Journal of Drug Delivery Science and Technology, Год журнала: 2025, Номер unknown, С. 106869 - 106869
Опубликована: Март 1, 2025
Язык: Английский
Frontiers in Cell and Developmental Biology, Год журнала: 2023, Номер 11
Опубликована: Фев. 27, 2023
Refractory skin defects such as pressure ulcers, diabetic and vascular ulcers represent a challenge for clinicians researchers in many aspects. The treatment strategies wound healing have high cost limited efficacy. To ease the financial psychological burden on patients, more effective therapeutic approach is needed to address chronic wound. MSC-derived exosomes (MSC-exosomes), main bioactive extracellular vesicles of paracrine effect MSCs, been proposed new potential cell-free regeneration. benefits MSC-exosomes include their ability promote angiogenesis cell proliferation, increase collagen production, regulate inflammation, finally improve tissue regenerative capacity. However, poor targeting easy removability from are major obstacles use clinical therapy. Thus, concept bioengineering technology has introduced modify exosomes, enabling higher concentrations construction particles greater stability with specific capability. biomaterials load may be promising strategy concentrate dose, create desired efficacy, maintain sustained release effect. beneficial role widely accepted; however, bioengineering-modified remains unclear. In this review, we attempt summarize applications modified challenges prospects bioengineered also discussed.
Язык: Английский
Процитировано
50
Asian Journal of Pharmaceutical Sciences, Год журнала: 2022, Номер 18(1), С. 100772 - 100772
Опубликована: Дек. 31, 2022
In the inflammatory microenvironment, there are numerous exosomes secreted by immune cells (Macrophages, neutrophils, dendritic cells), mesenchymal stem (MSCs) and platelets as intercellular communicators, which participate in regulation of inflammation modulating gene expression releasing anti-inflammatory factors. Due to their good biocompatibility, accurate targeting, low toxicity immunogenicity, these able selectively deliver therapeutic drugs site through interactions between surface-antibody or modified ligand with cell surface receptors. Therefore, role exosome-based biomimetic delivery strategies diseases has attracted increasing attention. Here we review current knowledge techniques for exosome identification, isolation, modification drug loading. More importantly, highlight progress using treat chronic such rheumatoid arthritis (RA), osteoarthritis (OA), atherosclerosis (AS), bowel disease (IBD). Finally, also discuss potential challenges carriers.
Язык: Английский
Процитировано
49
Molecules, Год журнала: 2023, Номер 28(2), С. 742 - 742
Опубликована: Янв. 11, 2023
Curcumin, a traditional Chinese medicine extracted from natural plant rhizomes, has become candidate drug for the treatment of different diseases due to its anti-inflammatory, anticancer, antioxidant, and antibacterial activities. Curcumin is generally beneficial improve human health with anti-inflammatory antioxidative properties as well antitumor immunoregulatory properties. Inflammasomes are NLR family, pyrin domain-containing 3 (NLRP3) proteins that activated in response variety stress signals promote proteolytic conversion pro-interleukin-1β pro-interleukin-18 into active forms, which central mediators inflammatory response; inflammasomes can also induce pyroptosis, type cell death. The NLRP3 protein involved pathologies, including neurological autoimmune disorders, lung diseases, atherosclerosis, myocardial infarction, many others. Different functional foods may have preventive therapeutic effects wide range pathologies inflammasome activated. In this review, we focused on curcumin evidenced potential such neurodegenerative respiratory arthritis by acting inflammasome.
Язык: Английский
Процитировано
24
Small, Год журнала: 2024, Номер 20(43)
Опубликована: Июль 14, 2024
This review explores the evolution of lipid-based nanoparticles (LBNPs) for drug delivery (DD). Herein, LBNPs are classified into liposomes and cell membrane-based (CMNPs), each with unique advantages challenges. Conventional possess drawbacks such as poor targeting, quick clearance, limited biocompatibility. One possible alternatives to overcome these challenges is surface modification (NPs) materials polyethylene glycol (PEG), aptamers, antibody fragments, peptides, CD44, hyaluronic acid, folic palmitic lactoferrin. Thus, main focus this will be on different modifications that enable have beneficial properties DD, enhancing mass transport properties, immune evasion, improved stability, targeting. Moreover, various CMNPs explored used DD derived from cells red blood (RBCs), platelets, leukocytes, cancer cells, stem highlighting their natural (e.g., biocompatibility ability evade system). discussion extends biomimicking hybrid NPs accomplished through coating synthetic (mainly polymeric) membranes. aims provide a comprehensive resource researchers recent advances in field CMNPs. Overall, provides valuable insights dynamic systems.
