The Association between Vascular Abnormalities and Glaucoma—What Comes First?

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(17), С. 13211 - 13211

Опубликована: Авг. 25, 2023

Glaucoma is a leading cause of irreversible blindness worldwide. While intraocular pressure (IOP) presents major risk factor, the underlying pathophysiology still remains largely unclear. The correlation between vascular abnormalities and glaucoma has been deliberated for decades. Evidence role played by factors in pathogenesis glaucomatous neurodegeneration already postulated. In addition, fact that causes both structural functional changes to retinal blood vessels described. This review aims investigate published evidence concerning relationship glaucoma, provide an overview "chicken or egg" dilemma glaucoma. this study, several biomarkers progression from perspective, including endothelin-1 (ET-1), nitric oxide, endothelial growth factor (VEGF), matrix metalloproteinases (MMPs), were identified subsequently assessed their potential as pharmacological intervention targets.

Язык: Английский

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Association between migraine and primary open-angle glaucoma: A two-sample Mendelian randomization study

Cephalalgia Reports, Год журнала: 2025, Номер 8

Опубликована: Янв. 1, 2025

Introduction To investigate the association of genetically predicted migraine with risk primary open-angle glaucoma (POAG). Methods estimate shared genetic basis and POAG, we conducted genome-wide correlation analyses using cross-trait linkage disequilibrium score regression. assess potential causal effects on POAG risk, two-sample Mendelian randomization (MR) data from European ancestry individuals. Genetic instruments (N = 54 variants minor allele frequency (MAF) ≥ 0.01) were derived our previous study (GWAS) in UK Biobank (16,709 cases 438,178 controls). For used GWAS summary statistics GERA cohort (3836 48,065 controls) or International Glaucoma Genetics Consortium (15,229 177,473 The inverse-variance weighted (IVW) method was source MR estimates common sensitivity conducted. Results We found that not associated ( r g 0.05; SE 0.11; P 0.69). Further, did detect any evidence between POAG. Conclusion Our results provide for may be a strong factor

Язык: Английский

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Personalized Management of Physiologic/Ophthalmologic Particularities for Predictive Approach and Targeted Prevention of Primary Angle Closure Glaucoma Applied to Persons at Risk

Advances in predictive, preventive and personalised medicine, Год журнала: 2024, Номер unknown, С. 171 - 192

Опубликована: Янв. 1, 2024

Язык: Английский

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Integrative neurovascular coupling and neurotransmitter analyses in anisometropic and visual deprivation amblyopia children

iScience, Год журнала: 2024, Номер 27(6), С. 109988 - 109988

Опубликована: Май 16, 2024

The association between visual abnormalities and impairments in cerebral blood flow brain region potentially results neural dysfunction of amblyopia. Nevertheless, the differences complex mechanisms network coupling its relationship with neurotransmitters remain unclear. Here, neurovascular mechanism neurotransmitter activity children anisometropic amblyopia (AA) deprivation (VDA) was explored. 17 regions significantly abnormal than normal controls. classification abilities units differed two types Correlations different effects were different. findings this study demonstrate a correlation AA VDA, implying their impaired function potential molecular underpinnings. neuroimaging evidence revealed herein offers for development therapies

Язык: Английский

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Genetic association of lipid traits and lipid-related drug targets with normal tension glaucoma: a Mendelian randomization study for predictive preventive and personalized medicine

The EPMA Journal, Год журнала: 2024, Номер 15(3), С. 511 - 524

Опубликована: Июль 13, 2024

Язык: Английский

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Analysis of retinal arteriolar and venular parameters in primary open angle glaucoma

International Journal of Ophthalmology, Год журнала: 2023, Номер 16(5), С. 671 - 679

Опубликована: Апрель 28, 2023

AIM: To measure the retinal vessels of primary open angle glaucoma (POAG) patients on spectral domain optical coherence tomography (SD-OCT) with a full-width at half-maximum (FWHM) algorithm to better explore their structural changes in pathogenesis POAG. METHODS: In this retrospective case-control study, right eyes 32 POAG and 30 healthy individuals were routinely selected. Images supratemporal infratemporal B zones obtained by SD-OCT, edges identified FWHM method. The internal external diameters, wall thickness (WT), cross-sectional area (WCSA) wall-to-lumen ratio (WLR) blood studied. RESULTS: Compared control group, group showed significantly reduced arteriolar outer diameter (RAOD), lumen (RALD) WSCA (124.22±12.42 vs 138.32±10.73 µm, 96.09±11.09 108.53±9.89 4762.02±913.51 5785.75±1148.28 µm2, respectively, all P<0.05) regions (125.01±15.55 141.57±10.77 96.27±13.29 110.83±10.99 4925.56±1302.88 6087.78±1061.55 P<0.05). WT WLR not different between groups, nor venular (RVOD), (RVLD) or region. There was positive correlation parameters visual function. CONCLUSION: POAG, narrowing arterioles significant reduction is observed, while do change. Among parameters, diameter, WT, WLR, venules are affected.

