Abstract
Peripheral
nerve
block
is
performed
for
precise
pain
control
and
lesser
side
effects
after
surgery
by
reducing
opioid
consumption.
Injectable
hydrogel
delivery
systems
with
high
biosafety
moisture
content
have
good
clinical
application
prospects
local
anesthetic
delivery.
However,
how
to
achieve
drug
loading
long‐term
controlled
release
of
water‐soluble
narcotic
drugs
remains
a
big
challenge.
In
this
study,
heterogeneous
microspheres
an
injectable
gel‐matrix
composite
system
are
designed
in
two
steps.
First,
loaded
ropivacaine
(HMS‐ROP)
prepared
using
microfluidic
chip
situ
alkalization.
An
self‐healing
matrix
(Gel)
then
from
modified
carboxymethylcellulose
(CMC‐ADH)
oxidized
hyaluronic
acid
(OHA).
A
system,
Gel/HMS‐ROP/dexmedetomidine
(DEX),
retention
vivo
combining
HMS‐ROP
Gel/DEX.
The
reached
41.1%,
time
over
160
h
vitro,
sensory
motor
blockade
times
48
36
h,
respectively.
summary,
the
sequential
synergistic
analgesic
anesthetics
realized
core‐shell
microspheres,
DEX,
gel,
providing
promising
strategy
long‐acting
postoperative
management.
Sustained
release
is
highly
desired
for
"efficacious,
safe
and
convenient"
drug
delivery,
particularly
those
anticancer
molecules
with
toxicity.
In
this
study,
a
modified
coaxial
electrospraying
process
was
developed
to
coat
hydrophobic
lipid,
i.e.,
stearic
acid
(SA),
on
composites
composed
of
the
tamoxifen
citrate
(TC)
insoluble
polymeric
matrix
ethylcellulose
(EC).
Compared
electrosprayed
TC-EC
composite
microparticles
M1,
SA-coated
hybrid
M2
were
able
provide
an
improved
TC
sustained-release
profile.
The
30%
90%
loaded
time
periods
extended
3.21
h
19.43
M2,
respectively,
which
significantly
longer
than
provided
by
M1
(0.88
9.98
h,
respectively).
morphology,
inner
structure,
physical
state,
compatibility
components
particles
disclosed
through
SEM,
TEM,
XRD,
FTIR.
Based
analyses,
mechanism
multiple
factors
co-acting
suggested,
include
reasonable
selections
organizations
lipid
excipient,
blank
SA
shell
loading,
regularly
round
shape,
also
high
density.
reported
protocols
pioneered
brand-new
manner
developing
sustained
delivery
hybrids
combination
cellulose
gels
using
electrospraying.
Life Sciences,
Год журнала:
2024,
Номер
352, С. 122899 - 122899
Опубликована: Июль 9, 2024
This
comprehensive
review
provides
an
in-depth
analysis
of
how
nanotechnology
has
revolutionized
cancer
theragnostic,
which
combines
diagnostic
and
therapeutic
methods
to
customize
treatment.
The
study
examines
the
unique
attributes,
uses,
difficulties
linked
different
types
nanoparticles,
including
gold,
iron
oxide,
silica,
Quantum
dots,
Carbon
nanotubes,
liposomes,
in
context
In
addition,
paper
progression
nanotheranostics,
emphasizing
its
uses
precise
medication
administration,
photothermal
therapy,
sophisticated
such
as
MRI,
CT,
fluorescence
imaging.
Moreover,
article
highlights
capacity
nanoparticles
improve
effectiveness
drugs,
reduce
overall
toxicity
body,
open
up
new
possibilities
for
treating
by
releasing
drugs
a
controlled
manner
targeting
specific
areas.
Furthermore,
it
tackles
concerns
regarding
compatibility
their
potential
harmful
effects,
significance
continuous
nanotherapeutic
use
medical
treatments.
finishes
outlining
future
applications
predictive
oncology
customized
medicine.
Gels,
Год журнала:
2024,
Номер
10(4), С. 262 - 262
Опубликована: Апрель 13, 2024
Hydrogels,
with
their
distinctive
three-dimensional
networks
of
hydrophilic
polymers,
drive
innovations
across
various
biomedical
applications.
