Why Does the Antioxidant Complex Twendee X® Prevent Dementia?

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(16), С. 13018 - 13018

Опубликована: Авг. 21, 2023

Alzheimer's disease (AD) is a complex neurodegenerative characterized by cognitive and short-term memory impairments. The involves multiple pathological factors such as amyloid plaque formation, mitochondrial dysfunction, telomere shortening; however, oxidative stress diabetes mellitus are significant risk factors. onset of AD begins approximately 20 years before clinical symptoms manifest; therefore, treating after become evident possibly too late to have effect. As such, preventing or using an effective treatment at early stage important. Twendee X® (TwX) antioxidant formulation consisting eight ingredients. TwX has been proven prevent the progression dementia in patients with mild impairment (MCI) multicenter, randomized, double-blind, placebo-controlled, prospective intervention trial. well, positive data already obtained several studies model mice. Since both aging for AD, we examined mechanisms behind effects on spontaneous hyperglycemia senescence aged C57BL/6 mice this study. was administered daily, its diabetes, autophagy brain, neurogenesis, length were examined. We observed that protected mitochondria from better than single antioxidant. not only lowered blood glucose levels but also suppressed brain neurogenesis autophagy. Telomeres TWX-treated significantly longer those non-treated There many can be implicated development dementia; suggest it may offer protection against dementia, through antioxidants targeting involved progression, deficiency, energy production.

Язык: Английский

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The Implications of Telomere Length: Advanced Aging, Cell Senescence, MRI Phenotypes, Stem Cells and Alzheimer’s Disease

Current Neurovascular Research, Год журнала: 2023, Номер 20(2), С. 171 - 174

Опубликована: Май 1, 2023

Язык: Английский

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Why an Antioxidant Complex Twendee X® Prevent Dementia?

Опубликована: Авг. 1, 2023

Alzheimer's disease (AD) is a complex involving multiple factors such as amyloid plaque formation, mitochondrial dysfunction, telomere length, and oxidative stress. As the began 20 years before onset of clinical symptoms, treatment AD after its likely to be too late have significant effect. Therefore, prevention from an early stage important. Twendee X®︎ (TwX, Oxicut®︎) antioxidant supplement consisting eight ingredients. TwX has been proven prevent dementia in patients with mild cognitive impairment (MCI) multicenter, randomized, double-blind, placebo-controlled, prospective intervention trial. To elucidate mechanisms on brain cellular function, was administered vitro experiments C57BL/6 old wild-type, spontaneous hyperglycemia model accelerated decline, effects diabetes, autophagy, neurogenesis, length were evaluated comparison those non-treated groups. protected mitochondria stress higher capacity than single antioxidant. not only lowered blood glucose levels, but also suppressed reduction neurogenesis loss autophagy. Telomeres aged mice significantly longer non-TwX-treated mice. Development based many function. suggested by effects, deficiency, energy production.

Язык: Английский

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Molecular Determinants of Neurocognitive Deficits in Glioma: Based on 2021 WHO Classification

Journal of Molecular Neuroscience, Год журнала: 2024, Номер 74(1)

Опубликована: Фев. 5, 2024

Abstract Cognitive impairment is a common feature among patients with diffuse glioma. The objective of the study to investigate relationship between preoperative cognitive function and clinical as well molecular factors, firstly based on new 2021 World Health Organization’s updated classification central nervous system tumors. A total 110 glioma enrolled underwent assessments using Mini-Mental State Examination Montreal Assessment. Clinical information was collected from medical records, gene sequencing performed analyze 18 most influenced genes. differences in without glioblastoma were compared under both 2016 WHO tumors assess their effect differentiation cognition. found that age, tumor location, had significant function. Several genetic alterations significantly correlated Especially, IDH , CIC ATRX are positively several domains, while other genes negatively correlated. For focused genes, low number tended have better Our suggested that, addition characteristics such histological type, play crucial role Further research into mechanisms by which affect brain expected enhance quality life for patients. This highlights importance considering factors management improve outcomes.

Язык: Английский

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Associations between weight-adjusted-waist index and telomere length: Results from NHANES: An observational study

Medicine, Год журнала: 2024, Номер 103(17), С. e37905 - e37905

Опубликована: Апрель 26, 2024

Previous studies have demonstrated the connection between obesity and telomere length. A recently devised metric for determining obesity, weight-adjusted-waist index (WWI), offers a distinct advantage in predicting fat lean mass by depicting weight-independent abdominal adiposity. This article presents results of inaugural study on relationship WWI length adult populations. The cross-sectional investigation analyzed data from 3479 participants National Health Nutrition Examination Survey (NHANES) conducted 1999 to 2000. To inspect linear nonlinear correlations, we adopted weighted multiple logistic regression analysis smooth curve fit, respectively. In addition, threshold effects subgroup analyses were accomplished. fully adapted model, significant adverse association with was detected [β = -0.02, 95% CI: (-0.03, -0.00), P value 0.01]. correlation remained consistent across all subcategories. We also discovered an inverted U-shaped linking length, conspicuous inflection point 10.07 cm/√kg. For first time, our research strong links suggests that controlling within optimum range might be essential aging health.

