An Overview of the Quality of Life of Post Severe Brain Injury Patients within 2018-2020 Period of Time in Dr. Soetomo General Academic Hospital based on Short Form-36 DOI Creative Commons
Agus Turchan, Alivery Raihanada Armando, Meisy Andriana

и другие.

AKSONA, Год журнала: 2022, Номер 2(2), С. 62 - 71

Опубликована: Июль 31, 2022

Highlight: Until today, Traumatic Brain Injury is still a major cause of death, disability, and serious health issue patients have good quality life if they get adequate therapy on time interventions ABSTRACT Introduction: Approximately 90 million traumatic brain injury (TBI) cases worldwide exist yearly. TBI pathophysiology varies, which may diverse complications. These complications decrease the patients’ life. Objective: Describing brain-injured after being treated at Dr. Soetomo General Academic Hospital Period 2018-2020. Methods: This research descriptive cross-sectional study using SF-36 questionnaire data from with post-severe in Results: The value physical component (59.9) mental (68.6) severe showed life, values ​​in domains, namely function (58.2), limitations (46.7), body pain (73.6), general (61.3), vitality (65.3), social functioning (72.5), emotional (60), (76.5) above threshold (50) except for (46.7).Conclusion: Patients had receiving treatment Hospital.

Язык: Английский

Long non-coding RNAs (lncRNAs); roles in tumorigenesis and potentials as biomarkers in cancer diagnosis DOI
Sajad Najafi, Seyyed Hossein Khatami, Marjan Khorsand

и другие.

Experimental Cell Research, Год журнала: 2022, Номер 418(2), С. 113294 - 113294

Опубликована: Июль 20, 2022

Язык: Английский

Процитировано

62

Recent insights into the roles of circular RNAs in human brain development and neurologic diseases DOI
Sajad Najafi, Seyed Mohsen Aghaei Zarch, Jamal Majidpoor

и другие.

International Journal of Biological Macromolecules, Год журнала: 2022, Номер 225, С. 1038 - 1048

Опубликована: Ноя. 18, 2022

Язык: Английский

Процитировано

44

Functional roles of lncRNA-TUG1 in hepatocellular carcinoma DOI

Maryam Farzaneh,

Majid Ghasemian, Farhoodeh Ghaedrahmati

и другие.

Life Sciences, Год журнала: 2022, Номер 308, С. 120974 - 120974

Опубликована: Сен. 17, 2022

Язык: Английский

Процитировано

29

microRNA-184 in the landscape of human malignancies: a review to roles and clinical significance DOI Creative Commons
Mehdi Fattahi, Delsuz Rezaee,

Fatemeh Fakhari

и другие.

Cell Death Discovery, Год журнала: 2023, Номер 9(1)

Опубликована: Ноя. 24, 2023

Abstract MicroRNAs (miRNAs) are a class of non-coding RNAs (ncRNAs) with short length 19–22 nucleotides. miRNAs posttranscriptional regulators gene expression involved in various biological processes like cell growth, apoptosis, and angiogenesis. miR-184 is well-studied miRNA, for which most studies report its downregulation cancer cells tissues experiments support role as tumor suppressor inhibiting malignant behaviors vitro vivo. To exert functions, affects some signaling pathways tumorigenesis Wnt β-catenin, AKT/mTORC1 pathway, oncogenic factors (e.g., c-Myc) or apoptotic proteins, such Bcl-2. Interestingly, clinical investigations have shown good performance prognostic/diagnostic biomarker cancers. Additionally, exogenous xenograft animal suggest it therapeutic anticancer target. In this review, we outline the that evaluated roles well significance.

Язык: Английский

Процитировано

23

Tumor-educated platelets DOI
Sajad Najafi, Yahya Asemani, Jamal Majidpoor

и другие.

Clinica Chimica Acta, Год журнала: 2023, Номер 552, С. 117690 - 117690

Опубликована: Дек. 4, 2023

Язык: Английский

Процитировано

17

Deep Learning Approaches for lncRNA-Mediated Mechanisms: A Comprehensive Review of Recent Developments DOI Open Access
Yoojoong Kim, Minhyeok Lee

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(12), С. 10299 - 10299

Опубликована: Июнь 18, 2023

This review paper provides an extensive analysis of the rapidly evolving convergence deep learning and long non-coding RNAs (lncRNAs). Considering recent advancements in increasing recognition lncRNAs as crucial components various biological processes, this aims to offer a comprehensive examination these intertwined research areas. The remarkable progress necessitates thoroughly exploring its latest applications study lncRNAs. Therefore, insights into growing significance incorporating methodologies unravel intricate roles By scrutinizing most spanning from 2021 2023, understanding how techniques are employed investigating lncRNAs, thereby contributing valuable field. is aimed at researchers practitioners looking integrate their lncRNA studies.

