Developmental Dynamics,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 9, 2024
The
rising
incidence
of
Alzheimer's
disease
(AD)
and
the
associated
economic
impacts
has
prompted
a
global
focus
in
field.
In
recent
years,
there
been
growing
understanding
pathogenic
mechanisms
AD,
including
aggregation
β-amyloid,
hyperphosphorylated
tau,
neuroinflammation.
These
processes
collectively
lead
to
neurodegeneration
cognitive
decline,
which
ultimately
results
loss
autonomy
patients.
Currently,
are
three
main
types
AD
treatments:
clinical
tools,
pharmacological
treatment,
material
interventions.
This
review
provides
comprehensive
analysis
underlying
etiology
pathogenesis
as
well
an
overview
current
prevalence
treatments.
We
believe
this
article
can
help
deepen
our
mechanism,
facilitate
translation
scientific
research
or
therapies,
address
problem
AD.
Signal Transduction and Targeted Therapy,
Год журнала:
2023,
Номер
8(1)
Опубликована: Дек. 10, 2023
Abstract
Ferroptosis,
a
unique
modality
of
cell
death
with
mechanistic
and
morphological
differences
from
other
modes,
plays
pivotal
role
in
regulating
tumorigenesis
offers
new
opportunity
for
modulating
anticancer
drug
resistance.
Aberrant
epigenetic
modifications
posttranslational
(PTMs)
promote
resistance,
cancer
progression,
metastasis.
Accumulating
studies
indicate
that
can
transcriptionally
translationally
determine
vulnerability
to
ferroptosis
functions
as
driver
nervous
system
diseases
(NSDs),
cardiovascular
(CVDs),
liver
diseases,
lung
kidney
diseases.
In
this
review,
we
first
summarize
the
core
molecular
mechanisms
ferroptosis.
Then,
roles
processes,
including
histone
PTMs,
DNA
methylation,
noncoding
RNA
regulation
such
phosphorylation,
ubiquitination,
SUMOylation,
acetylation,
ADP-ribosylation,
are
concisely
discussed.
The
PTMs
genesis
cancers,
NSD,
CVDs,
well
application
PTM
modulators
therapy
these
then
discussed
detail.
Elucidating
mediated
by
will
facilitate
development
promising
combination
therapeutic
regimens
containing
or
PTM-targeting
agents
inducers
be
used
overcome
chemotherapeutic
resistance
could
prevent
addition,
highlight
potential
approaches
chemoresistance
halt
Molecular Neurobiology,
Год журнала:
2024,
Номер
unknown
Опубликована: Июнь 27, 2024
Alzheimer's
disease
(AD)
is
a
major
contributor
to
dementia
and
the
most
common
neurodegenerative
disorder.
In
AD
pathophysiology,
matrix
metalloproteinases
(MMPs)-proteolytic
enzymes,
best
known
be
responsible
for
remodeling
degradation
of
extracellular
matrix-were
suggested
play
an
important
role.
Due
diverse
nature
published
data
frequent
inconsistent
results
presented
in
available
papers,
it
was
considered
essential
analyze
all
aspects
MMP
literature
with
respect
pathophysiology
attempt
outline
unifying
concept
understanding
their
role
AD.
Thus,
main
contribution
this
review
article
summarize
recent
research
on
participation
obtained
using
cell
cultures
understand
molecular
principles
action.
Furthermore,
updated
comprehensive
view
regarding
topic
based
exclusively
papers
from
human
studies
provided
as
well.
It
can
concluded
that
determining
exact
any
particular
MMPs
holds
promise
establishing
potential
biomarkers
reflecting
severity
or
progression
developing
new
therapeutic
agents
targeting
processes
lead
Frontiers in Aging Neuroscience,
Год журнала:
2024,
Номер
16
Опубликована: Янв. 16, 2024
Background
Currently,
the
prevalence
of
Alzheimer’s
disease
(AD)
is
progressively
rising,
particularly
in
developed
nations.
There
an
escalating
focus
on
onset
and
progression
AD.
A
mounting
body
research
indicates
that
epigenetics
significantly
contributes
to
AD
holds
substantial
promise
as
a
novel
therapeutic
target
for
its
treatment.
Objective
The
objective
this
article
present
areas
interest,
comprehend
contextual
framework
subject
research,
investigate
prospective
direction
future
development.
Methods
ln
Web
Science
Core
Collection
(WOSCC),
we
searched
documents
by
specific
terms
their
corresponding
free
words.
VOSviewer,
CiteSpace
Scimago
Graphica
were
used
perform
statistical
analysis
measurement
metrics
such
number
published
papers,
national
cooperative
networks,
publishing
countries,
institutions,
authors,
co-cited
journals,
keywords,
visualize
networks
related
content
elements.
Results
We
selected
1,530
articles
from
WOSCC
January
2013
June
2023
about
Based
visual
analysis,
could
get
China
United
States
countries
with
most
field.
Bennett
DA
was
contributed
prestigious
scientist.
top
3
cited
journals
Journal
Disease,
Neurobiology
Aging
Molecular
Neurobiology.
According
keywords
frequency
citations,
ncRNAs,
transcription
factor,
genome,
histone
modification,
blood
DNA
methylation,
acetylation,
biomarkers
hot
directions
today.
Conclusion
bibliometric
epigenetic
promising
direction,
had
potential
be
targets.
Deleted Journal,
Год журнала:
2024,
Номер
1(2), С. 138 - 153
Опубликована: Июнь 1, 2024
Alzheimer's
Disease
(AD)
is
a
neurodegenerative
disorder
characterized
by
beta-amyloid
plaques
and
tau
tangles,
disrupting
brain
cell
communication,
causing
atrophy,
leading
to
cognitive
decline.
