Current research trends of nanomedicines

Acta Pharmaceutica Sinica B, Год журнала: 2023, Номер 13(11), С. 4391 - 4416

Опубликована: Май 20, 2023

Owing to the inherent shortcomings of traditional therapeutic drugs in terms inadequate efficacy and toxicity clinical treatment, nanomedicine designs have received widespread attention with significantly improved reduced non-target side effects. Nanomedicines hold tremendous theranostic potential for treating, monitoring, diagnosing, controlling various diseases are attracting an unfathomable amount input research resources. Against backdrop exponentially growing number publications, it is imperative help audience get a panorama image activities field nanomedicines. Herein, this review elaborates on development trends nanomedicines, emerging nanocarriers, vivo fate safety their extensive applications. Moreover, challenges obstacles hindering translation nanomedicines also discussed. The elaboration aspects may enlighten readers set route future endeavors.

Язык: Английский

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Regulatory insights into nanomedicine and gene vaccine innovation: Safety assessment, challenges, and regulatory perspectives

Acta Biomaterialia, Год журнала: 2024, Номер 180, С. 1 - 17

Опубликована: Апрель 10, 2024

This analysis explores the principal regulatory concerns linked to nanomedicines and gene vaccines, including complexities involved perspectives on how navigate them. In realm of nanomedicines, ensuring safety nanomaterials is paramount due their unique characteristics potential interactions with biological systems. Regulatory bodies are actively formulating guidelines standards assess risks associated nanomedicine products, emphasizing need for standardized characterization techniques accurately gauge effectiveness. Regarding frameworks must be tailored address distinct challenges posed by genetic interventions, necessitating special considerations in efficacy evaluations, particularly concerning vector design, target specificity, long-term patient monitoring. Ethical such as autonomy, informed consent, privacy also demand careful attention, alongside intricate matter intellectual property rights, which balanced against imperative widespread access these life-saving treatments. Collaborative efforts among bodies, researchers, patent offices, private sector essential tackle effectively, international cooperation being especially crucial given global scope vaccine development. Striking right balance between safeguarding properties promoting public health vital fostering innovation equitable ground-breaking technologies, underscoring significance addressing hurdles fully harness benefits vaccines enhancing healthcare outcomes a scale. STATEMENT OF SIGNIFICANCE: Several biomaterials proposed development nanovaccines, from polymeric micelles, PLGA-/PEI-/PLL-nanoparticles, solid lipid nananoparticles, cationic lipoplexes, liposomes, hybrid materials, dendrimers, carbon nanotubes, hydrogels, quantum dots. Lipid nanoparticles (LNPs) have gained tremendous attention since US Food Drug Administration (FDA) approval Pfizer Moderna's COVID-19 raising awareness vaccines. review provides insights into current strategies issues, clinical trials. By navigating landscapes we can unlock full using range promising towards improving worldwide.

Язык: Английский

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Nanomedicine Combats Drug Resistance in Lung Cancer

Advanced Materials, Год журнала: 2023, Номер 36(3)

Опубликована: Ноя. 16, 2023

Lung cancer is the second most prevalent and leading cause of cancer-related death worldwide. Surgery, chemotherapy, molecular targeted therapy, immunotherapy, radiotherapy are currently available as treatment methods. However, drug resistance a significant factor in failure lung treatments. Novel therapeutics have been exploited to address complicated mechanisms advancement nanomedicine extremely promising terms overcoming resistance. Nanomedicine equipped with multifunctional tunable physiochemical properties alignment tumor genetic profiles can achieve precise, safe, effective while minimizing or eradicating cancer. Here, this work reviews discovered for radiotherapy, outlines novel strategies development against This focuses on engineering design, customized delivery, current challenges, clinical translation application resistant

Язык: Английский

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Recent Advances in Nanomedicine for Ocular Fundus Neovascularization Disease Management

Advanced Healthcare Materials, Год журнала: 2024, Номер 13(17)

