Carbon Dots: Synthesis, Characterizations, and Recent Advancements in Biomedical, Optoelectronics, Sensing, and Catalysis Applications

ACS Applied Bio Materials, Год журнала: 2024, Номер 7(4), С. 2086 - 2127

Опубликована: Март 21, 2024

Carbon nanodots (CNDs), a fascinating carbon-based nanomaterial (typical size 2–10 nm) owing to their superior optical properties, high biocompatibility, and cell penetrability, have tremendous applications in different interdisciplinary fields. Here, this Review, we first explore the superiority of CNDs over other nanomaterials biomedical, optoelectronics, analytical sensing, photocatalysis domains. Beginning with synthesis, characterization, purification techniques, even address fundamental questions surrounding such as emission origin excitation-dependent behavior. Then recent advancements applications, focusing on biological/biomedical uses like specific organelle bioimaging, drug/gene delivery, biosensing, photothermal therapy. In cover CND-based solar cells, perovskite role LEDs WLEDs. Analytical sensing include detection metals, hazardous chemicals, proteins. catalysis, examine roles photocatalysis, CO2 reduction, water splitting, stereospecific pollutant degradation. With intend further spark interest composites by highlighting many benefits across wide range applications.

Язык: Английский

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Biomass-derived carbon dots with pharmacological activity for biomedicine: Recent advances and future perspectives

Science Bulletin, Год журнала: 2024, Номер 69(19), С. 3127 - 3149

Опубликована: Авг. 16, 2024

Язык: Английский

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Progress in the Treatment of Central Nervous System Diseases Based on Nanosized Traditional Chinese Medicine

Advanced Science, Год журнала: 2024, Номер 11(16)

Опубликована: Фев. 28, 2024

Abstract Traditional Chinese Medicine (TCM) is widely used in clinical practice to treat diseases related central nervous system (CNS) damage. However, the blood‐brain barrier (BBB) constitutes a significant impediment effective delivery of TCM, thus substantially diminishing its efficacy. Advances nanotechnology and applications TCM (also known as nano‐TCM) can deliver active ingredients or components across BBB targeted brain region. This review provides an overview physiological pathological mechanisms systematically classifies common CNS types nanocarriers that effectively brain. Additionally, drug strategies for nano‐TCMs utilize vivo properties vitro devices bypass cross are discussed. further focuses on application treatment various diseases. Finally, this article anticipates design strategy with higher efficiency probes their potential treating wider range

Язык: Английский

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Collision of herbal medicine and nanotechnology: a bibliometric analysis of herbal nanoparticles from 2004 to 2023

Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)

Опубликована: Апрель 1, 2024

Abstract Background Herbal nanoparticles are made from natural herbs/medicinal plants, their extracts, or a combination with other nanoparticle carriers. Compared to traditional herbs, herbal lead improved bioavailability, enhanced stability, and reduced toxicity. Previous research indicates that medicine nanomaterials rapidly advancing making significant progress; however, bibliometric analysis knowledge mapping for currently lacking. We performed by retrieving publications related the Web of Science Core Collection (WoSCC) database spanning 2004 2023. Data processing was using R package Bibliometrix, VOSviewers, CiteSpace. Results In total, 1876 articles were identified, originating various countries, China being primary contributing country. The number in this field increases annually. Beijing University Chinese Medicine, Shanghai Traditional Saveetha India prominent institutions domain. Journal “International Nanomedicine” has highest publications. authors these reached 8234, Yan Zhao, Yue Zhang, Huihua Qu most prolific Zhao frequently cited author. “Traditional medicine,” “drug delivery,” “green synthesis” main focal points. Themes such as synthesis,” “curcumin,” “wound healing,” “carbon dots” may represent emerging areas. Conclusions Our study findings assist identifying latest frontiers hot topics, providing valuable references scholars investigating role nanotechnology medicine. Graphical

Язык: Английский

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Small Molecule Hydrogels Loading Small Molecule Drugs from Chinese Medicine for the Enhanced Treatment of Traumatic Brain Injury

ACS Nano, Год журнала: 2024, Номер 18(42), С. 28894 - 28909

Опубликована: Окт. 9, 2024

Self-assembly of hydrogels for mechanical support and drug delivery has been extensively researched in traumatic brain injury (TBI), where treatment options are limited. The chief challenge is that most self-assembled rely on high molecular carriers or the incorporation exogenous inactive substances as mediators. It difficult these systems to achieve clinical translation due concerns regarding biological safety. Here we report a small molecule hydrogel (GBR-gel) loading drugs (glycyrrhizic acid, berberine, rhein) originated from popular Chinese medicines without additional components under physiological conditions. In long run, GBR-gel possesses several advantages, including ease preparation, cost-effectiveness, biocompatibility. As proof-of-concept, allows prompt administration at site exert potent pharmacodynamic effects. Further single-cell RNA sequencing experimental validation indicated can effectively rescue suppressed glutamatergic synapse pathway after TBI, thereby attenuating inflammatory responses neural impairments. Our work provides an alternative strategy timely intervention TBI.

