Role of the Gut Microbiota in Osteoarthritis, Rheumatoid Arthritis, and Spondylarthritis: An Update on the Gut–Joint Axis
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(6), С. 3242 - 3242
Опубликована: Март 13, 2024
Dysregulation
of
the
gut
microbiota
and
their
metabolites
is
involved
in
pathogenic
process
intestinal
diseases,
several
pieces
evidence
within
current
literature
have
also
highlighted
a
possible
connection
between
unfolding
inflammatory
pathologies
joints.
This
dysregulation
defined
as
"gut-joint
axis"
based
on
joint-gut
interaction.
It
widely
recognized
that
produce
variety
compounds,
including
enzymes,
short-chain
fatty
acids,
metabolites.
As
consequence,
these
proinflammatory
compounds
bacteria
produce,
such
lipopolysaccharide,
move
from
"leaky
gut"
to
bloodstream,
thereby
leading
systemic
inflammation
which
then
reaches
joints,
with
consequences
osteoarthritis,
rheumatoid
arthritis,
spondylarthritis.
In
this
state-of-the-art
research,
authors
describe
connections
dysbiosis
Moreover,
diagnostic
tools,
outcome
measures,
treatment
options
are
elucidated.
There
accumulating
proof
suggesting
play
an
important
part
not
only
immune-mediated,
metabolic,
neurological
illnesses
but
According
authors,
future
studies
should
concentrate
developing
innovative
microbiota-targeted
treatments
effects
joint
pathology
well
organizing
screening
protocols
predict
onset
disease
dysbiosis.
Язык: Английский
Microbiota and immune dynamics in rheumatoid arthritis: Mechanisms and therapeutic potential
Best Practice & Research Clinical Rheumatology,
Год журнала:
2025,
Номер
unknown, С. 102035 - 102035
Опубликована: Янв. 1, 2025
Язык: Английский
Modulation of multiple sclerosis risk and pathogenesis by the gut microbiota: Complex interactions between host genetics, bacterial metabolism, and diet
Immunological Reviews,
Год журнала:
2024,
Номер
325(1), С. 131 - 151
Опубликована: Май 8, 2024
Multiple
sclerosis
(MS)
is
an
autoimmune
disease
of
the
central
nervous
system,
affecting
nearly
2
million
people
worldwide.
The
etiology
MS
multifactorial:
Approximately
30%
risk
genetic,
which
implies
that
remaining
~70%
environmental,
with
a
number
factors
proposed.
One
recently
implicated
factor
for
composition
gut
microbiome.
Numerous
case-control
studies
have
identified
changes
in
microbiota
(pwMS)
compared
healthy
control
individuals,
and
more
recent
animal
models
begun
to
identify
causative
microbes
underlying
mechanisms.
Here,
we
review
some
these
mechanisms,
specific
focus
on
role
host
genetic
variation,
dietary
inputs,
microbial
metabolism,
particular
emphasis
short-chain
fatty
acid
tryptophan
metabolism.
We
put
forward
model
where,
individual
genetically
susceptible
MS,
diet
can
synergize
as
potent
environmental
modifiers
possibly
progression,
diet-dependent
metabolites
serving
key
mechanism.
also
propose
taxa
may
divergent
effects
individuals
carrying
distinct
variants
alleles
or
other
polymorphisms,
consequence
gene-by-gut
interactions.
Finally,
taxa,
especially
those
exert
their
through
metabolites,
are
highly
dependent
intake.
What
emerges
complex
multifaceted
interaction
has
been
challenging
disentangle
human
studies,
contributing
divergence
findings
across
heterogeneous
cohorts
differing
geography,
preferences,
genetics.
Nonetheless,
this
provides
individualized,
yet
tractable,
how
regulate
susceptibility
potentially
progression
disease.
Thus,
conclude
prophylactic
therapeutic
modulation
microbiome
prevent
treat
will
require
careful
personalized
consideration
genetics,
baseline
composition,
inputs.
Язык: Английский
Microbiome’s role in musculoskeletal health through the gut-bone axis insights
Gut Microbes,
Год журнала:
2024,
Номер
16(1)
Опубликована: Окт. 10, 2024
The
interplay
between
the
human
microbiome
and
musculoskeletal
system
represents
a
burgeoning
field
of
research
with
profound
implications
for
understanding
treating
disorders.
