International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(14), С. 11466 - 11466
Опубликована: Июль 14, 2023
The
recognized
antimicrobial
activity
of
silver
nanoparticles
is
a
well-studied
property,
especially
when
designing
and
developing
biomaterials
with
medical
applications.
As
biological
closely
related
to
the
physicochemical
characteristics
material,
aspects
such
as
particle
morphology
dimension
should
be
considered.
Microfluidic
systems
in
continuous
flow
represent
promising
method
control
size,
shape,
size
distribution
synthesized
nanoparticles.
Moreover,
using
microfluidics
widens
synthesis
options
by
creating
controlling
parameters
that
are
otherwise
difficult
maintain
conventional
batch
procedures.
This
study
used
microfluidic
platform
cross-shape
design
an
innovative
for
synthesizing
varied
precursor
concentration
purging
speed
experimental
parameters.
compositional
microstructural
characterization
obtained
samples
was
carried
out
X-ray
diffraction
(XRD),
scanning
electron
microscopy
(SEM),
transmission
(TEM),
dynamic
light
scattering
(DLS).
Four
formulations
alginate-based
hydrogels
addition
hyaluronic
acid
were
highlight
efficiency
composite
wound
treatment.
porous
structure,
swelling
capacity,
properties
evaluated
through
analysis
(FT-IR
SEM)
contact
prokaryotic
eukaryotic
cells.
results
investigations
revealed
desirable
performant
dressings
(i.e.,
biocompatibility,
appropriate
rate,
degradation
ability
inhibit
biofilm
formation,
cell
growth
stimulation
capacity),
materials
thus
recommended
treating
chronic
infected
wounds.
Scientific Reports,
Год журнала:
2024,
Номер
14(1)
Опубликована: Янв. 3, 2024
Abstract
Recently,
multi-drug
resistant
(MDR)
bacteria
are
responsible
for
a
large
number
of
infectious
diseases
that
can
be
life-threatening.
Globally,
new
approaches
targeted
to
solve
this
essential
issue.
This
study
aims
discover
novel
antibiotic
alternatives
by
using
the
whole
components
biofilm
layer
as
macromolecule
synthesize
silver
nanoparticles
(AgNPs)
promising
agent
against
MDR.
In
particular,
biosynthesized
biofilm-AgNPs
were
characterized
UV-Vis
spectroscopy,
electron
microscopes,
Energy
Dispersive
X-ray
(EDX),
zeta
sizer
and
potential
while
their
effect
on
bacterial
strains
normal
cell
lines
was
identified.
Accordingly,
have
lavender-colored
solution,
spherical
shape,
with
size
range
20–60
nm.
Notably,
they
inhibitory
effects
when
used
various
concentrations
ranging
between
12.5
25
µg/mL.
addition,
an
effective
synergistic
combined
phage
ZCSE9
inhibit
kill
Salmonella
enterica
concentration
3.1
conclusion,
work
presents
biosynthesis
preparation
AgNPs
antibacterial
purposes
reduce
possible
toxicity
reducing
MICs
ZCSE9.
Green Processing and Synthesis,
Год журнала:
2024,
Номер
13(1)
Опубликована: Янв. 1, 2024
Abstract
Some
of
the
significant
globally
prevalent
vector-borne
illnesses
are
caused
by
Culex
pipiens
.
Synthetic
pesticides
have
been
widely
utilized
to
eradicate
C.
,
which
has
led
a
number
health
risks
for
people,
insect
resistance,
and
environmental
contamination.
Alternative
strategies
therefore
vitally
needed.
In
current
investigation,
Trichoderma
viride
fungal
culture
filtrate
was
used
create
selenium
silver
nanoparticles
(SeNPs
AgNPs,
respectively)
test
them
on
larvae
in
their
fourth
instar
stage.
The
death
rate
increased
significantly
when
SeNP
AgNP
concentrations
increased,
according
results.
SeNPs
AgNPs
affected
developmental
detoxification
enzymes
at
24
h
after
being
treated
with
sublethal
concentration
tested
NPs.
As
result
insecticidal
effect
larvae,
considered
effective
promising
larvicidal
agents.
Nanomaterials,
Год журнала:
2024,
Номер
14(20), С. 1618 - 1618
Опубликована: Окт. 10, 2024
Silver
nanoparticles
(NPs)
have
become
highly
promising
agents
in
the
field
of
biomedical
science,
offering
wide
therapeutic
potential
due
to
their
unique
physicochemical
properties.
The
characteristics
silver
NPs,
such
as
higher
surface-area-to-volume
ratio,
make
them
ideal
for
a
variety
biological
applications.
They
are
easily
processed
thanks
large
surface
area,
strong
plasmon
resonance
(SPR),
stable
nature,
and
multifunctionality.