Язык: Английский

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Comparison of the Choroid in Primary Open Angle and Angle Closure Glaucoma Using Optical Coherence Tomography

Journal of Glaucoma, Год журнала: 2023, Номер 32(11), С. e137 - e144

Опубликована: Сен. 4, 2023

The current study highlights distinct choroidal alterations in primary open angle (POAG) and closure (PACG) glaucomas, underscoring the potential of Choroidal Vascularity Index (CVI) as a valuable indicator for understanding glaucoma pathogenesis.To evaluate structural changes patients with POAG PACG healthy controls utilizing CVI subfoveal thickness by enhanced depth imaging optical coherence tomography.This was cross-sectional. A total 171 eyes subjects, comprising 69 untreated POAG, 58 PACG, 44 eyes, were enrolled this study. Subfoveal thickness, luminal area (LA), stromal (SA), measured on imaging-optical tomography scans. parameter is calculated proportion LA to area.This included mean age 51.4 ± 13.3 years, 57.0 7.3 subjects 51.11 10.7 years. groups significantly lower than that control group ( P = 0.001 0.005, respectively); however, not different between two 1.000). had 0.014 0.049, respectively), whereas greater SA 0.041).The normal eyes. reduced observed mainly an increased PACG. role choroid may differ

Язык: Английский

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Glaukompatient mit Verdacht auf Flammer-Syndrom: diagnostische Schritte und therapeutische Konsequenzen

Klinische Monatsblätter für Augenheilkunde, Год журнала: 2024, Номер 241(04), С. 355 - 360

Опубликована: Апрель 1, 2024

Zusammenfassung Entwickelt sich ein Glaukomschaden trotz eines völlig normalen Augendruckes oder schreitet der Schaden gut eingestellten weiter voran, dann finden wir meist andere Risikofaktoren. Eine wichtige Gruppe sind die vaskulären Faktoren. Dabei sollten uns nicht nur auf klassischen Risikofaktoren Arteriosklerose, wie arterielle Hypertonie Dyslipidämie fokussieren, sondern auch Fehlregulationen Durchblutung, insbesondere primäre vaskuläre Dysregulation (PVD). Ein tiefer Blutdruck, jetzt in Jugend, niedriger Body-Mass-Index oft kalte Hände und Füße geben Hinweise. Sehr ist eine PVD gekoppelt mit einer Reihe von anderen Symptomen Zeichen, sprechen einem Flammer-Syndrom (FS). Bei Hinweisen FS machen gezielte Anamnese, 24-h-Blutdruckmessung, Messung des retinalen Venendruckes, dynamische retinale Gefäßanalyse Nagelfalz-Kapillarmikroskopie. Das empfiehlt dann, wenn Patient noch relativ jung rasch fortschreitet. Erhärtet Verdacht, versuchen wir, Blutdruckabfälle zu vermindern, den Venendruck senken, Regulation Durchblutung verbessern oxidativen Stress Mitochondrien reduzieren.

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Characterising the Time Course of the Dilatory Response of Healthy Retinal Arteries during Flicker-Light Provocation

Journal of Vascular Research, Год журнала: 2024, Номер unknown, С. 1 - 9

Опубликована: Ноя. 19, 2024

Introduction: The dilatory response of healthy retinal arterioles to flicker-light (FL) provocation appears be biphasic. vessel diameter rapidly increases (acute phase) over 5–10 s, then barely thereafter (maintenance until FL cessation. This reaction is usually characterised at a single point by two parameters: maximum dilation (MD) relative baseline (MD, %) and time MD (RT, s). paper describes the biphasic arteries during using bi-linear function. Methods: Retinal from 45 adults were examined flicker provocation. Each individual course arterial change was equation compared with RT. Results: Slopes acute phase 0.506%/s, maintenance nearly flat (0.012%/s). mean which changed 7.4 s significantly different RT (16.0 Mean this (2.987%) (3.734%), but it still 80% in less than half Conclusion: Bi-linear fitting parameters better characterises Further stratification clinical groups may provide insight underlying physiology for pathologies.

Язык: Английский

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Eye Yoga for Glaucoma: Recovery of Vascular Dysregulation and Visual Field Loss - A Randomized Controlled Trial

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Ноя. 21, 2024

Purpose Because stress can aggravate primary open angle glaucoma (POAG) progress, we studied if reduction by eye muscle exercises and meditation (Eye Yoga, EY) normalize VD, intraocular pressure (IOP) visual field (VF) function as a complementary, personalized approach of care. Patients Methods: POAG patients were randomized 1:1 to an EY (n = 15) or control group 12). While was practiced daily for one hours month at home using iPod-audio guide, read relaxing books. Outcome criteria IOP, retinal vessel dynamics VF recovery. Results After intervention, patients, but not controls, showed 6.4% IOP (p 0.027). This associated with improvement (mean deviation) which greater in than controls < 0.001). Furthermore, EY, pattern deviation recovered regions where microvessel (third order-branch) vasoconstriction improved (artery: p 0.012; vein: 0.042) mean artery diameter significantly 0.015). When pooling data both groups, regions, non-recovered fields, larger arterial gains (2.4 [-0.3-5.3] MU). Neither treatment had any adverse events. Conclusions is able reduce improve confirms the hypothesis that mental contributing, even key mechanism POAG, blood flow fundamental vision recovery restoration. Daily yoga home-exercises are safe effective complementary PPPM method be easily adopted Trial Registration clinicaltrials.gov (NCT04037384)

Язык: Английский

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