This
review
articulates
pivotal
role
in
modulating
bone
health,
highlighting
gut-bone
axis
as
critical
nexus
potential
therapeutic
intervention.
Through
meticulous
analysis
recent
clinical
research,
we
underscore
microbiome's
influence
on
osteoporosis,
sarcopenia,
osteoarthritis,
rheumatoid
arthritis,
delineating
both
direct
indirect
mechanisms
by
which
microbiota
could
impact
integrity
function.
Our
investigation
reveals
novel
insights
into
microbiota's
contribution
to
density
regulation,
hormone
production,
immune
modulation,
nutrient
absorption,
laying
groundwork
innovative
microbiome-based
strategies
disease
management.
Significantly,
identify
challenges
hindering
translation
practice,
including
limitations
current
microbial
sequencing
techniques
need
standardized
methodologies
studies.
Furthermore,
highlight
promising
directions
future
particularly
realm
personalized
medicine,
where
variability
offers
unique
opportunities
tailored
treatment
approaches.
sets
new
agenda
leveraging
gut
diagnosis,
prevention,
conditions,
marking
step
toward
integrating
science
care.
Язык: Английский
Microbial players in autoimmunity: multicentric analysis of the association between Mycoplasma hominis serostatus and rheumatoid arthritis
G. L. Erre,
Ngoc Phan,
Nélida Ramos Díaz
и другие.
Microbiology Spectrum,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 4, 2025
ABSTRACT
Resident
mucosal
pathogens
may
induce
immune
tolerance
breach,
specific
autoimmune
response,
and
the
development
of
rheumatoid
arthritis
(RA)
in
susceptible
individuals.
Despite
a
number
studies
linking
infections
by
Mollicutes
bacteria
to
disorders’
onset
progression,
role
Mycoplasma
hominis
,
common
urogenital
mucosa
colonizing
bacterium,
inducing
humoral
response
RA
has
been
seldom
addressed.
This
study
reports
M.
seroprevalence
patients
compared
healthy
controls
(HC)
testing
two
separate
cohorts
sampled
distinct
geographical
settings
(Italy
Vietnam).
The
amount
circulating
anti-lipid-associated
membrane
proteins
(LAMPs)
antibodies
was
significantly
higher
than
HC
both
cohorts.
Also,
anti-
M
.
observed.
Notably,
neither
ELISA
OD
values
nor
positivity
anti-LAMPs
were
associated
with
RA-specific
variables.
Further
are
essential
elucidate
underlying
mechanisms
which
species
contribute
pathogenesis
RA,
thereby
advancing
our
understanding
potential
causal
links
between
disorders.
IMPORTANCE
Mycoplasmas
cause
persistent
asymptomatic
elicit
chronic
host
responses.
In
this
study,
we
evaluated
prevalence
serological
sexually
transmitted
bacterium
arthritis.
We
show
that
sera
enriched
specifically
recognizing
microbial
surface
antigens
general
population.
suggests
genital
infection,
its
peculiar
immunity
subversion
mechanisms,
might
play
predisposing
progression
Thus,
range
microbes
as
triggers
disease
(
P.
gingivalis
A.
actinomycetemcomitans
Streptococcus
spp.,
F.
nucleatum
among
others)
have
new
member
interactions
taking
place
at
host–pathogen
interface
during
autoimmunity
should
be
further
explored
characterized.
Язык: Английский
Natural and synthetic potential drug leads for rheumatoid arthritis probing innovative target: mitochondrial dysfunction and NLRP3 inflammasome activation
Naunyn-Schmiedeberg s Archives of Pharmacology,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 28, 2025
Язык: Английский
High-throughput metabolomics exploring the pharmacological effects and mechanism of icariin on rheumatoid arthritis rat based on ultrahigh-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry
Frontiers in Molecular Biosciences,
Год журнала:
2025,
Номер
12
Опубликована: Апрель 9, 2025
Metabolomics
could
provide
insights
into
the
pharmacological
effects
and
action
mechanisms
of
drugs
through
assessment
changes
in
relevant
biomarkers
biological
pathways.