Язык: Английский

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Efficacy, safety, and response predictors of Astragalus in patients with mild to moderate Alzheimer's disease: A study protocol of an assessor-blind, statistician-blind open-label randomized controlled trial

Contemporary Clinical Trials Communications, Год журнала: 2024, Номер 41, С. 101339 - 101339

Опубликована: Июль 28, 2024

This pragmatic clinical trial aims to determine the efficacy and safety of add-on Astragalus membranaceus (AM) for cognition non-cognition in patients with mild moderate Alzheimer's disease complicated orthostatic hypotension hypotension, elucidate underlying mechanisms, identify related response predictors, explore effective drug components. is an add-on, assessor-blinded, parallel, pragmatic, randomized controlled trial. At least 66 adults (AD) OH aged 50–85 years will be recruited. Participants a 1:1:1 ratio receive 24 weeks routine care or low dose AM high group. The primary outcome measured by Disease Assessment Scale-Cognitive Subscale, Chinese version. Secondary assessment include neuropsychological tests, blood pressure, plasma biomarkers, multimodal electroencephalograms, neuroimaging. Safety measures physical examinations, vital signs, electrocardiography, laboratory tests (such as hematologic chemical tests), adverse event records. was approved supervised Fujian Medical University Union Hospital (2021KJCX040). Independent results, findings published peer-reviewed journals presented at national international conferences. NCT05647473; ClinicalTrials.gov Identifier.

Язык: Английский

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Aging device: tau protein transposes the telomere fragment into promoter/enhancer to promote gene copy number decrement regulation

Опубликована: Авг. 2, 2024

The reasons for the significant impact of abnormal tau protein phosphorylation and aggregation on Alzheimer's disease are still unknown. This study used bioinformatics methods, including domain search tools, to investigate pathogenic mechanism in neurodegenerative diseases. reveals that possesses domains linked Aging Device. These include pyruvate kinase, phosphatase, telomere binding, transposition, HNH cas9, replicon helicase, DNA polymerase, nuclease, transcription factors-like, promoter binding (TATA-box), enhancer (Homeobox, MADS-box, HMG box), mitochondrial localization mtDNA polymerase. It implies protein's kinase supplies ATP energy its Device function. Cas9 , reverse transcriptase, transposase cut sequence between "TAA" from then transcript guide RNA sequence. factor slides specific region. excises intron region complementary RAN nuclease splice or add fragment We thought transposes fragments promoter/enhancer might mess up polymerase II, which would help Device's telomere-guided gene (DNA nucleus mitochondrial) copy number decrement regulation system work better. can us understand how stress injuries, like low blood sugar oxygen levels, cause clump together phosphorylate, turns off a way doesn't make sense. Thus, anomalous aging devices, such as protein, may be associated with diseases Alzheimer disease, amyotrophic lateral sclerosis.

Язык: Английский

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Aging device: tau protein transposes the telomerase fragment into promoter/enhancer to promote gene copy number decrement regulation

Опубликована: Авг. 2, 2024

The reasons for the significant impact of abnormal tau protein phosphorylation and aggregation on Alzheimer's disease are still unknown. This study used bioinformatics methods, including domain search tools, to investigate pathogenic mechanism in neurodegenerative diseases. reveals that possesses domains linked Aging Device. These include pyruvate kinase, phosphatase, telomere binding, transposition, HNH cas9, replicon helicase, DNA polymerase, nuclease, transcription factors-like, promoter binding (TATA-box), enhancer (Homeobox, MADS-box, HMG box), mitochondrial localization mtDNA polymerase. It implies protein's kinase supplies ATP energy its Device function. Cas9 , reverse transcriptase, transposase cut sequence between "TAA" from then transcript guide RNA sequence. factor slides specific region. excises intron region complementary RAN nuclease splice or add fragment We thought transposes fragments promoter/enhancer might mess up polymerase II, which would help Device's telomere-guided gene (DNA nucleus mitochondrial) copy number decrement regulation system work better. can us understand how stress injuries, like low blood sugar oxygen levels, cause clump together phosphorylate, turns off a way doesn't make sense. Thus, anomalous aging devices, such as protein, may be associated with diseases Alzheimer disease, amyotrophic lateral sclerosis.

Язык: Английский

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Telomere biology and its maintenance in schizophrenia spectrum disorders: Exploring links to cognition

Schizophrenia Research, Год журнала: 2024, Номер 272, С. 89 - 95

Опубликована: Авг. 28, 2024

Contemporary research suggests reduced telomere length in schizophrenia spectrum disorders (SZ) compared to age-adjusted non-affected individuals. However, the role of maintenance and repair SZ is poorly understood as well involvement biology cognitive abnormalities SZ.

Язык: Английский

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Migraine Disorders, Neurovascular Disease, and the Underlying Role of Oxidative Stress

Current Neurovascular Research, Год журнала: 2024, Номер 21(2), С. 111 - 115

Опубликована: Фев. 27, 2024

Язык: Английский

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