Clinical Rheumatology, Год журнала: 2024, Номер 43(6), С. 2061 - 2077
Опубликована: Май 2, 2024
Язык: Английский
ACS Nano, Год журнала: 2023, Номер 17(5), С. 4358 - 4372
Опубликована: Фев. 27, 2023
The synovial tissues under rheumatoid arthritis conditions are usually infiltrated by inflammatory cells, particularly M1 macrophages with aberrant redox homeostasis, which causes rapid deterioration of articular structure and function. Herein, we created an ROS-responsive micelle (HA@RH-CeOX) through the in situ host–guest complexation between ceria oxide nanozymes hyaluronic acid biopolymers, precisely delivered nanozyme clinically approved drug Rhein (RH) to proinflammatory macrophage populations inflamed tissues. abundant cellular ROS could cleave thioketal linker trigger release RH Ce. Specifically, Ce3+/Ce4+ pair present SOD-like enzymatic activity rapidly decompose alleviate oxidative stress macrophages, while inhibit TLR4 signaling both act a concerted manner induce their repolarization into anti-inflammatory M2 phenotype ameliorate local inflammation promote cartilage repair. Notably, rats bearing showed drastic increase M1-to-M2 ratio from 1:0.48 1:1.91 tissue significantly reduced cytokine levels including TNF-α IL-6 following intra-articular injection HA@RH-CeOX, accompanied efficient regeneration restored Overall, this study revealed approach modulate homeostasis reprogram polarization states micelle-complexed biomimetic enzymes, offers alternative opportunities for treatment arthritis.
Язык: Английский
Процитировано
72
International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(12), С. 9841 - 9841
Опубликована: Июнь 7, 2023
Collagens serve essential mechanical functions throughout the body, particularly in connective tissues. In articular cartilage, collagens provide most of biomechanical properties extracellular matrix for its function. Collagen plays a very important role maintaining cartilage and stability ECM. Noteworthily, many pathogenic factors course osteoarthritis rheumatoid arthritis, such as injury, inflammation, senescence, are involved irreversible degradation collagen, leading to progressive destruction cartilage. The collagen can generate new biochemical markers with ability monitor disease progression facilitate drug development. addition, also be used biomaterial excellent low immunogenicity, biodegradability, biocompatibility, hydrophilicity. This review not only provides systematic description analyzes structural characteristics mechanisms damage states but detailed characterization biomarkers production repair, providing ideas techniques clinical diagnosis treatment.
Язык: Английский
Процитировано
45
Chemistry & Biodiversity, Год журнала: 2024, Номер 21(5)
Опубликована: Март 20, 2024
Abstract Fruits and vegetables serve not only as sources of nutrition but also medicinal agents for the treatment diverse diseases maladies. These dietary components are significant resources phytochemicals that demonstrate therapeutic properties against many illnesses. Fraxin is a naturally occurring coumarin glycoside mainly present in various species Fraxinus genera, having multitude uses disorders. This study focuses to investigate pharmacological activities, botanical sources, biopharmaceutical profile phytochemical fraxin based on different preclinical non‐clinical studies show scientific evidence evaluate underlying molecular mechanisms effects ailments. For this, data was searched collected (as February 15, 2024) variety credible electronic databases, including PubMed/Medline, Scopus, Springer Link, ScienceDirect, Wiley Online, Web Science, Google Scholar. The findings demonstrated favorable outcomes relation range or medical conditions, inflammation, neurodegenerative disorders such cerebral ischemia‐reperfusion (I/R) depression, viral infection, well diabetic nephropathy. showed protective osteoprotective, renoprotective, pulmoprotective, hepatoprotective, gastroprotective due its antioxidant capacity. has great capability diminish oxidative stress‐related damage organs by stimulating enzymes, downregulating nuclear factor kappa B NLRP3, triggering Nrf2/ARE signaling pathways. exhibited poor oral bioavailability because reduced absorption wide distribution into tissues organs. However, extensive research required decipher profiles, clinical necessary establish efficacy natural compound reliable agent.
