Significance of flavonoids targeting PI3K/Akt/HIF-1α signaling pathway in therapy-resistant cancer cells – A potential contribution to the predictive, preventive, and personalized medicine

Journal of Advanced Research, Год журнала: 2023, Номер 55, С. 103 - 118

Опубликована: Март 4, 2023

Cancer management faces multiple obstacles, including resistance to current therapeutic approaches. In the face of challenging microenvironments, cancer cells adapt metabolically maintain their supply energy and precursor molecules for biosynthesis thus sustain rapid proliferation tumor growth. Among various metabolic adaptations observed in cells, altered glucose metabolism is most widely studied. The aberrant glycolytic modification has been associated with cell division, growth, progression, drug resistance. higher rates glycolysis as a hallmark modulated by transcription factor hypoxia inducible 1 alpha (HIF-1α), downstream target PI3K/Akt signaling, deregulated pathway cancer. We provide detailed overview current, primarily experimental, evidence on potential effectiveness flavonoids combat glycolysis-induced conventional targeted therapies. manuscript focuses reducing via affecting PI3K/Akt, HIF-1α (as critical that regulated pathway), key mediators PI3K/Akt/HIF-1α signaling (glucose transporters enzymes). working hypothesis proposes – an attractive application mitigate Phytochemicals represent source promising substances applicable primary, secondary, tertiary care. However, accurate patient stratification individualized profiling crucial steps paradigm shift from reactive predictive, preventive, personalized medicine (PPPM / 3PM). article focused targeting molecular patterns natural provides evidence-based recommendations 3PM relevant implementation.

Язык: Английский

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Systemic Inflammation as the Health-Related Communication Tool Between the Human Host and Gut Microbiota in the Framework of Predictive, Preventive, and Personalized Medicine

Advances in predictive, preventive and personalised medicine, Год журнала: 2024, Номер unknown, С. 203 - 241

Опубликована: Янв. 1, 2024

Язык: Английский

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Reprogramming of glucose metabolism: The hallmark of malignant transformation and target for advanced diagnostics and treatments

Biomedicine & Pharmacotherapy, Год журнала: 2024, Номер 178, С. 117257 - 117257

Опубликована: Авг. 12, 2024

Reprogramming of cancer metabolism has become increasingly concerned over the last decade, particularly reprogramming glucose metabolism, also known as "Warburg effect". The is considered a novel hallmark human cancers. A growing number studies have shown that can regulate many biological processes cancers, including carcinogenesis, progression, metastasis, and drug resistance. In this review, we summarize major functions, clinical significance, potential targets signaling pathways metabolic in Moreover, applications natural products small molecule inhibitors targeting are analyzed, some agents trial statuses summarized, well pros cons for therapy analyzed. Overall, plays an important role prediction, prevention, diagnosis treatment Glucose reprogramming-related great to serve biomarkers improving individual outcomes prognosis patients. innovations related will be hotspot research future. We suggest more high-quality trials with abundant formulations toxicology experiments would beneficial development application drugs metabolism.This review provide researchers broader perspective comprehensive understanding about significance

Язык: Английский

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Anti-cancer potential of hydroethanolic extracts of Kyllinga nemoralis: an in vitro and in-silico studies

Pharmacological Research - Natural Products, Год журнала: 2025, Номер 6, С. 100161 - 100161

Опубликована: Янв. 31, 2025

Язык: Английский

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Comparative efficacy of epigallocatechin gallate and its nano-formulation in prostate cancer 3D spheroids model

Journal of King Saud University - Science, Год журнала: 2023, Номер 35(4), С. 102627 - 102627

Опубликована: Март 2, 2023

Prostate cancer (PCa) remains one of the clinically relevant pathologies that needs pragmatic and effective treatment approaches. The current study aimed to evaluate anticancer potential epigallocatechin gallate (EGCG) EGCG-loaded nanoparticles (EGCG NP) for prostate in in-vitro 3D spheroid model. EGCG NPs was synthesized by using polymeric method as reported our previous study. A assay conducted human specific cell lines (PC3 22Rv1) cultured on poly-HEMA-covered plates at different time points. Once formed, spheroids were treated with either alone or continuously 6 days. Simultaneously, controls also taken comparison purpose. CellROX dye used quantitate formation reactive oxygen species (ROS) response 22Rv1 PC3, spheroids. evaluated measure modulation mitochondrial membrane quantification apoptotic live cells a flow cytometer. sizes both studied found be significantly (p < 0.05) reduced after its nanoformulation. significant increase ROS observed PC3 EGCG-NPs treatment. However, no change cells. Similarly, compounds NPs) did not show any changes Interestingly, showed between but nanoformulation didn't number Our doses highlighting possible advantage model specifically further preclinical vivo studies are recommended suitable decipher vitro data exploit against cancer. results indicate efficacy PCa lines.

