Laboratory Medicine, Год журнала: 2024, Номер 56(1), С. 55 - 63
Опубликована: Авг. 5, 2024
Increased proinflammatory molecules are a main reason for severe symptoms in patients infected with SARS-CoV-2. This study evaluated mutations the S gene of SARS-CoV-2 and expression hsa-miR-223-5p, interleukin 2 receptor α (IL-2Rα), CCL16 chemokine hospitalized patients.
Язык: Английский
Current Medical Research and Opinion, Год журнала: 2024, Номер 40(11), С. 1943 - 1961
Опубликована: Окт. 16, 2024
The development of therapies followed a generalized approach for long time, assuming that single treatment could effectively address various patient populations. However, recent breakthroughs have revealed the limitations this one-size-fits-all paradigm. More recently, field therapeutics has witnessed shift toward other modules, including cell therapies, high molecular weight remedies, personalized medicines, and gene therapies. Such advancements in therapeutic modules potential to revolutionize healthcare pave way medicines are more efficient with minimal side effects. Cell gained considerable attention regenerative medicine. Stem cell-based instance, hold promise tissue repair regeneration, ongoing research focusing on enhancing their efficacy safety. High drugs like peptides proteins emerged as promising because specificity diverse biological functions. Engineered developed targeted drug delivery, immunotherapy, disease-modulation. In medicine, tailored treatments individuals based specific genetic profiling, lifestyle, biomarkers, disease characteristics all implemented. Clinicians optimize outcomes minimize adverse effects, using mutations, yielding remarkable results. Gene revolutionized disorders by directly targeting underlying abnormalities. Innovative techniques, such CRISPR-Cas9 allowed precise editing, opening up possibilities curing previously incurable conditions. conclusion,
Язык: Английский
Процитировано
10
Frontiers in Immunology, Год журнала: 2023, Номер 14
Опубликована: Май 5, 2023
Background Gastric cancer (GC) represents a malignancy with multi-factorial combination of genetic, environmental, and microbial factors. Targeting lysosomes presents significant potential in the treatment numerous diseases, while lysosome-related genetic markers for early GC detection have not yet been established, despite implementing this process by assembling artificial intelligence algorithms would greatly break through its value translational medicine, particularly immunotherapy. Methods To end, study, utilizing transcriptomic as well single cell data integrating 20 mainstream machine-learning (ML) algorithms. We optimized an AI-based predictor diagnosis. Then, reliability model was initially confirmed results enrichment analyses currently use. And immunological implications genes comprising explored response patients were evaluated to immunotherapy chemotherapy. Further, we performed systematic laboratory work evaluate build-up central genes, both at expression stage functional aspect, which could also demonstrate guide Results Eight lysosomal-related selected predictive construction based on inclusion RMSE reference standard RF algorithm ranking, namely ADRB2, KCNE2, MYO7A, IFI30, LAMP3, TPP1, HPS4, NEU4. Taking into account accuracy, precision, recall, F1 measurements, preliminary determination our study carried out means applying extra tree random forest algorithms, incorporating ROC-AUC consideration, Extra Tree seems be optimal option AUC 0.92. The superiority diagnostic signature is reflected analysis immune features. Conclusion In summary, first integrate around ML construct gastric genes. This will facilitate accurate prediction incidence subsequent risk assessment or precise individualized immunotherapy, thus improving survival prognosis patients.
Язык: Английский
Процитировано
18
Environmental Science Advances, Год журнала: 2024, Номер 3(5), С. 635 - 660
Опубликована: Янв. 1, 2024
Iron oxide nanoparticles (IONPs) are ubiquitous in nature. They can play dual functions, one neuroprotection and other neurodegeneration.
Язык: Английский
Процитировано
6
Current Pharmaceutical Design, Год журнала: 2023, Номер 30(1), С. 31 - 47
Опубликована: Дек. 28, 2023
Medulloblastomas (MDB) are malignant, aggressive brain tumors that primarily affect children. The survival rate for children under 14 is approximately 72%, while ages 15 to 39, it around 78%. A growing body of evidence suggests dysregulation signaling mechanisms and noncoding RNA epigenetics play a pivotal role in this disease.
Язык: Английский
Процитировано
13
Functional & Integrative Genomics, Год журнала: 2025, Номер 25(1)
Опубликована: Март 28, 2025
Язык: Английский
Процитировано
0
The EPMA Journal, Год журнала: 2025, Номер unknown
Опубликована: Янв. 16, 2025
Язык: Английский
Процитировано
0
International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(16), С. 12648 - 12648
Опубликована: Авг. 10, 2023
Long COVID, also called post-acute sequelae of SARS-CoV-2, is characterized by a multitude lingering symptoms, including impaired cognition, that can last for many months. This symptom, often "brain fog", affects the life quality numerous individuals, increasing medical complications as well healthcare expenditures. The etiopathogenesis SARS-CoV-2-induced cognitive deficit unclear, but most likely cause chronic inflammation maintained viral remnant thriving in select body reservoirs. These sanctuaries are comprised fused, senescent cells, microglia and astrocytes, pathogen convert into neurotoxic phenotypes. Moreover, enteric nervous system contains neurons glia, virus lingers gastrointestinal tract well, accounting intestinal symptoms long COVID. Fusogens proteins overcome repulsive forces between cell membranes, allowing to coalesce with host cells enter cytoplasm. In intracellular compartment, hijacks actin cytoskeleton, fusing each other engendering pathological syncytia. Cell-cell fusion enables infect healthy neighboring cells. We surmise syncytia formation drives impairment facilitating "seeding" hyperphosphorylated Tau, documented COVID-19. our previous work, we hypothesized SARS-CoV-2 induces premature endothelial senescence, permeability blood-brain barrier. migration microbes and/or their components circulation, eventually reaching brain where they may induce dysfunction. For example, translocated lipopolysaccharides or microbial DNA Tau hyperphosphorylation, memory problems. this perspective article, examine pathogenetic mechanisms potential biomarkers cell-free DNA, interleukin 22, phosphorylated beneficial effect transcutaneous vagal nerve stimulation.
Язык: Английский
Процитировано
10
Chemosphere, Год журнала: 2024, Номер 355, С. 141765 - 141765
Опубликована: Март 24, 2024
Due to the increasing evidence of widespread sub-micron pollutants in atmosphere, impact airborne nanoparticles is a subject great relevance. In particular, smallest particles are considered most active and dangerous, having higher surface/volume ratio. Here we tested effect iron oxide (Fe3O4) (IONPs) with different mean diameter size distribution on model plant Tillandsia usneoides. Strands were placed home-built closed boxes exposed levels IONPs reported for roadside air, i.e. order 107 - 108 items m−2. Plant growth other morpho-physiological parameters monitored two weeks, showing that exposure significantly reduced length increment treated strands respect controls. A dose-dependence this impairing was found only few tens nanometers. These also proved be toxic at highest concentration tested. The IONP-induced hamper correlated altered macro- micronutrients plant, while no significant variation photosynthetic activity detected samples. Microscopy investigation showed could adhere surface preferentially located trichome wings. Our results report, first time, negative effects IONP pollution health, thus raising concerns about related environmental risks. Future research should devoted species assess plants devise suitable attenuation practices.
Язык: Английский
Процитировано
3
Interdisciplinary cancer research, Год журнала: 2024, Номер unknown
Опубликована: Янв. 1, 2024
Язык: Английский
Процитировано
2
International Journal of Biological Macromolecules, Год журнала: 2024, Номер 268, С. 131734 - 131734
Опубликована: Апрель 21, 2024
Язык: Английский
Процитировано
1