Опубликована: Фев. 26, 2024

As an indispensable part of the human sensory system, visual acuity may be impaired and even develop into irreversible blindness due to various ocular pathologies. Among diseases, fundus neovascularization diseases (FNDs) are prominent etiologies impairment worldwide. Intravitreal injection anti-vascular endothelial growth factor drugs remains primary therapy but is hurdled by common complications incomplete potency. To renovate current therapeutic modalities, nanomedicine emerged as times required, which endowed with advanced capabilities, able fulfill effective drug delivery achieve precise release control, thus further improving effect. This review provides a comprehensive summary advances in for FND management from state-of-the-art studies. First, modalities FNDs thoroughly introduced, focusing on key challenges delivery. Second, nanocarriers comprehensively reviewed posterior based nanostructures: polymer-based nanocarriers, lipid-based inorganic nanoparticles. Thirdly, characteristics microenvironment, their pathological changes during FNDs, corresponding strategies constructing smart elaborated. Furthermore, prospects discussed.

Язык: Английский

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Oxaliplatin-Loaded Mil-100(Fe) for Chemotherapy–Ferroptosis Combined Therapy for Gastric Cancer

ACS Omega, Год журнала: 2024, Номер 9(14), С. 16676 - 16686

Опубликована: Апрель 1, 2024

Oxaliplatin (Oxa) is a commonly used chemotherapy drug in the treatment of gastric cancer, but its toxic side effects and resistance after long-term use have seriously limited efficacy. Loading drugs with nanomaterials delivering them to tumor site are common ways overcome above problems. However, as carriers do not therapeutic functions on their own, effect single relatively limited, so there still room for progress related research. Herein, we construct Oxa@Mil-100(Fe) nanocomposites by loading Oxa metal–organic framework (MOF) Mil-100(Fe) high biocompatibility large specific surface area. The pore structure conducive amount drug-loading rate up 27.2%. responsive microenvironment (TME) can release Fe3+ under external stimulation. On one hand, inhibit synthesis DNA induce apoptosis cancer cells. other clear overexpressed glutathione (GSH) TME be reduced Fe2+, inhibiting activity peroxidase 4 (GPX4), leading accumulation intracellular lipid peroxides (LPO), at same time releasing number reactive oxygen species (ROS) through Fenton reaction, inducing ferroptosis With combination ferroptosis, shows good effect, killing cells obvious. In nude mouse model subcutaneous transplantation, significant inhibitory growth, an inhibition nearly 60%. addition excellent antitumor activity, has no obvious or effects. This study provides new idea method combined cancer.

Язык: Английский

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Biomolecule‐responsive polymers and their bio‐applications

Interdisciplinary materials, Год журнала: 2024, Номер 3(6), С. 865 - 896

Опубликована: Авг. 14, 2024

Abstract Precise recognition and specific interactions between biomolecules are key prerequisites for ensuring the performance of all actives within living organisms. The convergence biomolecular systems into synthetic materials could endow with high specificity biological sensitivity; this, in turn, enables precise drug release, monitoring or detection important biomolecules, cell manipulation through targeted capture release biomolecules. Meanwhile, from perspective science, application conventional polymers practical poses several challenges, such as low responsiveness sensitivity, inadequate targetability, insufficient anti‐interference capacities, unsatisfactory biocompatibility. These problems be partly attributed to polymers' weak discrimination abilities toward target presence interfering substances abundance. In particular, proposition “precision medicine” project raises higher demands design biomaterials terms their precision targetability. Therefore, there is an urgent demand development new‐generation sensitive comparable biomacromolecules. This promotes a new research direction biomolecule‐responsive diverse applications. review focuses on origin construction polymers, well attractive applications delivery systems, bio‐detection, bio‐sensing, separation, enrichment, regulating adhesion.

