AKSONA,
Journal Year:
2022,
Volume and Issue:
2(2), P. 62 - 71
Published: July 31, 2022
Highlight:
Until
today,
Traumatic
Brain
Injury
is
still
a
major
cause
of
death,
disability,
and
serious
health
issue
patients
have
good
quality
life
if
they
get
adequate
therapy
on
time
interventions
ABSTRACT
Introduction:
Approximately
90
million
traumatic
brain
injury
(TBI)
cases
worldwide
exist
yearly.
TBI
pathophysiology
varies,
which
may
diverse
complications.
These
complications
decrease
the
patients’
life.
Objective:
Describing
brain-injured
after
being
treated
at
Dr.
Soetomo
General
Academic
Hospital
Period
2018-2020.
Methods:
This
research
descriptive
cross-sectional
study
using
SF-36
questionnaire
data
from
with
post-severe
in
Results:
The
value
physical
component
(59.9)
mental
(68.6)
severe
showed
life,
values
in
domains,
namely
function
(58.2),
limitations
(46.7),
body
pain
(73.6),
general
(61.3),
vitality
(65.3),
social
functioning
(72.5),
emotional
(60),
(76.5)
above
threshold
(50)
except
for
(46.7).Conclusion:
Patients
had
receiving
treatment
Hospital.
Cell Death Discovery,
Journal Year:
2023,
Volume and Issue:
9(1)
Published: Nov. 24, 2023
Abstract
MicroRNAs
(miRNAs)
are
a
class
of
non-coding
RNAs
(ncRNAs)
with
short
length
19–22
nucleotides.
miRNAs
posttranscriptional
regulators
gene
expression
involved
in
various
biological
processes
like
cell
growth,
apoptosis,
and
angiogenesis.
miR-184
is
well-studied
miRNA,
for
which
most
studies
report
its
downregulation
cancer
cells
tissues
experiments
support
role
as
tumor
suppressor
inhibiting
malignant
behaviors
vitro
vivo.
To
exert
functions,
affects
some
signaling
pathways
tumorigenesis
Wnt
β-catenin,
AKT/mTORC1
pathway,
oncogenic
factors
(e.g.,
c-Myc)
or
apoptotic
proteins,
such
Bcl-2.
Interestingly,
clinical
investigations
have
shown
good
performance
prognostic/diagnostic
biomarker
cancers.
Additionally,
exogenous
xenograft
animal
suggest
it
therapeutic
anticancer
target.
In
this
review,
we
outline
the
that
evaluated
roles
well
significance.
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(12), P. 10299 - 10299
Published: June 18, 2023
This
review
paper
provides
an
extensive
analysis
of
the
rapidly
evolving
convergence
deep
learning
and
long
non-coding
RNAs
(lncRNAs).
Considering
recent
advancements
in
increasing
recognition
lncRNAs
as
crucial
components
various
biological
processes,
this
aims
to
offer
a
comprehensive
examination
these
intertwined
research
areas.
The
remarkable
progress
necessitates
thoroughly
exploring
its
latest
applications
study
lncRNAs.
Therefore,
insights
into
growing
significance
incorporating
methodologies
unravel
intricate
roles
By
scrutinizing
most
spanning
from
2021
2023,
understanding
how
techniques
are
employed
investigating
lncRNAs,
thereby
contributing
valuable
field.
is
aimed
at
researchers
practitioners
looking
integrate
their
lncRNA
studies.
Expert Review of Molecular Diagnostics,
Journal Year:
2023,
Volume and Issue:
23(8), P. 665 - 678
Published: July 5, 2023
Introduction
Breast
cancer
(BC)
is
a
major
public
health
concern,
and
identifying
new
biomarkers
therapeutic
targets
critical
to
improving
patient
outcomes.
MALAT1,
long
noncoding
RNA,
has
emerged
as
promising
candidate
due
its
overexpression
in
BC
the
associated
poor
prognosis.
Understanding
role
of
MALAT1
progression
paramount
for
development
effective
strategies.Covered
area
This
review
delves
into
structure
function
examines
expression
pattern
breast
association
with
different
subtypes.
focuses
on
interactions
between
microRNAs
(miRNAs)
various
signaling
pathways
involved
BC.
Furthermore,
this
study
investigates
influence
tumor
microenvironment
possible
immune
checkpoint
regulation.
also
sheds
light
resistance.Expert
opinion
been
shown
play
key
BC,
highlighting
importance
potential
target.
Further
studies
are
needed
elucidate
underlying
molecular
mechanisms
by
which
contributes
In
combination
standard
therapy,
there
need
evaluates
treatments
targeting
may
lead
improved
treatment
Moreover,
diagnostic
prognostic
marker
promises
management.
Continued
efforts
decipher
functional
explore
clinical
utility
advancing
research
field.
Bulletin du Cancer,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 1, 2025
Long
noncoding
RNAs
(lncRNAs)
play
a
crucial
role
in
modulating
cancer
progression
and
metastasis.
This
study
investigates
the
tumor-promoting
function
of
long
RNA
BCAR4
osteosarcoma
elucidates
its
regulatory
mechanism.
Although
acts
as
tumor
promoter
osteosarcoma,
mechanism
remains
unclear.
Bioinformatic
analysis
revealed
specific
interaction
between
miR-1260a,
with
exhibiting
elevated
miR-1260a
expression
inversely
correlated
expression.
Overexpression
significantly
suppressed
expression,
indicating
regulation
miR-1260a.
Luciferase
reporter
assays
confirmed
direct
association
at
sequence
level.
Silencing
inhibited
cell
proliferation
migration
while
promoting
cellular
apoptosis,
primarily
mediated
by
Our
findings
demonstrate
that
functions
promotor
activity
regulated
proposes
potential
therapeutic
approach
for
treating
targeting
BCAR4/miR-1260a
axis.
These
insights
shed
light
on
intricate
network
underlying
pathogenesis
offer
promising
avenues
developing
targeted
therapies
against
this
aggressive
cancer.
