Polyethylene Micro/Nanoplastics Exposure Induces Epithelial–Mesenchymal Transition in Human Bronchial and Alveolar Epithelial Cells

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(18), С. 10168 - 10168

Опубликована: Сен. 22, 2024

Micro/nanoplastics (MNPs), which are widely spread in the environment, have gained attention because of their ability to enter human body mainly through ingestion, inhalation, and skin contact, thus representing a serious health threat. Several studies reported presence MNPs lung tissue potential role MNP inhalation triggering fibrosis tumorigenesis. However, there is paucity knowledge regarding cellular response composed polyethylene (PE), one most common plastic pollutants biosphere. In this study, we investigated effects low/high concentrations PE on respiratory epithelial cell viability migration/invasion abilities, using MTT, scratch, transwell assays. Morphological molecular changes were assessed via immunofluorescence, Western blot, qRT-PCR. We demonstrated that acute exposure does not induce toxicity. Instead, cells displayed visible morphological also involving actin cytoskeleton reorganization. Our data underlined epithelial–mesenchymal transition (EMT) process. Moreover, remarkable increase migration was noticed, absence significant alteration cell’s invasive capacity. The present study highlights impact epithelium, suggesting possible carcinogenesis.

Язык: Английский

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Polystyrene nanoplastics promote colitis-associated cancer by disrupting lipid metabolism and inducing DNA damage

Environment International, Год журнала: 2025, Номер 195, С. 109258 - 109258

Опубликована: Янв. 1, 2025

Nanoplastics (NPs) have attracted widespread attention owing to their presence in the body. Recent studies highlighted detrimental effects of NPs on digestive tract. However, no reported an association between exposure and colitis-associated cancer (CAC). An azoxymethane/dextran sodium sulfate-induced CAC model was used, polystyrene nanoparticles (PS-NPs) were selected for long-term exposure. Non-targeted metabolomics 16S rRNA sequencing used detect changes colonic metabolites gut microbes following PS-NPs A lipopolysaccharide (LPS)-treated cell (Caco-2) exposed investigate underlying molecular mechanism. Compared normal control group, mice group exhibited more tumor nodes reactive oxygen species (ROS), higher expression pan-CK Ki-67, severe DNA damage. revealed that altered abundance Allobaculum Lactobacillus, whereas metabolic analysis showed most significant enriched mostly fatty acid metabolism. Experiments LPS intervened Caco-2 cells led lipid peroxidation, oxidative stress, damage Caco-2. Exposure activated phosphatidylinositol 3-kinase (PI3K)/AKT/mammalian target rapamycin (mTOR) signaling pathway both AOM/DSS mouse cellular model. Key proteins involved metabolism downregulated PS-NPs. The significantly inhibited by activation fenofibrate. disturbed induced via PI3K/AKT/mTOR promote progression. Inhibition is a therapeutic controlling PS-NP-induced CAC. Our study provides important reference prevention treatment from perspective environment enhances awareness necessity plastic control.

Язык: Английский

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Microplastics in the Human Body: Exposure, Detection, and Risk of Carcinogenesis: A State-of-the-Art Review

Cancers, Год журнала: 2024, Номер 16(21), С. 3703 - 3703

Опубликована: Ноя. 1, 2024

Humans cannot avoid plastic exposure due to its ubiquitous presence in the natural environment. The waste generated is poorly biodegradable and exists form of MPs, which can enter human body primarily through digestive tract, respiratory or damaged skin accumulate various tissues by crossing biological membrane barriers. There an increasing amount research on health effects MPs. Most literature reports focus impact plastics respiratory, digestive, reproductive, hormonal, nervous, immune systems, as well metabolic MPs accumulation leading epidemics obesity, diabetes, hypertension, non-alcoholic fatty liver disease. xenobiotics, undergo ADMET processes body, i.e., absorption, distribution, metabolism, excretion, are not fully understood. Of particular concern carcinogenic chemicals added during manufacturing adsorbed from environment, such chlorinated paraffins, phthalates, phenols, bisphenols, be released when absorbed body. continuous increase NMP has accelerated SARS-CoV-2 pandemic there was a need use single-use products daily life. Therefore, urgent diagnose problems related MP detection.

