying inflammatory response. As result, there growing interest in studying inflammation ICH. We systematically reviewed relevant articles using Web of Science understand literature on this subject. This study aims provide comprehensive overview field through bibliometric analysis, highlight its current status, identify frontiers, and speculate future directions. conducted analysis global English related ICH research based from 1993 present address publication trends hotspots. A total 885 publications were included 2023. These authored by 7,375 researchers 1,639 organizations 68 countries published 571 journals. Collectively, they cited 48,980 references 5,621 The author who most was Dr. Zhang, John H. Interestingly, 6 top ten authors China. Regarding articles, China at list, followed United States. frequently used keywords "Inflammation", "Neuroinflammation", "Microglia". journal reference citations, Stroke journal. Over past 30 years, has been considerable progress scientific concerning context pivotal themes these studies have immune cells mediators. It worth noting, however, pertains preclinical studies, with comparatively fewer clinical investigations. Several challenges must be addressed translate promising achievements into practice.
Язык: Английский
Процитировано
8
European Journal of Neurology, Год журнала: 2024, Номер 31(5)
Опубликована: Фев. 7, 2024
Ischemic stroke, a major contributor to global disability and mortality, is underpinned by intricate pathophysiological mechanisms, notably neuroinflammation immune cell dynamics. Prior research has identified nuanced often paradoxical link between phenotypes ischemic stroke susceptibility. The aim of this study was elucidate the potential causal links median fluorescence intensity (MFI) morphological parameters (MP) 731 types risk.
Язык: Английский
Процитировано
8
Frontiers in Cellular Neuroscience, Год журнала: 2024, Номер 18
Опубликована: Окт. 25, 2024
Neurovascular unit (NVU) inflammation via activation of glial cells and neuronal damage plays a critical role in neurodegenerative diseases. Though the exact mechanism disease pathogenesis is not understood, certain biomarkers provide valuable insight into pathogenesis, severity, progression therapeutic efficacy. These markers can be used to assess pathophysiological status brain including neurons, astrocytes, microglia, oligodendrocytes, specialized microvascular endothelial cells, pericytes, NVU, blood-brain barrier (BBB) disruption. Damage or derangements tight junction (TJ), adherens (AdJ), gap (GJ) components BBB lead increased permeability neuroinflammation various disorders disorders. Thus, neuroinflammatory evaluated blood, cerebrospinal fluid (CSF), tissues determine neurological progression, responsiveness. Chronic common age-related Alzheimer's (AD), Parkinson's (PD), dementia. Neurotrauma/traumatic injury (TBI) also leads acute chronic responses. The expression some may altered many years even decades before onset In this review, we discuss neuroinflammation, neurodegeneration associated with disorders, especially those neurovascular pathologies. CSF, tissues. Neurofilament light (NfL), ubiquitin C-terminal hydrolase-L1 (UCHL1), fibrillary acidic protein (GFAP), Ionized calcium-binding adaptor molecule 1 (Iba-1), transmembrane 119 (TMEM119), aquaporin, endothelin-1, platelet-derived growth factor receptor beta (PDGFRβ) are important markers. Recent BBB-on-a-chip modeling offers promising potential for providing an in-depth understanding neurotherapeutics. Integration these clinical practice could potentially enhance early diagnosis, monitor improve outcomes.
Язык: Английский
Процитировано
8
Frontiers in Immunology, Год журнала: 2024, Номер 15
Опубликована: Ноя. 8, 2024
Stroke ranks as the second most significant contributor to mortality worldwide and is a major factor in disability. Ischemic strokes account for 71% of all stroke incidences globally. The foremost approach treating ischemic prioritizes quick reperfusion, involving methods such intravenous thrombolysis endovascular thrombectomy. These techniques can reduce disability but necessitate immediate intervention. After cerebral ischemia, inflammation rapidly arises vascular system, producing pro-inflammatory signals that activate immune cells, which turn worsen neuronal injury. Following an overload intracellular iron triggers Fenton reaction, resulting excess free radicals cause lipid peroxidation damage cellular membranes, ultimately leading ferroptosis. relationship between ferroptosis increasingly recognized vital process ischemia-reperfusion (I/R). Inflammatory processes disturb balance encourage (LPO) through neuroglial while also reducing activity antioxidant systems, contributing Furthermore, products generated during ferroptosis, along with damage-associated molecular patterns (DAMPs) released from ruptured cell incite inflammation. Given complex inflammation, investigating their interaction brain I/R crucial understanding disease development creating innovative therapeutic options. Consequently, this article will provide comprehensive introduction mechanisms linking neuroinflammation, well evaluate potential treatment modalities, goal presenting various insights alleviating injury exploring new avenues.
Язык: Английский
Процитировано
8
International Journal of Molecular Medicine, Год журнала: 2025, Номер 55(3)
Опубликована: Янв. 21, 2025
Ischemic stroke, a leading cause of disability and mortality worldwide, is characterized by the sudden loss blood flow in specific area brain. Intravenous thrombolysis with recombinant tissue plasminogen activator only approved pharmacological treatment for acute ischemic stroke; however, aforementioned has significant clinical limitations, thus there an urgent need development novel mechanisms therapeutic strategies stroke. Astrocytes, abundant versatile cells central nervous system, offer crucial support to neurons nutritionally, structurally physically. They also contribute blood‑brain barrier formation regulate neuronal extracellular ion concentrations. Accumulated evidence revealed involvement astrocytes regulation host neurotransmitter metabolism, immune response repair, different metabolic characteristics can process suggesting that targeted astrocyte reprogramming may prognosis In present review, current understanding multifaceted along its regulatory factors pathways, as well promote polarization balance, which hold promise immunometabolism‑targeted therapies were summarized.
Язык: Английский
Процитировано
1
Engineering Research Express, Год журнала: 2025, Номер 7(1), С. 015270 - 015270
Опубликована: Янв. 22, 2025
Abstract Purpose of the study : Cerebrovascular accident (CVA) occurs quickly and disrupts brain blood flow, causing neurological problems. Risk factors include smoking, diabetes, hyperlipidemia, hypertension, atrial fibrillation. Many stroke prediction systems are computationally demanding, sluggish, unreliable. This uses interpolation spline curves that impute data Principal Component Analysis to identify most important for prediction. Using stack ensemble machine learning methods, goal is improve precision disease identification. Used method: curve imputation preprocess extract EHR unique. In addition, this article also proposes a novel stacking technique using bagging boosting as foundation learners. Bagging enhance by reducing variation bias. Stack-based classifies strokes. Build base meta-learners with Random Forest, XGBoost, Decision tree classifier, KNN, Logistic Regression. The evaluation efficiency model determines optimal meta-learner model. Brief Description Results: results emphasize best impact on representation electronic health record. PCA, have been identified detecting stroke. analysis showed logistic regression meta-educator had predictive performance, achieving 0.96 0.98 recall value, respectively, 97% accuracy AUC value 0.99. Findings: Tree Classifier K-Nearest Neighbor metalearner got 95%, 96% both 0.95 AOC values in set, showing method works. Precision 0.93, KNN Classifiers confirm their robustness. These findings suggest stacking-based can identification from incomplete records.
Язык: Английский
Процитировано
1