Molecules,
Год журнала:
2023,
Номер
28(1), С. 376 - 376
Опубликована: Янв. 2, 2023
In
response
to
stress
factors,
plants
produce
a
wide
range
of
biologically
active
substances,
from
group
secondary
metabolites,
which
are
applied
in
medicine
and
health
prophylaxis.
Chitosan
is
well-known
elicitor
affecting
metabolism
plants,
but
its
effect
on
the
phytochemical
profile
Plectranthus
amboinicus
has
not
been
assessed
yet.
present
experiment,
effectiveness
foliar
application
two
forms
chitosan
(chitosan
suspension
or
lactate)
was
compared
order
evaluate
their
potential
induce
accumulation
selected
polyphenolic
compounds
aboveground
parts
P.
amboinicus.
It
shown
that
lactate
had
substantially
higher
elicitation
efficiency,
as
use
this
form
exerted
beneficial
analysed
quality
parameters
raw
material,
especially
content
(total
polyphenols,
flavonols,
anthocyanins,
caffeic
acid
derivatives)
free
radical-scavenging
activity
extracts
elicited
plants.
Concurrently,
it
no
phytotoxic
effects.
Hence,
lactate-based
can
be
an
effective
method
for
optimisation
production
high-quality
material
characterised
by
increased
concentration
health-promoting
antioxidant
compounds.
Molecules,
Год журнала:
2022,
Номер
27(19), С. 6225 - 6225
Опубликована: Сен. 22, 2022
The
prevalence
of
cardiovascular
disease,
oxidative
stress-related
complications,
and
chronic
age-related
illnesses
is
gradually
increasing
worldwide.
Several
causes
include
the
ineffectiveness
medicinal
treatment
therapies,
their
toxicity,
inability
to
provide
radical
solutions
in
some
diseases,
necessity
multiple
drug
therapy
certain
diseases.
It
therefore
necessary
for
alternative
methods
be
sought.
In
this
review,
polyphenols
were
identified
classified
according
chemical
structure,
sources
these
polyphenol
molecules
are
indicated.
cardioprotective,
ROS
scavenging,
anti-aging,
anticancer
properties
polyphenolic
compounds
have
been
demonstrated
by
results
many
studies,
natural
antioxidant
potential
therapeutic
agents.
Nutrients,
Год журнала:
2023,
Номер
15(19), С. 4297 - 4297
Опубликована: Окт. 9, 2023
Phytochemicals
are
abundantly
occurring
natural
compounds
extracted
from
plant
sources.
Rosmarinic
acid
(RA)
is
an
abundant
phytochemical
of
Lamiaceae
species
with
various
therapeutic
implications
for
human
health.
In
recent
years,
have
gained
significant
attention
as
adjuvant
and
complementary
therapies
to
existing
medications
diseases.
RA
has
popularity
due
its
anti-inflammatory
antioxidant
properties
roles
in
life-threatening
conditions,
such
cancer,
neurodegeneration,
diabetes,
etc.
The
present
review
aims
offer
a
comprehensive
insight
into
the
multifaceted
RA,
including
potential
anticancer
agent,
neuroprotective
effects,
antidiabetic
potential.
Based
on
available
evidences,
could
be
considered
dietary
component
treating
diseases,
diabetes
neurodegenerative
disorders.
Antioxidants and Redox Signaling,
Год журнала:
2024,
Номер
40(7-9), С. 564 - 593
Опубликована: Янв. 22, 2024
Significance:
Currently,
a
large
amount
of
evidence
beneficial
effects
diets
enriched
with
polyphenols
on
various
aspects
health
has
been
accumulated.
These
phytochemicals
have
geroprotective
potential
slowing
down
the
pathological
processes
associated
aging
and
ensuring
longevity.
In
this
study,
comprehensive
analysis
was
conducted
to
determine
adherence
individual
geroprotector
criteria.
Data
from
experimental
models,
clinical
trials,
epidemiological
studies
were
analyzed.
Recent
Advances:
Sixty-two
described
increase
life
span
improve
biomarkers
in
animal
models.
They
act
via
evolutionarily
conserved
molecular
mechanisms,
including
hormesis
maintenance
redox
homeostasis,
epigenetic
regulation,
response
cellular
damage,
metabolic
control,
anti-inflammatory
senolytic
activity.
Epidemiological
suggest
that
certain
for
prevention
treatment
diseases,
cancer,
disorders,
cardiovascular
conditions
humans.
