Injectable Antiswelling and High-Strength Bioactive Hydrogels with a Wet Adhesion and Rapid Gelling Process to Promote Sutureless Wound Closure and Scar-free Repair of Infectious Wounds

ACS Nano, Год журнала: 2023, Номер 17(21), С. 22015 - 22034

Опубликована: Окт. 20, 2023

Developing injectable antiswelling and high-strength bioactive hydrogels with wet tissue adhesiveness a rapid gelling process to meet the requirements for hemostasis, sutureless wound closure, scar-free repair of infected skin wounds continues have ongoing challenges. Herein, injectable, antibacterial, antioxidant hydrogel adhesives based on poly(citric acid-co-polyethylene glycol)-g-dopamine amino-terminated Pluronic F127 (APF) micelles loaded astragaloside IV (AS) are prepared. The H2O2/horseradish peroxidase (HRP) system is used cause cross-linking network through oxidative coupling between catechol groups chemical group amino group. exhibit process, high mechanical strength, an effect, good property, H2O2 release behavior, degradability. In addition, present adhesiveness, bursting pressure, excellent antibacterial activity, long-term sustained AS, biocompatibility. perform hemostasis mouse liver, rat rabbit femoral vein bleeding models achieve much better closure healing incisions than biomedical glue surgical sutures. Furthermore, dressing significantly improved MRSA-infected full thickness defect by modulating inflammation, regulating ratio collagen I/III, improving vascularization granulation formation. Thus, AS-loaded show huge potential as multifunctional dressings in vivo wounds.

Язык: Английский

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Photothermal antibacterial antioxidant conductive self-healing hydrogel with nitric oxide release accelerates diabetic wound healing

Composites Part B Engineering, Год журнала: 2023, Номер 266, С. 110985 - 110985

Опубликована: Сен. 9, 2023

Язык: Английский

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Wound management materials and technologies from bench to bedside and beyond

Nature Reviews Materials, Год журнала: 2024, Номер 9(8), С. 550 - 566

Опубликована: Июнь 17, 2024

Язык: Английский

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Supramolecular hydrogels for wound repair and hemostasis

Materials Horizons, Год журнала: 2023, Номер 11(1), С. 37 - 101

Опубликована: Окт. 27, 2023

The unique network characteristics and stimuli responsiveness of supramolecular hydrogels have rendered them highly advantageous in the field wound dressings, showcasing unprecedented potential. However, there are few reports on a comprehensive review hydrogel dressings for repair hemostasis. This first introduces major cross-linking methods hydrogels, which includes hydrogen bonding, electrostatic interactions, hydrophobic host-guest metal ligand coordination some other interactions. Then, we advanced materials reported recent years then summarize basic principles each method. Next, classify structures before outlining their forming process propose potential future directions. Furthermore, also discuss raw materials, structural design principles, material used to achieve functions such as antibacterial function, tissue adhesion, substance delivery, anti-inflammatory antioxidant functions, cell behavior regulation, angiogenesis promotion, hemostasis innovative years. Finally, existing problems well development directions strategy, design, discussed. is proposed stimulate further exploration by researchers future.

Язык: Английский

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A Conductive and Adhesive Hydrogel Composed of MXene Nanoflakes as a Paintable Cardiac Patch for Infarcted Heart Repair

ACS Nano, Год журнала: 2023, Номер 17(13), С. 12290 - 12304

Опубликована: Июнь 20, 2023

Myocardial infarction (MI) is a major cause of death worldwide. After the occurrence MI, heart frequently undergoes serious pathological remodeling, leading to excessive dilation, electrical disconnection between cardiac cells, and fatal functional damage. Hence, extensive efforts have been made suppress remodeling promote repair infarcted heart. In this study, we developed hydrogel patch that can provide mechanical support, conduction, tissue adhesiveness aid in recovery an function. Specifically, conductive adhesive (CAH) by combining two-dimensional titanium carbide (Ti3C2Tx) MXene with natural biocompatible polymers [i.e., gelatin dextran aldehyde (dex-ald)]. The CAH was formed within 250 s mixing precursor solution could be painted. containing 3.0 mg/mL MXene, 10% gelatin, 5% dex-ald exhibited appropriate material characteristics for applications, including uniform distribution high conductivity (18.3 mS/cm), tissue-like elasticity (30.4 kPa), strong adhesion (6.8 resistance various deformations. cytocompatible induced cardiomyocyte (CM) maturation vitro, as indicated upregulation connexin 43 expression faster beating rate. Furthermore, painted onto remained stably adhered epicardium. vivo animal studies revealed treatment significantly improved function alleviated Thus, believe our MXene-based potentially serve promising platform effective electroactive tissues heart, muscle, nerve tissues.

