Postbiotics
are
the
non-viable
bacterial
products
or
low
molecular
weight
metabolites
produced
by
probiotics
that
have
received
considerable
attention
owing
to
their
health
promoting
effects.
The
present
study
aimed
investigate
safety
and
antibacterial
properties
of
postbiotic
components
Lacticaseibacillus
rhamnosus
(Lra)
Limosilactobacillus
reuteri
(Lre)
for
potential
applications
in
food
products.
freeze
dried
(FD-P)
from
Lra
Lre
were
extensively
analyzed
physico-chemical
actions
against
common
borne
pathogens.
Higher
levels
total
flavonoids
(1971.79
±
20
mg
Qu/
g),
short-chain
fatty
acid
(23
µg/g),
sugar
contents,
CAT,
SOD
anti-oxidative
enzymes
detected
postbiotic,
while
GSH-px
riboflavin
higher
postbiotics
(P
<
0.01).
No
significant
differences
recorded
phenolic
(2501
2518
GAE/
L)
crude
protein
contents
(305.
58
296.23
µg/g)
(p
≥
0.05),
respectively.
Both
FD-P
samples
showed
enhanced
activities
Gram-Positive
pathogens
compared
Gram-Negative
combining
two
further
potentiated
actions.
non-hemolytic
human
erythrocyte
cells,
exhibited
cytotoxicity
MRC
5
IPEC-J2
cell
lines
at
highest
used
concentrations
(150
mg/ml).
In
summary,
derived
safe
bioactive
ingredients
with
antioxidant
capabilities,
having
as
a
natural
preservatives
system,
potentially
enhancing
extending
shelf
life
Food & Function,
Год журнала:
2024,
Номер
15(10), С. 5496 - 5509
Опубликована: Янв. 1, 2024
Postbiotics
have
been
proposed
as
clinically
viable
alternatives
to
probiotics,
addressing
limitations
and
safety
concerns
associated
with
probiotic
use.
However,
direct
comparisons
between
the
functional
differences
health
benefits
of
probiotics
postbiotics
remain
scarce.
This
study
compared
directly
desensitization
effect
derived
from
Experimental & Molecular Medicine,
Год журнала:
2024,
Номер
56(8), С. 1691 - 1702
Опубликована: Авг. 1, 2024
Although
the
role
of
gut
microbiota
(GMB)-derived
metabolites
in
mitochondrial
and
endolysosomal
dysfunction
Alzheimer's
disease
(AD)
under
metabolic
syndrome
remains
unclear,
deciphering
these
host-metabolite
interactions
represents
a
major
public
health
challenge.
Dysfunction
mitochondria
networks
(ELNs)
plays
crucial
can
exacerbate
AD
progression,
highlighting
need
to
study
their
reciprocal
regulation
for
better
understanding
how
is
linked
syndrome.
Concurrently,
disorders
are
associated
with
alterations
composition
GMB.
Recent
evidence
suggests
that
changes
GMB
its
may
be
involved
pathology.
This
review
highlights
mechanisms
syndrome-mediated
development,
focusing
on
interconnected
roles
dysfunction,
ELN
abnormalities,
metabolites.
We
also
discuss
pathophysiological
GMB-derived
metabolites,
including
amino
acids,
fatty
other
extracellular
vesicles,
mediating
effects
dysfunction.
Finally,
this
proposes
therapeutic
strategies
by
directly
modulating
functions
through
targeting
Postbiotics
are
the
non-viable
bacterial
products
or
low
molecular
weight
metabolites
produced
by
probiotics
that
have
received
considerable
attention
owing
to
their
health
promoting
effects.
The
present
study
aimed
investigate
safety
and
antibacterial
properties
of
postbiotic
components
Lacticaseibacillus
rhamnosus
(Lra)
Limosilactobacillus
reuteri
(Lre)
for
potential
applications
in
food
products.
freeze
dried
(FD-P)
from
Lra
Lre
were
extensively
analyzed
physico-chemical
actions
against
common
borne
pathogens.
Higher
levels
total
flavonoids
(1971.79
±
20
mg
Qu/
g),
short-chain
fatty
acid
(23
µg/g),
sugar
contents,
CAT,
SOD
anti-oxidative
enzymes
detected
postbiotic,
while
GSH-px
riboflavin
higher
postbiotics
(P
<
0.01).
No
significant
differences
recorded
phenolic
(2501
2518
GAE/
L)
crude
protein
contents
(305.
58
296.23
µg/g)
(p
≥
0.05),
respectively.
Both
FD-P
samples
showed
enhanced
activities
Gram-Positive
pathogens
compared
Gram-Negative
combining
two
further
potentiated
actions.
non-hemolytic
human
erythrocyte
cells,
exhibited
cytotoxicity
MRC
5
IPEC-J2
cell
lines
at
highest
used
concentrations
(150
mg/ml).
In
summary,
derived
safe
bioactive
ingredients
with
antioxidant
capabilities,
having
as
a
natural
preservatives
system,
potentially
enhancing
extending
shelf
life