Язык: Английский

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An updated systematic review about various effects of microplastics on cancer: A pharmacological and in-silico based analysis

Molecular Aspects of Medicine, Год журнала: 2025, Номер 101, С. 101336 - 101336

Опубликована: Янв. 4, 2025

Язык: Английский

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Investigation of potential toxic effects of nano- and microplastics on human endometrial stromal cells

Reproductive Toxicology, Год журнала: 2025, Номер unknown, С. 108848 - 108848

Опубликована: Янв. 1, 2025

Язык: Английский

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Role of microplastics in the tumor microenvironment (Review)

Oncology Letters, Год журнала: 2025, Номер 29(4), С. 1 - 14

Опубликована: Фев. 21, 2025

Microplastics (MPs) are pervasive in several ecosystems and have the potential to infiltrate multiple aspects of human life through ingestion, inhalation dermal exposure, thus eliciting substantial concerns regarding their implications for health. Whilst initial research has documented effects MPs on disease development across physiological systems, may also facilitate tumor progression by influencing microenvironment (TME). This evolving focus underscores growing interest role tumorigenesis interactions within TME. In present review, relationship between TME is comprehensively assessed, providing a detailed analysis with cells, stromal cells (including macrophages, fibroblasts endothelial cells), extracellular matrix inflammatory processes. Recommendations future directions strategies address reduce microplastic pollution proposed.

Язык: Английский

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An electrochemical detection method for polyvinyl chloride microplastics in water bodies

Journal of Molecular Structure, Год журнала: 2025, Номер unknown, С. 142086 - 142086

Опубликована: Март 1, 2025

Язык: Английский

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Soy protein selectively accumulates formaldehyde

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Март 18, 2025

Soy protein (SP) is easily obtained from defatted soybeans that have had soybean oil removed. Therefore, the materials consisting of soy are not only environmentally benign but also sustainable materials. We prepared SP − GPTMS composite by mixing and a silane coupling reagent, 3-glycidoxypropyltrimethoxysilane (GPTMS), demonstrated accumulation various aldehydes, such as formaldehyde (HAld), acetaldehyde (AcAld), butyl aldehyde (BuAld), benzaldehyde (BnAld), As result, when were incubated in an aqueous multi-component solution containing four these effectively accumulated aldehydes. The amounts aldehydes BnAld < BuAld AcAld HAld amount was three times higher than BnAld, which lowest amount. These results suggested indicated molecular selectivity for HAld. In addition, further increased under acidic conditions. Furthermore, according to IR measurements, HAld-accumulated showed formation Schiff base bonds. material due high electrophilicity low steric hindrance.

Язык: Английский

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Microplastic Ingestion and Neoplasms: A Comprehensive Meta-Bibliometric Analysis

Physics and Chemistry of the Earth Parts A/B/C, Год журнала: 2025, Номер unknown, С. 103926 - 103926

Опубликована: Апрель 1, 2025

Язык: Английский

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Microplastic and Extracellular Vesicle Interactions: Recent Studies on Human Health and Environment Risks

Biophysica, Год журнала: 2024, Номер 4(4), С. 724 - 746

Опубликована: Дек. 21, 2024

Microplastics (MPs) are widespread environmental pollutants that have drawn significant attention due to their possible health risks humans and animals, as well extensive presence in ecosystems. Recent growing evidence highlights a remarkable relationship between MPs extracellular vesicles (EVs), nanoscale particles involved intercellular communication. The purpose of this review was investigate how the relationships EVs can affect cellular functions interaction could impact conditions leading broader ecological risks. patterns bioactivity both strongly influenced by biophysical characteristics such hydrophobicity, surface charge, particle size, which received particular from scientific community. studies indicate EV distribution capacity function appropriately biological systems. Additionally, modify molecular cargo EVs, may result alterations cell signaling pathways. Understanding interactions provide important opportunities comprehend potential effects on human systems, especially when it comes cancer development, endocrine, metabolic, inflammatory disorders, disruptions. This emphasizes necessity multidisciplinary research clarify mechanisms regulating EVs.

Язык: Английский

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