Harnessing Synthetic Strategies for Enhanced Gold Nanoparticle Functionality in Cancer Treatment

BioNanoScience, Год журнала: 2024, Номер 14(3), С. 3693 - 3714

Опубликована: Июль 6, 2024

Язык: Английский

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Green synthesized apigenin conjugated gold nanoparticles inhibit cholangiocarcinoma cell activity and endothelial cell angiogenesis in vitro

Heliyon, Год журнала: 2022, Номер 8(12), С. e12028 - e12028

Опубликована: Дек. 1, 2022

Cholangiocarcinoma (CCA) is a rare malignancy of the biliary tract with extremely poor clinical outcomes due to lack effective therapies improve disease management. The emerging green synthesis gold nanoparticles (AuNPs) has extensively provided their use in biomedical applications. In this study, we developed AuNPs via reducing salts apigenin (4',5,7-trihydroxyflavone). synthesized apigenin-conjugated (api-AuNPs) were physicochemically characterized by various techniques before evaluation biological and functional inhibition CCA cell line, KKU-M055. mean size api-AuNPs was 90.34 ± 22.82 nm zeta potential -36 0.55. half-maximal inhibitory concentration (IC

Язык: Английский

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Radiosensitising effect of iron oxide‐gold nanocomplex for electron beam therapy of melanoma in vivo by magnetic targeting

IET Nanobiotechnology, Год журнала: 2023, Номер 17(3), С. 212 - 223

Опубликована: Апрель 21, 2023

Abstract Melanoma is a dangerous type of skin cancer sometimes treated with radiotherapy. However, it induces damage to the surrounding healthy tissue and possibly further away areas. Therefore, necessary give lower dose patient targeted therapy. In this study, radio‐sensitising effect gold‐coated iron oxide nanoparticles on electron beam radiotherapy melanoma tumour magnetic targeting in mouse model was investigated. Gold‐coated were prepared steady procedure. The induced mice. Animals divided into five groups: (1) normal; (2) melanoma; (3) alone; (4) radiotherapy; (5) plus nanoparticles. magnet placed site for 2 h. tumours then exposed 6 MeV 8 Gy. Inductively coupled plasma optical emission spectrometry test, hematoxylin eosin staining, enzyme‐linked immunosorbent assay blood test also performed. before reduced growth compared control group. Blood tests did not show any significant toxicity. Deposition more spleen lesser extent liver, kidney, lung tissues. synergistic administered by intraperitoneal route concentrated area application an external permanent magnet, delivery improved overall treatment outcome prevented metal distribution side effects.

Язык: Английский

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Gold Nanocage-Based Multifunctional Nanosensitizers for Programmed Photothermal /Radiation/Chemical Coordinated Therapy Guided by FL/MR/PA Multimodal Imaging

International Journal of Nanomedicine, Год журнала: 2023, Номер Volume 18, С. 7237 - 7255

Опубликована: Дек. 1, 2023

Background: Radiotherapy is one of the main clinical methods for treatment malignant tumors at present. However, its application limited by radiation resistance some tumor cells and irradiation damage to surrounding normal tissues, limitation radiotherapy dose also affects therapeutic effect. Therefore, developing diagnostic agents with imaging radiosensitizing functions urgently needed improve accuracy efficacy radiotherapy. Materials Strategy: Herein, we synthesized multifunctional nanotheranostic FRNPs nanoparticles based on gold nanocages (GNCs) MnO 2 magnetic resonance (MR)/photoacoustic (PA) combined photothermal, radiosensitive chemical therapy. A programmed therapy strategy proposed. First, photothermal applied ablate large increase sensitivity tissue radiotherapy, then X-ray performed further reduce size, finally chemotherapeutic are used eliminate smaller residual distant metastases. Results: As revealed fluorescence, MR PA imaging, achieved efficient aggregation retention sites mice after intravenous injection. In vivo studies have shown that FRNPs-injected nude which were exposed 808 laser greatest inhibition growth compared other groups. Moreover, no obvious systemic toxicity was observed in all groups mice, indicating good biocompatibility safety scheme. Conclusion: To sum up, our work not only showed a new radiosensitizer, but provided promising theranostic cancer treatment. Keywords: nanoparticles, , radiosensitizing, multimodal

Язык: Английский

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QbD-assisted synthesis and exploration of plasmonic laser activatable nanoGold seeds for photothermal and photodynamic therapy of cancer cells

Journal of Materials Science, Год журнала: 2024, Номер 59(4), С. 1570 - 1592

Опубликована: Янв. 1, 2024

Язык: Английский

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Nanotechnology-based advancements for effective delivery of phytoconstituents for Ocular diseases

Nano TransMed, Год журнала: 2024, Номер unknown, С. 100056 - 100056

Опубликована: Окт. 1, 2024

Язык: Английский

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Overcoming Breast Cancer Treatment Resistance with Optimizing Sonodynamic Therapy and Radiation Sensitizers on lncRNA PVT1 and miR-1204 Expression

Photodiagnosis and Photodynamic Therapy, Год журнала: 2024, Номер unknown, С. 104433 - 104433

Опубликована: Дек. 1, 2024

Acoustic cavitation is a foundational mechanism in ultrasound therapy, primarily through inertial resulting from microbubble collapse. Sonodynamic with acoustic threshold and low-dose radiation the presence of sensitizers, may provide significant effects for cancer treatment, potentially overcoming resistance encountered single therapies.

Язык: Английский

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Eco-friendly Nanoparticle Phytosynthesis via Plant Extracts: Mechanistic Insights, Recent Advances, and Multifaceted Uses

Nano TransMed, Год журнала: 2025, Номер unknown, С. 100080 - 100080

Опубликована: Март 1, 2025

Язык: Английский

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Applications and Efficacy of Iron Oxide Nanoparticles in the Treatment of Brain Tumors

Pharmaceutics, Год журнала: 2025, Номер 17(4), С. 499 - 499

Опубликована: Апрель 9, 2025

Cancers of the central nervous system are particularly difficult to treat due a variety factors. Surgical approaches impeded by skull—an issue which is compounded severity possible harm that can result from damage parenchymal tissue. As result, chemotherapeutic agents have been standard care for brain tumors. While some drugs be effective on case-by-case basis, there remains critical need improve efficacy neurological cancers. Recently, advances in iron oxide nanoparticle research highlighted how their unique properties could leveraged address shortcomings conventional therapeutics. Iron nanoparticles combine advantages good biocompatibility, magnetic susceptibility, and functionalization via range coating techniques. Thus, used both imaging cancers with resonance imaging, as well acting trafficking vehicles across blood–brain barrier targeted drug delivery. Moreover, ability support minimally invasive therapies such hyperthermia makes them appealing neuro-oncological applications, where precision safety paramount. In this review, we will outline application various clinical settings including delivery paradigms. Importantly, review presents novel approach combining surface engineering internal targeting deep-seated tumors, proposing surgical implantation magnets next-generation strategy overcome limitations external fields.

Язык: Английский

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Biogenically produced Gold nanoparticles containing a fluoroquinolone molecule from the cell-free extract of E. hormaechei soil isolates with anti-bacterial and anti-cancer properties

Inorganic Chemistry Communications, Год журнала: 2025, Номер unknown, С. 114536 - 114536

Опубликована: Апрель 1, 2025

Язык: Английский

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