Язык: Английский
Процитировано
20
Aging Cell, Год журнала: 2024, Номер 23(4)
Опубликована: Янв. 29, 2024
Abstract Osteoarthritis (OA), a chronic degenerative joint disease, is highly prevalent among the aging population, and often leads to pain, disability, diminished quality of life. Although considerable research has been conducted, precise molecular mechanisms propelling OA pathogenesis continue be elusive, thereby impeding development effective therapeutics. Notably, recent studies have revealed subchondral bone lesions precede cartilage degeneration in early stage OA. This marked by escalated osteoclast‐mediated resorption, subsequent imbalances metabolism, accelerated turnover, decrease volume, contributing significantly pathological changes. While role hallmarks extensively elucidated from perspective chondrocytes, their connection with osteoclasts not yet fully understood. There compelling evidence suggest that age‐related abnormalities such as epigenetic alterations, proteostasis network disruption, cellular senescence, mitochondrial dysfunction, can stimulate osteoclast activity. review intends systematically discuss how contribute pathogenesis, placing particular emphasis on age‐induced shifts It also aims future probing into therapeutic approaches targeting during aging.
Язык: Английский
Процитировано
19
Frontiers in Immunology, Год журнала: 2025, Номер 16
Опубликована: Янв. 23, 2025
Objectives The association between the neutrophil percentage to albumin ratio (NPAR) and risk of osteoarthritis (OA) rheumatoid arthritis (RA) remains unclear. This study aims investigate NPAR OA RA. Methods cross-sectional analyzed data from 92,062 American adults in NHANES database 1999 2016. Various statistical analyses were conducted associations risks RA, including multivariable logistic regression, subgroup analysis, smooth curve fitting, threshold effect analysis. Results After screening, final population included 36,147 participants, with 3,881 individuals diagnosed 2,178 adjusting for confounding factors, higher levels associated an increased RA (OR=1.05; 95% CI: 1.03-1.07; P <0.0001), but not (OR=1.01; 0.99-1.02; =0.755). was remarkably consistent across subgroups by age, sex, body mass index (BMI), alcohol consumption, hypertension, diabetes, smoking status. Further using fitting models revealed a nonlinear inflection point identified at 15.56. Conclusion High is positively prevalence provides us new insights management treatment patients.
Язык: Английский
Процитировано
3
Ageing Research Reviews, Год журнала: 2023, Номер 85, С. 101864 - 101864
Опубликована: Янв. 25, 2023
Язык: Английский
Процитировано
33
Frontiers in Immunology, Год журнала: 2023, Номер 14
Опубликована: Июль 12, 2023
Osteoarthritis (OA) is a degenerative disease closely related to aging. Nevertheless, the role and mechanisms of aging in osteoarthritis remain unclear. This study aims identify potential aging-related biomarkers OA explore genes immune microenvironment synovial tissue.Normal gene expression profile microarrays were obtained from Gene Expression Omnibus (GEO) database (ARGs) Human Aging Genomic Resources (HAGR). Ontology (GO), Kyoto Encyclopedia Genes Genomes (KEGG), Disease (DO), set variation analysis (GSVA) enrichment used uncover underlying mechanisms. To Hub ARDEGs with highly correlated features (Hub OA-ARDEGs), Weighted Co-expression Network Analysis (WGCNA) machine learning methods used. Furthermore, we created diagnostic nomograms receiver operating characteristic curves (ROC) assess OA-ARDEGs' ability diagnose predict which miRNAs TFs they might act on. The Single sample (ssGSEA) algorithm was applied look at infiltration characteristics their relationship OA-ARDEGs.We discovered 87 normal synovium samples. According functional enrichment, are primarily associated inflammatory regulation, cellular stress response, cell cycle transcriptional regulation. OA-ARDEGs excellent identified as MCL1, SIK1, JUND, NFKBIA, JUN. Wilcox test showed that all significantly downregulated validated validation by qRT-PCR. Using ssGSEA algorithm, 15 types six activation increased samples well OA-ARDEGs.Synovial may promote progression inducing inflammation. JUN can be novel biomolecular markers therapeutic targets for OA.