Язык: Английский

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Phytochemical-based nanodrugs going beyond the state-of-the-art in cancer management—Targeting cancer stem cells in the framework of predictive, preventive, personalized medicine

Frontiers in Pharmacology, Год журнала: 2023, Номер 14

Опубликована: Март 23, 2023

Cancer causes many deaths worldwide each year, especially due to tumor heterogeneity leading disease progression and treatment failure. Targeted of heterogeneous population cells - cancer stem is still an issue in protecting affected individuals against associated multidrug resistance progression. Nanotherapeutic agents have the potential go beyond state-of-the-art approaches overall management. Specially assembled nanoparticles act as carriers for targeted drug delivery. Several nanodrugs already been approved by US Food Drug Administration (FDA) treating different types. Phytochemicals isolated from plants demonstrate considerable nanomedical applications oncology thanks their antioxidant, anti-inflammatory, anti-proliferative, other health benefits. Phytochemical-based NPs can enhance anticancer therapeutic effects, improve cellular uptake agents, mitigate side effects toxic treatments. Per evidence, phytochemical-based specifically target CSCs decreasing risks relapse metastatic manifestation. Therefore, this review focuses on current outlook targeting research studies consideration framework predictive, preventive, personalized medicine (3PM).

Язык: Английский

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Artificial intelligence in ovarian cancer drug resistance advanced 3PM approach: subtype classification and prognostic modeling

The EPMA Journal, Год журнала: 2024, Номер 15(3), С. 525 - 544

Опубликована: Июль 13, 2024

Язык: Английский

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Targeting benign prostate hyperplasia treatments: AR/TGF-β/NOX4 inhibition by apocynin suppresses inflammation and proliferation

Journal of Advanced Research, Год журнала: 2023, Номер 57, С. 135 - 147

Опубликована: Апрель 14, 2023

Apocynin (Apo), an NADPH oxidase (NOX) inhibitor, has been widely used to treat various inflammatory diseases. However, the therapeutic effects of Apo on benign prostatic hyperplasia (BPH), a multifactorial disease associated with chronic inflammation and hormone imbalance, remain unknown. The link between androgen signaling, reactive oxygen species (ROS), prostate cell proliferation may contribute pathogenesis BPH; therefore, aim this study was identify specific signaling pathway involved demonstrate whether anti-oxidant plays role in prevention treatment BPH. Ingenuity analysis si-RNA transfection were conducted receptor (AR) NOX4 linkage Pathological markers BPH measured by H&E staining, immunoblotting, ELISA, qRT-PCR, immunofluorescence examine effect Apo. Rats stimulated testosterone BPH-1 cells as models. AR network-mediated oxidative stress upregulated model. Next, we examined mouse In testosterone-induced rat model, alleviated pathological enlargement suppressed androgen/AR signaling. upregulation proinflammatory promoted expression factors. Furthermore, regulated TGF-β/Glut9/activin macrophage programming. cells, AR-mediated TGFB alleviating stress. activated anti-inflammatory systems polarization cells. knockdown partially abolished beneficial indicating AR-dependent contrast existing therapies, provide new application for treatment, especially BPH, targeting AR/TGF-β/NOX4 pathway.

Язык: Английский

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CVD phenotyping in oncologic disorders: cardio-miRNAs as a potential target to improve individual outcomes in revers cardio-oncology

Journal of Translational Medicine, Год журнала: 2024, Номер 22(1)

Опубликована: Янв. 12, 2024

Abstract With the increase of aging population and prevalence obesity, incidence cardiovascular disease (CVD) cancer has also presented an increasing tendency. These two different diseases, which share some common risk factors. Relevant studies in field reversing Cardio-Oncology have shown that phenotype CVD a significant adverse effect on tumor prognosis, is mainly manifested by positive correlation between malignant progression concomitant tumors. This distal crosstalk link diseases makes us aware importance diagnosis, prediction, management personalized treatment systemic diseases. The circulatory system bridges interaction cancer, suggests we need to fully consider holistic characteristics these process clinical treatment. circulating exosome-miRNAs been intrinsically associated with -related regulation, become one focuses basic research (as biomarker). changes expression profiles disease-associated miRNAs (Cardio-miRNAs) may adversely affect In this article, sorted screened tumor-related miRNA data based literature, then summarized their commonalities (several important pathways), further discussed conclusions related experimental studies. We take approach considering as factor for malignancy, provides in-depth analysis various regulatory mechanisms or pathways involved dual attribute (Cardio-/Onco-miRNAs). will be key revealing effects tumors highlight nature Therefore, Cardio-miRNAs should given great attention from researchers tumors, might new targets Meanwhile, principles precision medicine (such predictive preventive medicine, 3PM) reverse Cardio-oncology better improve individual outcomes, developing therapy perspective protecting function.

Язык: Английский

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The Role of Different Types of microRNA in the Pathogenesis of Breast and Prostate Cancer

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(3), С. 1980 - 1980

Опубликована: Янв. 19, 2023

Micro ribonucleic acids (microRNAs or miRNAs) form a distinct subtype of non-coding RNA and are widely recognized as one the most significant gene expression regulators in mammalian cells. Mechanistically, regulation occurs through microRNA binding with its response elements 3’-untranslated region target messenger RNAs (mRNAs), resulting post-transcriptional silencing genes, expressing mRNAs. Compared to small interfering RNAs, microRNAs have more complex regulatory patterns, making them suitable for fine-tuning expressions different tissues. Dysregulation is well known causative factors malignant cell growth. Today, there numerous data points regarding cancer transcriptomes, specificity changes various tissues, predictive value specific biomarkers. Breast (BCa) common women worldwide seriously impairs patients’ physical health. Its incidence has been predicted rise further. Mounting evidence indicates that play key roles tumorigenesis development. Prostate (PCa) commonly diagnosed cancers men. Different an important role PCa. Early diagnosis BCa PCa using very useful improving individual outcomes framework predictive, preventive, personalized (3P) medicine, thereby reducing economic burden. This article reviews types progression.

Язык: Английский

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