It
poses
substantial
global
health
challenge,
necessitating
urgent
research.
Molecular
biomarkers,
reflecting
AD
progression,
have
been
identified
in
diverse
bodily
tissues.
Notably,
emerging
epigenetic
biomarkers
introduce
novel
dimension
pathophysiology.
However,
their
precise
role
early
detection
prognosis
remains
unclear.
This
review
classifies
various
emphasizing
potential
prognosis.
Various
like
DNA
methylation,
non-coding
RNAs,
histone
modification,
OMICS,
many
more
get
significantly
altered
during
AD;
these
being
distinctly
expressed
normal
conditions
offer
huge
therapeutic
benefit
stop
the
progression
or
worsening
it.
We
explore
implications
propose
integration
with
existing
diagnostic
methods
intervene
mitigating
exacerbation.
Addressing
challenges,
we
envision
future
scope
of
synergy
computational
approaches
for
enhanced
detection.
contributes
field
proposing
multifaceted
approach
that
combines
markers
analysis
improve
facilitate
timely
interventions.
Furthermore,
discuss
economic
application
could
reduce
financial
burden
delaying
severity
disease.
Current Issues in Molecular Biology,
Год журнала:
2025,
Номер
47(3), С. 200 - 200
Опубликована: Март 18, 2025
The
rising
prevalence
of
Alzheimer’s
disease
(AD),
particularly
among
older
adults,
has
driven
increased
research
into
its
underlying
mechanisms
and
risk
factors.
Aging,
genetic
susceptibility,
cardiovascular
health
are
recognized
contributors
to
AD,
but
how
the
age
onset
affects
progression
remains
underexplored.
This
study
investigates
role
early-
versus
late-onset
(EOAD
LOAD,
respectively)
in
shaping
trajectory
cognitive
decline.
Leveraging
data
from
Religious
Orders
Study
Memory
Aging
Project
(ROSMAP),
two
cohorts
were
established:
individuals
with
early-onset
AD
those
AD.
Comprehensive
analyses,
including
differential
gene
expression
profiling,
pathway
enrichment,
co-expression
network
construction,
conducted
identify
distinct
molecular
signatures
associated
each
cohort.
Network
modularity
learning
algorithms
used
discern
inner
structure
networks
their
related
functional
features.
Computed
descriptors
provided
deeper
insights
influence
at
on
biological
PeerJ,
Год журнала:
2025,
Номер
13, С. e19100 - e19100
Опубликована: Апрель 7, 2025
Forty-eight
million
people
worldwide
suffer
from
dementia,
often
associated
with
the
growth
of
elderly
population.
There
are
also
concerns
about
younger
population,
where
increasing
acute
and
chronic
abuse
alcohol
neurotoxic
substances
may
contribute
to
brain
damage
early
onset
dementia.
Alzheimer’s
disease
(AD)
accounts
for
60%
dementia
cases
most
therapies
used
so
far
have
been
unsuccessful.
Genetic,
epigenetic
vascular
factors
pathogenesis
AD.
Among
mechanisms,
modulation
microRNA
(miRs)
plays
an
important
role.
To
detect
genes
pathways
involved
in
AD,
we
performed
original
bioinformatic
analysis
published
dysregulated
miRs
using
MIcroRNA
ENrichment
TURned
NETwork
(MIENTURNET)
followed
by
Reactome
tools.
The
interrogation
these
platforms
allowed
us
discover
common
putative
(by
MIENTURNET)
targeted
which
set
altered
tool).
Our
silico
showed
that
β-catenin
phosphorylation
cascade
Netrin-1
signalling,
resulted
as
significant.
Lastly,
based
on
assumption
food
bioactive
compounds
(BC)
modulate
miRs,
turn
a
literature
search
demonstrated
some
BC
indeed
able
genes.
Curcumin,
osthole,
puerarin,
xanthoceraside,
sulforaphane,
salvianolic
acid
A,
resveratrol
andrographolide
lead
upregulation
Wnt/β-catenin
pathway.
Choline,
methionine,
folate
vitamin
B6/B12
In
conclusion,
our
identified
their
pathways,
paving
interesting
new
insights
diagnosis
potential
therapeutic
interventions.
Environmental Toxicology,
Год журнала:
2023,
Номер
39(4), С. 2043 - 2051
Опубликована: Дек. 14, 2023
Abstract
Environmental
cadmium
exposure
during
pregnancy
or
adolescence
can
cause
neurodevelopmental
toxicity,
lead
to
neurological
impairment,
and
reduce
cognitive
abilities,
such
as
learning
memory.
However,
the
mechanisms
by
which
causes
toxicity
impairment
are
still
not
fully
elucidated.
This
study
used
hippocampal
neurons
cultured
in
vitro
observe
impact
of
on
mitochondrial
dynamics
apoptosis.
Exposure
5
μM
degradation
neuron
cell
bodies
axons,
morphological
destruction,
low
viability,
apoptosis
increase.
Cadmium
upregulates
expression
fission
proteins
Drp1
Fis1,
reduces
fusion‐related
MFN1,
MFN2,
OPA1,
well
PGC‐1a.
Mitochondrial
morphology
detection
demonstrated
that
changes
structure
mitochondria
neurons,
increasing
number
punctate
granular
mitochondria,
reducing
tubular
reticular
decreasing
mass,
dissipating
membrane
potential
(ΔΨm),
adenosine
triphosphate
(ATP)
production.
increases
global
methylation
level
genome
DNMT1
DNMT3α
neurons.
5‐Aza‐CdR
cadmium‐induced
levels
promotes
viability.
In
conclusion,
regulates
dynamics‐related
methylation,
changing
function,
exerting
neurotoxic
effects.