With
an
emphasis
on
mechanisms
action,
efficacy,
prospective
advantages
this
review
attempts
give
thorough
overview
numerous
applications
these
particles.
utilization
NPs
diagnostics,
bioimaging
biosensing,
well
functions
interventions
antimicrobial
therapies,
cancer
therapy,
diabetes
treatment,
bone
repair,
wound
healing,
investigated.
underlying
processes
by
which
exercise
effects,
oxidative
stress
induction,
apoptosis,
microbial
cell
membrane
rupture,
explored.
Furthermore,
toxicological
concerns
regulatory
issues
discussed,
present
difficulties
restrictions
related
application
medicine.
Frontiers in Bioengineering and Biotechnology,
Год журнала:
2024,
Номер
12
Опубликована: Июнь 27, 2024
Introduction:
This
study
explores
the
therapeutic
potential
of
silver
nanoparticles
(Ag
NPs)
synthesized
using
a
Helianthemum
lippii
extract
in
mitigating
cadmium-induced
hepatotoxicity
Wistar
rats.
Given
increasing
environmental
and
health
concerns
associated
with
cadmium
exposure,
novel
eco-friendly
strategies
are
essential.
Methods:
Ag
NPs
were
characterized
X-ray
diffraction,
UV-Vis
spectrometry,
energy-dispersive
spectroscopy
scanning
electron
microscopy,
confirming
their
formation
cubic
crystal
structure
particle
sizes
ranging
from
4.81
to
12.84
nm.
A
sub-acute
toxicity
(2
mg/kg
10
mg/kg)
was
conducted,
showing
no
significant
difference
compared
untreated
control
rats
(
n
=
3
animals/group).
Subsequently,
adult
5/group)
divided
into
group
three
experimental
groups:
alone,
exposure
50
CdCl
2
drinking
water
for
35
days,
followed
by
0.1
mg/kg/day
intraperitoneally
15
days.
Results:
In
-exposed
group,
there
decrease
body
weight
increases
alanine
aspartate
transaminase
levels
p
<
0.05
vs.
control),
indicating
hepatotoxicity.
Additionally,
antioxidant
defenses
decreased,
malondialdehyde
elevated.
Liver
histology
revealed
portal
fibrosis,
inflammation,
necrosis,
sinusoid
hepatic
vein
dilation,
cytoplasmic
vacuolations.
Treatment
post-CdCl
mitigated
several
adverse
effects
on
liver
function
architecture
improved
weight.
Discussion:
demonstrates
efficacy
via
green
method
reducing
damage.
These
findings
support
applications
highlight
importance
sustainable
nanoparticle
synthesis
methods.
By
addressing
both
efficacy,
this
research
aligns
growing
emphasis
environmentally
conscious
practices
scientific
healthcare.
Scientific Reports,
Год журнала:
2023,
Номер
13(1)
Опубликована: Сен. 27, 2023
Human
pathogenic
fungi
and
bacteria
pose
a
huge
threat
to
human
life,
accounting
for
high
rates
of
mortality
every
year.
Unfortunately,
the
past
few
years
have
seen
an
upsurge
in
multidrug
resistance
pathogens.
Consequently,
finding
effective
alternative
antimicrobial
agent
is
utmost
importance.
Hence,
this
study
aimed
phytofabricate
silver
nanoparticles
(AgNPs)
using
aqueous
extracts
solid
endosperm
Cocos
nucifera
L,
also
known
as
coconut
meat
(Cm).
Green
synthesis
facile,
cost-effective
eco-friendly
methods
which
has
several
benefits
over
other
physical
chemical
methods.
The
synthesized
were
characterized
by
UV-Vis
spectroscopy,
Fourier
transform
infrared
spectroscopy
(FTIR),
X-ray
diffraction
analysis
(XRD),
field
emission
scanning
electron
microscopy
(FE-SEM),
transmission
(TEM),
dynamic
light
scattering
(DLS).
Cm-AgNPs
showed
peak
at
435
nm
crystalline
quasi-spherical,
with
average
size
15
nm.
FTIR
spectrum
displayed
functional
groups
phenols,
alkaloids,
sugars,
amines,
carbonyl
compounds,
are
vital
reduction
capping
NPs.
antibacterial
anticandidal
efficacy
was
assessed
agar-well
diffusion
method
expressed
zone
inhibition
(ZOI).
Amongst
all
test
isolates,
Staphylococcus
epidermidis,
Candida
auris,
methicillin-resistant
epidermidis
more
susceptible
NPs
ZOI
26.33
±
0.57
mm,
19.33
18
0.76
mm.
MIC
MFC
values
spp.
higher
than
bacterial
isolates.
Scanning
microscopic
studies
isolates
their
concentrations
drastically
altered
cell
morphology,
indicating
that
could
successfully
cross
barrier
damage
integrity,
causing
death.
This
reports
against
strains,
had
not
been
reported
earlier
studies.
Furthermore,
AgNPs
exhibited
significant
antioxidant
activity.
Thus,
findings
strongly
imply
can
serve
promising
candidates
therapeutic
applications,
especially
multidrug-resistant
bacteria.
However,
further
investigation
needed
understand
mode
action
biosafety.
