Highlight:
Until
today,
Traumatic
Brain
Injury
is
still
a
major
cause
of
death,
disability,
and
serious
health
issue
patients
have
good
quality
life
if
they
get
adequate
therapy
on
time
interventions
ABSTRACT
Introduction:
Approximately
90
million
traumatic
brain
injury
(TBI)
cases
worldwide
exist
yearly.
TBI
pathophysiology
varies,
which
may
diverse
complications.
These
complications
decrease
the
patients’
life.
Objective:
Describing
brain-injured
after
being
treated
at
Dr.
Soetomo
General
Academic
Hospital
Period
2018-2020.
Methods:
This
research
descriptive
cross-sectional
study
using
SF-36
questionnaire
data
from
with
post-severe
in
Results:
The
value
physical
component
(59.9)
mental
(68.6)
severe
showed
life,
values
in
domains,
namely
function
(58.2),
limitations
(46.7),
body
pain
(73.6),
general
(61.3),
vitality
(65.3),
social
functioning
(72.5),
emotional
(60),
(76.5)
above
threshold
(50)
except
for
(46.7).Conclusion:
Patients
had
receiving
treatment
Hospital.
Cell Death Discovery,
Год журнала:
2023,
Номер
9(1)
Опубликована: Ноя. 24, 2023
Abstract
MicroRNAs
(miRNAs)
are
a
class
of
non-coding
RNAs
(ncRNAs)
with
short
length
19–22
nucleotides.
miRNAs
posttranscriptional
regulators
gene
expression
involved
in
various
biological
processes
like
cell
growth,
apoptosis,
and
angiogenesis.
miR-184
is
well-studied
miRNA,
for
which
most
studies
report
its
downregulation
cancer
cells
tissues
experiments
support
role
as
tumor
suppressor
inhibiting
malignant
behaviors
vitro
vivo.
To
exert
functions,
affects
some
signaling
pathways
tumorigenesis
Wnt
β-catenin,
AKT/mTORC1
pathway,
oncogenic
factors
(e.g.,
c-Myc)
or
apoptotic
proteins,
such
Bcl-2.
Interestingly,
clinical
investigations
have
shown
good
performance
prognostic/diagnostic
biomarker
cancers.
Additionally,
exogenous
xenograft
animal
suggest
it
therapeutic
anticancer
target.
In
this
review,
we
outline
the
that
evaluated
roles
well
significance.
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(12), С. 10299 - 10299
Опубликована: Июнь 18, 2023
This
review
paper
provides
an
extensive
analysis
of
the
rapidly
evolving
convergence
deep
learning
and
long
non-coding
RNAs
(lncRNAs).
Considering
recent
advancements
in
increasing
recognition
lncRNAs
as
crucial
components
various
biological
processes,
this
aims
to
offer
a
comprehensive
examination
these
intertwined
research
areas.
The
remarkable
progress
necessitates
thoroughly
exploring
its
latest
applications
study
lncRNAs.
Therefore,
insights
into
growing
significance
incorporating
methodologies
unravel
intricate
roles
By
scrutinizing
most
spanning
from
2021
2023,
understanding
how
techniques
are
employed
investigating
lncRNAs,
thereby
contributing
valuable
field.
is
aimed
at
researchers
practitioners
looking
integrate
their
lncRNA
studies.
Expert Review of Molecular Diagnostics,
Год журнала:
2023,
Номер
23(8), С. 665 - 678
Опубликована: Июль 5, 2023
Introduction
Breast
cancer
(BC)
is
a
major
public
health
concern,
and
identifying
new
biomarkers
therapeutic
targets
critical
to
improving
patient
outcomes.
MALAT1,
long
noncoding
RNA,
has
emerged
as
promising
candidate
due
its
overexpression
in
BC
the
associated
poor
prognosis.
Understanding
role
of
MALAT1
progression
paramount
for
development
effective
strategies.Covered
area
This
review
delves
into
structure
function
examines
expression
pattern
breast
association
with
different
subtypes.
focuses
on
interactions
between
microRNAs
(miRNAs)
various
signaling
pathways
involved
BC.
Furthermore,
this
study
investigates
influence
tumor
microenvironment
possible
immune
checkpoint
regulation.
also
sheds
light
resistance.Expert
opinion
been
shown
play
key
BC,
highlighting
importance
potential
target.
Further
studies
are
needed
elucidate
underlying
molecular
mechanisms
by
which
contributes
In
combination
standard
therapy,
there
need
evaluates
treatments
targeting
may
lead
improved
treatment
Moreover,
diagnostic
prognostic
marker
promises
management.
Continued
efforts
decipher
functional
explore
clinical
utility
advancing
research
field.
Frontiers in Endocrinology,
Год журнала:
2023,
Номер
14
Опубликована: Июнь 26, 2023
Endometriosis
is
a
gynecological
condition
that
significantly
impacting
women’s
daily
lives.
In
recent
years,
the
incidence
of
endometriosis
has
been
rising
yearly
and
now
an
essential
contributor
to
female
infertility.
Exosomes
are
extracellular
vesicles
(EVs)
carry
long
noncoding
RNA
(lncRNA)
shield
lncRNA
from
outside
environment
thanks
their
vesicle-like
structure.
The
role
exosome-derived
lncRNAs
in
also
receiving
more
study
as
high-throughput
sequencing
technology
develops.
Several
with
variable
expression
may
be
crucial
emergence
growth
endometriosis.
early
diagnosis
will
considerably
improved
by
further
high
specificity
sensitivity
Exosome
screening.
assist
carrying
out
roles,
offering
new
target
for
creating
endometriosis-specific
medications.
order
serve
reference
clinical
research
on
pathogenesis,
diagnosis,
treatment
options
endometriosis,
this
paper
covers
exosome
related
molecular
mechanisms.
Frontiers in Endocrinology,
Год журнала:
2023,
Номер
14
Опубликована: Сен. 7, 2023
Preeclampsia,
gestational
diabetes
mellitus,
and
recurrent
spontaneous
abortion
are
common
maternal
pregnancy
complications
that
seriously
endanger
women’s
lives
health,
their
occurrence
is
increasing
year
after
with
a
rejuvenation
trend.
In
contrast
to
biomarkers
found
freely
in
tissues
or
body
fluids,
exosomes
exist
relatively
independent
environment
provide
higher
level
of
stability.
As
backbone
molecules,
guidance
signaling
molecules
the
nucleus,
lncRNAs
can
regulate
gene
expression.
cytoplasm,
influence
expression
levels
by
modifying
mRNA
stability,
acting
as
competitive
endogenous
RNAs
bind
miRNAs,
so
on.
Exosomal
indefinitely
important
intercellular
communication
signal
transduction.
Changes
serum
exosome
lncRNA
accurately
timely
reflect
progression
regression
pregnancy-related
diseases.
The
purpose
this
paper
reference
for
clinical
research
on
pathogenesis,
diagnosis,
treatment
methods
diseases
reviewing
role
female
pathological
related
molecular
mechanisms.