Язык: Английский

Процитировано

12

The MALAT1-breast cancer interplay: insights and implications DOI
Muhammad Tufail

Expert Review of Molecular Diagnostics, Год журнала: 2023, Номер 23(8), С. 665 - 678

Опубликована: Июль 5, 2023

Introduction Breast cancer (BC) is a major public health concern, and identifying new biomarkers therapeutic targets critical to improving patient outcomes. MALAT1, long noncoding RNA, has emerged as promising candidate due its overexpression in BC the associated poor prognosis. Understanding role of MALAT1 progression paramount for development effective strategies.Covered area This review delves into structure function examines expression pattern breast association with different subtypes. focuses on interactions between microRNAs (miRNAs) various signaling pathways involved BC. Furthermore, this study investigates influence tumor microenvironment possible immune checkpoint regulation. also sheds light resistance.Expert opinion been shown play key BC, highlighting importance potential target. Further studies are needed elucidate underlying molecular mechanisms by which contributes In combination standard therapy, there need evaluates treatments targeting may lead improved treatment Moreover, diagnostic prognostic marker promises management. Continued efforts decipher functional explore clinical utility advancing research field.

Язык: Английский

Процитировано

11

A comprehensive overview of exosome lncRNAs: emerging biomarkers and potential therapeutics in endometriosis DOI Creative Commons
Min Wang,

Lianwen Zheng,

Ruixin Lin

и другие.

Frontiers in Endocrinology, Год журнала: 2023, Номер 14

Опубликована: Июнь 26, 2023

Endometriosis is a gynecological condition that significantly impacting women’s daily lives. In recent years, the incidence of endometriosis has been rising yearly and now an essential contributor to female infertility. Exosomes are extracellular vesicles (EVs) carry long noncoding RNA (lncRNA) shield lncRNA from outside environment thanks their vesicle-like structure. The role exosome-derived lncRNAs in also receiving more study as high-throughput sequencing technology develops. Several with variable expression may be crucial emergence growth endometriosis. early diagnosis will considerably improved by further high specificity sensitivity Exosome screening. assist carrying out roles, offering new target for creating endometriosis-specific medications. order serve reference clinical research on pathogenesis, diagnosis, treatment options endometriosis, this paper covers exosome related molecular mechanisms.

Язык: Английский

Процитировано

10

Biogenesis and function of exosome lncRNAs and their role in female pathological pregnancy DOI Creative Commons
Min Wang,

Lianwen Zheng,

Shuai Ma

и другие.

Frontiers in Endocrinology, Год журнала: 2023, Номер 14

Опубликована: Сен. 7, 2023

Preeclampsia, gestational diabetes mellitus, and recurrent spontaneous abortion are common maternal pregnancy complications that seriously endanger women’s lives health, their occurrence is increasing year after with a rejuvenation trend. In contrast to biomarkers found freely in tissues or body fluids, exosomes exist relatively independent environment provide higher level of stability. As backbone molecules, guidance signaling molecules the nucleus, lncRNAs can regulate gene expression. cytoplasm, influence expression levels by modifying mRNA stability, acting as competitive endogenous RNAs bind miRNAs, so on. Exosomal indefinitely important intercellular communication signal transduction. Changes serum exosome lncRNA accurately timely reflect progression regression pregnancy-related diseases. The purpose this paper reference for clinical research on pathogenesis, diagnosis, treatment methods diseases reviewing role female pathological related molecular mechanisms.

Язык: Английский

Процитировано

10

METTL3 Mediated MALAT1 m6A Modification Promotes Proliferation and Metastasis in Osteosarcoma Cells DOI

Yuanzhuang Zhang,

Yeqiu Xu,

Guanzhen Qiu

и другие.

Molecular Biotechnology, Год журнала: 2023, Номер 66(12), С. 3538 - 3548

Опубликована: Окт. 28, 2023

Язык: Английский

Процитировано

10