Язык: Английский

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Hydrogel-based dressings designed to facilitate wound healing

Materials Advances, Год журнала: 2023, Номер 5(4), С. 1364 - 1394

Опубликована: Дек. 20, 2023

This review provides an overview of the functionalities hydrogel-based dressings and their role in promoting wound healing.

Язык: Английский

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Conductive Hyaluronic Acid/Deep Eutectic Solvent Composite Hydrogel as a Wound Dressing for Promoting Skin Burn Healing Under Electrical Stimulation

Advanced Healthcare Materials, Год журнала: 2024, Номер 13(17)

Опубликована: Апрель 3, 2024

Abstract Burns can cause severe damage to the skin due bacterial infection and inflammation. Although conductive hydrogels as electroactive burn‐wound dressings achieve remarkable effects on accelerating wound healing, issues such imbalance between their high conductivity mechanical properties, easy dehydration, low transparency must be addressed. Herein, a double‐network eutectogel is fabricated by integrating polymerizable deep eutectic solvents (PDESs)including acrylamide/choline chloride/glycerol (acrylamide‐polymerization crosslink) thiolated hyaluronic acid (disulfide‐bonding crosslink). The introduction of PDESs provides with (up 0.25 S·m −1 ) strength (tensile strain 59–77%) simulating those natural human skin, well satisfactory tissue adhesiveness, self‐healing ability, antibacterial properties. When combined exogenous electrical stimulation, exhibits ability reduce inflammation, stimulate cell proliferation migration, promote collagen deposition angiogenesis, facilitate remodeling. This shows great potential dressing for healing major burn wounds.

Язык: Английский

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Advances in electroactive biomaterials: Through the lens of electrical stimulation promoting bone regeneration strategy

Journal of Orthopaedic Translation, Год журнала: 2024, Номер 47, С. 191 - 206

Опубликована: Июнь 27, 2024

The regenerative capacity of bone is indispensable for growth, given that accidental injury almost inevitable. Bone relevant the aging population globally and repair large defects after osteotomy (e.g., following removal malignant tumours). Among many therapeutic modalities proposed to regeneration, electrical stimulation has attracted significant attention owing its economic convenience exceptional curative effects, various electroactive biomaterials have emerged. This review summarizes current knowledge progress regarding strategies improving repair. Such range from traditional methods delivering via electroconductive materials using external power sources self-powered biomaterials, such as piezoelectric nanogenerators. Electrical osteogenesis are related piezoelectricity. examines cell behaviour potential mechanisms electrostimulation in healing, aiming provide new insights regeneration biomaterials. roles rehabilitating microenvironment facilitate addressing whereby cues mediate regeneration. Interactions between osteogenesis-related cells summarized, leading proposals use stimulation-based therapies accelerate healing.

Язык: Английский

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PEDOTs‐Based Conductive Hydrogels: Design, Fabrications, and Applications

Advanced Materials, Год журнала: 2024, Номер unknown

Опубликована: Дек. 23, 2024

Abstract Conductive hydrogels combine the benefits of soft with electrical conductivity and have gained significant attention over past decade. These innovative materials, including poly(3,4‐ethylenedioxythiophene) (PEDOTs)‐based conductive (P‐CHs), are promising for flexible electronics biological applications due to their tunable flexibility, biocompatibility, hydrophilicity. Despite recent advances, intrinsic correlation between design, fabrications, P‐CHs has been mostly based on trial‐and‐error‐based Edisonian approaches, significantly limiting further development. This review comprehensively examines design strategies, fabrication technologies, diverse P‐CHs. By summarizing such as molecular, network, phase, structural engineering, exploring both 2D 3D techniques, this offers a comprehensive overview in fields bioelectronics, actuators, energy devices, solar evaporators. Establishing critical internal connection fabrication, application aims guide future research stimulate innovation field functional P‐CHs, offering broad multidisciplinary researchers.

Язык: Английский

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Polymer ionogels and their application in flexible ionic devices

SmartMat, Год журнала: 2024, Номер 5(2)

Опубликована: Янв. 2, 2024

Abstract Polymer ionogel (PIG) is a new type of flexible, stretchable, and ion‐conductive material, which generally consists two components (polymer matrix materials ionic liquids/deep eutectic solvents). More more attention has been received owing to its excellent properties, such as nonvolatility, good conductivity, thermal stability, high electrochemical transparency. In this review, the latest research developments PIGs are comprehensively reviewed according different polymer matrices. Particularly, development novel structural designs, preparation methods, basic their advantages respectively summarized. Furthermore, typical applications in flexible skin, electrochromic devices, actuators, power supplies reviewed. The working mechanism, device structure design strategies, unique functions PIG‐based devices briefly introduced. Finally, perspectives on current challenges future directions application discussed.

Язык: Английский

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