Role of the Gut Microbiota in Osteoarthritis, Rheumatoid Arthritis, and Spondylarthritis: An Update on the Gut–Joint Axis

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(6), P. 3242 - 3242

Published: March 13, 2024

Dysregulation of the gut microbiota and their metabolites is involved in pathogenic process intestinal diseases, several pieces evidence within current literature have also highlighted a possible connection between unfolding inflammatory pathologies joints. This dysregulation defined as "gut-joint axis" based on joint-gut interaction. It widely recognized that produce variety compounds, including enzymes, short-chain fatty acids, metabolites. As consequence, these proinflammatory compounds bacteria produce, such lipopolysaccharide, move from "leaky gut" to bloodstream, thereby leading systemic inflammation which then reaches joints, with consequences osteoarthritis, rheumatoid arthritis, spondylarthritis. In this state-of-the-art research, authors describe connections dysbiosis Moreover, diagnostic tools, outcome measures, treatment options are elucidated. There accumulating proof suggesting play an important part not only immune-mediated, metabolic, neurological illnesses but According authors, future studies should concentrate developing innovative microbiota-targeted treatments effects joint pathology well organizing screening protocols predict onset disease dysbiosis.

Language: Английский

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Microbiota and immune dynamics in rheumatoid arthritis: Mechanisms and therapeutic potential

Best Practice & Research Clinical Rheumatology, Journal Year: 2025, Volume and Issue: unknown, P. 102035 - 102035

Published: Jan. 1, 2025

Language: Английский

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Modulation of multiple sclerosis risk and pathogenesis by the gut microbiota: Complex interactions between host genetics, bacterial metabolism, and diet

Immunological Reviews, Journal Year: 2024, Volume and Issue: 325(1), P. 131 - 151

Published: May 8, 2024

Multiple sclerosis (MS) is an autoimmune disease of the central nervous system, affecting nearly 2 million people worldwide. The etiology MS multifactorial: Approximately 30% risk genetic, which implies that remaining ~70% environmental, with a number factors proposed. One recently implicated factor for composition gut microbiome. Numerous case-control studies have identified changes in microbiota (pwMS) compared healthy control individuals, and more recent animal models begun to identify causative microbes underlying mechanisms. Here, we review some these mechanisms, specific focus on role host genetic variation, dietary inputs, microbial metabolism, particular emphasis short-chain fatty acid tryptophan metabolism. We put forward model where, individual genetically susceptible MS, diet can synergize as potent environmental modifiers possibly progression, diet-dependent metabolites serving key mechanism. also propose taxa may divergent effects individuals carrying distinct variants alleles or other polymorphisms, consequence gene-by-gut interactions. Finally, taxa, especially those exert their through metabolites, are highly dependent intake. What emerges complex multifaceted interaction has been challenging disentangle human studies, contributing divergence findings across heterogeneous cohorts differing geography, preferences, genetics. Nonetheless, this provides individualized, yet tractable, how regulate susceptibility potentially progression disease. Thus, conclude prophylactic therapeutic modulation microbiome prevent treat will require careful personalized consideration genetics, baseline composition, inputs.

Language: Английский

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Microbiome’s role in musculoskeletal health through the gut-bone axis insights

Gut Microbes, Journal Year: 2024, Volume and Issue: 16(1)

Published: Oct. 10, 2024

The interplay between the human microbiome and musculoskeletal system represents a burgeoning field of research with profound implications for understanding treating disorders. This review articulates pivotal role in modulating bone health, highlighting gut-bone axis as critical nexus potential therapeutic intervention. Through meticulous analysis recent clinical research, we underscore microbiome's influence on osteoporosis, sarcopenia, osteoarthritis, rheumatoid arthritis, delineating both direct indirect mechanisms by which microbiota could impact integrity function. Our investigation reveals novel insights into microbiota's contribution to density regulation, hormone production, immune modulation, nutrient absorption, laying groundwork innovative microbiome-based strategies disease management. Significantly, identify challenges hindering translation practice, including limitations current microbial sequencing techniques need standardized methodologies studies. Furthermore, highlight promising directions future particularly realm personalized medicine, where variability offers unique opportunities tailored treatment approaches. sets new agenda leveraging gut diagnosis, prevention, conditions, marking step toward integrating science care.