Critical
Issues:
Among
reviewed
phytochemicals,
chlorogenic
acid,
quercetin,
epicatechin,
genistein,
resveratrol,
curcumin
identified
as
compounds
highest
potential.
However,
there
is
lack
unambiguous
information
effectiveness
safety
increasing
span,
preventing
treating
aging-associated
diseases
Future
Directions:
Further
research
needed
fully
understand
considering
their
long-term
consumption,
modification
bioavailability,
complex
interactions
between
different
groups
other
well
individuals
status.
Antioxid.
Redox
Signal.
40,
564–593.
Color
images
are
available
online.
Intelligent Pharmacy,
Год журнала:
2024,
Номер
2(4), С. 528 - 539
Опубликована: Авг. 1, 2024
A
number
of
dengue
viruses
can
seriously
impact
public
health,
and
their
spread
has
long
been
a
concern.
The
development
administration
antiviral
drugs
have
played
crucial
role
in
combating
viral
infections
recent
years.
These
shown
that
they
effectively
inhibit
replication
alleviate
associated
complications.
aim
this
article
is
to
provide
an
overview
current
evidence
on
the
effectiveness
administered
controlling
treating
problems.
In
present
study,
PyRx
tool
was
used
produce
proteins
ligands.
summary,
study
shows
rosmarinic
acid
remarkable
docking
values
against
various
targets.
Specifically,
it
value
−8.0
for
DENV1-E111,
-8.1
RNA-dependent
RNA
polymerase
(NS5),
−8.2
non-structural
chain
protein
1
(NS1),
−8.6
helicase.
results
suggest
may
effect
virus's
target
proteins.
Further
research
needed
investigate
therapeutic
effects
fighting
infections.
addition,
many
enzymatic
activities
reported
by
PASS
(Prediction
Activity
Spectra
Substances)
tool.
investigation
led
definitive
conclusion
possesses
properties.
promising
future
applications,
particularly
search
drug
molecule
combat
variety
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
13(15)
Опубликована: Март 4, 2024
Abstract
Abdominal
wall
defects
are
common
clinical
diseases,
and
mesh
repair
is
the
standard
treatment
method.
The
most
commonly
used
polypropylene
(PP)
in
practice
has
advantages
of
good
mechanical
properties,
stable
performance,
effective
tissue
integration
effect.
However,
direct
contact
between
abdominal
viscera
PP
can
lead
to
severe
adhesions.
To
prevent
this,
development
a
hydrogel‐PP
composite
with
anti‐adhesive
properties
may
be
an
measure.
Herein,
biofunctional
hydrogel
loaded
rosmarinic
acid
developed
by
modifying
chitosan
Pluronic
F127,
which
possesses
suitable
physical
chemical
commendable
vitro
biocompatibility.
In
full‐thickness
rats,
hydrogels
injected
onto
surface
applied
intraperitoneal
repair.
results
indicate
that
use
alleviate
adhesions
resulting
from
traditional
implantation
decreasing
local
inflammatory
response,
reducing
oxidative
stress,
regulating
fibrinolytic
system.
Combined
ability
mesh,
great
potential
for
repairing
defects.
Antioxidants,
Год журнала:
2024,
Номер
13(11), С. 1313 - 1313
Опубликована: Окт. 28, 2024
Rosmarinic
acid
(RA),
a
polyphenolic
compound
found
in
herbs,
such
as
rosemary,
basil,
and
mint,
has
garnered
significant
attention
due
to
its
potent
antioxidant
anticancer
properties.
This
review
examined
the
molecular
mechanisms
underlying
these
properties
their
potential
application
cancer
prevention
therapy.
It
focuses
specifically
on
RA's
role
modulating
cancer-related
pathways
presents
detailed
analysis
of
recent
advancements
this
area.
A
systematic
PubMed,
Scopus,
Web
Science
databases
was
conducted
accordance
with
PRISMA
(Reporting
Items
for
Systematic
Reviews
Meta-Analysis)
guidelines,
focusing
studies
published
between
2019
2024.
total
25
articles
providing
evidence
from
vitro,
vivo,
silico
were
selected.
These
findings
elucidate
RA
inhibiting
tumor
cell
proliferation,
inducing
apoptosis,
preventing
metastasis
various
types
through
diverse
mechanisms,
including
Despite
promising
results,
bioavailability
challenges
limit
therapeutic
efficacy,
underscoring
necessity
improved
delivery
methods.
concludes
that
exhibits
natural
agent
treatment,
although
further
clinical
trials
are
warranted.
