Nrf-2 as a novel target in radiation induced lung injury
Heliyon,
Год журнала:
2024,
Номер
10(8), С. e29492 - e29492
Опубликована: Апрель 1, 2024
Radiation-induced
lung
injury
(RILI)
is
a
common
and
fatal
complication
of
chest
radiotherapy.
The
underlying
mechanisms
include
radiation-induced
oxidative
stress
caused
by
damage
to
the
deoxyribonucleic
acid
(DNA)
production
reactive
oxygen
species
(ROS),
resulting
in
apoptosis
endothelial
cells
recruitment
inflammatory
myofibroblasts
expressing
NADPH
oxidase
site
injury,
which
turn
contribute
cytokine
production.
Nuclear
factor
erythroid
2-related
2
(Nrf-2)
vital
transcription
that
regulates
inhibits
inflammation.
Studies
have
shown
Nrf-2
protects
against
inflammation
fibrosis.
This
review
discusses
protective
role
RILI
its
possible
mechanisms.
Язык: Английский
Therapeutic potential of flavonoids from traditional Chinese medicine in pancreatic cancer treatment
Frontiers in Nutrition,
Год журнала:
2024,
Номер
11
Опубликована: Ноя. 22, 2024
Pancreatic
cancer
(PC)
is
a
highly
aggressive
malignancy
with
rising
mortality
rates
globally.
Its
diagnosis
often
challenging
due
to
its
asymptomatic
nature
in
the
early
stages.
Consequently,
most
patients
receive
poor
prognosis,
low
survival
within
5
years,
as
disease
typically
detected
at
an
advanced
stage,
complicating
effective
treatment.
Flavonoids,
especially
those
derived
from
traditional
Chinese
herbal
medicines,
have
attracted
considerable
attention
for
their
potent
anti-PC
properties.
This
review
highlights
therapeutic
potential
of
these
bioactive
compounds,
which
modulate
key
biological
pathways,
making
them
promising
candidates
PC
intervention.
Their
mechanisms
action
include
regulation
autophagy,
apoptosis,
cell
growth,
epithelial-mesenchymal
transition,
and
oxidative
stress,
well
enhancing
chemotherapeutic
sensitivity,
exerting
antiangiogenic
effects,
potentially
boosting
immunomodulatory
responses.
The
demonstrated
benefits
natural
compounds
management
spurred
extensive
academic
interest.
Beyond
role
anti-cancer
agents,
flavonoids
may
provide
both
preventive
advantages
PC,
resonating
core
principles
medicine
prevention
holistic
Язык: Английский
Exosomes and exosomal miRNAs: A new avenue for the future treatment of rheumatoid arthritis
Heliyon,
Год журнала:
2024,
Номер
10(6), С. e28127 - e28127
Опубликована: Март 1, 2024
Rheumatoid
arthritis
is
a
chronic
systemic
autoimmune
disease
that
involves
mainly
synovitis
and
joint
injury
one
of
the
main
causes
disability.
The
pathogenesis
rheumatoid
complicated,
treatment
cycle
long.
traditional
methods
inhibiting
inflammation
immunosuppression
are
no
longer
sufficient
for
disease,
so
there
an
urgent
need
to
seek
new
treatments.
exocrine
microenvironment
kind
microvesicle
with
lipid
bilayer
membrane
structure
can
be
secreted
by
most
cells
in
body.
This
contains
cell-specific
proteins,
lipids
nucleic
acids
transmit
this
information
from
cell
another.
To
achieve
cell-to-cell
communication.
Exocrine
microRNAs
contained
selectively
transferred
target
receptor
via
signaling,
thus
regulating
physiological
function
cells.
article
focuses
on
pathological
changes
occur
during
development
biological
regulation
joints.
Research
roles
inflammatory
response,
proliferation/apoptosis,
autophagy,
effects
fibroblast-like
synoviocytes
immune
was
reviewed.
In
addition,
challenges
faced
discussed.
Язык: Английский
Mechanistic role of pyroptosis in tumor microenvironment and tumor immunotherapy
Cellular and Molecular Biology,
Год журнала:
2024,
Номер
70(4), С. 260 - 267
Опубликована: Апрель 28, 2024
Язык: Английский
Lactoferrin-mediated targeting of oncogenic pathways for cancer chemoprevention and adjunct treatment: From mechanistic insights to clinical trials
Arhiv za farmaciju,
Год журнала:
2024,
Номер
74(4), С. 509 - 522
Опубликована: Янв. 1, 2024
Genetic,
genomic
and
proteomic
analyses
of
cells,
tissues
body
fluids
have
generated
a
wealth
precious
information
about
the
intricate
mechanisms
which
underlie
carcinogenesis
metastasis.
Lactoferrin,
multifunctional
cationic
glycoprotein,
has
attracted
widespread
appreciation
because
its
characteristically
novel
properties
for
cancer
chemoprevention.
Tumor
microenvironment
is
highly
complicated
sophisticated
ecosystem,
significantly
reshaped
by
wide
variety
treatment
regimes.
Therefore,
lactoferrin-mediated
immunostimulatory
role
reshapes
tumor
inhibits
progression.
There
sufficient
experimental
evidence
related
to
ability
lactoferrin
in
microenvironment.
Different
clinical
trials
been
conducted
evaluation
efficacy
different
patients.
It
necessary
carefully
interpret
identify
major
gaps
our
understanding
selection
group
patients
likely
benefit
most
from
combinatorial
regime
comprised
chemotherapeutic
drugs.
Moreover,
lack
should
be
analyzed
team
interdisciplinary
researchers
broader
comprehensive
underlying
failure.
Язык: Английский