Язык: Английский
Процитировано
28
Pharmacological Research, Год журнала: 2023, Номер 192, С. 106768 - 106768
Опубликована: Апрель 13, 2023
Osteoarthritis (OA) is one of the most prevalent musculoskeletal disorders globally, and treating OA remains a significant challenge. Currently, pharmacological treatments primarily aim to alleviate symptoms associated with inflammation pain, no disease-modifying therapies are available delay development progression. Reactive oxygen species (ROS) play an essential role in progression, which promising target for curing OA. In this study, it was found that photothermal properties near-infrared (NIR) irradiation enhanced ROS scavenging activity molybdenum-based polyoxometalate (POM) nanoclusters. Because scavenging, NIR-responsive POM nanoclusters were developed as novel excellent nano-antioxidants protection. The results demonstrated exhibited outstanding antioxidant superexcellent anti-inflammatory effects, could effectively clinical mice, diminish inflammatory cytokines, reduce catabolic proteases, mitigate progression Meanwhile, local treatment had side effects on normal tissues. Thus, study pioneered application alleviating expected safety efficiency.
Язык: Английский
Процитировано
26
BMC Public Health, Год журнала: 2024, Номер 24(1)
Опубликована: Июнь 13, 2024
Abstract Background Chronic inflammation may contribute to increased mortality risk in individuals with osteoarthritis (OA), but research on the prognostic value of inflammatory biomarkers is limited. We aimed evaluate associations systemic immune–inflammation index (SII) and response (SIRI) all-cause cardiovascular among US adults OA. Methods This cohort study included 3545 OA aged ≥ 20 years from National Health Nutrition Examination Survey 1999–2020. The SII SIRI were calculated using complete blood cell count data. Participants categorized as having a higher or lower cutoff points derived by maximally selected rank statistics method. Cox proportional hazards models, Fine–Gray competing regression models time-dependent receiver operating characteristic (ROC) analysis used between SII/SIRI patients. Results Over median follow-up 5.08 (3.42–9.92) years, 636 (17.94%) deaths occurred, including 149 (4.20%) deaths. According multivariable-adjusted involving demographic, socioeconomic, health factors, patients had twofold greater than (HR 2.01; 95% CI: 1.50–2.68). Similarly, was associated an 86% relative 1.86; 1.46–2.38). Similar trend found mortality, elevated 88% 67% respectively, compared 1.88; 1.16–3.03) 1.67; 1.14–2.44). Time-dependent ROC curves showed that both have moderate valid performance predicting short- long-term Conclusions Higher values
Язык: Английский
Процитировано
15
Free Radical Biology and Medicine, Год журнала: 2024, Номер 212, С. 336 - 348
Опубликована: Янв. 2, 2024
Ferroptosis is involved in the pathogenesis of osteoarthritis (OA) while suppression chondrocyte ferroptosis has a beneficial effect on OA. However, molecular mechanism OA remains to be elucidated. P21, an indicator aging, been reported inhibit ferroptosis, but relationship between P21 and unclear. Here, we aimed investigate expression function chondrocytes, involvement regulation chondrocytes. First, demonstrated that high was observed cartilage from patients destabilized medial meniscus (DMM) mice, osteoarthritic chondrocytes induced by IL-1β, FAC erastin. knockdown exacerbated reduction Col2a1 promoted upregulation MMP13 Meanwhile, degradation DMM-induced mouse models decreased GPX4 vivo. Furthermore, sensitized erastin, which closely associated with accumulation lipid peroxides. In mechanism, regulated stability protein, independent NRF2. found significantly affected recruitment linear ubiquitin chain assembly complex (LUBAC) level M1-linked ubiquitination GPX4. Overall, our results suggest plays essential anti-ferroptosis role regulating
Язык: Английский
Процитировано
13