Язык: Английский

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Intratumor delivery of amino-modified graphene oxide as a multifunctional photothermal agent for efficient antitumor phototherapy

Journal of Colloid and Interface Science, Год журнала: 2023, Номер 652, С. 1108 - 1116

Опубликована: Авг. 22, 2023

Язык: Английский

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Cyanine Polymersomes Inbreathe Gas Signaling Molecule: SO₂‐Driven Bilayer Tubular Deformation for Transmembrane Traffic Regulation

Angewandte Chemie International Edition, Год журнала: 2023, Номер 62(28)

Опубликована: Май 16, 2023

Abstract Fabricating nanoscale assemblies that can respond to gas signaling molecules has emerged as a field of growing interest owing their unique biomedical applications in gas‐guided delivery and therapeutics. Yet, among variety endogenous gaseous biosignals, exploiting sulfur dioxide (SO 2 ) cue for controllable self‐assembly remains elusive, despite its crucial two‐sided roles both physiology pathology. Here we show SO ‐responsive polymersome system assembled from novel class cyanine‐containing block copolymers. By intake gas, the tautomerism cyanine drives such vesicles continuously deform, change into long nanotubes through axial stretching anisotropic extrusion membranes. Unexpectedly, during this order‐to‐order phase transition, membranes manifest well ‐dose‐dependent permselectivity, which allows cargos different sizes loaded therein be selectively transferred across bilayers. This study would inspire us better understand mimic function shifting biomembrane shape managing transmembrane traffic.

Язык: Английский

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Hypoxia‐Responsive Tetrameric Supramolecular Polypeptide Nanoprodrugs for Combination Therapy

Advanced Healthcare Materials, Год журнала: 2023, Номер 13(6)

Опубликована: Ноя. 4, 2023

Abstract Despite the intense progress of photodynamic and chemotherapy, however, they cannot prevent solid tumor invasion, metastasis, relapse, along with inferior efficacy severe side effects. The hypoxia‐responsive nanoprodrugs integrating functions are highly sought to address above‐mentioned problems overcome hypoxia‐reduced efficacy. Herein, a tetrameric supramolecular polypeptide nanoprodrug (SPN‐TAPP‐PCB4) is constructed from self‐assembly porphyrin‐central poly( l ‐lysine‐azobenzene‐chlorambucil) (TAPP‐(PLL‐Azo‐CB)4) an anionic water‐soluble [2]biphenyl‐extended‐pillar[6]arene (AWBpP6) via synergy hydrophobic, π – stacking, host–guest interactions. Upon laser irradiation, central TAPP can convert oxygen generate single ( 1 O 2 ) kill cells. Furthermore, under acidic PDT‐aggravated hypoxia cell microenvironment, SPN‐TAPP‐PCB4 rapidly disassembled, then efficiently releases activated CB through hypoxic‐responsive cleavage azobenzene linkages. Both in vitro vivo biological studies showcase synergistic cancer‐killing actions between therapy (PDT) chemotherapy (CT) negligible toxicity. Consequently, this offers effective strategy design for potential combo PDT‐CT transition.

Язык: Английский

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Red blood cell-derived materials for cancer therapy: Construction, distribution, and applications

Materials Today Bio, Год журнала: 2023, Номер 24, С. 100913 - 100913

Опубликована: Дек. 15, 2023

Cancer has become an increasingly important public health issue owing to its high morbidity and mortality rates. Although traditional treatment methods are relatively effective, they have limitations such as highly toxic side effects, easy drug resistance, individual variability. Meanwhile, emerging therapies remain limited, their actual anti-tumor effects need be improved. Nanotechnology received considerable attention for development application. In particular, artificial nanocarriers emerged a crucial approach tumor therapy. However, certain deficiencies persist, including immunogenicity, permeability, targeting, biocompatibility. The application of erythrocyte-derived materials will help overcome the above problems enhance therapeutic effects. Erythrocyte-derived can acquired via physical chemical techniques from natural erythrocyte membranes, or through integration these membranes with synthetic inner core using cell membrane biomimetic technology. Their properties biocompatibility long circulation time make them ideal choice delivery nanoparticle biocoating. Thus, red blood cell-derived widely used in field biomedicine. further studies required evaluate efficacy, vivo metabolism, preparation, design, clinical translation. Based on latest research reports, this review summarizes biology, synthesis, characteristics, distribution materials. Furthermore, we provide reference transformation by comprehensively discussing applications technical challenges faced malignant tumors.

Язык: Английский

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