Icariin
(ICA)
is
a
promising
ffavonoid
compound
known
to
have
significant
anticancer
activity;
however,
ICA
treatment
rheumatoid
arthritis
(RA)
need
be
explored
further.
The
metabolic
profiles
serum
samples
were
revealed
using
non-targeted
metabolomics
based
on
ultrahigh-performance
liquid
chromatography
coupled
with
quadrupole
time-of-fight
mass
spectrometry.
Tissue
histopathology,
physical
parameters,
biochemical
indicators
also
measured
analyzed
reveal
RA.
Thirty-one
potential
identified
highlight
disorders
an
RA
animal
model,
out
which
twenty-three
regulated
by
treatment.
These
mainly
involved
alanine,
aspartate,
glutamate
metabolism;
arachidonic
acid
citrate
cycle;
pyruvate
glycolysis/gluconeogenesis
mechanism
may
attributed
amelioration
amino
metabolism,
unsaturated
fatty
cycle,
others,
turn
regulate
oxidative
stress
state
inflammatory
effects.
Thus,
approach
for
revealing
biomarker
distribution
pathways
determine
ICA,
can
benefit
development
natural
medicines.
Язык: Английский
Targeting Therapeutic Windows for Rheumatoid Arthritis Prevention
Chinese Journal of Integrative Medicine,
Год журнала:
2024,
Номер
30(9), С. 842 - 851
Опубликована: Май 16, 2024
Язык: Английский
Gut Microbiota Modulation: A Novel Strategy for Rheumatoid Arthritis Therapy
Biomolecules,
Год журнала:
2024,
Номер
14(12), С. 1653 - 1653
Опубликована: Дек. 23, 2024
Rheumatoid
arthritis
(RA)
is
a
chronic
autoimmune
disease
that
leads
to
joint
inflammation,
progressive
tissue
damage
and
significant
disability,
severely
impacting
patients’
quality
of
life.
While
the
exact
mechanisms
underlying
RA
remain
elusive,
growing
evidence
suggests
strong
link
between
intestinal
microbiota
dysbiosis
disease’s
development
progression.
Differences
in
microbial
composition
healthy
individuals
patients
point
role
gut
modulating
immune
responses
promoting
inflammation.
Therapies
targeting
restoration
have
demonstrated
promise
improving
treatment
efficacy,
enhancing
patient
outcomes
slowing
However,
complex
interplay
pathways
requires
further
investigation
establish
causative
relationships
mechanisms.
Here,
we
review
current
understanding
microbiota’s
pathogenesis
its
potential
as
therapeutic
target.
Язык: Английский
Assessment of antimicrobial, free radical scavenging, and anti-inflammatory activities of Holarrhena pubescens (Buch.-Ham.) Wall. seeds using in vitro methods and evaluation of antiarthritic potential using an in vivo method
Journal of Herbmed Pharmacology,
Год журнала:
2024,
Номер
14(1), С. 82 - 89
Опубликована: Дек. 25, 2024
Introduction:
Holarrhena
pubescens
is
used
traditionally
for
treating
several
infectious
and
inflammatory
disorders
with
no
scientific
evidence.
The
present
study
was
designed
to
evaluate
the
antimicrobial
free
radical
scavenging
properties
of
different
fractions
ethanolic
extract
H.
seeds.
Furthermore,
potential
plant
in
acute
chronic
inflammation
through
vitro
vivo
experiments
also
evaluated.
Methods:
successive
seeds,
including
petroleum
ether
(HPF),
chloroform
(HCF),
methanol
(HMF)
were
subjected
eradicate
microorganisms
using
disc
diffusion
method
scavenge
oxidants
DPPH
method.
HCF
further
an
anti-inflammatory
activity
by
inhibition
bovine
serum
albumin
denaturation
assay
effect
drug
a
condition
adjuvant-induced
arthritis
rats’
model.
Results:
showed
most
potent
among
all
test
drugs.
fraction
broad-spectrum
80.35
±
0.46%
(IC50
value
=
28.41
0.33
µg/mL)
antioxidant
study.
Further,
68.37
1.11%
75.16%
(0.38
0.16
mL,
P<0.05)
rat
paw
edema
Conclusion:
exhibited
antimicrobial,
potentials
Язык: Английский