Research Square (Research Square),
Год журнала:
2023,
Номер
unknown
Опубликована: Июль 24, 2023
Abstract
Pain
derived
from
rheumatoid
arthritis
(RA)
is
the
most
debilitating
symptom
suffered
by
patients
although
inflammation
successfully
controlled.
It
main
concern
that
frequently
overlooked
due
to
unclear
understandings
of
its
occurrence.
Medications
alleviate
pain
are
limited
and
produce
severe
side
effects.
This
study
aimed
uncover
possible
involvement
nociceptive
signalling
N-methyl-D-aspartate-2B
receptor
(NMDAR-2B)
or
P2X4
(P2X4R)-induced
microglial
activation
at
thalamus
chronic
polyarthritis
rat
mimicking
RA
upon
CORM-2
(selective
P2X4R
antagonist)
ifenprodil
(non-competitive
NMDAR-2B
administrations.
Eighty
Sprague-Dawley
male
rats
were
randomly
assigned
into
five
groups
(n
=
16):
non-arthritic
control(C),
arthritic
control(A),
treated
with
either
diclofenac
(positive
control)
(A
+
Diclofenac),
CORM-2),
Ifenprodil).
The
was
induced
complete
Freund’s
adjuvant
state
for
15
days.
Treatment
sodium
diclofenac,
ifenprodil,
saline
(as
vehicle)
performed
seven
days
intrathecally.
Bilateral
ankle
joint
diameter
spontaneous
behaviour
activity
(mobility)
evaluated
assess
oedema-induced
responses.
Thalamus
tissue
collected
qRT-PCR
immunohistochemistry
analyses.
Results
revealed
a
significant
reduction
in
improved
mobility
ifenprodil.
treatments
significantly
attenuated
mRNA
level
protein
expression
thalamic
activated
microglia
rats.
deduced
contribution
NMDAR-2B-P2X4R-induced
pathogenesis
pain.
also
provides
insights
understand
suggests
as
new
therapeutics
management.
Biomedicines,
Год журнала:
2024,
Номер
12(1), С. 178 - 178
Опубликована: Янв. 13, 2024
Apigenin
is
a
flavone
widely
present
in
different
fruits
and
vegetables
has
been
suggested
to
possess
neuroprotective
effects
against
some
neurological
disorders.
In
this
study,
we
systematically
reviewed
preclinical
studies
that
investigated
the
of
apigenin
on
learning
memory,
locomotion
activity,
anxiety-like
behaviour,
depressive-like
behaviour
sensorimotor
motor
coordination
rats
mice
with
impaired
memory
behaviour.
We
searched
SCOPUS,
Web
Science,
PubMed
Google
Scholar
for
relevant
articles.
A
total
34
were
included
review.
The
revealed
enhanced
exhibited
anxiolytic
effects,
attenuated
improved
animals
cognitive
impairment
neurobehavioural
deficit.
Some
molecular
biochemical
mechanisms
include
activation
ERK/CREB/BDNF
signalling
pathway;
modulation
neurotransmitter
levels
monoaminergic,
cholinergic,
dopaminergic
serotonergic
systems;
inhibition
pro-inflammatory
cytokine
production;
attenuation
oxidative
neuronal
damage.
These
results
necessity
further
research
using
established
doses
short
or
long
durations
ascertain
effective
safe
apigenin.
also
point
need
clinical
experiment
therapeutic
effect
Antioxidants,
Год журнала:
2024,
Номер
13(5), С. 606 - 606
Опубликована: Май 15, 2024
Epigenetics
defines
changes
in
cell
function
without
involving
alterations
DNA
sequence.
Neuroepigenetics
bridges
neuroscience
and
epigenetics
by
regulating
gene
expression
the
nervous
system
its
impact
on
brain
function.
With
increase
research
recent
years,
it
was
observed
that
did
not
always
originate
from
genetic
sequence,
which
has
led
to
understanding
role
of
neurodegenerative
diseases
(NDDs)
including
Alzheimer's
disease
(AD)
Parkinson's
(PD).
Epigenetic
contribute
aberrant
genes
involved
neuroinflammation,
protein
aggregation,
neuronal
death.
Natural
phytochemicals
have
shown
promise
as
potential
therapeutic
agents
against
NDDs
because
their
antioxidant,
anti-inflammatory,
neuroprotective
effects
cellular
animal
models.
For
instance,
resveratrol
(grapes),
curcumin
(turmeric),
epigallocatechin
gallate
(EGCG;
green
tea)
exhibit
through
influence
methylation
patterns,
histone
acetylation,
non-coding
RNA
profiles.
Phytochemicals
also
aid
slowing
progression,
preserving
function,
enhancing
cognitive
motor
abilities.
The
present
review
focuses
various
epigenetic
modifications
pathology
NDDs,
AD
PD,
regulation
related
alterations,
specific
polyphenols
influencing
PD.
Journal of Food Biochemistry,
Год журнала:
2025,
Номер
2025(1)
Опубликована: Янв. 1, 2025
Background:
This
study
aimed
to
evaluate
the
effect
of
Shenbing
Decoction
III
(SBD
III)
and
its
key
Apigenin
on
peritoneal
dialysis
(PD)–induced
fibrosis
explore
underlying
mechanisms.
Methods:
Liquid
chromatography–mass
spectrometry
confirmed
presence
in
SBD
III.
Human
mesothelial
cells
(HMrSV5)
were
stimulated
with
PD
solution
(PDS)
induce
fibrosis,
treatment
was
administered.
Results:
PDS
decreased
cell
viability
increased
migration
invasion
capabilities
HMrSV5
cells.