Язык: Английский

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Ultrasmall and highly biocompatible carbon dots derived from natural plant with amelioration against acute kidney injury

Journal of Nanobiotechnology, Год журнала: 2023, Номер 21(1)

Опубликована: Фев. 23, 2023

Acute kidney injury (AKI) refers to a tricky clinical disease, known by its high morbidity and mortality, with no real specific medicine for AKI. The carbonization product from Pollen Typhae (i.e., Pu-huang in China) has been extensively employed clinic, it is capable of relieving the renal damage other diseases China since acient times.Inspired process Traditional Chinese Medicine (TCM), novel species carbon dots derived (PT-CDs) was separated then collected using one-pot pyrolysis method. as-prepared PT-CDs (4.85 ± 2.06 nm) negative charge abundant oxygenated groups exhibited solubility, they were stable water. Moreover, rhabdomyolysis (RM)-induced AKI rat model used, first demonstrated that had significant activity improving level BUN CRE, urine volume index, histopathological morphology RM-induced rats. It noteworthy interventions significantly reduced degree inflammatory reaction oxidative stress, which may be correlated basial potential mechanism anti-AKI activities. Furthermore, cytotoxicity assay biosafety evaluation biocompatibility PT-CDs.This study offers strategy based on suggests related candidate applications.

Язык: Английский

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Carbonized Platycladus orientalis Derived Carbon Dots Accelerate Hemostasis through Activation of Platelets and Coagulation Pathways

Small, Год журнала: 2023, Номер 19(49)

Опубликована: Авг. 22, 2023

Achieving rapid and effective hemostasis remains a multidisciplinary challenge. Here, distinctive functional carbon dots derived from carbonized Platycladus orientalis (CPO-CDs) are developed using one-step hydrothermal method. The negatively charged surface of CPO-CDs retains partial groups CPO precursor, exhibiting excellent water solubility high biocompatibility. Both rat liver injury model tail amputation have confirmed the hemostatic performance on exogenous hemorrhage. Further, endogenous blood-heat hemorrhage syndrome model, could inhibit alleviate inflammation response. Interestingly, is ascribed to activate coagulation pathway common pathway. More importantly, metabolomics plasma suggests that effect closely related platelet functions. Therefore, designed in vitro experiments performed it discovered significantly promote platelets adhesion, activation, aggregation. underlying mechanism investigation Src/Syk signal plays key role activation triggered by CPO-CDs. Overall, with for first time, which be an candidate treatment hemorrhagic diseases.

Язык: Английский

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Multifunctional carbon quantum dots decorated self-healing hydrogel for highly effective treatment of superbug infected wounds

Chemical Engineering Journal, Год журнала: 2023, Номер 480, С. 148218 - 148218

Опубликована: Дек. 21, 2023

Язык: Английский

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Review on carbon dots: Synthesis and application in biology field

BMEMat, Год журнала: 2023, Номер 1(4)

Опубликована: Сен. 8, 2023

Abstract As a multifunctional fluorescent nanomaterial, carbon dots (CDs) not only have small size, stable chemical properties, excellent photoluminescence characteristics, but also exhibit good biocompatibility and low toxicity. It has attracted considerable attention in the field of nanotechnology biological science. CDs contain abundant functional groups on surface, which retain part properties raw materials, may new photoelectric, catalytic, biomedical, other functions. In this review, we systematically summarize synthesis methods, modifications, optical main functions recent years. The application functionalized modified detection, imaging, photodynamic therapy, photothermal targeted drug delivery, gene protein biomedical fields is introduced. latest progress with its own function antioxidant, anti‐pathogen, disease treatment summarized. Finally, discuss some problems practical look forward to future development trend self‐functional combined surface modification achieve multimodal diseases.

Язык: Английский

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A Self‐Gelling Powder Directly Co‐Assembled by Natural Small Molecules for Traumatic Brain Injury

Advanced Functional Materials, Год журнала: 2024, Номер 34(29)

Опубликована: Март 14, 2024

Abstract The prognosis for traumatic brain injury (TBI) depends largely on prompt hemostasis and effective pharmacologic interventions. Natural all‐small‐molecule self‐gelling powder, integrating the advantages of self‐assembled small‐molecule hydrogels powders, is expected to provide timely prehospital management TBI. However, synthesis application natural powder still uncharted territory. In this study, an co‐assembled MGF‐H 3 BO ‐RUT (MBR) fabricated through co‐assembly mangiferin (MGF) rutin (RUT) in H /NaOH aqueous solution. Both compounds can bind with boric acid, leading co‐assembling into hydrogen‐bonding interactions π – stacking. MBR then obtained by drying as‐prepared hydrogels, thus pharmacodynamics one. Remarkably, it displays robust regeneration capabilities, while retaining excellent self‐healing properties injectability after drying‐hydration cycles. Moreover, not only achieves rapid but also attenuates conspicuously cerebral edema inflammatory response TBI situ spraying, exhibiting notable neuroprotective effects without discernible toxic side effects. This study provides a novel assembly strategy form gel materials originating from small molecules, offering promising avenues treatment acute phase.

Язык: Английский

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