Light-eye-body axis: exploring the network from retinal illumination to systemic regulation DOI Creative Commons
Yi Zeng, Rong Rong,

Mengling You

et al.

Theranostics, Journal Year: 2024, Volume and Issue: 15(4), P. 1496 - 1523

Published: Dec. 31, 2024

The human body is an intricate system, where diverse and complex signaling among different organs sustains physiological activities. eye, as a primary organ for information acquisition, not only plays crucial role in visual perception but also, increasing evidence suggests, exerts broad influence on the entire through circuits upon receiving light signals which called non-image-forming vision. However, extent mechanisms of light's impact eyes remain insufficiently explored. There also dearth comprehensive reviews elucidating interplay between light, systemic connections to body. Herein, we propose concept light-eye-body axis systematically encapsulate extensive effects received by retina We reviewed visual-neural structure basis axis, summarized mechanism regulate whole current research status challenges within pathological processes involved axis. Future should aim expand explore its deeper mechanisms. Understanding investigating will contribute improving lighting conditions optimize health guide establishment phototherapy standards clinical practice.

Language: Английский

Circadian-independent light regulation of mammalian metabolism DOI
Feng Rao, Tian Xue

Nature Metabolism, Journal Year: 2024, Volume and Issue: 6(6), P. 1000 - 1007

Published: June 3, 2024

Language: Английский

Citations

14
Chronotherapeutic Treatments for Psychiatric Disorders: A Narrative Review of Recent Literature DOI
Leslie M. Swanson, Jessica R. Schubert, Greta B. Raglan

et al.

Current Psychiatry Reports, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 6, 2025

Language: Английский

Citations

1
Bright light therapy has a positive effect on sleep quality in patients with cancer: A meta-analysis DOI
Fengxia Lai, Zhen Luo,

Jiyin Zhang

et al.

Sleep Medicine Reviews, Journal Year: 2024, Volume and Issue: 75, P. 101925 - 101925

Published: March 21, 2024

Language: Английский

Citations

7
Sleep–wake modulation and pathogenesis of Alzheimer disease: Suggestions for postponement and treatment DOI

Ya-Jing Liu,

Dick F. Swaab,

Jiang-Ning Zhou

et al.

Handbook of clinical neurology, Journal Year: 2025, Volume and Issue: unknown, P. 211 - 229

Published: Jan. 1, 2025

Language: Английский

Citations

0
Violet light photobiomodulation therapy for depression: A double-blind randomized crossover trial DOI
Yoshihiro Noda,

Keita Taniguchi,

Mayuko Takano

et al.

Journal of Affective Disorders, Journal Year: 2025, Volume and Issue: 376, P. 325 - 332

Published: Feb. 15, 2025

Language: Английский

Citations

0
Efficacy of bright light therapy for perinatal depression: A meta-analysis of a randomized controlled trial DOI
Xue Yang, Yuanyuan Gao,

Shuqi Xu

et al.

World Journal of Meta-Analysis, Journal Year: 2025, Volume and Issue: 13(1)

Published: March 14, 2025

BACKGROUND Pharmacological treatments are commonly used in individuals experiencing perinatal depression (PPD); however, a debate regarding the reproductive safety of antidepressants is ongoing. Many pregnant women opt to discontinue antidepressant out concern about potential negative effects on developing fetus, while slow and ineffective medications hinder improved outcomes with PPD. In recent years, bright light therapy (BLT) has gained traction as treatment option for PPD; clinical trials findings examining efficacy BLT this population have been inconclusive. AIM To validate feasibility METHODS We performed meta-analysis randomized controlled patients PPD treated vs placebo following Preferred Reporting Items Systematic Reviews Meta-Analysis. searched PubMed, Embase, Cochrane Library, Web Science studies published up December 2023. The results were evaluated using standardized mean difference improvement scores odds ratios (ORs) remission rate, response incidence adverse events, dropout rate. RESULTS group had higher rate [50.68% 33.08%; OR = 2.05; 95% confidence interval (CI): 1.25-3.35; P 0.004; I ² 35%] (54.10% 18.52%; 5.00; 95%CI: 2.09-11.99; 0.0003; 0%) than group. Improvements overall (standardized -0.47; -0.80 -0.13; 0.007). No significant differences between two groups drop-outs (21.84% 29.63%; 0.63; 0.31-1.29; 0.21; or events (17.89% 9.68%; 2.01; 0.95-4.25; 0.07; observed. CONCLUSION can potentially treat PPD, showing better control study. effective safe could increase available therapeutic options

Language: Английский

Citations

0
Efficiency evaluation and facial expressions biomarker of light therapy in youths with subthreshold depression: A randomized control trial study DOI
Xin Chen, Lin Liu, Huan Mei

et al.

Journal of Affective Disorders, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

0
Bright light therapy-induced improvements of mood, cognitive functions and cerebellar functional connectivity in subthreshold depression: A randomized controlled trial DOI Creative Commons
Guanmao Chen, Zixuan Guo, Pan Chen

et al.

International Journal of Clinical and Health Psychology, Journal Year: 2024, Volume and Issue: 24(3), P. 100483 - 100483

Published: July 1, 2024

The efficacy of bright light therapy (BLT) in ameliorating depression has been validated. present study is to investigate the changes depressive symptoms, cognitive function and cerebellar functional connectivity (FC) following BLT individuals with subthreshold (StD). Participants were randomly assigned group (N = 47) or placebo 41) this randomized controlled trial between March 2020 June 2022. Depression severity assessed, as well resting-state MRI scan was conducted before after 8-weeks treatment. Seed-based whole-brain static FC (sFC) dynamic (dFC) analyses bilateral subfields conducted. Besides, a multivariate regression model examined whether baseline brain associated during After 8-week treatment, StD showed improved symptoms attention/vigilance function. also increased sFC right lobule IX left temporal pole, decreased within cerebellum, dFC medial prefrontal cortex. Moreover, fusion at could predict improvement response BLT. current identified that attention/vigilance, changed cerebellum-DMN connectivity, especially cerebellar-frontotemporal internal FC. In addition, features pre-treatment serve an imaging biomarker for StD.

Language: Английский

Citations

2
Non-image-forming photoreceptors improve visual orientation selectivity and image perception DOI
Yiming Shi, Jiaming Zhang,

Xingyi Li

et al.

Neuron, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 1, 2024

Language: Английский

Citations

2
A visual circuit related to the parabrachial nucleus for the antipruritic effects of bright light treatment DOI Creative Commons

Zhengfang Hu,

Xiaodan Huang,

Jianyu Liu

et al.

Cell Reports, Journal Year: 2024, Volume and Issue: 43(6), P. 114356 - 114356

Published: June 1, 2024

In addition to its role in vision, light also serves non-image-forming visual functions. Despite clinical evidence suggesting the antipruritic effects of bright treatment, circuit mechanisms underlying on itch-related behaviors remain poorly understood. this study, we demonstrate that treatment reduces mice through a related lateral parabrachial nucleus (LPBN). Specifically, subset retinal ganglion cells (RGCs) innervates GABAergic neurons ventral geniculate and intergeniculate leaflet (vLGN/IGL), which subsequently inhibit CaMKIIα+ LPBN. Activation both vLGN/IGL-projecting RGCs vLGN/IGL-to-LPBN projections is sufficient reduce induced by various pruritogens. Importantly, rely activation retina-vLGN/IGL-LPBN pathway. Collectively, our findings elucidate LPBN underlies treatment.

Language: Английский

Citations

1