Язык: Английский
Процитировано
11
Life Sciences, Год журнала: 2025, Номер 368, С. 123499 - 123499
Опубликована: Фев. 22, 2025
Язык: Английский
Процитировано
1
Journal of Drug Delivery Science and Technology, Год журнала: 2022, Номер 80, С. 104105 - 104105
Опубликована: Дек. 21, 2022
Язык: Английский
Процитировано
31
International Immunopharmacology, Год журнала: 2023, Номер 122, С. 110531 - 110531
Опубликована: Июль 10, 2023
Язык: Английский
Процитировано
20
Biomolecules, Год журнала: 2023, Номер 13(8), С. 1250 - 1250
Опубликована: Авг. 16, 2023
Mesenchymal stem cells (MSCs) are a type of versatile adult present in various organs. These give rise to extracellular vesicles (EVs) containing diverse array biologically active elements, making them promising approach for therapeutics and diagnostics. This article examines the potential therapeutic applications MSC-derived EVs addressing neurodegenerative disorders such as Alzheimer’s disease (AD), multiple sclerosis (MS), Parkinson’s (PD), amyotrophic lateral (ALS), Huntington’s (HD). Furthermore, state-of-the-art MSC-EV-based therapy AD, HD, PD, ALS, MS is discussed. Significant progress has been made understanding etiology treatments range diseases (NDs) over last few decades. The contents carried across intercellular contact, which often results control recipient cell’s homeostasis. Since represent therapeutically beneficial cargo parent devoid many ethical problems connected with cell-based treatments, they offer viable cell-free alternative tissue regeneration repair. Developing innovative EV-dependent medicines proven difficult due lack standardized procedures EV extraction processes well their pharmacological characteristics mechanisms action. However, recent biotechnology engineering research greatly enhanced content applicability MSC-EVs.
Язык: Английский
Процитировано
16
Biomedical Materials, Год журнала: 2024, Номер 19(3), С. 032002 - 032002
Опубликована: Март 12, 2024
Abstract Exosomes, typically 30–150 nm in size, are lipid-bilayered small-membrane vesicles originating endosomes. Exosome biogenesis is regulated by the coordination of various mechanisms whereby different cargoes (e.g. proteins, nucleic acids, and lipids) sorted into exosomes. These components endow exosomes with bioregulatory functions related to signal transmission intercellular communication. Exosomes exhibit substantial potential as drug-delivery nanoplatforms owing their excellent biocompatibility low immunogenicity. Proteins, miRNA, siRNA, mRNA, drugs have been successfully loaded exosomes, these exosome-based delivery systems show satisfactory therapeutic effects disease models. To enable targeted drug delivery, genetic engineering chemical modification lipid bilayer performed. Stimuli-responsive designed appropriate modifications based on stimuli allow precise control on-demand can be utilized clinical treatment. In this review, we summarize general properties, isolation methods, characterization, biological functions, role systems. Moreover, effective combination intrinsic advantages advanced bioengineering, materials science, translational technologies required accelerate development nanoplatforms.
Язык: Английский
Процитировано
6
Saudi Pharmaceutical Journal, Год журнала: 2024, Номер 32(6), С. 102096 - 102096
Опубликована: Май 6, 2024
The aim of the current study was to explore potential human plasma-derived exosomes as versatile carriers for drug delivery by employing various active and passive loading methods. Exosomes were isolated from plasma using differential centrifugation ultrafiltration method. Drug achieved sonication freeze thaw methods, facilitating effective encapsulation within delivery. Each approach examined its effectiveness, efficiency ability preserve membrane stability. Methotrexate (MTX), a weak acid model loaded at concentration 2.2 µM underwent characterization techniques such particle size analysis, transmission electron microscopy capacity. Human derived showed mean 162.15 ± 28.21 nm zeta −30.6 0.71 mV. These successfully with MTX demonstrated better 64.538 1.54 % method in comparison 55.515 1.907 sonication. In-vitro release displayed 60 released 72 h that significantly different i.e., 99 (p value 0.0045). Moreover, cell viability higher than 0.0091) suggested there disruption In conclusion, this offers valuable insights into suggest promising carrier improved maintenance exosomal integrity.
Язык: Английский
Процитировано
6