It
also
reduced
E‐cadherin
expression,
while
increasing
expression
α‐SMA,
fibronectin,
collagen
I,
TGF‐β1.
effectively
counteracted
these
effects.
Additionally,
inhibited
PDS‐induced
upregulation
phosphorylation
transforming
growth
factor‐β‐activated
kinase
1
(TAK1),
p38,
nuclear
factor‐κB
(NF‐κB),
similar
effects
5z‐7‐oxozeaenol.
Chronic
kidney
disease
(CKD)
induced
mice
by
5/6
nephrectomy,
followed
treatment.
The
therapeutic
evaluated.
CKD
exhibited
body
weight
indices,
along
elevated
blood
urea
nitrogen,
urinary
creatinine,
protein
levels.
Fibrosis
observed
kidneys
peritoneum.
significantly
alleviated
Notably,
further
augmented
when
Conclusion:
ameliorated
inhibiting
epithelial–mesenchymal
transition
via
TAK1/p38MAPK/NF‐κB
pathway,
indicating
promising
pharmaceutical
candidates
for
CKD.
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(7), С. 2916 - 2916
Опубликована: Март 23, 2025
Serotonin
(5-HT),
dopamine
(DA),
and
norepinephrine
(NE)
are
key
monoamine
neurotransmitters
regulating
behaviors,
mood,
cognition.
5-HT
affects
early
brain
development,
its
dysfunction
induces
vulnerability
to
stress,
raising
the
risk
of
depression,
anxiety,
autism
in
adulthood.
These
synthesized
from
tryptophan
tyrosine
via
hydroxylation
decarboxylation,
metabolized
by
oxidase
(MAO).
This
review
aims
summarize
current
findings
on
role
dietary
phytochemicals
modulating
neurotransmitter
biosynthesis,
metabolism,
function,
with
an
emphasis
their
potential
therapeutic
applications
neuropsychiatric
disorders.
Phytochemicals
exert
antioxidant,
neurotrophic,
neurohormonal
activities,
regulate
gene
expression,
induce
epigenetic
modifications.
Phytoestrogens
activate
estrogen
receptors
or
estrogen-responsive
elements
promoter
target
genes,
enhance
transcription
hydroxylase
hydroxylase,
while
inhibiting
that
MAO.
compounds
also
influence
interaction
between
genetic
environmental
factors,
potentially
reversing
dysregulated
neurotransmission
architecture
associated
conditions.
Despite
promising
preclinical
findings,
clinical
remain
challenging.
Advances
nanotechnology
targeted
delivery
systems
offer
solutions
efficacy.
discusses
mechanisms,
challenges,
strategies,
underscoring
need
for
further
research
advance
phytochemical-based
interventions
diseases.
Ankara Üniversitesi Veteriner Fakültesi Dergisi,
Год журнала:
2025,
Номер
unknown, С. 1 - 9
Опубликована: Апрель 24, 2025
Methotrexate
(MTX)
is
a
widely
used
antiarthritic
and
chemotherapeutic
agent
known
to
cause
damage
various
tissues.
This
study
investigated
the
potential
protective
effects
of
parsley
extract
against
MTX-induced
brain
intestinal
tissue
damage.
Sprague-Dawley
rats
were
divided
into
control,
control
+
parsley,
MTX,
MTX
parsley.
(20
mg/kg,
i.p.)
was
administered
groups.
The
groups
2
g/kg
by
oral
gavage
for
five
consecutive
days.
After
fifth
day,
small
tissues
taken.
Total
protein,
nitric
oxide,
lipid
peroxidation,
glutathione
levels,
factor,
superoxide
dismutase,
S-transferase
activities
determined
in
these
protein
profiles
evaluated
using
SDS
polyacrylamide
gel
electrophoresis.
Parsley
administration
caused
decrease
peroxidation
levels
both
group.
On
other
hand,
level,
glutathione-S-transferase,
dismutase
found
be
increased.
decreased
oxide
level
which
increased
There
no
significant
change
factor
activity
between
altered
expression,
leading
appearance
or
disappearance
specific
bands
In
conclusion,
alleviated
reducing
modulating
antioxidant
defenses.
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(15), С. 12449 - 12449
Опубликована: Авг. 4, 2023
Exosomes
are
cell-derived
membranous
structures
primarily
involved
in
the
delivery
of
payload
to
recipient
cells,
and
they
play
central
roles
carcinogenesis
metastasis.
Radiotherapy
is
a
common
cancer
treatment
that
occasionally
generates
exosomal
miRNA-associated
modulation
regulate
therapeutic
anticancer
function
side
effects.
Combining
radiotherapy
natural
products
may
modulate
radioprotective
radiosensitizing
responses
non-cancer
but
there
knowledge
gap
regarding
connection
this
combined
with
miRNAs
their
downstream
targets
for
radiation
exosome
biogenesis.
This
review
focuses
on
terms
impacts
target
radiation-modulating
biogenesis
(secretion
assembly)
genes.
Several
have
individually
demonstrated
miRNA-modulating
However,
impact
natural-product-modulated
response
remains
unclear.
In
review,
by
searching
through
PubMed/Google
Scholar,
available
reports
potential
functions
show
radioprotection
tissues
radiosensitization
among
these
were
assessed.
Next,
accessing
miRNA
database
(miRDB),
predicted
radiation-
biogenesis-modulating
genes
from
Gene
Ontology
(MGI)
retrieved
bioinformatically
based
miRNAs.
Moreover,
target-centric
analysis
showed
several
share
same
As
result,
miRNA-radiomodulation
(radioprotection
radiosensitization)-exosome
axis
regard
natural-product-mediated
radiotherapeutic
effects
well
organized.
regulating
assess
radiomodulation
both
cells
cells.
