Journal of Drug Delivery Science and Technology, Год журнала: 2025, Номер unknown, С. 106912 - 106912
Опубликована: Апрель 1, 2025
Язык: Английский
Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)
Опубликована: Янв. 28, 2024
Malignancy is a major public health problem and among the leading lethal diseases worldwide. Although current tumor treatment methods have therapeutic effect to certain extent, they still some shortcomings such as poor water solubility, short half-life, local systemic toxicity. Therefore, how deliver agent so realize safe effective anti-tumor therapy become urgently be solved in this field. As medium of information exchange material transport between cells, exosomes are considered promising drug delivery carrier due their nano-size, good biocompatibility, natural targeting, easy modification. In review, we summarize recent advances isolation, identification, loading, modification carriers for alongside application therapy. Basic knowledge exosomes, biogenesis, sources, characterization methods, also introduced herein. addition, challenges related use vehicles discussed, along with future trends. This review provides scientific basis exosome systems oncological
Язык: Английский
Процитировано
41
PLoS ONE, Год журнала: 2024, Номер 19(1), С. e0296259 - e0296259
Опубликована: Янв. 4, 2024
Inflammation is a temporary response of the immune system that can be treated using common anti-inflammatory drugs. However, prolonged use these drugs increases risk adverse side effects. Accordingly, there an increasing need for alternative treatments inflammation with fewer Exosomes are extracellular vesicles secreted by most eukaryotic cells and have been studied as candidate cell-free therapy inflammatory diseases due to their immunomodulatory properties. In recent years, focus exosome research has shifted from animal cell-derived exosomes plant-derived exosome-like nanoparticles (PDENs). Plant-derived (PDENs) easier obtain, minimal safety concerns, produced in higher quantities lower cost than derived cells. this study, isolation analysis potential PDENs black nightshade berries ( Solanum nigrum L.) were carried out. The results characterization showed had spherical morphology, measuring around 107 nm zeta -0.6 mV, protein concentration 275.38 μg/mL. also shown internalized RAW264.7 macrophage cell line after 2 hours incubation no cytotoxicity effect up 2.5 Furthermore, exposure several doses LPS-stimulated significantly decreased expression pro-inflammatory cytokine gene IL-6, well IL-6 97,28%. GC-MS presence neral, monoterpene compound known properties, which may contribute activity isolated L. berries. Taken together, present study was first isolate characterize demonstrated PDEN suppressing production
Язык: Английский
Процитировано
22
Advanced Science, Год журнала: 2023, Номер 10(32)
Опубликована: Сен. 25, 2023
Extracellular vesicles (EVs), involved in essential physiological and pathological processes of the organism, have emerged as powerful tools for disease treatment owing to their unique natural biological characteristics artificially acquired advantages. However, limited targeting ability, insufficient production yield, low drug-loading capability simplex EVs greatly hindered development clinical translation. Therefore, establishment multifunctional hybrid membrane nanovesicles (HMNVs) with favorable adaptability flexibility has become key expanding practical application EVs. This timely review summarizes current progress HMNVs biomedical applications. Different preparation strategies including physical, chemical, chimera approaches are first discussed. then individually describes diverse types based on homologous or heterologous cell substances, a fusion liposome, well bacterial membrane. Subsequently, specific emphasis is placed highlight applications toward various diseases representative examples. Finally, ongoing challenges prospects currently developed translational briefly presented. will not only stimulate broad interest among researchers from disciplines but also provide valuable insights promising nanoplatforms precision medicine.