The
ability
hydrogels
to
absorb
and
retain
significant
volumes
water,
coupled
structural
integrity
responsiveness
environmental
stimuli,
renders
them
ideal
for
drug
delivery,
tissue
engineering,
wound
healing.
This
review
delves
into
the
classification
based
on
cross-linking
methods,
providing
insights
synthesis,
properties,
We
further
discuss
recent
advancements
in
hydrogel-based
delivery
systems,
including
oral,
injectable,
topical,
ocular
approaches,
highlighting
significance
enhancing
therapeutic
outcomes.
Additionally,
we
address
challenges
faced
clinical
translation
propose
future
directions
leveraging
potential
personalized
medicine
regenerative
healthcare
solutions.
Gels,
Год журнала:
2024,
Номер
10(4), С. 216 - 216
Опубликована: Март 22, 2024
Hydrogels,
being
hydrophilic
polymer
networks
capable
of
absorbing
and
retaining
aqueous
fluids,
hold
significant
promise
in
biomedical
applications
owing
to
their
high
water
content,
permeability,
structural
similarity
the
extracellular
matrix.
Recent
chemical
advancements
have
bolstered
versatility,
facilitating
integration
molecules
guiding
cellular
activities
enabling
controlled
activation
under
time
constraints.
However,
conventional
synthetic
hydrogels
suffer
from
inherent
weaknesses
such
as
heterogeneity
network
imperfections,
which
adversely
affect
mechanical
properties,
diffusion
rates,
biological
activity.
In
response
these
challenges,
hybrid
emerged,
aiming
enhance
strength,
drug
release
efficiency,
therapeutic
effectiveness.
These
hydrogels,
featuring
improved
formulations,
are
tailored
for
tissue
regeneration
across
both
soft
hard
tissues.
The
scientific
community
has
increasingly
recognized
versatile
characteristics
particularly
sector.
This
comprehensive
review
delves
into
recent
hydrogel
systems,
covering
diverse
types,
modification
strategies,
nano/microstructures.
discussion
includes
innovative
fabrication
techniques
click
reactions,
3D
printing,
photopatterning
alongside
elucidation
mechanisms
bioactive
molecules.
By
addressing
underscores
envisages
a
promising
future
various
domains
field.
Nano-Micro Letters,
Год журнала:
2024,
Номер
16(1)
Опубликована: Март 8, 2024
Abstract
Sustainable
agriculture
plays
a
crucial
role
in
meeting
the
growing
global
demand
for
food
while
minimizing
adverse
environmental
impacts
from
overuse
of
synthetic
pesticides
and
conventional
fertilizers.
In
this
context,
renewable
biopolymers
being
more
sustainable
offer
viable
solution
to
improve
agricultural
sustainability
production.
Nano/micro-structural
supramolecular
are
among
these
innovative
that
much
sought
after
their
unique
features.
These
biomaterials
have
complex
hierarchical
structures,
great
stability,
adjustable
mechanical
strength,
stimuli-responsiveness,
self-healing
attributes.
Functional
molecules
may
be
added
flexible
structure,
enabling
novel
uses.
This
overview
scrutinizes
how
nano/micro-structural
radically
alter
farming
practices
solve
lingering
problems
sector
namely
production,
soil
health,
resource
efficiency.
Controlled
bioactive
ingredient
released
allows
tailored
administration
agrochemicals,
agents,
biostimulators
as
they
enhance
nutrient
absorption,
moisture
retention,
root
growth.
protect
crops
by
appending
antimicrobials
biosensing
entities
eco-friendliness
supports
agriculture.
Despite
potential,
further
studies
warranted
understand
optimize
usage
domain.
effort
seeks
bridge
knowledge
gap
investigating
applications,
challenges,
future
prospects
sector.
Through
experimental
investigations
theoretical
modeling,
aims
provide
valuable
insights
into
practical
implementation
optimization
agriculture,
ultimately
contributing
development
eco-friendly
solutions
productivity
impact.
