At
present,
the
incidence
of
tumours
is
increasing
on
a
yearly
basis,
and
tumourigenesis
usually
associated
with
chromosomal
instability
cell
cycle
dysregulation.
Moreover,
abnormalities
in
structure
often
lead
to
DNA
damage,
further
exacerbating
gene
mutations
rearrangements.
However,
non‑SMC
condensin
I
complex
subunit
G
(NCAPG)
structural
maintenance
chromosomes
family
known
exert
key
role
tumour
development.
It
has
been
shown
that
high
expression
NCAPG
closely
development
progression.
Overexpression
variously
affects
chromosome
condensation
segregation
during
mitosis,
influences
regulation,
promotes
proliferation
invasion,
inhibits
apoptosis.
In
addition,
stemness,
resistance
recurrence.
The
aim
present
review
was
explore
underlying
mechanisms
development,
view
towards
providing
novel
targets
strategies
for
therapy,
through
elucidation
involved,
lay
foundation
future
developments
health.
Frontiers in Cell and Developmental Biology,
Год журнала:
2024,
Номер
12
Опубликована: Янв. 31, 2024
The
current
situation
of
hepatocellular
carcinoma
(HCC)
management
is
challenging
due
to
its
high
incidence,
mortality,
recurrence
and
metastasis.
Recent
advances
in
gene
genetic
expression
regulation
have
unveiled
the
significant
role
non-coding
RNA
(ncRNA)
various
cancers.
This
led
formulation
competing
endogenous
(ceRNA)
hypothesis,
which
posits
that
both
coding
ncRNA,
containing
miRNA
response
elements
(MRE),
can
share
same
sequence.
results
a
competitive
network
between
ncRNAs,
such
as
lncRNA
mRNA,
allowing
them
regulate
each
other.
Extensive
research
has
highlighted
crucial
ceRNA
HCC
development,
impacting
cellular
processes
including
proliferation,
metastasis,
cell
death,
angiogenesis,
tumor
microenvironment,
organismal
immunity,
chemotherapy
resistance.
Additionally,
network,
mediated
by
or
circRNA,
offers
potential
early
diagnosis
prevention
HCC.
Consequently,
ceRNAs
are
emerging
therapeutic
targets
for
complexity
these
networks
aligns
with
multi-target
approach
traditional
Chinese
medicine
(TCM),
presenting
novel
perspective
TCM
combating
Research
beginning
show
compounds
prescriptions
affect
progression
through
inhibiting
proliferation
inducing
apoptosis.
Currently,
lncRNAs
TUG1,
NEAT1,
CCAT1,
along
their
associated
networks,
among
most
promising
ncRNAs
research.
However,
this
field
still
infancy,
necessitating
advanced
technology
extensive
basic
fully
understand
mechanisms
treatment.
Cell Death Discovery,
Год журнала:
2023,
Номер
9(1)
Опубликована: Ноя. 24, 2023
Abstract
MicroRNAs
(miRNAs)
are
a
class
of
non-coding
RNAs
(ncRNAs)
with
short
length
19–22
nucleotides.
miRNAs
posttranscriptional
regulators
gene
expression
involved
in
various
biological
processes
like
cell
growth,
apoptosis,
and
angiogenesis.
miR-184
is
well-studied
miRNA,
for
which
most
studies
report
its
downregulation
cancer
cells
tissues
experiments
support
role
as
tumor
suppressor
inhibiting
malignant
behaviors
vitro
vivo.
To
exert
functions,
affects
some
signaling
pathways
tumorigenesis
Wnt
β-catenin,
AKT/mTORC1
pathway,
oncogenic
factors
(e.g.,
c-Myc)
or
apoptotic
proteins,
such
Bcl-2.
Interestingly,
clinical
investigations
have
shown
good
performance
prognostic/diagnostic
biomarker
cancers.
Additionally,
exogenous
xenograft
animal
suggest
it
therapeutic
anticancer
target.
In
this
review,
we
outline
the
that
evaluated
roles
well
significance.
Cancer Insight,
Год журнала:
2024,
Номер
3(2), С. 37 - 48
Опубликована: Янв. 9, 2024
<p
style="margin-top:
12.0pt;
text-align:
justify;
text-justify:
inter-ideograph;"><strong><span
lang="EN-US"
style="font-family:
Nunito;
mso-bidi-font-family:
'Times
New
Roman';
mso-bidi-theme-font:
minor-bidi;
color:
#212529;
background:
white;">Background: </span></strong><span
style="font-size:
10.5pt;
font-family:
white;">Hepatocellular
carcinoma
(HCC)
stands
out
as
one
of
the
most
lethal
cancers
globally,
given
its
complexity,
recurrence
following
surgical
resection,
metastatic
potential,
and
inherent
heterogeneity.</span><strong><span
white;"> </span></strong><span
white;">In<strong>
</strong></span><span
white;">recent
years,
researchers
have
systematically
elucidated
significance
long
non-coding
RNA
(lncRNA)
in
initiation
progression
HCC.
The
introduction
Cancer
Genome
Atlas
(TCGA)
Gene
Expression
Omnibus
(GEO)
databases
has
significantly
enhanced
prognostic
assessment
However,
association
between
HCC
cell
senescence
been
infrequently
explored
literature.
</span><strong><span
white;">Method:</span></strong><span
white;"> We
downloaded
liver
hepatocellular
(LIHC)-related
messenger
lncRNA
expression
levels
from
TCGA.
Correlation
analysis,
Cox
regression,
least
absolute
shrinkage
selection
operator
(LASSO)
regression
analysis
were
employed
to
validate
risk
model
associated
with
cellular
aging.
Comparing
infiltration
diverse
immune
cells
enabled
identification
distinct
differences
immunological
microenvironments
two
groups.
Subsequently,
we
conducted
a
real-time
polymerase
chain
reaction
(qPCR)
experiment
confirm
accuracy
selected
lncRNAs.
white;">Results:</span></strong><span
white;"> A
predictive
framework
for
was
constructed
based
on
five
Multivariate
univariate
analyses
revealed
that
signatures
independently
correlated
an
increased
Additionally,
nomogram
also
provides
more
refined
sensitive
model.
Further
investigation
into
variations
functions
high-risk
low-risk
groups
conducted.
qPCR
results
underexpression
AC068756.1,
AC090578.1,
AC145343.1,
LINC0022
Huh7
LM3
cells.
In
contrast,
AP003392.4
did
not
exhibit
significant
difference
control
white;">Conclusion:</span></strong><span
white;"> The
features
nomogram,
consisting
aging-related
lncRNAs
(AC068756.1,
AP003392.4,
LINC00221),
may
be
useful
predicting
overall
survival
HCC.</span></p>
Translational Cancer Research,
Год журнала:
2024,
Номер
13(1), С. 423 - 436
Опубликована: Янв. 1, 2024
Background:
Hepatocellular
carcinoma
(HCC),
a
malignant
tumor
with
high
mortality
rate,
is
serious
problem
worldwide.
This
research
sought
to
examine
how
long
non-coding
RNA
(lncRNA)
expression
in
hepatocellular
(HEIH)
affects
the
development
and
progression
of
HCC.