Language: Английский

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Microbial players in autoimmunity: multicentric analysis of the association between Mycoplasma hominis serostatus and rheumatoid arthritis

Microbiology Spectrum, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 4, 2025

ABSTRACT Resident mucosal pathogens may induce immune tolerance breach, specific autoimmune response, and the development of rheumatoid arthritis (RA) in susceptible individuals. Despite a number studies linking infections by Mollicutes bacteria to disorders’ onset progression, role Mycoplasma hominis , common urogenital mucosa colonizing bacterium, inducing humoral response RA has been seldom addressed. This study reports M. seroprevalence patients compared healthy controls (HC) testing two separate cohorts sampled distinct geographical settings (Italy Vietnam). The amount circulating anti-lipid-associated membrane proteins (LAMPs) antibodies was significantly higher than HC both cohorts. Also, anti- M . observed. Notably, neither ELISA OD values nor positivity anti-LAMPs were associated with RA-specific variables. Further are essential elucidate underlying mechanisms which species contribute pathogenesis RA, thereby advancing our understanding potential causal links between disorders. IMPORTANCE Mycoplasmas cause persistent asymptomatic elicit chronic host responses. In this study, we evaluated prevalence serological sexually transmitted bacterium arthritis. We show that sera enriched specifically recognizing microbial surface antigens general population. suggests genital infection, its peculiar immunity subversion mechanisms, might play predisposing progression Thus, range microbes as triggers disease ( P. gingivalis A. actinomycetemcomitans Streptococcus spp., F. nucleatum among others) have new member interactions taking place at host–pathogen interface during autoimmunity should be further explored characterized.

Language: Английский

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Natural and synthetic potential drug leads for rheumatoid arthritis probing innovative target: mitochondrial dysfunction and NLRP3 inflammasome activation

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 28, 2025

Language: Английский

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High-throughput metabolomics exploring the pharmacological effects and mechanism of icariin on rheumatoid arthritis rat based on ultrahigh-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry

Frontiers in Molecular Biosciences, Journal Year: 2025, Volume and Issue: 12

Published: April 9, 2025

Metabolomics could provide insights into the pharmacological effects and action mechanisms of drugs through assessment changes in relevant biomarkers biological pathways. Icariin (ICA) is a promising ffavonoid compound known to have significant anticancer activity; however, ICA treatment rheumatoid arthritis (RA) need be explored further. The metabolic profiles serum samples were revealed using non-targeted metabolomics based on ultrahigh-performance liquid chromatography coupled with quadrupole time-of-fight mass spectrometry. Tissue histopathology, physical parameters, biochemical indicators also measured analyzed reveal RA. Thirty-one potential identified highlight disorders an RA animal model, out which twenty-three regulated by treatment. These mainly involved alanine, aspartate, glutamate metabolism; arachidonic acid citrate cycle; pyruvate glycolysis/gluconeogenesis mechanism may attributed amelioration amino metabolism, unsaturated fatty cycle, others, turn regulate oxidative stress state inflammatory effects. Thus, approach for revealing biomarker distribution pathways determine ICA, can benefit development natural medicines.

Language: Английский

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Targeting Therapeutic Windows for Rheumatoid Arthritis Prevention

Chinese Journal of Integrative Medicine, Journal Year: 2024, Volume and Issue: 30(9), P. 842 - 851

Published: May 16, 2024

Language: Английский

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Gut Microbiota Modulation: A Novel Strategy for Rheumatoid Arthritis Therapy

Biomolecules, Journal Year: 2024, Volume and Issue: 14(12), P. 1653 - 1653

Published: Dec. 23, 2024

Rheumatoid arthritis (RA) is a chronic autoimmune disease that leads to joint inflammation, progressive tissue damage and significant disability, severely impacting patients’ quality of life. While the exact mechanisms underlying RA remain elusive, growing evidence suggests strong link between intestinal microbiota dysbiosis disease’s development progression. Differences in microbial composition healthy individuals patients point role gut modulating immune responses promoting inflammation. Therapies targeting restoration have demonstrated promise improving treatment efficacy, enhancing patient outcomes slowing However, complex interplay pathways requires further investigation establish causative relationships mechanisms. Here, we review current understanding microbiota’s pathogenesis its potential as therapeutic target.

Language: Английский

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Assessment of antimicrobial, free radical scavenging, and anti-inflammatory activities of Holarrhena pubescens (Buch.-Ham.) Wall. seeds using in vitro methods and evaluation of antiarthritic potential using an in vivo method

Journal of Herbmed Pharmacology, Journal Year: 2024, Volume and Issue: 14(1), P. 82 - 89

Published: Dec. 25, 2024

Introduction: Holarrhena pubescens is used traditionally for treating several infectious and inflammatory disorders with no scientific evidence. The present study was designed to evaluate the antimicrobial free radical scavenging properties of different fractions ethanolic extract H. seeds. Furthermore, potential plant in acute chronic inflammation through vitro vivo experiments also evaluated. Methods: successive seeds, including petroleum ether (HPF), chloroform (HCF), methanol (HMF) were subjected eradicate microorganisms using disc diffusion method scavenge oxidants DPPH method. HCF further an anti-inflammatory activity by inhibition bovine serum albumin denaturation assay effect drug a condition adjuvant-induced arthritis rats’ model. Results: showed most potent among all test drugs. fraction broad-spectrum 80.35 ± 0.46% (IC50 value = 28.41 0.33 µg/mL) antioxidant study. Further, 68.37 1.11% 75.16% (0.38 0.16 mL, P<0.05) rat paw edema Conclusion: exhibited antimicrobial, potentials

Language: Английский

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