Язык: Английский
Процитировано
34
Journal of Controlled Release, Год журнала: 2024, Номер 369, С. 493 - 505
Опубликована: Апрель 6, 2024
Язык: Английский
Процитировано
15
International Journal of Nanomedicine, Год журнала: 2024, Номер Volume 19, С. 1597 - 1627
Опубликована: Фев. 1, 2024
Abstract: The development of numerous diseases is significantly influenced by inflammation. Macrophage-derived exosomes (M-Exos) play a role in controlling inflammatory reactions various conditions, including chronic pain, hypertension, and diabetes. However, the specific targets roles M-Exos regulating inflammation remain largely unknown. This review summarizes current knowledge on biogenesis provides updated information M-Exos' biological function modulation. Furthermore, this highlights functionalization engineering strategies M-Exos, while providing an overview cutting-edge approaches to advancements their application as therapeutics for Finally, multiple mechanisms are presented along with perspectives challenges, potential contribution that may have through modulation discussed. Keywords: inflammation, macrophage-derived exosomes, functions, modulation,
Язык: Английский
Процитировано
13
Theranostics, Год журнала: 2024, Номер 14(6), С. 2490 - 2525
Опубликована: Янв. 1, 2024
Inflammatory dysregulation is intimately associated with the occurrence and progression of many life-threatening diseases.Accurate detection timely therapeutic intervention on inflammatory are crucial for effective therapy inflammation-associated diseases.However, clinical outcomes inflammation-involved disorders still unsatisfactory.Therefore, there an urgent need to develop innovative anti-inflammatory strategies by integrating emerging technological innovations traditional therapeutics.Biomedical nanotechnology one promising fields that can potentially transform diagnosis treatment inflammation.In this review, we outline recent advances in biomedical inflammation, special attention paid nanosensors nanoprobes precise inflammation-related diseases, nanotherapeutics, as well nanotheranostics combined applications.Moreover, prospects challenges translation nanomedicines highlighted.
Язык: Английский
Процитировано
13
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(12), С. 6533 - 6533
Опубликована: Июнь 13, 2024
Extracellular vesicles (EVs) hold great promise for clinical application as new diagnostic and therapeutic modalities. This paper describes major GMP-based upstream downstream manufacturing processes EV large-scale production, also focusing on post-processing technologies such surface bioengineering uploading studies to yield novel EV-based diagnostics advanced therapy medicinal products. focuses the quality, safety, efficacy issues of bioengineered drug candidates before first-in-human studies. Because trials involving extracellular are global rise, this encompasses different registered clinical-trial register platforms, with varying levels advancement, highlighting growing interest in EV-related programs. Navigating regulatory affairs EVs poses real challenges, obtaining marketing authorization medicines remains complex due lack specific guidelines discusses state-of-the-art knowledge date products, further research needs safe reliable implementation tools settings. Post-marketing pharmacovigilance products is presented, mainly addressing topics risk assessment management.
Язык: Английский
Процитировано
13
Science Advances, Год журнала: 2024, Номер 10(30)
Опубликована: Июль 26, 2024
The artificial mucus layer, such as hydrogels, used to repair the damaged intestinal barrier, is a promising treatment for inflammatory bowel disease (IBD). However, currently reported hydrogel-based barriers are administered via rectal injection, causing unnecessary discomfort patients. Herein, we report an oral hydrogel precursor solution based on thiol-modified hyaluronic acid (HASH). Owing reactive oxygen species (ROS)–responsive gelling behavior, our formed coating over inflamed regions of intestines, blocking microbial invasion and reducing abnormally activated immune responses. Notably, HASH also modulated gut microbiota, including increasing diversity enhancing abundance short-chain fatty acid–associated bacteria, which play key role in homeostasis. We believe that ROS-responsive layer strategy IBD.
Язык: Английский
Процитировано
12
Applied Materials Today, Год журнала: 2024, Номер 36, С. 102078 - 102078
Опубликована: Янв. 20, 2024
Язык: Английский
Процитировано
9
Arthritis Research & Therapy, Год журнала: 2025, Номер 27(1)
Опубликована: Янв. 9, 2025
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by joint inflammation, tissue damage, and fibrosis, significantly affecting the quality of life. While there are currently some effective treatments available, they often come with side effects. There an urgent need to find new that can further improve therapeutic outcomes reduce Our study investigates role Mesenchymal Stem Cell exosomes (MSC-exo) combined Ginsenoside Rh2 (Rh2) in treatment RA. We specifically focus on how this strategy influences macrophage polarization pyroptosis. This research utilized collagen-induced rat model. The findings reveal combination MSC-exo inhibit M1 macrophages, increase proportion M2-like suppress M1-like pyroptosis via NLRP3/Caspase11/GSDMD-N pathway. In model, showed synergistic contributes deeper understanding RA's pathogenesis presents potential targeted interventions. application offers promising insights for future innovative strategies RA treatment, paving way more management disease.
Язык: Английский
Процитировано
1